Cited by 372Memory and Neural MechanismsMemory Processes and InfluencesNeural dynamics and brain function

Robust Conjunctive Item–Place Coding by Hippocampal Neurons Parallels Learning What Happens Where

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Komorowski, Robert W., Manns, Joseph R., Eichenbaum, Howard·2009·The Journal of Neuroscience

Abstract

Previous research indicates a critical role of the hippocampus in memory for events in the context in which they occur. However, studies to date have not provided compelling evidence that hippocampal neurons encode event–context conjunctions directly associated with this kind of learning. Here we report that, as animals learn different meanings for items in distinct contexts, individual hippocampal neurons develop responses to specific stimuli in the places where they have differential significance. Furthermore, this conjunctive coding evolves in the form of enhanced item-specific responses within a subset of the preexisting spatial representation. These findings support the view that conjunctive representations in the hippocampus underlie the acquisition of context-specific memories.

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Crossref · 10.1523/jneurosci.1378-09.2009

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  • Place cells encode the animal's position in an environment and, more generally, events of episodic experience, and have been causally linked to memory functions.

    “These neurons encode the animal’s position in an environment1 and, more generally, events of episodic experience2–4 and have been causally linked to memory functions5–7.”

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Authors
Komorowski, R. W., Manns, J. R., & Eichenbaum, H.
Affiliations
Boston University (US)
Venue
The Journal of Neuroscience
Published
2009-08-05
Volume
29
Issue
31
Pages
9918-9929
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2073778714
Cited by
372
References
47
Citations by year
2026: 13 · 2025: 22 · 2024: 22 · 2023: 22 · 2022: 21 · 2021: 25 · 2020: 22 · 2019: 19 · 2018: 27 · 2017: 27 · 2016: 19 · 2015: 24 · 2014: 27 · 2013: 27 · 2012: 22
FWCI
8.74
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH-71702, R01MH051570, MH051570, P50MH071702)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
hippocampal neurons, place cells, spatial representation, memory encoding, hippocampus
MeSH terms
Action Potentials, Analysis of Variance, Animals, Discrimination Learning, Electrodes, Implanted, Environment, Hippocampus, Male, Memory, Neurons, Practice, Psychological, Reward, Space Perception, Rats, Long-Evans, Rats

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