The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Antioxidant Supplementation in the Treatment of Aging-Associated Diseases
Open accessAbstract
Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level. Elderly people are more susceptible to oxidative stress and this depends, almost in part, from a decreased performance of their endogenous antioxidant system. As many studies reported an inverse correlation between systemic levels of antioxidants and several diseases, primarily cardiovascular diseases, but also diabetes and neurological disorders, antioxidant supplementation has been foreseen as an effective preventive and therapeutic intervention for aging-associated pathologies. However, the expectations of this therapeutic approach have often been partially disappointed by clinical trials. The interplay of both endogenous and exogenous antioxidants with the systemic redox system is very complex and represents an issue that is still under debate. In this review a selection of recent clinical studies concerning antioxidants supplementation and the evaluation of their influence in aging-related diseases is analyzed. The controversial outcomes of antioxidants supplementation therapies, which might partially depend from an underestimation of the patient specific metabolic demand and genetic background, are presented.
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Cites
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Cited by
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971
“Along with the “free radical theory of aging” popularization, İthis has started the trend of antioxidant supplement consumption (Conti et al., 2016).”
BackgroundCellular ROS and Antioxidants: Physiological and Pathological Role
Kozlov, A. V., Javadov, S., & Sommer, N. (2024) · Antioxidants · doi:10.3390/antiox13050602 · Cited by 259
Molecular mechanisms of renal aging
Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235
Sha, J., Li, J., Zhou, Y., Yang, J., Liu, W., Jiang, S., Wang, Y., Zhang, R., Di, P., & Li, W. (2021) · Phytotherapy Research · doi:10.1002/ptr.7142 · Cited by 112
Metadata
- Authors
- Conti, V., Izzo, V., Corbi, G., Russomanno, G., Manzo, V., De Lise, F., Di Donato, A., & Filippelli, A.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2016-02-12
- Volume
- 7
- Pages
- 24-24
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2265394739
- Cited by
- 304
- References
- 135
- FWCI
- 26.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- Conti, V., Izzo, V., Corbi, G., Russomanno, G., Manzo, V., De Lise, F., Di Donato, A., & Filippelli, A. (2016). Antioxidant Supplementation in the Treatment of Aging-Associated Diseases. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2016.00024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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