Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach

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Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

Liu, J., Zhang, C., Lin, M., Zhu, W. J., Liang, Y., Hong, X., Zhao, Y., Young, K. H., Hu, W., & Feng, Z. (2014) · Oncotarget · doi:10.18632/oncotarget.1862 · Cited by 97 · see citing works

L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure # †

Ytreb, L. M., Kristiansen, R. G., Mæhre, H. K., Fuskevåg, O., Kalstad, T., Revhaug, A., Jover‐Cobos, M., Jalan, R., & Rose, C. F. (2009) · Hepatology · doi:10.1002/hep.22917 · Cited by 96 · see citing works

The Oxidative Metabolism of Glutamine

Goossens, V., Grooten, J., & Fiers, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.192 · Cited by 91 · see citing works

ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation

Qie, S., Chu, C., Li, W., Wang, C., & Sang, N. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24684 · Cited by 87 · see citing works

Rho GTPases and their roles in cancer metabolism

Wilson, K. F., Erickson, J. W., Antonyak, M. A., & Cerione, R. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.10.011 · Cited by 87 · see citing works

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

Velletri, T., Romeo, F., Tucci, P., Peschiaroli, A., Annicchiarico‐Petruzzelli, M., Niklison-Chirou, M. V., Amelio, I., Knight, R. A., Mak, T. W., Melino, G., et al. (2013) · Cell Cycle · doi:10.4161/cc.26771 · Cited by 87 · see citing works

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

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Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site

Li, C., Li, M., Chen, P., Narayan, S. B., Matschinsky, F. M., Bennett, M. J., Stanley, C. A., & Smith, T. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.268599 · Cited by 78 · see citing works

Pathways from glutamine to apoptosis

Matés, J. M. (2006) · Frontiers in bioscience · doi:10.2741/2040 · Cited by 75 · see citing works

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors

Thomas, A. G., Rojas, C. J., Tanega, C., Shen, M., Simeonov, A. M., Boxer, M. B., Auld, D. S., Ferraris, D. V., Tsukamoto, T., & Slusher, B. S. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.110 · Cited by 75 · see citing works

Inactivation of rat renal phosphate-dependent glutaminase with 6-diazo-5-oxo-L-norleucine. Evidence for interaction at the glutamine binding site.

Shapiro, R. A., Clark, V. M., & Curthoys, N. P. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30149-7 · Cited by 74 · see citing works

Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake

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Glutamine Deprivation Induces the Expression ofGADD45 and GADD153 Primarily by mRNA Stabilization

Abcouwer, S. F., Schwarz, C., & Meguid, R. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28645 · Cited by 73 · see citing works

Glutamine depletion impairs cellular stress response in human leucocytes

Oehler, R., Pusch, E., Dungel, P., Zellner, M., Eliasen, M. M., Brabec, M., & Roth, E. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2001453 · Cited by 73 · see citing works

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

Lee, Y., Yang, C., Chang, H.-Y., Hsu, H., Chen, I.-S., Chang, H.-S., Lee, C., Lee, J., Kumar, C. R., Qiu, Y., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2173 · Cited by 73 · see citing works

Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells

Fuchs, B. C., Pérez, J. C., Suetterlin, J. E., Chaudhry, S. B., & Bode, B. P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00344.2003 · Cited by 72 · see citing works

Small molecule glutaminase inhibitors block glutamate release from stimulated microglia

Thomas, A. G., O’Driscoll, C. M., Bressler, J. P., Kaufmann, W. E., Rojas, C. J., & Slusher, B. S. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.043 · Cited by 69 · see citing works

Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopy of Tumors

Dutta, P., Le, A., Jagt, D. L. V., Tsukamoto, T., Martinez, G. V., Dang, C. V., & Gillies, R. J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0465 · Cited by 66 · see citing works

Rapid induction of the intrinsic apoptotic pathway by L ‐glutamine starvation

Paquette, J. C., Guérin, P. J., & Gauthier, E. R. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20194 · Cited by 60 · see citing works

Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas

Sidoryk‐Wȩgrzynowicz, M., Matyja, E., Dybel, A., Zielińska, M., Bogucki, J., Jaskólski, D. J., Liberski, P. P., Kowalczyk, P., & Albrecht, J. (2004) · Neuroreport · doi:10.1097/00001756-200403220-00001 · Cited by 59 · see citing works

Inhibitors of Glutamate Dehydrogenase Block Sodium-Dependent Glutamate Uptake in Rat Brain Membranes

Whitelaw, B. S., & Robinson, M. B. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00123 · Cited by 59 · see citing works

The mutant p53 mouse as a pre-clinical model

Jackson, J. G., & Lozano, G. (2013) · Oncogene · doi:10.1038/onc.2012.610 · Cited by 57 · see citing works

The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).

Allen, L., Meck, R. A., & Yunis, A. A. (1980) · PubMed · Cited by 57 · see citing works

A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies.

Hidalgo, M. M., Rodriguez, G., Kuhn, J. G., Brown, T., Weiss, G. R., MacGovren, J. P., Hoff, D. D. V., & Rowinsky, E. K. (1998) · PubMed · Cited by 56 · see citing works

Interferon-α Regulates Glutaminase 1 Promoter through STAT1 Phosphorylation: Relevance to HIV-1 Associated Neurocognitive Disorders

Zhao, L., Huang, Y., Tian, C., Taylor, L., Curthoys, N. P., Wang, Y., Vernon, H., & Zheng, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032995 · Cited by 53 · see citing works

Determination of Copy Number of c-Myc Protein per Cell by Quantitative Western Blotting

Rudolph, C., Adam, G., & Simm, A. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.3095 · Cited by 53 · see citing works

Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling

Zhdanov, A. V., Waters, A. H. C., Golubeva, A. V., Dmitriev, R. I., & Papkovsky, D. B. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.07.008 · Cited by 52 · see citing works

Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration

Janpipatkul, K., Suksen, K., Borwornpinyo, S., Jearawiriyapaisarn, N., Hongeng, S., Piyachaturawat, P., & Chairoungdua, A. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.04.002 · Cited by 49 · see citing works

Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats

Jover‐Cobos, M., Noiret, L., Lee, K. C. L., Sharma, V., Habtesion, A., Romero‐Gómez, M., Davies, N. A., & Jalan, R. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.10.012 · Cited by 47 · see citing works

BPTES inhibition of hGA124–551, a truncated form of human kidney-type glutaminase

Hartwick, E. W., & Curthoys, N. P. (2011) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2011.622272 · Cited by 46 · see citing works

Tumor Cytotoxicity by Endothelial Cells

Ortega, Á., Carretero, J., Obrador, E., Gambini, J., Asensi, M. A., Rodilla, V., & Estrela, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207140200 · Cited by 46 · see citing works

Expression of functional human glutaminase in baculovirus system: Affinity purification, kinetic and molecular characterization

Campos-Sandoval, J. A., de la Oliva, A. R. L., Lobo, C., Segura, J. A., Matés, J. M., Alonso, F. J., & Márquez, J. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.12.002 · Cited by 45 · see citing works

Glutamine Deprivation Enhances Antitumor Activity of 3-Bromopyruvate through the Stabilization of Monocarboxylate Transporter-1

Cardaci, S., Rizza, S., Filomeni, G., Bernardini, R., Bertocchi, F., Mattei, M., Paci, M., Rotilio, G., & Ciriolo, M. R. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1741 · Cited by 45 · see citing works

Glutamine transport in C6 glioma cells shows ASCT2 system characteristics

Dolinska, M. B., Dybel, A., Zabłocka, B., & Albrecht, J. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00040-8 · Cited by 44 · see citing works

Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.

Rosenfeld, H., & Roberts, J. (1981) · PubMed · Cited by 41 · see citing works

Simultaneously Targeting Tissue Transglutaminase and Kidney Type Glutaminase Sensitizes Cancer Cells to Acid Toxicity and Offers New Opportunities for Therapeutic Intervention

Katt, W. P., Antonyak, M. A., & Cerione, R. A. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500405h · Cited by 33 · see citing works

Characterization of l -glutamine transport by a human neuroblastoma cell line

Wasa, M., Wang, H., & Okada, A. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00324.2001 · Cited by 32 · see citing works

Glutamine in Clinical Nutrition

Gianotti, L., Oldani, M., Coppola, S., Nespoli, L., Braga, M., & M, Z. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1932-1 · Cited by 28 · see citing works

Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up‐regulating glutamate cysteine ligase

de Tudela, M. V.-P., Delgado‐Esteban, M., Cuende, J., Bolaños, J. P., & Almeida, Á. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06648.x · Cited by 27 · see citing works

Pharmacoanalytical assays of Erwinia asparaginase (erwinase) and pharmacokinetic results in high-risk acute lymphoblastic leukemia (HR ALL) patients: simulations of erwinase population PK-PD models.

Avramis, V. I., Martín‐Aragón, S., Avramis, E. V., & Asselin, B. L. (2007) · PubMed · Cited by 26 · see citing works

Intersections between mitochondrial sirtuin signaling and tumor cell metabolism

Herrera, K. N. G., Lee, J. J., & Haigis, M. C. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1031879 · Cited by 24 · see citing works

Novel Form of Phosphate Activated Glutaminase in Cultured Astrocytes and Human Neuroblastoma Cells, PAG in Brain Pathology and Localization in the Mitochondria

Kvamme, E., Nissen‐Meyer, L. S. H., Roberg, B., & Torgner, I. A. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9589-9 · Cited by 23 · see citing works

Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition

Santana, S. M., Antonyak, M. A., Cerione, R. A., & Kirby, B. J. (2014) · Physical Biology · doi:10.1088/1478-3975/11/6/065001 · Cited by 23 · see citing works

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression

Kruspig, B., Nilchian, A., Bejarano, I., Orrenius, S., Zhivotovsky, B., & Gogvadze, V. G. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0918-4 · Cited by 19 · see citing works

Abstract 1416: CB-839, a novel potent and selective glutaminase inhibitor, has broad antiproliferative activity in cell lines derived from both solid tumors and hematological malignancies

Parlati, F., Demo, S. D., Gross, M. I., Janes, J. R., Lewis, E. R., MacKinnon, A. L., Rodriguez, M. L. M., Shwonek, P. J., Wang, T., Yang, J., et al. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-1416 · Cited by 16 · see citing works

Evaluating the Toxicity of the Analgesic Glutaminase Inhibitor 6-Diazo-5-Oxo-L-Norleucine in vitro and on Rat Dermal Skin Fibroblasts

Crosby, H. A. (2015) · MOJ Toxicology · doi:10.15406/mojt.2015.01.00005 · Cited by 15 · see citing works

Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi

Maeda, K., Nakajima, Y., Motoyama, T., Kitou, Y., Kosaki, T., Saito, T., Nishiuchi, T., Kanamaru, K., Osada, H., Kobayashi, T., et al. (2014) · Letters in Applied Microbiology · doi:10.1111/lam.12289 · Cited by 13 · see citing works

Effects of glutamine on tumor growth and apoptosis of hepatoma cells.

Liu, S. L., Shi, D., Shen, Z., & Wu, Y. (2000) · PubMed · Cited by 13 · see citing works

Properties of glutaminase of crayfish CNS: implications for axon–glia signaling

Engler, J. A., Gottesman, J. M., Harkins, J. C., Urazaev, A. K., Lieberman, E. M., & Grossfeld, R. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00357-3 · Cited by 12 · see citing works

Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway

Yamaguchi, Y., Takenobu, H., Ohira, M., Nakazawa, A., Yoshida, S., Akita, N., Shimozato, O., Iwama, A., Nakagawara, A., & Kamijo, T. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.01.023 · Cited by 12 · see citing works

Efficacy of Novel Glutaminase Inhibitor CB-839 in Acute Myeloid Leukemia

Matre, P. R., Shariati, M., Vélez, J., Qi, Y., Konoplev, S. N., Su, X., Dinardo, C. D., Daver, N. G., Majeti, R., Andreeff, M., et al. (2014) · Blood · doi:10.1182/blood.v124.21.3763.3763 · Cited by 12 · see citing works

c-Myc inactivation by mutant max alters growth and morphology of NCI-H-630 colon cancer cells

Borrè, A., Cultraro, C. M., & Segal, S. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199610)169:1 · Cited by 10 · see citing works

Glutamine antagonist with diet deficient in glutamine and aspartate reduce tumor growth.

Yoshioka, K., Takehara, H., Okada, A., & Komi, N. (1992) · PubMed · Cited by 9 · see citing works

Anti-Myeloma Activity of a Novel Glutaminase Inhibitor CB-839

Das, D. S., Ravillah, D., Ray, A., Song, Y. Y., Munshi, N. C., Richardson, P. G. G., Chauhan, D., & Anderson, K. C. (2014) · Blood · doi:10.1182/blood.v124.21.3439.3439 · Cited by 7 · see citing works

NT-39 * GLUTAMINASE-MEDIATED METABOLIC PATHWAY INVOLVES GLIOBLASTOMA RESISTANCE TO mTOR-TARGETED THERAPIES

Tanaka, K., Sasayama, T., Irino, Y., Takata, K., Nagashima, H., Masui, K., Gini, B., Yang, H., Mischel, P. S., & Kohmura, E. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou265.37 · Cited by 5 · see citing works

Abstract 2440: RNF5 mediates ER stress-induced degradation of SLC1A5 in breast cancer

Jeon, Y. J., Khelifa, S., Feng, Y., Lau, E. K., Cardiff, R. D., Kim, H., Rimm, D. L., Kluger, Y., & Ronai, Z. A. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-2440 · Cited by 4 · see citing works

P0143 ASC amino acid transporter 2 (ASCT2) as a novel prognostic marker in non-small-cell lung cancer

Shimizu, K., Kaira, K., Tomizawa, Y., Sunaga, N., Kawashima, O., Oriuchi, N., Kana, Y., Yamada, M., Oyama, T., & Takeyoshi, I. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.03.187 · Cited by 2 · see citing works

Abstract C42: Mitochondrial glutaminase regulation and small molecule inhibition of glutamine metabolism

Stalnecker, C. A., Erickson, J. W., Ramachandran, S., DeBerardinis, R. J., & Cerione, R. A. (2013) · Cancer Research · doi:10.1158/1538-7445.fbcr13-c42 · Cited by 1 · see citing works

Glutamine Transporter Expression Profiling Reveal Major Role for ASCT2 and LAT1 in Primary and Metastatic Human Hepatocellular Carcinoma Cells

Kron, C., & Bode, B. P. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.1000.4 · Cited by 1 · see citing works

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Targeting Glutamine Metabolism for Cancer Treatment

Choi, Y., & Park, K. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.178 · Cited by 321 · see citing works

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

Chen, Q., Kirk, K., Shurubor, Y. I., Zhao, D., Arreguin, A. J., Shahi, I., Valsecchi, F., Primiano, G., Calder, E. L., Carelli, V., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.002 · Cited by 210 · see citing works

SLC transporters: structure, function, and drug discovery

Colas, C., Ung, P. M. U., & Schlessinger, A. (2016) · MedChemComm · doi:10.1039/c6md00005c · Cited by 201 · see citing works

Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma

Poff, A. M., Koutnik, A. P., Egan, K. M., Sahebjam, S., D’Agostino, D. P., & Kumar, N. B. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.12.011 · Cited by 203 · see citing works

Phosphatidylserine: A cancer cell targeting biomarker

Sharma, B., & Kanwar, S. S. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.012 · Cited by 198 · see citing works

Metabolic reprogramming in cholangiocarcinoma

Raggi, C., Taddei, M. L., Rae, C. J., Braconi, C., & Marra, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.04.038 · Cited by 177 · see citing works

Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy

Li, J., Eu, J. Q., Kong, L. R., Wang, L., Lim, Y. C., Goh, B. C., & Wong, A. L. (2020) · Molecules · doi:10.3390/molecules25204831 · Cited by 159 · see citing works

Glutamine metabolism in breast cancer and possible therapeutic targets

Li, S., Zeng, H., Fan, J., Wang, X., Xu, C., Li, Y., Tu, J., Nephew, K. P., & Long, X. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115464 · Cited by 135 · see citing works

Investigation of Mitochondrial Metabolic Response to Doxorubicin in Prostate Cancer Cells: An NADH, FAD and Tryptophan FLIM Assay

Alam, S. R., Wallrabe, H. K., Švindrych, Z., Chaudhary, A. K., Christopher, K. G., Chandra, D., & Periasamy, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-10856-3 · Cited by 121 · see citing works

HIV infection and latency induce a unique metabolic signature in human macrophages

Castellano, P., Prevedel, L., Valdebenito, S., & Eugenín, E. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-39898-5 · Cited by 109 · see citing works

Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging

Aboud, O. A., Habib, S. L., Trott, J. F., Stewart, B. J., Liang, S., Chaudhari, A. J., Sutcliffe-Goulden, J., & Weiss, R. H. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0930 · Cited by 106 · see citing works

Plasma-free amino acid profiles are predictors of cancer and diabetes development

Bi, X., & Henry, C. J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2016.55 · Cited by 106 · see citing works

TCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma

Todisco, S., Convertini, P., Iacobazzi, V., & Infantino, V. (2019) · Cancers · doi:10.3390/cancers12010068 · Cited by 103 · see citing works

Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer

Saha, S. K., Islam, S. M. R., Abdullah-Al-Wadud, M., Islam, M. S., Ali, F., & Park, K. S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030355 · Cited by 97 · see citing works

Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 96 · see citing works

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

Tyszka‐Czochara, M., Bukowska-Straková, K., Kocemba-Pilarczyk, K. A., & Majka, M. (2018) · Nutrients · doi:10.3390/nu10070841 · Cited by 87 · see citing works

Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts

Bai, L., Bernard, K., Tang, X., Hu, M., Horowitz, J. C., Thannickal, V. J., & Sanders, Y. Y. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0180oc · Cited by 88 · see citing works

Aminoacyl-tRNA synthetases and amino acid signaling

Yu, Y. C., Han, J. M., & Kim, S. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118889 · Cited by 82 · see citing works

DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation

Li, M., Thorne, R. F., Shi, R., Zhang, X. D., Li, J., Li, J., Zhang, Q., Wu, M., & Liu, L. (2021) · Advanced Science · doi:10.1002/advs.202003732 · Cited by 81 · see citing works

Integrated microbiome, metabolome, and proteome analysis identifies a novel interplay among commensal bacteria, metabolites and candidate targets in non‐small cell lung cancer

Xiang, Q., Zhang, H., Li, Q., Ma, G., Chen, Z., Ji, X., Li, C., & Zhang, A. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.947 · Cited by 81 · see citing works

Metabolic Features of Multiple Myeloma

Arfani, C. E., Veirman, K. D., Maes, K., Bruyne, E. D., & Menu, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041200 · Cited by 75 · see citing works

Filament formation by metabolic enzymes—A new twist on regulation

Lynch, E. M., Kollman, J. M., & Webb, B. A. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.04.006 · Cited by 78 · see citing works

Dietary restriction of amino acids for Cancer therapy

Kang, J. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00439-x · Cited by 73 · see citing works

Nutrient sensors and their crosstalk

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Targeting cancer metabolic pathways for improving chemotherapy and immunotherapy

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