Cited by 535Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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The Role of NMDA Receptors in Alzheimer’s Disease

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Liu, Jinping, Chang, Lirong, Song, Yizhi, Li, Hui, Wu, Yan·2019·Frontiers in Neuroscience

DOI 10.3389/fnins.2019.00043PMC PMC6375899

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Abstract

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.

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Authors: Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y.
Affiliations: Tsinghua University (CN)
Capital Medical University (CN)
Corresponding author: Wu, Yan
ORCID: Liu, Jinping
Chang, Lirong
Song, Yizhi
Li, Hui
Wu, Yan
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2019-02-08
Volume: 13
Pages: 43-43
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2019.00043
PMC: PMC6375899
OpenAlex: W2911747652
Cited by: 535
References: 339
Citations by year: 2026: 51 · 2025: 80 · 2024: 82 · 2023: 103 · 2022: 92 · 2021: 71 · 2020: 47 · 2019: 9
FWCI: 6.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: NMDA receptor, Alzheimer's disease, amyloid-beta oligomers, synaptic dysfunction, synaptic depression, memantine, NMDA receptor subunits

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The Role of NMDA Receptors in Alzheimer’s Disease

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