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Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity
Open accessAbstract
Immunotherapies, such as chimeric antigen receptor T cells, bispecific antibodies, and immune checkpoint inhibitors, have emerged as promising modalities in multiple hematologic malignancies. Despite the excitement surrounding immunotherapy, it is currently not possible to predict which patients will respond. Within solid tumors, the status of the immune microenvironment provides valuable insight regarding potential responses to immune therapies. Much less is known about the immune microenvironment within hematologic malignancies but the characteristics of this environment are likely to serve a similar predictive role. Acute myeloid leukemia (AML) is the most common hematologic malignancy in adults, and only 25% of patients are alive 5 years following their diagnosis. There is evidence that manipulation of the immune microenvironment by leukemia cells may play a role in promoting therapy resistance and disease relapse. In addition, it has long been documented that through modulation of the immune system following allogeneic bone marrow transplant, AML can be cured, even in patients with the highest risk disease. These concepts, along with the poor prognosis associated with this disease, have encouraged many groups to start exploring the utility of novel immune therapies in AML. While the implementation of these therapies into clinical trials for AML has been supported by preclinical rationale, many questions still exist surrounding their efficacy, tolerability, and the overall optimal approach. In this review, we discuss what is known about the immune microenvironment within AML with a specific focus on T cells and checkpoints, along with their implications for immune therapies.
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“MSCs play a role in innate and acquired immunity directly through cell-cell contact or secretion of soluble factors.32,33”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [32]
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“AML can lead to the induction of MDSCs and Tregs, which dampen adaptive immune response in close proximity to leukemic cells.32”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [32]
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Cites
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., et al. (2017) · Science · doi:10.1126/science.aan6733 · Cited by 6,645
Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 3×
“Curr Opin Immunol (2007) 19(3):309–14.”
InfluentialIntratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
McGranahan, N., Furness, A. J. S., Rosenthal, R., Ramskov, S., Lyngaa, R., Saini, S. K., Jamal-Hanjani, M., Wilson, G. A., Birkbak, N. J., Hiley, C. T., et al. (2016) · Science · doi:10.1126/science.aaf1490 · Cited by 3,065
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
Van Allen, E. M., Miao, D., Schilling, B., Shukla, S. A., Blank, C., Zimmer, L., Sucker, A., Hillen, U., Geukes Foppen, M. H., Goldinger, S. M., et al. (2015) · Science · doi:10.1126/science.aad0095 · Cited by 2,839
Graft-versus-leukemia reactions after bone marrow transplantation
Horowitz, M., Rp, G., Pm, S., Goldman, J. M., Kersey, J., Kolb, H., Rimm, A., Ringdén, O. T. H., Rozmán, C., & SPECK, B. (1990) · Blood · doi:10.1182/blood.v75.3.555.555 · Cited by 2,769
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680
Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W., & Sakaguchi, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.303 · Cited by 2,233
CTLA-4 can function as a negative regulator of T cell activation
Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B., & Bluestone, J. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90071-x · Cited by 2,222
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
Anderson, A. C., Joller, N., & Kuchroo, V. K. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.001 · Cited by 2,096
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K., & Anderson, A. C. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100643 · Cited by 2,072
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
Francisco, L. M., Salinas, V. H., Brown, K. E., Vanguri, V. K., Freeman, G. J., Kuchroo, V. K., & Sharpe, A. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090847 · Cited by 2,072
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Zhu, C., Anderson, A. C., Schubart, A., Xiong, H., Imitola, J., Khoury, S. J., Zheng, X. X., Strom, T. B., & Kuchroo, V. K. (2005) · Nature Immunology · doi:10.1038/ni1271 · Cited by 2,057
Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.011 · Cited by 2,022
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993
Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,990
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
Garcia-Diaz, A., Shin, D. S., Moreno, B. H., Saco, J., Escuin-Ordinas, H., Rodriguez, G. A., Zaretsky, J. M., Sun, L., Hugo, W., Wang, X., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.031 · Cited by 1,942
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
Matsushita, H., Vesely, M. D., Koboldt, D. C., Rickert, C. G., Uppaluri, R., Magrini, V. J., Arthur, C. D., White, J. M., Chen, Y.-S., Shea, L. K., et al. (2012) · Nature · doi:10.1038/nature10755 · Cited by 1,285
Moskophidis, D., Lechner, F., Pircher, H., & Zinkernagel, R. M. (1993) · Nature · doi:10.1038/362758a0 · Cited by 1,240
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
Munn, D. H., & Mellor, A. L. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.002 · Cited by 1,081
An Immune Atlas of Clear Cell Renal Cell Carcinoma
Chevrier, S., Levine, J., Zanotelli, V. R., Siliņa, K., Schulz, D., Bacac, M., Ries, C. H., Ailles, L., Jewett, M. A. S., Moch, H., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.016 · Cited by 1,036
Sharma, M. D., Baban, B., Chandler, P., Hou, D., Singh, N., Yagita∥, H., Azuma, M., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31911 · Cited by 791
DNA methylation controls Foxp3 gene expression
Polansky, J. K., Kretschmer, K., Freyer, J., Floess, S., Garbe, A. I., Baron, U., Olek, S., Hamann, A., von Boehmer, H., & Huehn, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838105 · Cited by 784
Gallimore, A., Glithero, A., Godkin, A. J., Tissot, A. C., Plückthun, A., Elliott, T. J., Hengartner, H., & Zinkernagel, R. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1383 · Cited by 768
Yang, H., Bueso-Ramos, C., DiNardo, C., Estecio, M. R., Davanlou, M., Geng, Q.-R., Fang, Z., Nguyen, M., Pierce, S., Wei, Y., et al. (2014) · Leukemia · doi:10.1038/leu.2013.355 · Cited by 688
Zhou, Q., Munger, M. E., Veenstra, R. G., Weigel, B. J., Hirashima, M., Munn, D. H., Murphy, W. J., Azuma, M., Anderson, A. C., Kuchroo, V. K., et al. (2011) · Blood · doi:10.1182/blood-2010-10-310425 · Cited by 675
Acute myeloid leukemia: Epidemiology and etiology
Deschler-Baier, B., & Lübbert, M. (2006) · Cancer · doi:10.1002/cncr.22233 · Cited by 646
Nakano, O., Sato, M., Naito, Y., Suzuki, K., Orikasa, S., Aizawa, M., Suzuki, Y., Shintaku, I., Nagura, H., & Ohtani, H. (2001) · PubMed · Cited by 639
Ipilimumab for Patients with Relapse after Allogeneic Transplantation
Davids, M. S., Kim, H. T., Bachireddy, P., Costello, C. L., Liguori, R., Savell, A., Lukez, A. P., Avigan, D., Chen, Y., McSweeney, P. A., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1601202 · Cited by 595
CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation
Kim, H., & Leonard, W. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070109 · Cited by 590
Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation
Lal, G., Zhang, N., van der Touw, W., Ding, Y., Ju, W., Böttinger, E. P., Reid, S. P., Levy, D. E., & Bromberg, J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.259 · Cited by 564
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R.-W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.022 · Cited by 537
Riches, J. C., DAVIES, J. K., McClanahan, F., Fatah, R., Iqbal, S., Agrawal, S. G., Ramsay, A. G., & Gribben, J. G. (2012) · Blood · doi:10.1182/blood-2012-09-457531 · Cited by 528
Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas.
Schumacher, K., Haensch, W., Röefzaad, C., & Schlag, P. M. (2001) · PubMed · Cited by 503
TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells
Kikushige, Y., Shima, T., Takayanagi, S., Urata, S., Miyamoto, T., Iwasaki, H., Takenaka, K., Teshima, T., Tanaka, T. T., Inagaki, Y., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.11.014 · Cited by 492
The TIGIT/CD226 Axis Regulates Human T Cell Function
Lozano, E., Dominguez‐Villar, M., Kuchroo, V. K., & Hafler, D. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103627 · Cited by 488
Jiménez-Sánchez, A., Memon, D., Pourpe, S., Veeraraghavan, H., Li, Y., Vargas, H. A., Gill, M. B., Park, K. J., Zivanovic, O., Konner, J. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.025 · Cited by 456
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens
Hundal, J., Carreno, B. M., Petti, A. A., Linette, G. P., Griffith, O. L., Mardis, E. R., & Griffith, M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0264-5 · Cited by 454
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
Pentcheva‐Hoang, T., Egen, J. G., Wojnoonski, K., & Allison, J. P. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.017 · Cited by 446
PD-1 and its ligands in T-cell immunity
Keir, M. E., Francisco, L. M., & Sharpe, A. H. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.04.012 · Cited by 444
Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus
Feng, Y., Arvey, A., Chinen, T., van der Veeken, J., Gasteiger, G., & Rudensky, A. Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.031 · Cited by 422
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
Zhang, L., Gajewski, T. F., & Kline, J. P. (2009) · Blood · doi:10.1182/blood-2009-03-206672 · Cited by 417
Curti, A., Pandolfi, S., Valzasina, B., Aluigi, M., Isidori, A., Ferri, E., Salvestrini, V., Bonanno, G., Rutella, S., Durelli, I., et al. (2006) · Blood · doi:10.1182/blood-2006-07-036863 · Cited by 409
Goodyear, O. C., Dennis, M., Jilani, N., Loke, J. C. T., Siddique, S., Ryan, G. B., Nunnick, J., Khanum, R., Raghavan, M., Cook, M. A., et al. (2012) · Blood · doi:10.1182/blood-2011-09-377044 · Cited by 400
Vstm3 is a member of the CD28 family and an important modulator of T‐cell function
Levin, S. D., Taft, D. W., Brandt, C. S., Bucher, C. M., Howard, E. D., Chadwick, E. M., Johnston, J. V., Hammond, A. J., Bontadelli, K., Ardourel, D., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201041136 · Cited by 361
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
Mussai, F., Santo, C. D., Abu‐Dayyeh, I., Booth, S., Quek, L. S., McEwen-Smith, R. M., Qureshi, A., Dazzi, F., Vyas, P., & Cerundolo, V. (2013) · Blood · doi:10.1182/blood-2013-01-480129 · Cited by 346
Goodyear, O. C., Agathanggelou, A., Novitzky‐Basso, I., Siddique, S., McSkeane, T., Ryan, G. B., Vyas, P., Cavenagh, J. D., Stankovic, T., Moss, P. A. H., et al. (2010) · Blood · doi:10.1182/blood-2009-11-249474 · Cited by 340
Trial watch: IDO inhibitors in cancer therapy
Vacchelli, E., Aranda, F., Eggermont, A. M. M., Sautès‐Fridman, C., Tartour, É., Kennedy, E. P., Platten, M., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2014) · OncoImmunology · doi:10.4161/21624011.2014.957994 · Cited by 333
Szczepański, M. J., Szajnik, M. E., Czystowska, M., Mandapathil, M., Strauss, L., Welsh, A., Foon, K. A., Whiteside, T. L., & Boyiadzis, M. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3010 · Cited by 309
Kong, Y., Zhu, L., Schell, T. D., Zhang, J., Claxton, D. F., Ehmann, W. C., Rybka, W. B., George, M. R., Zeng, H., & Zheng, H. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2626 · Cited by 306
Regulatory T Cells: Differentiation and Function
Plitas, G., & Rudensky, A. Y. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0193 · Cited by 298
Zhou, Q., Munger, M. E., Highfill, S. L., Tolar, J., Weigel, B. J., Riddle, M. J., Sharpe, A. H., Vallera, D. A., Azuma, M., Levine, B. L., et al. (2010) · Blood · doi:10.1182/blood-2010-03-275446 · Cited by 294
Mumprecht, S., Schürch, C. M., Schwaller, J., Solenthaler, M., & Ochsenbein, A. F. (2009) · Blood · doi:10.1182/blood-2008-09-179697 · Cited by 275
Reactivating the expression of methylation silenced genes in human cancer
Karpf, A. R., & Jones, D. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205602 · Cited by 264
Vesalainen, S., Lipponen, P., Talja, M. T., & Syrjänen, K. J. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)e0159-2 · Cited by 254
Scheibenbogen, C., Letsch, A., Thiel, E., Schmittel, A. H., Mailänder, V., Baerwolf, S., Nagorsen, D., & Keilholz, U. (2002) · Blood · doi:10.1182/blood-2002-01-0163 · Cited by 248
Dieu, R. L., Taussig, D. C., Ramsay, A. G., Mitter, R., Miraki-Moud, F., Fatah, R., Lee, A. M., Lister, T. A., & Gribben, J. G. (2009) · Blood · doi:10.1182/blood-2009-02-206946 · Cited by 245
The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
Governa, V., Trella, E., Mele, V., Tornillo, L., Amicarella, F., Cremonesi, E., Muraro, M. G., Xu, H., Droeser, R. A., Däster, S., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2047 · Cited by 237
Anguille, S., Van de Velde, A. L., Smits, E. L., Van Tendeloo, V. F., Juliusson, G., Cools, N., Nijs, G., Stein, B., Lion, E., Van Driessche, A., et al. (2017) · Blood · doi:10.1182/blood-2017-04-780155 · Cited by 230
Targeting regulatory T cells in tumors
Liu, C., Workman, C. J., & Vignali, D. A. A. (2016) · The FEBS Journal · doi:10.1111/febs.13656 · Cited by 228
Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting
Sánchez-Abarca, L. I., Gutierrez-Cosío, S., Santamaría, C., Caballero‐Velázquez, T., Blanco, B., Herrero-Sánchez, C., Garcı́a, J. L., Carrancio, S., Hernández‐Campo, P. M., González, F. J., et al. (2009) · Blood · doi:10.1182/blood-2009-03-210393 · Cited by 226
Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
Üstün, C., Miller, J. S., Munn, D. H., Weisdorf, D. J., & Blazar, B. R. (2011) · Blood · doi:10.1182/blood-2011-07-365817 · Cited by 222
Wilms' tumour 1 (WT1) in development, homeostasis and disease
Hastie, N. D. (2017) · Development · doi:10.1242/dev.153163 · Cited by 216
Greiner, J., Schmitt, M. W., Li, L., Giannopoulos, K., Bosch, K., Schmitt, A., Döhner, K., Schlenk, R. F., Pollack, J. R., Döhner, H., et al. (2006) · Blood · doi:10.1182/blood-2006-01-023127 · Cited by 209
Zhang, S., Han, Y., Wu, J., Kang, Y., Bi, L., Yan, Z., & Xu, X. (2010) · International Journal of Cancer · doi:10.1002/ijc.25791 · Cited by 201
MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia
Pyzer, A. R., Stroopinsky, D., Rajabi, H. N., Washington, A. J., Tagde, A., Coll, M. D., Fung, J., Bryant, M. P., Cole, L., Palmer, K. A., et al. (2017) · Blood · doi:10.1182/blood-2016-07-730614 · Cited by 199
Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents
Héninger, E., Krueger, T. E. G., & Lang, J. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00029 · Cited by 194
Yamamoto, T., Price, D. A., Casazza, J. P., Ferrari, G., Nason, M., Chattopadhyay, P. K., Roederer, M., Emma Gostick, D., Katsikis, P. D., Douek, D. C., et al. (2011) · Blood · doi:10.1182/blood-2010-11-317297 · Cited by 193
Ørskov, A. D., Treppendahl, M. B., Skovbo, A., Holm, M. S., Friis, L. S., Hokland, M., & Grønbæk, K. (2015) · Oncotarget · doi:10.18632/oncotarget.3324 · Cited by 190
Kozako, T., Yoshimitsu, M., Fujiwara, H., Masamoto, I., Horai, S., White, Y., Akimoto, M., Suzuki, S., Matsushita, K., Uozumi, K., et al. (2008) · Leukemia · doi:10.1038/leu.2008.272 · Cited by 181
Berthon, C., Driss, V., Liu, J., Kuranda, K., Leleu, X. P., Jouy, N., Hétuin, D., & Quesnel, B. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0909-y · Cited by 175
Almstedt, M., Blagitko‐Dorfs, N., Duque‐Afonso, J., Karbach, J., Pfeifer, D., Jäger, E., & Lübbert, M. (2010) · Leukemia Research · doi:10.1016/j.leukres.2010.02.004 · Cited by 171
Rosenblatt, J. M., Stone, R. M., Uhl, L., Neuberg, D. S., Joyce, R., Levine, J. D., Arnason, J. E., McMasters, M., Luptakova, K., Jain, S. S., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1298 · Cited by 168
Saha, A., Aoyama, K., Taylor, P. A., Koehn, B. H., Veenstra, R. G., Panoskaltsis‐Mortari, A., Munn, D. H., Murphy, W. J., Azuma, M., Yagita∥, H., et al. (2013) · Blood · doi:10.1182/blood-2013-05-500801 · Cited by 167
Al-Matary, Y. S., Botezatu, L., Opalka, B., Hönes, J. M., Lams, R. F., Thivakaran, A., Schütte, J., Koster, R., Lennartz, K., Schroeder, T. A., et al. (2016) · Haematologica · doi:10.3324/haematol.2016.143180 · Cited by 161
Kornblau, S. M., McCue, D. L., Singh, N., Chen, W., Estrov, Z. E., & Coombes, K. R. (2010) · Blood · doi:10.1182/blood-2010-01-262071 · Cited by 160
Kong, Y., Zhang, J., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Zhu, L., Zeng, H., Schell, T. D., & Zheng, H. (2015) · Blood Cancer Journal · doi:10.1038/bcj.2015.58 · Cited by 155
Schnorfeil, F. M., Lichtenegger, F. S., Emmerig, K., Schlueter, M., Neitz, J. S., Draenert, R., Hiddemann, W., & Subklewe, M. S. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0189-2 · Cited by 152
Matulonis, U. A., Dosiou, C., Freeman, G., Lamont, C., Mauch, P., Nadler, L. M., & Griffin, J. D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1126 · Cited by 150
CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
Peretz, Y., He, Z., Shi, Y., Yassine‐Diab, B., Goulet, J.-P., Bordi, R., Filali‐Mouhim, A., Loubert, J.-B., Far, M. E., Dupuy, F. P., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002840 · Cited by 150
Nunes, C., Wong, R., Mason, M. D., Fegan, C., Man, S., & Pepper, C. J. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2630 · Cited by 150
Zhou, Q., Bucher, C. M., Munger, M. E., Highfill, S. L., Tolar, J., Munn, D. H., Levine, B. L., Riddle, M. J., June, C. H., Vallera, D. A., et al. (2009) · Blood · doi:10.1182/blood-2009-03-208181 · Cited by 147
Wang, X., Zheng, J., Liu, J., Yao, J., He, Y., Li, X., Yu, J., Yang, J. X., Liu, Z., & Huang, S. (2005) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2005.00537.x · Cited by 147
Immunity to WT1 in the animal model and in patients with acute myeloid leukemia
Gaiger, A., Reese, V. A., Disis, M. L., & Cheever, M. A. (2000) · Blood · doi:10.1182/blood.v96.4.1480 · Cited by 142
Buggins, A. G. S., Milojković, D., Arno, M. J., Lea, N. C., Mufti, G. J., Thomas, N. S. B., & Hirst, W. J. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.6021 · Cited by 141
Dual biological effects of the cytokines interleukin-10 and interferon-γ
Wilke, C. M., Wei, S., Wang, L., Kryczek, I., Kao, J., & Zou, W. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1104-5 · Cited by 138
Kittang, A. O., Kordasti, S. Y., Sand, K. E., Costantini, B., Kramer, A. M., Abellan, P. P., Seidl, T., Rye, K. P., Hagen, K. M., Kulasekararaj, A. G., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1062208 · Cited by 132
Christiansson, L. H., Söderlund, S., Svensson, E., Mustjoki, S. M., Bengtsson, M., Simonsson, B., Olsson‐Strömberg, U., & Loskog, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055818 · Cited by 129
Pistillo, M. P. (2002) · Blood · doi:10.1182/blood-2002-06-1668 · Cited by 127
Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L., Snyder, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.03.036 · Cited by 126
Costantini, B., Kordasti, S. Y., Kulasekararaj, A. G., Jiang, J., Seidl, T., Abellan, P. P., Mohamedali, A., Thomas, N. S. B., Farzaneh, F., & Mufti, G. J. (2012) · Haematologica · doi:10.3324/haematol.2012.074823 · Cited by 124
Clinical significance of B7-H1(PD-L1)expression in human acute leukemia
Chen, X., Liu, S., Wang, L., Zhang, W., Ji, Y., & Ma, X. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.5.5689 · Cited by 122
The emerging role of immune checkpoint based approaches in AML and MDS
Boddu, P. C., Kantarjian, H. M., Garcia‐Manero, G., Allison, J. P., Sharma, P., & Daver, N. G. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1344905 · Cited by 120
Elisseeva, O. A., Oka, Y., Tsuboi, A., Ogata, K., Wu, F., Kim, E. H., Soma, T., Tamaki, H., Kawakami, M., Oji, Y., et al. (2002) · Blood · doi:10.1182/blood.v99.9.3272 · Cited by 119
Wang, L., Mei, Z.-Y., Zhou, J., Yao, Y., Li, Y.-H., Xu, Y., Li, J., Gao, X., Zhou, M., Jiang, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062924 · Cited by 113
Folgiero, V., Goffredo, B. M., Filippini, P., Masetti, R., Bonanno, G., Caruso, R., Bertaina, V., Mastronuzzi, A., Gaspari, S., Zecca, M., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1504 · Cited by 110
Epigenetic Changes in the Myelodysplastic Syndrome
Issa, J. J. (2010) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2010.02.007 · Cited by 110
Krönig, H., Kremmler, L., Haller, B., Englert, C., Peschel, C., Andreesen, R., & Blank, C. U. (2013) · European Journal Of Haematology · doi:10.1111/ejh.12228 · Cited by 110
Johanns, T. M., Ward, J. P., Miller, C. A., Wilson, C., Kobayashi, D. K., Bender, D. E., Fu, Y., Alexandrov, A., Mardis, E. R., Artyomov, M. N., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0156 · Cited by 106
Stasi, A. D., Jiménez, A., Minagawa, K., Al‐Obaidi, M., & Rezvani, K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00036 · Cited by 103
Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL-6, IL-1 and TNF
Joseph, S. B., Miner, K. T., & Croft, M. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199801)28:01 · Cited by 100
Corm, S., Berthon, C., Imbenotte, M., Biggio, V., Lhermitte, M., Dupont, C., Briche, I., & Quesnel, B. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.06.014 · Cited by 97
Shimauchi, T., Kabashima, K., Nakashima, D., Sugita, K., Yamada, Y., Hino, R., & TOKURA, Y. (2007) · International Journal of Cancer · doi:10.1002/ijc.23042 · Cited by 94
Expression of checkpoint molecules on myeloid-derived suppressor cells
Ballbach, M., Dannert, A., Singh, A., Siegmund, D. M., Handgretinger, R., Piali, L., Rieber, N. P., & Hartl, D. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.10.001 · Cited by 91
Tan, J., Chen, S., Lu, Y., Yao, D., Xu, L., Zhang, Y., Yang, L., Chen, J., Lai, J., Yu, Z. H., et al. (2017) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2017.05.11 · Cited by 89
Ersvær, E., Liseth, K., Skavland, J., Gjertsen, B. T., & Bruserud, Ø. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-38 · Cited by 88
Gang, A. O., Frøsig, T. M., Brimnes, M. K., Lyngaa, R., Treppendahl, M. B., Grønbæk, K., Dufva, I. H., Straten, P. T., & Hadrup, S. R. (2014) · Blood Cancer Journal · doi:10.1038/bcj.2014.14 · Cited by 86
Wang, M., Bu, J., Zhou, M., Sido, J. M., Lin, Y., Liu, G., Lin, Q., Xu, X., Leavenworth, J. W., & Shen, E. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.08.021 · Cited by 83
Orleans‐Lindsay, J. K., Barber, L. D., Prentice, H. G., & Lowdell, M. W. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01692.x · Cited by 81
Li, Y.-Q., Liu, F., Zhang, X.-M., Guo, X.-J., Ren, M.-J., & Fu, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076379 · Cited by 81
Panoskaltsis, N., Reid, C. D. L., & Knight, S. C. (2003) · Leukemia · doi:10.1038/sj.leu.2402835 · Cited by 78
den Hove, L. E. V., Vandenberghe, P., Gool, S. W. V., Ceuppens, J. L., Demuynck, H., Verhoef, G. E. G., & Boogaerts, M. (1998) · Leukemia Research · doi:10.1016/s0145-2126(97)00152-5 · Cited by 73
Kanakry, C. G., Hess, A. D., Gocke, C. D., Thoburn, C. J., Kos, F. J., Meyer, C. F., Briel, J., Luznik, L., Smith, B. D., Levitsky, H. I., et al. (2010) · Blood · doi:10.1182/blood-2010-04-277939 · Cited by 67
Li, C., Chen, X., Xiao, Y., Zhu, Y., Ma, C., Xia, R., Ma, J., Gu, C., Ye, L., & Wu, D. (2014) · PubMed Central · Cited by 58
Myeloid-derived suppressor cells in B cell malignancies
Yazdani, Y., Mohammadnia‐Afrouzi, M., Yousefi, M., Anvari, E., Ghalamfarsa, G., Hassannia, H., Sadreddini, S., & Jadidi‐Niaragh, F. (2015) · Tumor Biology · doi:10.1007/s13277-015-4004-z · Cited by 58
Zhong, R., Loken, M. R., Lane, T. A., & Ball, E. (2006) · Cytotherapy · doi:10.1080/14653240500499507 · Cited by 57
Wendelbo, �., Nesthus, I., Sjo, M., Rye, K. P., Ernst, P., & Bruserud, �. (2004) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-004-0505-0 · Cited by 55
Indoleamine 2,3-dioxygenase and regulatory T cells in acute myeloid leukemia
Mansour, I., Zayed, R. A., Said, F., & Soliman, L. (2016) · Hematology · doi:10.1080/10245332.2015.1106814 · Cited by 51
Rey, J., Fauriat, C., Kochbati, E., Orlanducci, F., Charbonnier, A., D’Incan, E., André, P., Romagné, F., Barbarat, B., Vey, N., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00064 · Cited by 51
Expression of CD86 in acute myelogenous leukemia is a marker of dendritic/monocytic lineage
Re, F., Arpinati, M., Testoni, N., Ricci, P., Terragna, C., PREDA, P., Ruggeri, D., Senese, B., Chirumbolo, G., Martelli, V., et al. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00768-8 · Cited by 49
Dölen, Y., & Esendağlı, G. (2012) · European Journal of Immunology · doi:10.1002/eji.201242814 · Cited by 48
LaBelle, J. L., Hanke, C. A., Blazar, B. R., & Truitt, R. L. (2002) · Blood · doi:10.1182/blood.v99.6.2146 · Cited by 48
Mabuchi, R., Hara, T., Matsumoto, T., Shibata, Y., Nakamura, N., Nakamura, H., Kitagawa, J., Kanemura, N., Goto, N., Shimizu, M., et al. (2015) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1041388 · Cited by 47
Fozza, C., Corda, G., Barraqueddu, F., Virdis, P., Contini, S., Galleu, A., Isoni, A., Dore, F., Angelucci, E., & Longinotti, M. (2015) · Leukemia Research · doi:10.1016/j.leukres.2015.06.007 · Cited by 44
Maszyna, F., Hoff, H., Kunkel, D., Radbruch, A., & Brunner-Weinzierl, M. C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3459 · Cited by 44
Fukuno, K., Hara, T., Tsurumi, H., Shibata, Y., Mabuchi, R., Nakamura, N., Kitagawa, J., Shimizu, M., Ito, H., Saito, K., et al. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.953150 · Cited by 44
Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia
Giallongo, C., Parrinello, N. L., Brundo, M. V., Raccuia, S. A., Rosa, M. D., Cava, P. L., & Tibullo, D. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00107 · Cited by 42
Laurent, S., Palmisano, G. L., Martelli, A. M., Kato, T., Tazzari, P. L., Pierri, I., Clavio, M., Dozin, B., Balbi, G., Megna, M., et al. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06472.x · Cited by 41
Gassner, F. J., Zaborsky, N., Neureiter, D., Huemer, M., Melchardt, T., Egle, A., Rebhandl, S., Catakovic, K., Hartmann, T. N., Greil, R., et al. (2014) · Haematologica · doi:10.3324/haematol.2013.098459 · Cited by 40
Vídriales, M., Orfao, A., López-Berges, M. C., González, M., Hernández‐Rivas, J. M., Ciudad, J., López, A., Moro, M., Martínez, M. D. L., & Miguel, J. F. S. (1993) · Annals of Hematology · doi:10.1007/bf01715050 · Cited by 39
Targeting immune checkpoints in lymphoma
Ansell, S. M. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000158 · Cited by 39
Bone marrow T-cell percentage: A novel prognostic indicator in acute myeloid leukemia
Ismail, M. M., & Abdulateef, N. A. B. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2153-5 · Cited by 38
Fisher, S. A., Lamikanra, A., Doree, C. J., Gration, B., Tsang, P., Danby, R., & Roberts, D. J. (2017) · British Journal of Haematology · doi:10.1111/bjh.14433 · Cited by 36
Lichtenegger, F. S., Lorenz, R., Gellhaus, K., Hiddemann, W., Beck, B., & Subklewe, M. S. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.05.014 · Cited by 32
The in situ local immune response, tumour senescence and proliferation in colorectal cancer
Roxburgh, C. S. D., Richards, C. H., Macdonald, A. I., Powell, A. G. M. T., McGlynn, L. M., McMillan, D. C., Horgan, P. G., Edwards, J., & Shiels, P. G. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.556 · Cited by 29
Soiffer, R. J., Davids, M. S., & Chen, Y. (2018) · Blood · doi:10.1182/blood-2017-10-752154 · Cited by 26
Beneficial role of increased FOXP 3+ regulatory T‐cells in acute myeloid leukaemia therapy response
Menter, T., Kuzmanic, B., Bucher, C. M., Medinger, M., Halter, J. P., Dirnhofer, S., & Tzankov, A. (2017) · British Journal of Haematology · doi:10.1111/bjh.14819 · Cited by 9
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Tang, L., Wu, J., Li, C.-G., Jiang, H., Xu, M., Du, M., Yin, Z., Mei, H., & Hu, Y. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3003 · Cited by 140
Abbas, H. A., Hao, D., Tomczak, K. J., Barrodia, P., Im, J. S., Reville, P. K., Alaniz, Z., Wang, W., Wang, R., Wang, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26282-z · Cited by 130
Lamble, A. J., Kosaka, Y., Laderas, T., Maffit, A., Kaempf, A. J., Brady, L., Wang, W., Long, N., Saultz, J. N., Mori, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916206117 · Cited by 98
Immune Biology of Acute Myeloid Leukemia: Implications for Immunotherapy
Khaldoyanidi, S. K., Nagorsen, D., Stein, A. S., Ossenkoppele, G. J., & Subklewe, M. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.00475 · Cited by 108
Immune Checkpoint Inhibitors in Acute Myeloid Leukemia: Novel Combinations and Therapeutic Targets
Stahl, M. F., & Goldberg, A. D. (2019) · Current Oncology Reports · doi:10.1007/s11912-019-0781-7 · Cited by 102
Metadata
- Authors
- Lamble, A. J., & Lind, E. F.
- Affiliations
- Seattle Children's Hospital (US)
- Oregon Health & Science University (US)
- Corresponding author
- Lind, Evan F.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-13
- Volume
- 8
- Pages
- 213-213
- ISSN
- 2234-943X (ISSN-L)
- PMC
- PMC6008423
- OpenAlex
- W2807706866
- Cited by
- 119
- References
- 145
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 12 · 2023: 14 · 2022: 12 · 2021: 29 · 2020: 19 · 2019: 15
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Oncology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Cancer Center (U54CA224019, U01CA217862)
- Leukemia and Lymphoma Society
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- acute myeloid leukemia, tumor immune microenvironment, T cell immunity, immune checkpoint, immunotherapy, chimeric antigen receptor T cells, bispecific antibodies, immune checkpoint inhibitors, allogeneic bone marrow transplantation, treatment resistance, recurrence, predictive biomarkers
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