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Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer’s Disease

Cui, Weigang, Sun, Chunli, Ma, Yuqi, Wang, Songtao, Wang, Xianwei, Zhang, Yinghua·2020·Frontiers in Neuroscience
DOI 10.3389/fnins.2020.00444PMC PMC7251077
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Research works printed but not linked: 45

  1. Al, 2018, Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice., Eur. J. Neurosci., 47, 140, 10.1111/ejn.13778 · DOI
  2. Aryanpour, 2017, Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model., Int. Immunopharmacol., 51, 131, 10.1016/j.intimp.2017.08.007 · DOI
  3. Oliveira, 2018, Inflammation as a possible link between dyslipidemia and Alzheimer’s disease., Neuroscience, 376, 127, 10.1016/j.neuroscience.2018.02.012 · DOI
  4. Businaro, 2018, Modulation of inflammation as a way of delaying Alzheimer’s disease progression: the Diet’s role., Curr Alzheimer Res, 15, 363, 10.2174/1567205014666170829100100 · DOI
  5. Cui, 2012, Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice., Neuroscience, 210, 200, 10.1016/j.neuroscience.2012.02.047 · DOI
  6. Cui, 2013, Neuregulin1beta1 antagonizes apoptosis via ErbB4-dependent activation of PI3-kinase/Akt in APP/PS1 transgenic mice., Neurochem. Res., 38, 2237, 10.1007/s11064-013-1131-z · DOI
  7. Cui, 2017, Inhibition of PTEN attenuates endoplasmic reticulum stress and apoptosis via activation of PI3K/AKT pathway in Alzheimer’s disease., Neurochem. Res., 42, 3052, 10.1007/s11064-017-2338-1 · DOI
  8. Fahnestock, 2019, ProNGF and neurodegeneration in Alzheimer’s disease., Front. Neurosci., 13, 10.3389/fnins.2019.00129 · DOI
  9. Fiala, 2018, Immunotherapy of mild cognitive impairment by omega-3 supplementation: why are Amyloid-beta Antibodies and omega-3 not working in clinical trials., J. Alzheimers Dis., 62, 1013, 10.3233/JAD-170579 · DOI · Paper page
  10. Henn, 2009, The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation., ALTEX, 26, 83, 10.1016/j.jmpt.2008.11.018 · DOI
  11. Hu, 2017, Inhibition of TLR4 alleviates the inflammation and apoptosis of retinal ganglion cells in high glucose., Graefes Arch. Clin. Exp. Ophthalmol., 255, 2199, 10.1007/s00417-017-3772-0 · DOI
  12. Hu, 2012, Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia., Stroke, 43, 3063, 10.1161/STROKEAHA.112.659656 · DOI
  13. Hua, 2015, TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice., J. Cereb. Blood Flow Metab., 35, 536, 10.1038/jcbfm.2014.240 · DOI
  14. Huang, 2017, TLR4 is a link between diabetes and Alzheimer’s disease., Behav. Brain Res., 316, 234, 10.1016/j.bbr.2016.08.047 · DOI
  15. Jankowsky, 2004, Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase., Hum. Mol. Genet., 13, 159, 10.1093/hmg/ddh019 · DOI · Paper page
  16. Latta-Mahieu, 2018, Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-beta burden in several amyloid transgenic mouse models., Glia, 66, 492, 10.1002/glia.23260 · DOI
  17. Li, 2014, Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats., J. Neuroinflam., 11, 10.1186/1742-2094-11-62 · DOI
  18. Lu, 2018, Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization., Biochem. Pharmacol., 154, 203, 10.1016/j.bcp.2018.05.007 · DOI
  19. Ma, 2018, LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-kappaB/NLRP3 inflammasome pathway., Cell Prolif., 52, 10.1111/cpr.12525 · DOI
  20. Maezawa, 2018, Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept., Brain, 141, 596, 10.1093/brain/awx346 · DOI · Paper page
  21. Matsunaga, 2011, TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules., Mol. Pharmacol., 79, 34, 10.1124/mol.110.068064 · DOI · Paper page
  22. McCarthy, 2016, Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta., J. Neuroinflam., 13, 10.1186/s12974-016-0484-z · DOI
  23. McClain, 2011, Adolescent binge alcohol exposure induces long-lasting partial activation of microglia., Brain Behav. Immun., S120, 10.1016/j.bbi.2011.01.006 · DOI
  24. Miron, 2018, TLR4 gene expression and pro-inflammatory cytokines in Alzheimer’s disease and in response to hippocampal deafferentation in rodents., J. Alzheimers Dis., 63, 1547, 10.3233/JAD-171160 · DOI · Paper page
  25. Mohammad, 2018, Reno-protective effects of TAK-242 on acute kidney injury in a rat model., Biochem. Biophys. Res. Commun., 503, 304, 10.1016/j.bbrc.2018.06.020 · DOI
  26. Moser, 2018, TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity., J. Neuroinflam., 15, 10.1186/s12974-018-1340-0 · DOI
  27. O’Halloran, 2014, MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-beta in macrophages., Immunol. Lett., 162, 109, 10.1016/j.imlet.2014.08.001 · DOI
  28. Rosciszewski, 2018, Toll-Like Receptor 4 (TLR4) AND TRIGGERING RECEPTOR EXPRESSED ON Myeloid Cells-2 (TREM-2) activation balance astrocyte polarization into a proinflammatory phenotype., Mol. Neurobiol., 55, 3875
  29. Saresella, 2014, A complex proinflammatory role for peripheral monocytes in Alzheimer’s disease., J. Alzheimers Dis., 38, 403, 10.3233/JAD-131160 · DOI
  30. Shi, 2013, Prion protein participates in the regulation of classical and alternative activation of BV2 microglia., J. Neurochem., 124, 168, 10.1111/jnc.12053 · DOI
  31. Shibata, 2017, Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA., J. Autoimmun., 80, 28, 10.1016/j.jaut.2017.01.007 · DOI
  32. Song, 2018, Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells., J. Mol. Endocrinol., 61, 101, 10.1530/JME-18-0069 · DOI
  33. Su, 2018, Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine., Mol. Pain, 14, 1, 10.1177/1744806918754612 · DOI
  34. Su, 2018, Effects of the TLR4/Myd88/NF-kappaB Signaling Pathway on NLRP3 inflammasome in coronary microembolization-induced myocardial injury., Cell. Physiol. Biochem., 47, 1497, 10.1159/000490866 · DOI
  35. Tai, 2018, Magnesium Lithospermate B suppresses lipopolysaccharide-induced neuroinflammation in BV2 Microglial cells and attenuates neurodegeneration in Lipopolysaccharide-injected mice., J. Mol. Neurosci., 64, 80, 10.1007/s12031-017-1007-9 · DOI
  36. Tan, 2013, The NLRP3 inflammasome in Alzheimer’s disease., Mol. Neurobiol., 48, 875, 10.1007/s12035-013-8475-x · DOI
  37. Tao, 2018, Andrographolide alleviates acute brain injury in a rat model of traumatic brain injury: possible involvement of inflammatory signaling., Front. Neurosci., 12, 10.3389/fnins.2018.00657 · DOI
  38. Tramullas, 2016, Obesity takes its toll on Visceral pain: high-Fat diet induces toll-like receptor 4-Dependent Visceral hypersensitivity., PLoS One, 11, 10.1371/journal.pone.0155367 · DOI
  39. Wang, 2017, TAK-242 protects against apoptosis in Coronary Microembolization-INDUCED MYOCARDIAL INJURY IN RATS BY SUPPRESSING TLR4/NF-kappaB signaling pathway., Cell. Physiol. Biochem., 41, 1675, 10.1159/000471248 · DOI
  40. Xie, 2016, Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-kappaB Signaling Pathway., Cell Physiol. Biochem., 39, 1705, 10.1159/000447871 · DOI
  41. Yang, 2018, Toll-like receptor 4-induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca(2+) leakage promote cardiac contractile dysfunction in sepsis., J. Biol. Chem., 293, 794, 10.1074/jbc.M117.812289 · DOI
  42. Zhang, 2017, Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-kappaB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates., Front. Aging Neurosci, 9, 10.3389/fnagi.2017.00282 · DOI
  43. Zhang, 2015, TAK-242, a Toll-Like receptor 4 antagonist, protects against Aldosterone-Induced cardiac and renal injury., PLoS One, 10, 10.1371/journal.pone.0142456 · DOI
  44. Zhao, 2016, Inhibition of TLR4 signalling-induced inflammation attenuates secondary injury after diffuse axonal injury in rats., Mediators Inflamm., 2016, 10.1155/2016/4706915 · DOI
  45. Zhou, 2017, Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo., Sci. Rep., 7, 10.1038/srep44822 · DOI

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Metadata

Authors
Cui, W., Sun, C., Ma, Y., Wang, S., Wang, X., & Zhang, Y.
Venue
Frontiers in Neuroscience
Publisher
Frontiers Media SA
Published
2020-05-20
Volume
14
ISSN
1662-453X
DOI
10.3389/fnins.2020.00444
PMC
PMC7251077
Cited by
220
References
2
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • National Natural Science Foundation of China (U1804185, 81873459, U1804166)
  • Science and Technology Department of Henan Province (192102310346)

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