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Cited by 18Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Interactions between inhibitory interneurons and excitatory associational circuitry in determining Spatio-Temporal dynamics of hippocampal dentate granule cells: A Large-Scale computational study

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Hendrickson, Phillip J., Yu, Gene J., Song, Dong, Berger, Theodore W.·2015·Frontiers in Systems Neuroscience
DOI 10.3389/fnsys.2015.00155PMC PMC4647071
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Abstract

This paper reports on findings from a million-cell granule cell model of the rat dentate gyrus that was used to explore the contributions of local interneuronal and associational circuits to network-level activity. The model contains experimentally derived morphological parameters for granule cells, which each contain approximately 200 compartments, and biophysical parameters for granule cells, basket cells, and mossy cells that were based both on electrophysiological data and previously published models. Synaptic input to cells in the model consisted of glutamatergic AMPA-like EPSPs and GABAergic-like IPSPs from excitatory and inhibitory neurons, respectively. The main source of input to the model was from layer II entorhinal cortical neurons. Network connectivity was constrained by the topography of the system, and was derived from axonal transport studies, which provided details about the spatial spread of axonal terminal fields, as well as how subregions of the medial and lateral entorhinal cortices project to subregions of the dentate gyrus. Results of this study show that strong feedback inhibition from the basket cell population can cause high-frequency rhythmicity in granule cells, while the strength of feedforward inhibition serves to scale the total amount of granule cell activity. Results furthermore show that the topography of local interneuronal circuits can have just as strong an impact on the development of spatio-temporal clusters in the granule cell population as the perforant path topography does, both sharpening existing clusters and introducing new ones with a greater spatial extent. Finally, results show that the interactions between the inhibitory and associational loops can cause high frequency oscillations that are modulated by a low-frequency oscillatory signal. These results serve to further illustrate the importance of topographical constraints on a global signal processing feature of a neural network, while also illustrating how rich spatio-temporal and oscillatory dynamics can evolve from a relatively small number of interacting local circuits.

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  • Although PV basket cells appear to be important for theta-generation both in the biological and the model CA1 network, endowing all interneurons with PV basket cell-like properties does not lead to a network configuration conducive to theta oscillations.

    “Therefore, although PV basket cells appear to be important for theta-generation both in the biological and the model CA1 network, endowing all interneurons with PV basket cell-like properties does not lead to a network configuration conducive to theta oscillations (Hendrickson et al., 2015).”

    From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Hendrickson et al., 2015

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Authors
Hendrickson, P. J., Yu, G. J., Song, D., & Berger, T. W.
Affiliations
University of Southern California (US)
Corresponding author
Hendrickson, Phillip J.
ORCID
Venue
Frontiers in Systems Neuroscience
Publisher
Frontiers Media SA
Published
2015-11-17
Volume
9
Pages
155-155
ISSN
1662-5137 (ISSN-L)
DOI
10.3389/fnsys.2015.00155
PMC
PMC4647071
OpenAlex
W2215357565
Cited by
18
References
83
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3
FWCI
1.40
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Systems Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (EB001978)
  • Office of Naval Research (N00014-13-1-0211, N00014)
  • National Institute of General Medical Sciences (U01GM104604)
  • National Institute of Biomedical Imaging and Bioengineering (EB-001978, P41EB001978)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dentate gyrus, granule cells, basket cells, mossy cells, entorhinal cortex, perforant path, product inhibition, feedforward inhibition, spatiotemporal dynamics, oscillations, topographic connectivity, axonal transport, computational neuron model, hippocampus

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