Robust Conjunctive Item–Place Coding by Hippocampal Neurons Parallels Learning What Happens Where
Open accessAbstract
Previous research indicates a critical role of the hippocampus in memory for events in the context in which they occur. However, studies to date have not provided compelling evidence that hippocampal neurons encode event–context conjunctions directly associated with this kind of learning. Here we report that, as animals learn different meanings for items in distinct contexts, individual hippocampal neurons develop responses to specific stimuli in the places where they have differential significance. Furthermore, this conjunctive coding evolves in the form of enhanced item-specific responses within a subset of the preexisting spatial representation. These findings support the view that conjunctive representations in the hippocampus underlie the acquisition of context-specific memories.
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Place cells encode the animal's position in an environment and, more generally, events of episodic experience, and have been causally linked to memory functions.
“These neurons encode the animal’s position in an environment1 and, more generally, events of episodic experience2–4 and have been causally linked to memory functions5–7.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [3]
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- Authors
- Komorowski, R. W., Manns, J. R., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-08-05
- Volume
- 29
- Issue
- 31
- Pages
- 9918-9929
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2746931
- OpenAlex
- W2073778714
- Cited by
- 372
- References
- 47
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 22 · 2023: 22 · 2022: 21 · 2021: 25 · 2020: 22 · 2019: 19 · 2018: 27 · 2017: 27 · 2016: 19 · 2015: 24 · 2014: 27 · 2013: 27 · 2012: 22
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH-71702, R01MH051570, MH051570, P50MH071702)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hippocampal neurons, place cells, spatial representation, memory encoding, hippocampus
- MeSH terms
- Action Potentials, Analysis of Variance, Animals, Discrimination Learning, Electrodes, Implanted, Environment, Hippocampus, Male, Memory, Neurons, Practice, Psychological, Reward, Space Perception, Rats, Long-Evans, Rats
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