The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective
Open accessAbstract
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning to treat comorbid conditions is an additional, overlooked application of multi-target ligands. While medicinal chemists usually rely on some version of the lock and key paradigm to design novel therapeutics, modern pharmacology recognizes that the mid- and long-term effects of a given drug on a biological system may depend not only on the specific ligand-target recognition events but also on the influence of the repeated administration of a drug on the cell gene signature. The design of multi-target agents usually imposes challenging restrictions on the topology or flexibility of the candidate drugs, which are briefly discussed in the present article. Finally, computational strategies to approach the identification of novel multi-target agents are overviewed.
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Cites
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Cited by
Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds
Proschak, E., Stark, H., & Merk, D. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00760 · Cited by 498
Gunter, N. V., Teh, S. S., Lim, Y. M., & Mah, S. H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.594202 · Cited by 91
Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy
Tan, L., Zhang, J., Wang, Y., Wang, X., Wang, Y., Zhang, Z., Shuai, W., Wang, G., Chen, J., Wang, C., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01714 · Cited by 88
Stevenson, G. A., Kirshner, D., Bennion, B. J., Yang, Y., Zhang, X., Zemla, A., Torres, M. W., Epstein, A., Jones, D., Kim, H., et al. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c00722 · Cited by 7
Metadata
- Authors
- Talevi, A.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2015-09-22
- Volume
- 6
- Pages
- 205-205
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W1808513053
- Cited by
- 381
- References
- 44
- FWCI
- 15.31
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
