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RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A
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The reported recruitment of LRRK2 to the Golgi complex by RAB29 is only observed when RAB29 is overexpressed to a larger extent.
“Finally, our data show that the reported recruitment of LRRK2 to the Golgi complex by RAB29 [23,54,55,56] is only observed when RAB29 is overexpressed to a larger extent.”
From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [55]
Other studies reported a physical interaction between LRRK2 and RAB29, and when overexpressed, RAB29 can recruit LRRK2 to the Golgi network.
“Other studies have reported a physical interaction between LRRK2 and RAB29, and when overexpressed, RAB29 can recruit LRRK2 to the Golgi network [23,54,55,56].”
From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [55]
Two mutant RAB29 versions previously described to cause RAB29 inactivation did not rescue the LRRK2-mediated endolysosomal trafficking deficits.
“In contrast, two mutant RAB29 versions previously described to cause RAB29 inactivation [23,54,55] did not rescue the LRRK2-mediated endolysosomal trafficking deficits (Figure 5B,C).”
From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [55]
Most endogenous LRRK2 is not present on the Golgi complex, and phospho-RAB8A/RAB10 is not trapped on the Golgi complex under normal conditions.
“This is consistent with findings indicating that most endogenous LRRK2 is not present on the Golgi complex, and that phospho-RAB8A/RAB10 is not trapped on the Golgi complex under normal conditions either [39,55,57].”
From Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations (2020) · cites this paper as [55]
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Sorted by citations
Rivero-Ríos, P., Romo-Lozano, M., Fernández, B., Fdez, E., & Hilfiker, S. (2020) · Cells · doi:10.3390/cells9071719 · Cited by 38
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Metadata
- Authors
- Madero-Pérez, J., Fernández, B., Lara Ordóñez, A. J., Fdez, E., Lobbestael, E., Baekelandt, V., & Hilfiker, S.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-11-13
- Volume
- 11
- ISSN
- 1662-5099
- PMC
- PMC6243087
- Cited by
- 48
- References
- 1
- Funders
- Michael J. Fox Foundation for Parkinson’s Research
- Fundación BBVA
- Ministerio de Economía y Competitividad
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