Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

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Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

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The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

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The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

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MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

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Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

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miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

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Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

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MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300

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Oxygen Sensing, Hypoxia-Inducible Factor-1 and the Regulation of Mammalian Gene Expression

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Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

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Accumulation of HIF-1α under the influence of nitric oxide

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Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways

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Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

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Involvement of MicroRNAs in Hydrogen Peroxide-mediated Gene Regulation and Cellular Injury Response in Vascular Smooth Muscle Cells*

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Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides

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Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

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MicroRNA-21 Modulates the Levels of Reactive Oxygen Species by Targeting SOD3 and TNF α

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microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects

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Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 1

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S‐nitrosation of Cys‐800 of HIF‐1α protein activates its interaction with p300 and stimulates its transcriptional activity

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Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2

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Oxygen-Dependent and -Independent Regulation of HIF-1alpha

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Redox regulation of pro-inflammatory cytokines and IκB-α/NF-κB nuclear translocation and activation

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Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

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Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the PI 3K Pathway

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Nitric oxide and superoxide: Interference with hypoxic signaling

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Superoxide fluxes limit nitric oxide-induced signaling

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HIF‐1α protein as a target for S‐nitrosation

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The cellular response to hypoxia: tuning the system with microRNAs

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Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

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PI3K and ERK-Induced Rac1 Activation Mediates Hypoxia-Induced HIF-1α Expression in MCF-7 Breast Cancer Cells

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Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1α Induction via Superoxide

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Oxygen versus Reactive Oxygen in the Regulation of HIF-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">α</mml:mi></mml:mrow></mml:math>: The Balance Tips

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Regulation of Cytokine‐Induced HIF‐1α Expression in Rheumatoid Synovial Fibroblasts

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The involvement of l-γ-glutamyl-l-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPKp38-dependent regulation of pro-inflammatory cytokine production

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Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1α stabilization

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Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2-• and H2O2

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Evaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models

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Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1α expression in oral squamous cell carcinoma cells

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Phosphatidylinositol 3′-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1α and vascular endothelial growth factor expression

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Inhibition of endothelial nitric oxyde synthase increases capillary formation via Rac1-dependent induction of hypoxia-inducible factor-1α and plasminogen activator inhibitor-1

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The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy

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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

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Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

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The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

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Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

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Cellular Stress Responses in Radiotherapy

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Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

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Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

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Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

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Engineered algae: A novel oxygen-generating system for effective treatment of hypoxic cancer

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mTORC 1 and mTORC 2 as regulators of cell metabolism in immunity

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Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors

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The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

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An Overview: The Diversified Role of Mitochondria in Cancer Metabolism

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Hypoxia-Inducible Factors and Cancer

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Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain

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Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

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Mitochondria in cancer

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Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes

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Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

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Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

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Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?

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Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects

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Nutrigenomics of extra‐virgin olive oil: A review

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Reactive oxygen species: Role in carcinogenesis, cancer cell signaling and tumor progression

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Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

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Interfering with Tumor Hypoxia for Radiotherapy Optimization

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Interactive effect of thermal and hypoxia on largemouth bass (Micropterus salmoides) gill and liver: Aggravation of oxidative stress, inhibition of immunity and promotion of cell apoptosis

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Oxygen and reactive oxygen species-dependent regulation of plant growth and development

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Pyruvate kinase M2: A simple molecule with complex functions

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Mitochondrial Transfer in Cancer: A Comprehensive Review

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HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

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Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews

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Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells

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The Distinct Role of HIF-1α and HIF-2α in Hypoxia and Angiogenesis

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Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of Atherosclerosis

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HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart

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mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes

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Hypoxia-Induced Signaling Promotes Prostate Cancer Progression: Exosomes Role as Messenger of Hypoxic Response in Tumor Microenvironment

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Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli

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Hypoxia Triggers Osteochondrogenic Differentiation of Vascular Smooth Muscle Cells in an HIF-1 (Hypoxia-Inducible Factor 1)–Dependent and Reactive Oxygen Species–Dependent Manner

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Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

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Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation

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Macrophage Polarization Mediated by Mitochondrial Dysfunction Induces Adipose Tissue Inflammation in Obesity

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Senescent tumor cells: an overlooked adversary in the battle against cancer

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Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma

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MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1

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Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy

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Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation

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Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

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SIRT3 a Major Player in Attenuation of Hepatic Ischemia‐Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP‐D, and HIF‐1α

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Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

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Effect of polystyrene nanoplastics and their degraded forms on stem cell fate

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Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic β-Cells

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Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy

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Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1

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Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease

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Network Pharmacology as a Tool to Investigate the Antioxidant and Anti-Inflammatory Potential of Plant Secondary Metabolites—A Review and Perspectives

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Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

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σ1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury

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Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation

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Hypoxia, Inflammation and Necrosis as Determinants of Glioblastoma Cancer Stem Cells Progression

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Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress

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