The DOI matches its Crossref record; 339 of the 339 references it cites were found in a registry or an index.
The Role of NMDA Receptors in Alzheimer’s Disease
Open accessAbstract
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.
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“N-methyl-d-aspartate receptor (NMDAR) activation and related excitotoxic events that lead to synaptic dysfunction has also been associated with AD pathology (Liu et al. 2019).”
From Alzheimer’s disease: Targeting the glutamatergic system (2020) · cites this paper as Liu et al. 2019
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Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
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Alzheimer’s disease: Targeting the glutamatergic system
Conway, M. E. (2020) · Biogerontology · doi:10.1007/s10522-020-09860-4 · Cited by 180
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease
Zhang, F., Zhong, R.-J., Cheng, C., Li, S., & Le, W.-D. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00565-5 · Cited by 105
Alzheimer’s disease as type 3 diabetes: understanding the link and implications
Kciuk, M., Kruczkowska, W., Gałęziewska, J., Wanke, K., Kałuzińska-Kołat, Ż., Aleksandrowicz, M., & Kontek, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211955 · Cited by 98
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Mitochondria and Cellular Redox State on the Route from Ageing to Alzheimer's Disease
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Role of Ion Channels in Alzheimer’s Disease Pathophysiology
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“…articles (Babaei 2021; Bordji et al. 2011; Chałupnik and Szymanska 2023; Chang et al. 2012; Chohan and Iqbal 2006; Henley and Wilkinson 2016; Kocahan & Do ǧ an 2017; Liu et al. 2019; Malinow 2012; Mota et al. 2014; Ning et al. 2024; Olney et al. 1996; Riss-man et al. 2007; Zhang et al. 2016).”
Synaptic Organizers in Alzheimer’s Disease: A Classification Based on Amyloid-β Sensitivity
Lee, A. K., Khaled, H., Chofflet, N., & Takahashi, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00281 · Cited by 14
Auvelity as a Potential Treatment for Alzheimer’s Disease
Lepkowsky, C. M. (2022) · Medical Research Archives · doi:10.18103/mra.v10i10.3206 · Cited by 2
Metadata
- Authors
- Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y.
- Affiliations
- Tsinghua University (CN)
- Capital Medical University (CN)
- Corresponding author
- Wu, Yan
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-02-08
- Volume
- 13
- Pages
- 43-43
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC6375899
- OpenAlex
- W2911747652
- Cited by
- 535
- References
- 339
- Citations by year
- 2026: 51 · 2025: 80 · 2024: 82 · 2023: 103 · 2022: 92 · 2021: 71 · 2020: 47 · 2019: 9
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- NMDA receptor, Alzheimer's disease, amyloid-beta oligomers, synaptic dysfunction, synaptic depression, memantine, NMDA receptor subunits
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