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LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

Matta, Samer, Van Kolen, Kristof, da Cunha, Raquel, van den Bogaart, Geert, Mandemakers, Wim, Miskiewicz, Katarzyna, De Bock, Pieter-Jan, Morais, Vanessa A., Vilain, Sven, Haddad, Dominik, Delbroek, Lore, Swerts, Jef, Chávez-Gutiérrez, Lucía, Esposito, Giovanni, Daneels, Guy, Karran, Eric, Holt, Matthew, Gevaert, Kris, Moechars, Diederik W., De Strooper, Bart, Verstreken, Patrik·2012·Neuron
DOI 10.1016/j.neuron.2012.08.022
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  • LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors.

    “LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors [2, 7, 10, 24, 25, 36, 51, 59, 62, 75, 77, 96].”

    From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [51]

    The Introduction (page unavailable) reports that changes in LRRK2 kinase activity inhibit synaptic endocytosis, supporting the synaptic-vesicle endocytosis part of the claim. Our copy does not establish that LRRK2 activates autophagy or controls axonal transport of growth factor receptors; searches for those terms returned no supporting passage. (LLM, conf=0.88)

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Research works printed but not linked: 46

  1. Arnesen, 2010, The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation, Mol. Cell. Biol., 30, 1898, 10.1128/MCB.01199-09 · DOI
  2. Bai, 2010, Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis, Cell, 143, 430, 10.1016/j.cell.2010.09.024 · DOI
  3. Bazinet, 1993, The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism, Genetics, 134, 1119, 10.1093/genetics/134.4.1119 · DOI
  4. Cookson, 2010, The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson’s disease, Nat. Rev. Neurosci., 11, 791, 10.1038/nrn2935 · DOI
  5. Correia Guedes, 2010, Worldwide frequency of G2019S LRRK2 mutation in Parkinson’s disease: a systematic review, Parkinsonism Relat. Disord., 16, 237, 10.1016/j.parkreldis.2009.11.004 · DOI
  6. Cypionka, 2009, Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS, Proc. Natl. Acad. Sci. USA, 106, 18575, 10.1073/pnas.0906677106 · DOI
  7. Deng, 2011, Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2, Nat. Chem. Biol., 7, 203, 10.1038/nchembio.538 · DOI
  8. Esposito, 2012, Synaptic vesicle trafficking and Parkinson’s disease, Dev. Neurobiol., 72, 134, 10.1002/dneu.20916 · DOI
  9. Farsad, 2001, Generation of high curvature membranes mediated by direct endophilin bilayer interactions, J. Cell Biol., 155, 193, 10.1083/jcb.200107075 · DOI
  10. Fergestad, 1999, The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal, J. Neurosci., 19, 5847, 10.1523/JNEUROSCI.19-14-05847.1999 · DOI
  11. Gad, 2000, Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin, Neuron, 27, 301, 10.1016/S0896-6273(00)00038-6 · DOI
  12. Gallop, 2006, Mechanism of endophilin N-BAR domain-mediated membrane curvature, EMBO J., 25, 2898, 10.1038/sj.emboj.7601174 · DOI
  13. Ghesquière, 2009, In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography, Mol. Cell. Proteomics, 8, 2642, 10.1074/mcp.M900259-MCP200 · DOI
  14. González-Gaitán, 1997, Role of Drosophila alpha-adaptin in presynaptic vesicle recycling, Cell, 88, 767, 10.1016/S0092-8674(00)81923-6 · DOI
  15. Greggio, 2009, Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions, ASN Neuro, 1, 1, 10.1042/AN20090007 · DOI
  16. Guichet, 2002, Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction, EMBO J., 21, 1661, 10.1093/emboj/21.7.1661 · DOI
  17. Jao, 2010, Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation, J. Biol. Chem., 285, 20164, 10.1074/jbc.M110.127811 · DOI
  18. Jung, 2010, A mutational analysis of the endophilin-A N-BAR domain performed in living flies, PLoS ONE, 5, e9492, 10.1371/journal.pone.0009492 · DOI
  19. Kjaerulff, 2011, The structure and function of endophilin proteins, Cell Biochem. Biophys., 60, 137, 10.1007/s12013-010-9137-5 · DOI
  20. Koh, 2004, Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis, Neuron, 43, 193, 10.1016/j.neuron.2004.06.029 · DOI
  21. Koh, 2007, Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development, J. Cell Biol., 178, 309, 10.1083/jcb.200701030 · DOI
  22. Lee, 2007, Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila, Biochem. Biophys. Res. Commun., 358, 534, 10.1016/j.bbrc.2007.04.156 · DOI
  23. Lee, 2010, LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction, J. Neurosci., 30, 16959, 10.1523/JNEUROSCI.1807-10.2010 · DOI
  24. Lin, 2010, LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß, J. Neurosci., 30, 13138, 10.1523/JNEUROSCI.1737-10.2010 · DOI
  25. Masuda, 2006, Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms, EMBO J., 25, 2889, 10.1038/sj.emboj.7601176 · DOI
  26. Milosevic, 2011, Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission, Neuron, 72, 587, 10.1016/j.neuron.2011.08.029 · DOI
  27. Miśkiewicz, 2011, ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot, Neuron, 72, 776, 10.1016/j.neuron.2011.10.010 · DOI
  28. Paisán-Ruíz, 2004, Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease, Neuron, 44, 595, 10.1016/j.neuron.2004.10.023 · DOI
  29. Pawlu, 2004, Postfusional control of quantal current shape, Neuron, 42, 607, 10.1016/S0896-6273(04)00269-7 · DOI
  30. Piccoli, 2011, LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool, J. Neurosci., 31, 2225, 10.1523/JNEUROSCI.3730-10.2011 · DOI
  31. Plowey, 2011, Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?, Neurobiol. Dis., 43, 60, 10.1016/j.nbd.2010.10.011 · DOI
  32. Ringstad, 1997, The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain, Proc. Natl. Acad. Sci. USA, 94, 8569, 10.1073/pnas.94.16.8569 · DOI
  33. Schmid, 2006, Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly, PLoS Biol., 4, e262, 10.1371/journal.pbio.0040262 · DOI
  34. Schuette, 2004, Determinants of liposome fusion mediated by synaptic SNARE proteins, Proc. Natl. Acad. Sci. USA, 101, 2858, 10.1073/pnas.0400044101 · DOI
  35. Schuske, 2003, Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin, Neuron, 40, 749, 10.1016/S0896-6273(03)00667-6 · DOI
  36. Shin, 2008, LRRK2 regulates synaptic vesicle endocytosis, Exp. Cell Res., 314, 2055, 10.1016/j.yexcr.2008.02.015 · DOI
  37. Tonikian, 2009, Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins, PLoS Biol., 7, e1000218, 10.1371/journal.pbio.1000218 · DOI
  38. Uytterhoeven, 2011, Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins, Cell, 145, 117, 10.1016/j.cell.2011.02.039 · DOI
  39. van den Bogaart, 2007, On the decrease in lateral mobility of phospholipids by sugars, Biophys. J., 92, 1598, 10.1529/biophysj.106.096461 · DOI
  40. van den Bogaart, 2010, One SNARE complex is sufficient for membrane fusion, Nat. Struct. Mol. Biol., 17, 358, 10.1038/nsmb.1748 · DOI
  41. Venken, 2008, Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation, Nucleic Acids Res., 36, e114, 10.1093/nar/gkn486 · DOI
  42. Verstreken, 2002, Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release, Cell, 109, 101, 10.1016/S0092-8674(02)00688-8 · DOI
  43. Weissenhorn, 2005, Crystal structure of the endophilin-A1 BAR domain, J. Mol. Biol., 351, 653, 10.1016/j.jmb.2005.06.013 · DOI
  44. Yoon, 2010, Molecular basis of the potent membrane-remodeling activity of the epsin 1 N-terminal homology domain, J. Biol. Chem., 285, 531, 10.1074/jbc.M109.068015 · DOI
  45. Zhang, 1998, Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis, Neuron, 21, 1465, 10.1016/S0896-6273(00)80664-9 · DOI · Paper page
  46. Zimprich, 2004, Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology, Neuron, 44, 601, 10.1016/j.neuron.2004.11.005 · DOI

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Metadata

Authors
Matta, S., Van Kolen, K., da Cunha, R., van den Bogaart, G., Mandemakers, W., Miskiewicz, K., De Bock, P.-J., Morais, V. A., Vilain, S., Haddad, D., Delbroek, L., Swerts, J., Chávez-Gutiérrez, L., Esposito, G., Daneels, G., Karran, E., Holt, M., Gevaert, K., Moechars, D. W., De Strooper, B., & Verstreken, P.
Venue
Neuron
Publisher
Elsevier BV
Published
2012-09
Volume
75
Issue
6
Pages
1008-1021
ISSN
0896-6273
DOI
10.1016/j.neuron.2012.08.022
Cited by
337
References
0
Language
en
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