Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
Open accessAbstract
Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Electrical stimulation of the EC enhances neurogenesis in the dentate gyrus of the hippocampus.
“and to enhance neurogenesis in the dentate gyrus of the hippocampus”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Stone et al., 2011
Proliferation of newborn neurons in the dentate gyrus increases in response to direct hippocampal stimulation and processes stimulating the hippocampus, such as exercise, spatial learning, and an enriched environment.
“Proliferation of newborn neurons in the dentate gyrus increases in response to direct hippocampal stimulation as well as processes stimulating the hippocampus, such as exercise, spatial learning, and an enriched environment [14–16].”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
A randomized trial of deep-brain stimulation for Parkinson's disease.
Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschländer, A., Dillmann, U., Eisner, W., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060281 · Cited by 2,919 · see citing works
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · see citing works
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R. S., Salanova, V., Witt, T. C., Worth, R. M., Henry, T. R., Gross, R. E., Oommen, K. J., Osorio, I., Nazzaro, J. M., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,930 · see citing works
Parent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., & Lowenstein, D. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03727.1997 · Cited by 1,853 · see citing works
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,829 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia.
Vidailhet, M., Vercueil, L., Houeto, J., Krystkowiak, P., Benabid, A., Cornu, P., Lagrange, C., du Montcel, S. T., Dormont, D., Grand, S., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042187 · Cited by 1,058 · see citing works
Subthalamic nucleus stimulation in severe obsessive-compulsive disorder
Mallet, L., Polosan, M., Jaafari, N., Baup, N., Welter, M.-L., Fontaine, D., Montcel, S. T. D., Yelnik, J., Chéreau, I., Arbus, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708514 · Cited by 965 · see citing works
Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis
Dengke, K., Jang, M., Guo, J. U., Kitabatake, Y., Chang, M.-L., Pow-anpongkul, N., Flavell, R. A., Lu, B., Ming, G., & Song, H. (2009) · Science · doi:10.1126/science.1166859 · Cited by 929 · see citing works
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875 · see citing works
Self-citationGallagher, M., Burwell, R. D., & Burchinal, M. A. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000080 · Cited by 861 · see citing works
Translational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853 · see citing works
A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
Laxton, A. W., Tang‐Wai, D. F., McAndrews, M. P., Zumsteg, D., Wennberg, R. A., Keren, R., Wherrett, J. R., Naglie, G., Hamani, C., Smith, G. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22089 · Cited by 808 · see citing works
Increased neurogenesis in a model of electroconvulsive therapy
Madsen, T. M., Treschow, A., Bengzon, J., Bolwig, T. G., Lindvall, O., & Tingström, A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00228-6 · Cited by 765 · see citing works
Neurons born in the adult dentate gyrus form functional synapses with target cells
Toni, N., Laplagne, D. A., Zhao, C., Lombardi, G., Ribak, C. E., Gage, F. H., & Schinder, A. F. (2008) · Nature Neuroscience · doi:10.1038/nn.2156 · Cited by 741 · see citing works
Charge density and charge per phase as cofactors in neural injury induced by electrical stimulation
McCreery, D. B., Agnew, W. F., Yuen, T. G. H., & Bullara, L. (1990) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.102812 · Cited by 708 · see citing works
Gallagher, M., Burwell, R. D., & Burchinal, M. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.4.618 · Cited by 675 · see citing works
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies
Garthe, A., Behr, J., & Kempermann, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005464 · Cited by 597 · see citing works
Synapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579 · see citing works
Memory enhancement induced by hypothalamic/fornix deep brain stimulation
Hamani, C., McAndrews, M. P., Cohn, M., Oh, M. Y., Zumsteg, D., Shapiro, C. M., Wennberg, R. A., & Lozano, A. M. (2008) · Annals of Neurology · doi:10.1002/ana.21295 · Cited by 530 · see citing works
Tashiro, A., Makino, H., & Gage, F. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4941-06.2007 · Cited by 521 · see citing works
High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor
Koller, W., Pahwa, R., Busenbark, K., Hubble, J., Wilkinson, S., Lang, A., Tuite, P., Sime, E., Lazano, A., Hauser, R., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410420304 · Cited by 516 · see citing works
Brandt, M., Jessberger, S., Steiner, B., Kronenberg, G., Reuter, K., Bick‐Sander, A., von der Behrens, W., & Kempermann, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00207-0 · Cited by 498 · see citing works
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458 · see citing works
Basic algorithms for the programming of deep brain stimulation in Parkinson's disease
Volkmann, J., Moro, E., & Pahwa, R. (2006) · Movement Disorders · doi:10.1002/mds.20961 · Cited by 431 · see citing works
Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat
Gould, E. A., & Tanapat, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00127-9 · Cited by 406 · see citing works
Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy
Parent, J. M., Elliott, R. C., Pleasure, S. J., Barbaro, N. M., & Lowenstein, D. H. (2005) · Annals of Neurology · doi:10.1002/ana.20699 · Cited by 363 · see citing works
Jessberger, S., Zhao, C., Toni, N., Clemenson, G. D., Li, Y., & Gage, F. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2002-07.2007 · Cited by 360 · see citing works
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
Laplagne, D. A., Esposito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040409 · Cited by 359 · see citing works
The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation
van Groen, T., Miettinen, P., & Kadish, I. (2002) · Hippocampus · doi:10.1002/hipo.10037 · Cited by 349 · see citing works
Parent, J. M., Valentin, V. V., & Lowenstein, D. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03174.2002 · Cited by 318 · see citing works
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus
Bruel‐Jungerman, E., Davis, S., Rampon, C., & Laroche, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0782-06.2006 · Cited by 296 · see citing works
Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory
Teixeira, C. M., Pomedli, S., Maei, H. R., Kee, N., & Frankland, P. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1068-06.2006 · Cited by 282 · see citing works
The connections of presubiculum and parasubiculum in the rat
van Groen, T., & Wyss, J. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90976-i · Cited by 269 · see citing works
Davis, K. D., Taub, E., Houle, S., Lang, A. E., Dostrovsky, J. O., Tasker, R. R., & Lozano, A. M. (1997) · Nature Medicine · doi:10.1038/nm0697-671 · Cited by 211 · see citing works
GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities
Shahed, J. J., Poysky, J., Kenney, C., Simpson, R. K., & Jankovic, J. J. (2007) · Neurology · doi:10.1212/01.wnl.0000250354.81556.90 · Cited by 207 · see citing works
Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
Tronel, S., Fabre, A., Charrier, V., Oliet, S. H. R., Gage, F. H., & Abrous, D. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914613107 · Cited by 207 · see citing works
Genetically modified mice and cognition
Lipp, H., & Wolfer, D. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80151-7 · Cited by 203 · see citing works
The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
Toda, H., Hamani, C., Fawcett, A. P., Hutchison, W. D., & Lozano, A. M. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/108/01/0132 · Cited by 198 · see citing works
Trouche, S. G., Bontempi, B., Roullet, P., & Rampon, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811054106 · Cited by 192 · see citing works
Stone, S. S. D., Teixeira, C. M., Zaslavsky, K., Wheeler, A. L., Martínez-Canabal, A., Wang, A. H., Sakaguchi, M., Lozano, A. M., & Frankland, P. W. (2010) · Hippocampus · doi:10.1002/hipo.20845 · Cited by 167 · see citing works
Bath, K. G., Mandairon, N., Jing, D., Rajagopal, R., Kapoor, R., Chen, Z.-Y., Khan, T., Proenca, C. C., Kraemer, R. T., Cleland, T. A., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4387-07.2008 · Cited by 165 · see citing works
Mechanisms and functional significance of aberrant seizure‐induced hippocampal neurogenesis
Parent, J. M., & Murphy, G. G. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01634.x · Cited by 141 · see citing works
Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo
Tashiro, A., Zhao, C., & Gage, F. H. (2006) · Nature Protocols · doi:10.1038/nprot.2006.473 · Cited by 136 · see citing works
Choosing electrodes for deep brain stimulation experiments–electrochemical considerations
Gimsa, J., Habel, B., Schreiber, U., van Rienen, U., Strauß, U., & Gimsa, U. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.09.001 · Cited by 128 · see citing works
Vega, C. J., & Peterson, D. A. (2005) · Nature Methods · doi:10.1038/nmeth741 · Cited by 128 · see citing works
Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis
Laplagne, D. A., Kamienkowski, J. E., Esposito, M. S., Piatti, V. C., Zhao, C., Gage, F. H., & Schinder, A. F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05549.x · Cited by 125 · see citing works
Electroconvulsive Seizure Treatment Increases Cell Proliferation in Rat Frontal Cortex
Madsen, T. M., Yeh, D. D., Valentine, G. W., & Duman, R. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300565 · Cited by 124 · see citing works
Neurogenic hippocampal targets of deep brain stimulation
Encinas, J. M., Hamani, C., Lozano, A. M., & Enikolopov, G. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22503 · Cited by 122 · see citing works
The Timing of Neuronal Development in Adult Hippocampal Neurogenesis
Piatti, V. C., Esposito, M. S., & Schinder, A. F. (2006) · The Neuroscientist · doi:10.1177/1073858406293538 · Cited by 98 · see citing works
Anterior thalamus deep brain stimulation at high current impairs memory in rats
Hamani, C., Dubiela, F. P., Soares, J. C. K., Shin, D. S.-H., Bittencourt, S., Covolan, L., Carlen, P. L., Laxton, A. W., Hodaie, M., Stone, S. S. D., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.06.007 · Cited by 92 · see citing works
Species differences in the projections from the entorhinal cortex to the hippocampus
van Groen, T., Kadish, I., & Wyss, J. M. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00683-9 · Cited by 88 · see citing works
Chun, S., Sun, W., Park, J., & JUNG, M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.05.005 · Cited by 84 · see citing works
Derrick, B. E., York, A., & Martinez, J. L. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02464-6 · Cited by 81 · see citing works
From Stem Cells to Grandmother Cells: How Neurogenesis Relates to Learning and Memory
Shors, T. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.08.010 · Cited by 73 · see citing works
Imaging activation of adult-generated granule cells in spatial memory
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Protocols · doi:10.1038/nprot.2007.415 · Cited by 67 · see citing works
Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats
Jiang, W., Wan, Q., Zhang, Z., Wang, W., Huang, Y., Rao, Z., & Zhang, X. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02438-7 · Cited by 66 · see citing works
Ponce, F. A., & Lozano, A. M. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)84016-6 · Cited by 65 · see citing works
Wolfer, D. P., Mohajeri, H. M., Lipp, H., & Schachner, M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00089.x · Cited by 60 · see citing works
Clapcote, S. J. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.030 · Cited by 56 · see citing works
Gimsa, U., Schreiber, U., Habel, B., Flehr, J., van Rienen, U., & Gimsa, J. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.06.013 · Cited by 54 · see citing works
Entorhinal cortex of the mouse: Cytoarchitectonical organization
van Groen, T. (2001) · Hippocampus · doi:10.1002/hipo.1054 · Cited by 53 · see citing works
北村, 貴., Saitoh, Y., Murayama, A., Sugiyama, H., & Inokuchi, K. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-13 · Cited by 49 · see citing works
Bizon, J. L., Lauterborn, J. C., Isackson, P. J., & Gall, C. M. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960311)366:3 · Cited by 22 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Amaral D, Lavenex P (2007) Hippocampal neuroanatomy. In: The hip- pocampus book, Ed 1 (Anderson P, Morris RG, Amaral DG, Bliss T, O'Keefe J, eds). New York: Oxford UP.
Cited by
Sorted by citations
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014 · see citing works
Adult hippocampal neurogenesis and its role in Alzheimer’s disease
Mu, Y., & Gage, F. H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-85 · Cited by 1,021 · see citing works
Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911 · see citing works
Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H.-L. (., Wheeler, A. L., Guskjolen, A., Niibori, Y., Shoji, H., et al. (2014) · Science · doi:10.1126/science.1248903 · Cited by 761 · see citing works
Self-citationProbing and regulating dysfunctional circuits using deep brain stimulation
Lozano, A. M., & Lipsman, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.020 · Cited by 665 · see citing works
Heck, C. N., King‐Stephens, D., Massey, A. D., Nair, D. R., Jobst, B. C., Barkley, G. L., Salanova, V., Cole, A. J., Smith, M. C. F., Gwinn, R. P., et al. (2014) · Epilepsia · doi:10.1111/epi.12534 · Cited by 654 · see citing works
Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
Bergey, G. K., Morrell, M. J., Mizrahi, E. M., Goldman, A., King-Stephens, D., Nair, D., Srinivasan, S., Jobst, B., Gross, R. E., Shields, D. C., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001280 · Cited by 634 · see citing works
Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area
Suthana, N., Haneef, Z., Stern, J. M., Mukamel, R., Behnke, E., Knowlton, B. J., & Fried, I. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107212 · Cited by 491 · see citing works
Wang, J., Gallagher, D., DeVito, L. M., Cancino, G. I., Tsui, D., He, L., Keller, G. M., Frankland, P. W., Kaplan, D. R., & Miller, F. D. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.03.016 · Cited by 474 · see citing works
Neurogenesis, inflammation and behavior
Kohman, R. A., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.003 · Cited by 363 · see citing works
A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease
Lozano, A. M., Fosdick, L., Chakravarty, M. M., Leoutsakos, J., Munro, C. A., Oh, E. S., Drake, K. E., Lyman, C. H., Rosenberg, P. B., Anderson, W. S., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160017 · Cited by 329 · see citing works
Hippocampal neurogenesis: Learning to remember
Lazarov, O., & Hollands, C. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.006 · Cited by 281 · see citing works
Neurogenesis-mediated forgetting minimizes proactive interference
Epp, J. R., Mera, R. S., Köhler, S., Josselyn, S. A., & Frankland, P. W. (2016) · Nature Communications · doi:10.1038/ncomms10838 · Cited by 229 · see citing works
Jakobs, M., Fomenko, A., Lozano, A. M., & Kiening, K. L. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809575 · Cited by 229 · see citing works
Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease
Sankar, T., Chakravarty, M. M., Bescós, A., Lara, M., Obuchi, T., Laxton, A. W., McAndrews, M. P., Tang‐Wai, D. F., Workman, C. I., Smith, G. S., et al. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.11.020 · Cited by 220 · see citing works
Khacho, M., Clark, A., Svoboda, D. S., MacLaurin, J. G., Lagace, D. C., Park, D. S., & Slack, R. S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx217 · Cited by 192 · see citing works
Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer Disease
Smith, G. S., Laxton, A. W., Tang‐Wai, D. F., McAndrews, M. P., Diaconescu, A. O., Workman, C. I., & Lozano, A. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.590 · Cited by 180 · see citing works
Low‐frequency electrical stimulation of a fiber tract in temporal lobe epilepsy
Koubeissi, M. Z., Kahriman, E. S., Syed, T. U., Miller, J., & Durand, D. M. (2013) · Annals of Neurology · doi:10.1002/ana.23915 · Cited by 178 · see citing works
Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice
Hao, S., Tang, B., Wu, Z.-Y., Ure, K., Sun, Y., Tao, H., Gao, Y., Patel, A. J., Curry, D. J., Samaco, R. C., et al. (2015) · Nature · doi:10.1038/nature15694 · Cited by 173 · see citing works
Sparse activity of identified dentate granule cells during spatial exploration
Diamantaki, M., Frey, M., Berens, P., Preston‐Ferrer, P., & Burgalossi, A. (2016) · eLife · doi:10.7554/elife.20252 · Cited by 162 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Lithium rescues synaptic plasticity and memory in Down syndrome mice
Contestabile, A., Greco, B., Ghezzi, D., Tucci, V., Benfenati, F., & Gasparini, L. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64650 · Cited by 157 · see citing works
Deep Brain Stimulation for Psychiatric Disease: Contributions and Validity of Animal Models
Hamani, C., & Temel, Y. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003722 · Cited by 157 · see citing works
The mechanisms of action of deep brain stimulation and ideas for the future development
Udupa, K., & Chen, R. E. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.08.001 · Cited by 149 · see citing works
Functional circuits of new neurons in the dentate gyrus
Vivar, C., & van Praag, H. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00015 · Cited by 150 · see citing works
Bourne, S. K., Eckhardt, C. A., Sheth, S. A., & Eskandar, E. N. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00029 · Cited by 146 · see citing works
Infantile amnesia: A neurogenic hypothesisPreprint
Josselyn, S. A., & Frankland, P. W. (2012) · Learning & Memory · doi:10.1101/lm.021311.110 · Cited by 149 · see citing works
Deep brain stimulation for enhancement of learning and memory
Suthana, N., & Fried, I. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.066 · Cited by 145 · see citing works
Hosseini, S. M., Borys, B., & Karimi‐Abdolrezaee, S. (2023) · Brain · doi:10.1093/brain/awad392 · Cited by 134 · see citing works
Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis
Yun, S., Reynolds, R. P., Masiulis, I., & Eisch, A. J. (2016) · Nature Medicine · doi:10.1038/nm.4218 · Cited by 127 · see citing works
Deep Brain Stimulation for the Treatment of Alzheimer Disease and Dementias
Laxton, A. W., & Lozano, A. M. (2012) · World Neurosurgery · doi:10.1016/j.wneu.2012.06.028 · Cited by 126 · see citing works
Alderman, B. L., Olson, R. L., Brush, C. J., & Shors, T. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.225 · Cited by 125 · see citing works
Crosstalk among Epigenetic Pathways Regulates Neurogenesis
Jobe, E. M., McQuate, A. L., & Zhao, X. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00059 · Cited by 124 · see citing works
Interaction between Neurogenesis and Hippocampal Memory System: New VistasPreprint
Abrous, D. N., & Wojtowicz, J. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018952 · Cited by 121 · see citing works
Hornsby, A., Redhead, Y. T., Rees, D., Ratcliff, M., Reichenbach, A., Wells, T., Francis, L., Amstalden, K. A. Z., Andrews, Z., & Davies, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.023 · Cited by 112 · see citing works
Hippocampal Neurogenesis Levels Predict WATERMAZE Search Strategies in the Aging Brain
Gil‐Mohapel, J., Brocardo, P. S., Choquette, W., Gothard, R., Simpson, J. M., & Christie, B. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075125 · Cited by 119 · see citing works
Miller, J. P., Sweet, J. A., Bailey, C. M., Munyon, C. N., Lüders, H. O., & Fastenau, P. S. (2015) · Brain · doi:10.1093/brain/awv095 · Cited by 118 · see citing works
Restivo, L., Niibori, Y., Mercaldo, V., Josselyn, S. A., & Frankland, P. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3238-14.2015 · Cited by 112 · see citing works
Fontaine, D., Deudon, A., Lemaire, J., Razzouk, M., Viau, P., Darcourt, J., & Robert, P. H. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121579 · Cited by 110 · see citing works
Chao, O. Y.-H., Huston, J. P., Li, J., Wang, A., & Silva, M. A. D. S. (2015) · Hippocampus · doi:10.1002/hipo.22547 · Cited by 110 · see citing works
Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders
Jun, H., Hussaini, S. M. Q., Rigby, M. J., & Jang, M. (2012) · Neural Plasticity · doi:10.1155/2012/854285 · Cited by 108 · see citing works
Gouveia, F. V., Warsi, N. M., Suresh, H., Matin, R., & Ibrahim, G. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2023.e00308 · Cited by 118 · see citing works
Electrical Stimuli in the Central Nervous System Microenvironment
Thompson, D. M., Koppes, A. N., Hardy, J. G., & Schmidt, C. E. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-121813-120655 · Cited by 107 · see citing works
Hescham, S., Lim, L. W., Jahanshahi, A., Steinbusch, H. W. M., Prickaerts, J., Blokland, A., & Temel, Y. (2012) · Brain stimulation · doi:10.1016/j.brs.2012.01.008 · Cited by 106 · see citing works
Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive
Yun, S., Reynolds, R. P., Petrof, I., White, A., Rivera, P. D., Segev, A., Gibson, A. D., Suarez, M., DeSalle, M. J., Ito, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0002-1 · Cited by 120 · see citing works
Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry
Mankin, E. A., & Fried, I. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.024 · Cited by 107 · see citing works
Leoutsakos, J.-M. S., Yan, H., Anderson, W. S., Asaad, W. F., Baltuch, G., Burke, A., Chakravarty, M. M., Drake, K. E., Foote, K. D., Fosdick, L., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180121 · Cited by 104 · see citing works
Nam, S. M., Choi, J. H., Yoo, D. Y., Kim, W., Jung, H. Y., Kim, J. W., Yoo, M., Lee, S., Kim, C. J., Yoon, Y. S., et al. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.2965 · Cited by 102 · see citing works
Alcohol and adult hippocampal neurogenesis: Promiscuous drug, wanton effects
Geil, C., Hayes, D. M., McClain, J. A., Liput, D. J., Marshall, S. A., Chen, K. Y., & Nixon, K. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.05.003 · Cited by 104 · see citing works
Deep brain stimulation: potential for neuroprotection
McKinnon, C., Gros, P., Lee, D. J., Hamani, C., Lozano, A., Kalia, L., & Kalia, S. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.682 · Cited by 81 · see citing works
Johnston, S. T., Shtrahman, M., Parylak, S., Gonçalves, J. T., & Gage, F. H. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.10.013 · Cited by 98 · see citing works
Sekeres, M. J., Bradley-Garcia, M., Martínez-Canabal, A., & Winocur, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312697 · Cited by 99 · see citing works
Neurogenesis and Hippocampal Plasticity in Adult Brain
Gu, Y., Janoschka, S., & Ge, S. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_217 · Cited by 93 · see citing works
Gao, A., Xia, F., Guskjolen, A. J., Ramsaran, A. I., Santoro, A., Josselyn, S. A., & Frankland, P. W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3126-17.2018 · Cited by 91 · see citing works
Ontogeny of memory: an update on 40 years of work on infantile amnesia
Madsen, H. B., & Kim, J. H. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.030 · Cited by 92 · see citing works
Gondard, E., Chau, H. N., Mann, A., Tierney, T. S., Hamani, C., Kalia, S. K., & Lozano, A. M. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.07.044 · Cited by 90 · see citing works
Differential Effects of Stress and Glucocorticoids on Adult Neurogenesis
Schoenfeld, T. J., & Gould, E. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_233 · Cited by 89 · see citing works
Emerging Therapeutics for Alzheimer's Disease
Chiang, K., & Koo, E. H. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135932 · Cited by 88 · see citing works
Preserved neurogenesis in non-demented individuals with AD neuropathology
Briley, D., Ghirardi, V., Woltjer, R. L., Renck, A., Zolochevska, O., Taglialatela, G., & Micci, M. (2016) · Scientific Reports · doi:10.1038/srep27812 · Cited by 87 · see citing works
Deep brain stimulation for stroke: Current uses and future directions.
Elias, G., Namasivayam, A. A., & Lozano, A. (2018) · Brain Stimulation · doi:10.1016/j.brs.2017.10.005 · Cited by 79 · see citing works
Schmuckermair, C., Gaburro, S., Sah, A., Landgraf, R., Sartori, S. B., & Singewald, N. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.21 · Cited by 81 · see citing works
Mann, A., Gondard, E., Tampellini, D., MILSTED, J. A. T., Marillac, D., Hamani, C., Kalia, S. K., & Lozano, A. M. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.11.012 · Cited by 86 · see citing works
Appel, J. R., Ye, S., Tang, F., Sun, D., Zhang, H., Mei, L., & Xiong, W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3621-17.2018 · Cited by 82 · see citing works
Netzahualcoyotzi, C., & Pellerin, L. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101888 · Cited by 81 · see citing works
Liu, A., Jain, N. K., Vyas, A., & Lim, L. W. (2015) · eLife · doi:10.7554/elife.04803 · Cited by 78 · see citing works
Deep brain stimulation in dementia-related disorders
Hescham, S., Lim, L. W., Jahanshahi, A., Blokland, A., & Temel, Y. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.002 · Cited by 77 · see citing works
Deep brain stimulation for Alzheimer's Disease: An update
Hescham, S., Aldehri, M., Temel, Y., Alnaami, I., & Jahanshahi, A. (2018) · Surgical Neurology International · doi:10.4103/sni.sni_342_17 · Cited by 77 · see citing works
Bambico, F. R., Bregman, T., Diwan, M., Li, J., Darvish-Ghane, S., Li, Z., Laver, B., Amorim, B. O., Covolan, L., Nóbrega, J. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.166 · Cited by 77 · see citing works
Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation.
Jakobs, M., Lee, D. J., & Lozano, A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107860 · Cited by 68 · see citing works
Harris, L., Zalucki, O. H., Clément, O., Fraser, J., Matuzelski, E., Oishi, S., Harvey, T. J., Burne, T. H. J., Heng, J. I., Gronostajski, R. M., et al. (2018) · Development · doi:10.1242/dev.155689 · Cited by 72 · see citing works
Leplus, A., Lauritzen, I., Melon, C., Goff, L. K., Fontaine, D., & Checler, F. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1779-x · Cited by 72 · see citing works
Berkowitz, L. E., Harvey, R. E., Drake, E., Thompson, S. M., & Clark, B. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-34368-w · Cited by 68 · see citing works
Alonso, S. B., Reinert, J. K., Marichal, N., Massalini, S., Berninger, B., Kuner, T., & Calegari, F. (2019) · The EMBO Journal · doi:10.15252/embj.201798791 · Cited by 69 · see citing works
Rogers, J., Churilov, L. P., Hannan, A. J., & Renoir, T. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.12.007 · Cited by 68 · see citing works
Leschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 70 · see citing works
Hardenacke, K., Shubina, E., Bührle, C., Zapf, A. C., Lenartz, D., Klosterkötter, J., Visser-Vandewalle, V. E. R. M., & Kuhn, J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00159 · Cited by 68 · see citing works
Neurostimulation for traumatic brain injury
Shin, S. S., Dixon, C. E., Okonkwo, D. O., & Richardson, R. M. (2014) · Journal of neurosurgery · doi:10.3171/2014.7.jns131826 · Cited by 66 · see citing works
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs
Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00025 · Cited by 64 · see citing works
Luo, Y., Sun, Y., Tian, X., Zheng, X., Wang, X., Li, W., Wu, X., Shu, B., & Hou, W. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.619543 · Cited by 65 · see citing works
Xia, F., Yiu, A. P., Stone, S. S. D., Oh, S. J., Lozano, A. M., Josselyn, S. A., & Frankland, P. W. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.100 · Cited by 65 · see citing works
Lowet, E., Kondabolu, K., Zhou, S. L., Mount, R. A., Wang, Y., Ravasio, C. R., & Han, X. (2022) · Nature Communications · doi:10.1038/s41467-022-35314-1 · Cited by 57 · see citing works
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
Huang, Y. H., Li, Y., Chen, J., Zhou, H., & Tan, S. H. D. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00586 · Cited by 60 · see citing works
Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation
Akwa, Y., Gondard, E., Mann, A., Capetillo‐Zarate, E., Alberdi, E. M., Matute, C., Marty, S., Vaccari, T., Lozano, A. M., Baulieu, E. E., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.142 · Cited by 62 · see citing works
Fatt, M. P., Tran, L. M., Vetere, G., Storer, M. A., Simonetta, J. V., Miller, F. D., Frankland, P. W., & Kaplan, D. R. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.010 · Cited by 58 · see citing works
Hernández-Mercado, K., & Zepeda, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.782947 · Cited by 58 · see citing works
Sweet, J. A., Eakin, K. C., Munyon, C. N., & Miller, J. P. (2014) · Hippocampus · doi:10.1002/hipo.22338 · Cited by 58 · see citing works
Winkle, C. C., Olsen, R. H. J., Kim, H., Moy, S. S., Song, J., & Gupton, S. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3876-15.2016 · Cited by 57 · see citing works
Comparison and Selection of Current Implantable Anti-Epileptic Devices
Wong, S., Mani, R., & Danish, S. F. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00727-2 · Cited by 59 · see citing works
Krzisch, M., Temprana, S. G., Mongiat, L. A., Armida, J., Schmutz, V., Virtanen, M. A., Kocher-Braissant, J., Kraftsik, R., Vutskits, L., Conzelmann, K.-K., et al. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0768-y · Cited by 57 · see citing works
An entorhinal-visual cortical circuit regulates depression-like behaviors
Lu, J., Zhang, Z., Yin, X., Tang, Y., Ji, R., Chen, H., Guang, Y., Gong, X., He, Y., Zhou, W., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01540-8 · Cited by 58 · see citing works
Zhang, W., Gu, G., Zhang, Q., Liu, J., Zhang, B., Guo, Y. C., Wang, M., Gong, Q., & Xu, J. (2017) · Hippocampus · doi:10.1002/hipo.22794 · Cited by 57 · see citing works
Deep brain stimulation: a mechanistic and clinical update
Karas, P. J., Mikell, C. B., Christian, E., Liker, M. A., & Sheth, S. A. (2013) · Neurosurgical FOCUS · doi:10.3171/2013.9.focus13383 · Cited by 57 · see citing works
de Haas, R., Struikmans, R., Plasse, G., van Kerkhof, L. W. M., Brakkee, J. H., Kas, M. J., & Westenberg, H. G. M. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.05.028 · Cited by 56 · see citing works
Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease
Irwin, R. W., Wang, J. M., Chen, S., & Brinton, R. D. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00117 · Cited by 56 · see citing works
Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease
Buntwal, L., Sassi, M., Morgan, A. H., Andrews, Z. B., & Davies, J. S. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.07.001 · Cited by 55 · see citing works
Intrinsic Mechanisms Regulating Neuronal Migration in the Postnatal Brain
Bressan, C., & Saghatelyan, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.620379 · Cited by 54 · see citing works
Chan, D., Suk, H., Jackson, B., Milman, N., Stark, D., Beach, S. D., & Tsai, L. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13329 · Cited by 51 · see citing works
Physiological and pathological roles of the γ-secretase complex
Carroll, C. M., & Li, Y. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.019 · Cited by 53 · see citing works
Chakravarty, M. M., Hamani, C., Martínez-Canabal, A., Ellegood, J., Laliberté, C. L., Nóbrega, J. N., Sankar, T., Lozano, A. M., Frankland, P. W., & Lerch, J. P. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.049 · Cited by 52 · see citing works
A fight for survival: The challenges faced by a newborn neuron integrating in the adult hippocampus
Bergami, M., & Berninger, B. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22025 · Cited by 52 · see citing works
- Authors
- Stone, S. S. D., Teixeira, C. M., DeVito, L. M., Zaslavsky, K., Josselyn, S. A., Lozano, A. M., & Frankland, P. W.
- Affiliations
- Hospital for Sick Children (CA)
- Universidade do Porto (PT)
- University of Toronto (CA)
- Corresponding author
- Frankland, Paul W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-09-21
- Volume
- 31
- Issue
- 38
- Pages
- 13469-13484
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6623309
- OpenAlex
- W2132668024
- Cited by
- 384
- References
- 68
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 18 · 2023: 16 · 2022: 24 · 2021: 32 · 2020: 27 · 2019: 24 · 2018: 27 · 2017: 21 · 2016: 38 · 2015: 41 · 2014: 24 · 2013: 30 · 2012: 39
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Toronto
- Canadian Institutes of Health Research (MOP- 86762, 102234_1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- entorhinal cortex, deep brain stimulation, adult neurogenesis, dentate gyrus, dentate gyrus granule cells, spatial memory, cell proliferation, neuronal differentiation, apoptosis
- MeSH terms
- Animals, Cell Survival, Memory, Mice, Inbred Strains, Neural Pathways, Neurons, Spatial Behavior, Time Factors, Apoptosis, Entorhinal Cortex, Maze Learning, Dentate Gyrus, Deep Brain Stimulation, Mice, Neurogenesis, Neuroanatomical Tract-Tracing Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
