Cited by 349Protease and Inhibitor MechanismsCellular Mechanics and InteractionsTGF-β signaling in diseases

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Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

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Brassart-Pasco, Sylvie, Brézillon, Stéphane, Brassart, Bertrand, Ramont, Laurent, Oudart, Jean-Baptiste, Monboisse, Jean Claude·2020·Frontiers in Oncology

DOI 10.3389/fonc.2020.00397PMC PMC7174611

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Abstract

The tumor microenvironment (TME) is composed of various cell types embedded in an altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also regulates cell-cell or cell-matrix cross-talks. Alterations in ECM may be induced by hypoxia and acidosis, by oxygen free radicals generated by infiltrating inflammatory cells or by tumor- or stromal cell-secreted proteases. A poorer diagnosis for patients is often associated with ECM alterations. Tumor ECM proteome, also named cancer matrisome, is strongly altered, and different ECM protein signatures may be defined to serve as prognostic biomarkers. Collagen network reorganization facilitates tumor cell invasion. Proteoglycan expression and location are modified in the TME and affect cell invasion and metastatic dissemination. ECM macromolecule degradation by proteases may induce the release of angiogenic growth factors but also the release of proteoglycan-derived or ECM protein fragments, named matrikines or matricryptins. This review will focus on current knowledge and new insights in ECM alterations, degradation, and reticulation through cross-linking enzymes and on the role of ECM fragments in the control of cancer progression and their potential use as biomarkers in cancer diagnosis and prognosis.

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Additional file 17 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
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Additional file 10 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916739
Additional file 9 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916736
Additional file 5 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916724
Additional file 8 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916733
Additional file 4 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916721
Additional file 2 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916715
Additional file 13 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916748
Additional file 1 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916712
Additional file 6 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916727
Additional file 12 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916745
Additional file 11 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916742
Additional file 3 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916718
Additional file 14 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916751
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Jurj, A., Ionescu, C., Berindan‐Neagoe, I., & Braicu, C. (2022) · Figshare · doi:10.6084/m9.figshare.21151438
Additional file 1 of Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche
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Additional file 7 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916730
Additional file 15 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916754
Additional file 16 of Prognostic and immune infiltrative biomarkers of CENPO in pan–cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis
Wang, Y., Ye, D., Li, Y., Lv, F., Shen, W., Li, H., Tian, L., Fan, Z., Li, Y., wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23916757

Authors: Brassart-Pasco, S., Brézillon, S., Brassart, B., Ramont, L., Oudart, J.-B., & Monboisse, J. C.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Brézillon, Stéphane
Brassart, Bertrand
Ramont, Laurent
Oudart, Jean-Baptiste
Venue: Frontiers in Oncology
Publisher: Frontiers Media SA
Published: 2020-04-15
Volume: 10
Pages: 397-397
ISSN: 2234-943X (ISSN-L)
DOI: 10.3389/fonc.2020.00397
PMC: PMC7174611
OpenAlex: W3016553015
Cited by: 335
References: 168
Citations by year: 2026: 48 · 2025: 53 · 2024: 62 · 2023: 46 · 2022: 65 · 2021: 46 · 2020: 13
FWCI: 4.69
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Oncology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion)
HAL (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Centre National de la Recherche Scientifique (UMR 7369)
Université de Reims Champagne-Ardenne
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: tumor microenvironment, extracellular matrix, tumor progression, proteoglycans, matrikines, protease degradation, hypoxia, acidosis, cell invasion, metastasis, prognostic factors, angiogenesis

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Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

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