Electrical stimulation of the lateral entorhinal cortex causes a frequency-specific BOLD response pattern in the rat brain
Open accessAbstract
Although deep brain stimulation of the entorhinal cortex has recently shown promise in the treatment of early forms of cognitive decline, the underlying neurophysiological processes remain elusive. Therefore, the lateral entorhinal cortex (LEC) was stimulated with trains of continuous 5 Hz and 20 Hz pulses or with bursts of 100 Hz pulses to visualize activated neuronal networks, i.e., neuronal responses in the dentate gyrus and BOLD responses in the entire brain were simultaneously recorded. Electrical stimulation of the LEC caused a wide spread pattern of BOLD responses. Dependent on the stimulation frequency, BOLD responses were only triggered in the amygdala, infralimbic, prelimbic, and dorsal peduncular cortex (5 Hz), or in the nucleus accumbens, piriform cortex, dorsal medial prefrontal cortex, hippocampus (20 Hz), and contralateral entorhinal cortex (100 Hz). In general, LEC stimulation caused stronger BOLD responses in frontal cortex regions than in the hippocampus. Identical stimulation of the perforant pathway, a fiber bundle projecting from the entorhinal cortex to the dentate gyrus, hippocampus proper, and subiculum, mainly elicited significant BOLD responses in the hippocampus but rarely in frontal cortex regions. Consequently, BOLD responses in frontal cortex regions are mediated by direct projections from the LEC rather than via signal propagation through the hippocampus. Thus, the beneficial effects of deep brain stimulation of the entorhinal cortex on cognitive skills might depend more on an altered prefrontal cortex than hippocampal function.
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Brain activities measured by fMRI were increased in the rat mPFC and hippocampus by 5-20 Hz electrical stimulation of the LEC.
“Brain activities, measured by fMRI, were increased in the rat mPFC and hippocampus by 5–20 Hz electrical stimulation of the LEC”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Krautwald et al., 2019
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Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
RARE imaging: A fast imaging method for clinical MR
Hennig, J., Nauerth, A., & Friedburg, H. (1986) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910030602 · Cited by 2,088 · see citing works
The role of medial prefrontal cortex in memory and decision making
Euston, D. R., Gruber, A. J., & McNaughton, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.12.002 · Cited by 1,541 · see citing works
Interplay of Hippocampus and Prefrontal Cortex in Memory
Preston, A. R., & Eichenbaum, H. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.041 · Cited by 1,389 · see citing works
Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area
Suthana, N., Haneef, Z., Stern, J. M., Mukamel, R., Behnke, E., Knowlton, B. J., & Fried, I. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107212 · Cited by 491 · see citing works
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
Stone, S. S. D., Teixeira, C. M., DeVito, L. M., Zaslavsky, K., Josselyn, S. A., Lozano, A. M., & Frankland, P. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3100-11.2011 · Cited by 384 · see citing works
Direct and Indirect Activation of Cortical Neurons by Electrical Microstimulation
Tehovnik, E. J., Tolias, A. S., Sultan, F. R., Slocum, W. M., & Logothetis, N. K. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00126.2006 · Cited by 355 · see citing works
Memory: organization and control.
Eichenbaum, H. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044131 · Cited by 257 · see citing works
Schlichting, M. L., & Preston, A. R. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.005 · Cited by 149 · see citing works
Deep brain stimulation for enhancement of learning and memory
Suthana, N., & Fried, I. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.066 · Cited by 145 · see citing works
Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory
McMahan, R. W., Sobel, T. J., & Baxter, M. G. (1997) · Hippocampus · doi:10.1002/(sici)1098-1063(1997)7:2 · Cited by 109 · see citing works
Entorhinal cortex and consolidated memory
Takehara‐Nishiuchi, K. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.02.012 · Cited by 105 · see citing works
Deep brain stimulation in dementia-related disorders
Hescham, S., Lim, L. W., Jahanshahi, A., Blokland, A., & Temel, Y. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.002 · Cited by 77 · see citing works
Agster, K. L., Pereira, I. T., Saddoris, M. P., & Burwell, R. D. (2016) · Hippocampus · doi:10.1002/hipo.22600 · Cited by 76 · see citing works
Hardenacke, K., Shubina, E., Bührle, C., Zapf, A. C., Lenartz, D., Klosterkötter, J., Visser-Vandewalle, V. E. R. M., & Kuhn, J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00159 · Cited by 68 · see citing works
Xia, F., Yiu, A. P., Stone, S. S. D., Oh, S. J., Lozano, A. M., Josselyn, S. A., & Frankland, P. W. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.100 · Cited by 65 · see citing works
Yaniv, D., Vouimba, R., Diamond, D. M., & Richter‐Levin, G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00386-5 · Cited by 50 · see citing works
Neuromodulation for restoring memory
Bick, S. K. B., & Eskandar, E. N. (2016) · Neurosurgical FOCUS · doi:10.3171/2016.3.focus162 · Cited by 48 · see citing works
Frequency-Dependent Gating of Hippocampal–Neocortical Interactions
Moreno, A., Morris, R., & Canals, S. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv033 · Cited by 41 · see citing works
Neuregulin-1β modulates in vivo entorhinal–hippocampal synaptic transmission in adult rats
Roysommuti, S., Carroll, S. L., & Wyss, J. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00503-7 · Cited by 37 · see citing works
Carmona, M. B., Menigoz, A., Pinto, S., Tambuyzer, T., Krautwald, K., Voets, T., Aerts, J., Angenstein, F., Vennekens, R., & Balschun, D. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1706-1 · Cited by 21 · see citing works
Self-citationHelbing, C., Werner, G., & Angenstein, F. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.001 · Cited by 15 · see citing works
Self-citationAngenstein, F., Krautwald, K., Wetzel, W., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.007 · Cited by 13 · see citing works
Self-citationKrautwald, K., Min, H.-K. P., Lee, K. H., & Angenstein, F. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.046 · Cited by 12 · see citing works
Self-citationRiemann, S., Helbing, C., & Angenstein, F. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16634715 · Cited by 12 · see citing works
Self-citationScherf, T., & Angenstein, F. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.252 · Cited by 8 · see citing works
Self-citationScherf, T., & Angenstein, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172926 · Cited by 8 · see citing works
Self-citationHelbing, C., Tischmeyer, W., & Angenstein, F. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.077 · Cited by 5 · see citing works
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Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
- Authors
- Krautwald, K., Mahnke, L., & Angenstein, F.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Leibniz Institute for Neurobiology (DE)
- Corresponding author
- Angenstein, Frank
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-05-24
- Volume
- 13
- Pages
- 539-539
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC6547013
- OpenAlex
- W2945581354
- Cited by
- 6
- References
- 28
- Citations by year
- 2026: 2 · 2024: 1 · 2021: 2 · 2020: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- DZNE Pub (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- lateral entorhinal cortex, electrical stimulation, BOLD signal, stimulation frequency, perforant path, dentate gyrus, hippocampus, prefrontal cortex, amygdala, nucleus accumbens, piriform cortex, deep brain stimulation, cognitive decline, rat brain
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