The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Vitamin B12 deficiency from the perspective of a practicing hematologist
Abstract
B12 deficiency is the leading cause of megaloblastic anemia, and although more common in the elderly, can occur at any age. Clinical disease caused by B12 deficiency usually connotes severe deficiency, resulting from a failure of the gastric or ileal phase of physiological B12 absorption, best exemplified by the autoimmune disease pernicious anemia. There are many other causes of B12 deficiency, which range from severe to mild. Mild deficiency usually results from failure to render food B12 bioavailable or from dietary inadequacy. Although rarely resulting in megaloblastic anemia, mild deficiency may be associated with neurocognitive and other consequences. B12 deficiency is best diagnosed using a combination of tests because none alone is completely reliable. The features of B12 deficiency are variable and may be atypical. Timely diagnosis is important, and treatment is gratifying. Failure to diagnose B12 deficiency can have dire consequences, usually neurological. This review is written from the perspective of a practicing hematologist.
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Cites
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Cited by
Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970
Self-citationZhang, N., Li, R.-H., Ma, L., Li, N., Shan, P.-Y., Wang, X.-B., & Liu, A.-F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00001 · Cited by 490
A Pesco-Mediterranean Diet With Intermittent Fasting
O’Keefe, J. H., Torres-Acosta, N., O’Keefe, E. L., Saeed, I. M., Lavie, C. J., Smith, S. E., & Ros, E. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.07.049 · Cited by 45
Nutrient effects on motor neurons and the risk of amyotrophic lateral sclerosis
Goncharova, P. S., Davydova, T. K., Popova, T. E., Novitsky, M. A., Petrova, M. M., Gavrilyuk, O. A., Al-Zamil, M., Zhukova, N. G., Nasyrova, R. F., & Shnayder, N. A. (2021) · Nutrients · doi:10.3390/nu13113804 · Cited by 35
Metadata
- Authors
- Green, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-05-11
- Volume
- 129
- Issue
- 19
- Pages
- 2603-2611
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2602639364
- Cited by
- 398
- References
- 73
- FWCI
- 25.14
- Type
- journal article
- Language
- en
- Open access
- closed
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