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Genetic Architectures and Cell-of-Origin in Glioblastoma

Kim, Hyun Jung, Park, Jung Won, Lee, Jeong Ho·2021·Frontiers in Oncology
DOI 10.3389/fonc.2020.615400PMC PMC7859479
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Abstract

An aggressive primary brain cancer, glioblastoma (GBM) is the most common cancer of the central nervous system in adults. However, an inability to identify its cell-of-origin has been a fundamental issue hindering further understanding of the nature and pathogenesis of GBM, as well as the development of novel therapeutic targets. Researchers have hypothesized that GBM arises from an accumulation of somatic mutations in neural stem cells (NSCs) and glial precursor cells that confer selective growth advantages, resulting in uncontrolled proliferation. In this review, we outline genomic perspectives on IDH-wildtype and IDH-mutant GBMs pathogenesis and the cell-of-origin harboring GBM driver mutations proposed by various GBM animal models. Additionally, we discuss the distinct neurodevelopmental programs observed in either IDH-wildtype or IDH-mutant GBMs. Further research into the cellular origin and lineage hierarchy of GBM will help with understanding the evolution of GBMs and with developing effective targets for treating GBM cancer cells.

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Figure 1 Overview of genetic alterations and cell-of-origin in IDH-wildtype and IDH-mutant GBMs. (Upper panel) Frequently occurring driver mutations and CNVs in IDH-wildtype and IDH-mutant high-grade gliomas (WHO grade 3 & 4) were listed as above. The frequencies were obtained from published data using cBioPortal (19, 20). (Lower panel) Multipotent neural stem cells (NSCs) have capability to self-renewal and differentiate into progenitors with restricted potential including glial precursor cells (GPCs), oligodendrocyte precursor cells (OPCs), astrocyte precursor cells (APCs), and neural progenitor cells (NPCs). Using specific genetic alterations and cell-specific promoters, NSCs and progenitor cells can be transformed to generate either IDH-wildtype or IDH-mutant GBMs in GEMMs.
Figure 1 Overview of genetic alterations and cell-of-origin in IDH-wildtype and IDH-mutant GBMs. (Upper panel) Frequently occurring driver mutations and CNVs in IDH-wildtype and IDH-mutant high-grade gliomas (WHO grade 3 & 4) were listed as above. The frequencies were obtained from published data using cBioPortal (19, 20). (Lower panel) Multipotent neural stem cells (NSCs) have capability to self-renewal and differentiate into progenitors with restricted potential including glial precursor cells (GPCs), oligodendrocyte precursor cells (OPCs), astrocyte precursor cells (APCs), and neural progenitor cells (NPCs). Using specific genetic alterations and cell-specific promoters, NSCs and progenitor cells can be transformed to generate either IDH-wildtype or IDH-mutant GBMs in GEMMs.CC BY · PubMed Central

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Cites

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Metadata

Authors
Kim, H. J., Park, J. W., & Lee, J. H.
Venue
Frontiers in Oncology
Publisher
Frontiers Media SA
Published
2021-01-21
Volume
10
ISSN
2234-943X
DOI
10.3389/fonc.2020.615400
PMC
PMC7859479
Cited by
69
References
9
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Research Foundation of Korea

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CoChat. (2026). Citation check: Genetic Architectures and Cell-of-Origin in Glioblastoma. https://app.cochat.ai/papers/10.3389/fonc.2020.615400
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Kim, H. J., Park, J. W., & Lee, J. H. (2021). Genetic Architectures and Cell-of-Origin in Glioblastoma. Frontiers in Oncology. https://doi.org/10.3389/fonc.2020.615400