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Cited by 64Memory and Neural MechanismsNeural dynamics and brain functionMemory Processes and Influences

Donor/recipient enhancement of memory in rat hippocampus

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Deadwyler, Sam A., Berger, Theodore W., Sweatt, Andrew J., Song, Dong, Chan, Rosa H. M., Opris, Ioan, Gerhardt, Greg A., Marmarelis, Vasilis Z. +1 more·2013·Frontiers in Systems Neuroscience
DOI 10.3389/fnsys.2013.00120PMC PMC3872745
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Abstract

The critical role of the mammalian hippocampus in the formation, translation and retrieval of memory has been documented over many decades. There are many theories of how the hippocampus operates to encode events and a precise mechanism was recently identified in rats performing a short-term memory task which demonstrated that successful information encoding was promoted via specific patterns of activity generated within ensembles of hippocampal neurons. In the study presented here, these "representations" were extracted via a customized non-linear multi-input multi-output (MIMO) mathematical model which allowed prediction of successful performance on specific trials within the testing session. A unique feature of this characterization was demonstrated when successful information encoding patterns were derived online from well-trained "donor" animals during difficult long-delay trials and delivered via online electrical stimulation to synchronously tested naïve "recipient" animals never before exposed to the delay feature of the task. By transferring such model-derived trained (donor) animal hippocampal firing patterns via stimulation to coupled naïve recipient animals, their task performance was facilitated in a direct "donor-recipient" manner. This provides the basis for utilizing extracted appropriate neural information from one brain to induce, recover, or enhance memory related processing in the brain of another subject.

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  • Neuroscientists have demonstrated the technological capability of brain-to-brain communication, including transferring sensory and perceptual experiences and memories directly between animals using invasive techniques, and manipulating and controlling them.

    “Neuroscientists have also demonstrated the technological capability of brain-to-brain communication; that is, the ability to transfer sensory and perceptual experiences 26 and memories 11 directly between animals using invasive techniques, as well as to manipulate 31 and control them. 6”

    From AI and Neurotechnology (2023) · cites this paper as [11]

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Authors
Deadwyler, S. A., Berger, T. W., Sweatt, A. J., Song, D., Chan, R. H. M., Opris, I., Gerhardt, G. A., Marmarelis, V. Z., & Hampson, R. E.
Affiliations
  • Wake Forest University Health Sciences (US)
  • University of Southern California (US)
  • University of Kentucky (US)
Corresponding author
Deadwyler, Sam A.
ORCID
Venue
Frontiers in Systems Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
7
Pages
120-120
ISSN
1662-5137 (ISSN-L)
DOI
10.3389/fnsys.2013.00120
PMC
PMC3872745
OpenAlex
W2135254109
Cited by
64
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 11
FWCI
4.75
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Systems Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science Foundation (0310723)
  • Defense Advanced Research Projects Agency (N66001)
  • National Institute on Drug Abuse (R01DA007625, DA-07625)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampus, memory enhancement, memory transfer, neuronal firing, MIMO model, short-term memory, memory encoding, rats

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