Effects of the Modified DASH Diet on Adults With Elevated Blood Pressure or Hypertension: A Systematic Review and Meta-Analysis
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Background: The modified Dietary Approaches to Stop Hypertension (DASH) diet was a potentially effective treatment for pre-hypertensive and hypertensive patients. The evidence for the effect of the modified DASH diet on blood pressure reduction was inconsistent. The study was designed to assess the effects of the modified DASH diet on blood pressure (BP) in hypertensive and pre-hypertensive adults. Methods: We searched Medline, Embase, CENTRAL, CNKI, VIP, Wanfang Data, SINOMED, Google Scholar, the World Health Organization's International Clinical Trials Registry Platform, and Clinicaltrials.gov from inception to July 1st, 2021. Randomized controlled trials (RCTs) assessing the effects of the modified DASH diet on systolic and diastolic BP, cardiovascular risk factors (body weight, body mass index, waist circumference, fasting glucose, blood lipids), cardiovascular events, and all-cause mortality were included. Statistical analysis was performed using Stata software. Risk of bias was assessed with the Cochrane tool and quality of evidence with GRADE. Results: A total of 10 RCTs were included. Compared with control diet, the modified DASH diet could reduce mean systolic (−3.26 mmHg; 95% confidence interval −5.58, −0.94 mmHg; P = 0.006) and diastolic (−2.07 mmHg; 95% confidence interval −3.68, −0.46 mmHg; P = 0.01) BP. Compared with the controlling diet, the modified DASH diet could reduce systolic BP to a greater extent in trials with a mean baseline BP ≥ 140/90 mmHg compared with <140/90 mmHg. Diastolic BP reduction was greater when the mean body mass index was ≥30 kg/m2 than <30 kg/m2. Diastolic BP reduction was more marked in trials with a follow-up time of >8 weeks compared with ≤8 weeks. The modified DASH diet could affect mean waist circumference (difference: 1.57 cm; 95% confidence interval −2.98, −0.15) and triglyceride concentration (difference: 1.04 mol/L; 95% confidence interval −1.47, −0.60). Conclusions: The modified DASH diet can reduce BP, waist circumference, and triglyceride concentration in hypertension patients. A higher baseline BP is associated with more marked systolic and diastolic BP reduction. Systematic Review Registration: PROSPERO registration number: CRD42020190860.
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A systematic review of 10 randomized controlled trials reported that compared with control diet, the modified DASH eating pattern could reduce mean systolic (-3.26 mmHg [95% CI -5.58 to -0.94 mmHg]; P = 0.006) and diastolic (-2.07 mmHg [95% CI -3.68 to -0.46 mmHg]; P = 0.01) blood pressure.
“A systematic review of 10 randomized controlled trials reported that compared with control diet, the modified Dietary Approaches to Stop Hypertension (DASH) eating pattern could reduce mean systolic (À3.26 mmHg [95% CI À5.58 to À0.94 mmHg]; P = 0.006) and diastolic (À2.07 mmHg [95% CI À3.68 to À0.46 mmHg]; P = 0.01) blood pressure (60).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [60]
A systematic review of 10 randomized controlled trials reported that compared with control diet, the modified DASH eating pattern could reduce mean systolic (−3.26 mmHg [95% CI −5.58 to −0.94 mmHg]; P = 0.006) and diastolic (−2.07 mmHg [95% CI −3.68 to −0.46 mmHg]; P = 0.01) blood pressure.
“A systematic review of 10 randomized controlled trials reported that compared with control diet, the modified Dietary Approaches to Stop Hypertension (DASH) eating pattern could reduce mean systolic (−3.26 mmHg [95% CI −5.58 to −0.94 mmHg]; P = 0.006) and diastolic (−2.07 mmHg [95% CI −3.68 to −0.46 mmHg]; P = 0.01) blood pressure (54).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [54]
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- Authors
- Guo, R., Li, N., Yang, R., Liao, X.-Y., Zhang, Y., Zhu, B.-F., Zhao, Q., Chen, L., Zhang, Y.-G., & Lei, Y.
- Affiliations
- Sichuan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Lei, Yi
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2021-09-07
- Volume
- 8
- Pages
- 725020-725020
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC8452928
- OpenAlex
- W3198347139
- Cited by
- 62
- References
- 40
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 1
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Update notices
- corrigendum (2021-10-05)
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Sichuan University
- National Key Research and Development Program of China (2017YFC 0907303)
- West China Hospital, Sichuan University (Z20191009)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- hypertension, prehypertension, blood pressure reduction, systolic blood pressure, diastolic blood pressure, waist circumference, triglycerides, body mass index, cardiovascular risk factors, all-cause mortality, dietary intervention, adults, follow-up duration, body weight, fasting blood glucose, serum lipids, cardiovascular events, risk of bias
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