Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases
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Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.
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ROS accumulation causes in vivo oxidative stress conditions, leading to chronic inflammatory conditions in the gut and degenerative systemic diseases such as atherosclerosis, diabetes, Alzheimer's disease, inflammatory bowel disease, cardiovascular diseases, aging and cancer.
“there is an increasing scientific interest in the effects of reactive oxygen species (ROS) accumulation that cause in vivo oxidative stress conditions, leading to many chronic inflammatory conditions in the gut, as well as degenerative systemic diseases (atherosclerosis, diabetes, Alzheimer’s disease, inflammatory bowel disease, cardiovascular diseases, aging, and cancer) [111,112].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [111]
The Introduction says excess ROS can cause oxidative stress, and the section on chronic diseases links ROS or oxidative stress to atherosclerosis, cardiovascular disease, diabetes, Alzheimer’s disease, aging, and cancer (page numbers unavailable). The passages found do not establish the claimed link to chronic inflammatory conditions in the gut or inflammatory bowel disease; searches for those terms found no relevant discussion. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA higher intake of antioxidant molecules is associated with lower occurrence of human diseases.
“a higher intake of antioxidant molecules is associated with lower occurrence of human diseases [111,112].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [111]
The Clinical Studies section reports that normal β-carotene intake may benefit cancer risk and that α-tocopherol supplementation reduced prostate-cancer incidence in one study. It does not support the broader claim that higher antioxidant intake is generally associated with fewer human diseases: the same section reports null findings and increased risks for some supplements, while the Discussion cautions that more is not necessarily better. Our copy provides section labels but no page numbers. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPhysiological levels of reactive species (ROS and RNS) are important in cellular signaling, but higher concentrations and prolonged exposure can fight infections by damaging important microbial biomolecules.
“Physiological levels of reactive species (ROS and RNS) are important in cellular signaling, but higher concentrations and prolonged exposure can fight infections by damaging important microbial biomolecules [6].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [6]
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1 retracted
Miltonprabu, S., Sumedha, N. C., & Senthilraja, P. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.011 · Cited by 46 · see citing works
RetractedFree radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works
Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,557 · see citing works
Sharma, P., Jha, A. B., Dubey, R. S., & Pessarakli, M. (2012) · Journal of Botany · doi:10.1155/2012/217037 · Cited by 5,492 · see citing works
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
Chemistry and Biological Activities of Flavonoids: An Overview
Kumar, S., & Pandey, A. K. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/162750 · Cited by 5,178 · see citing works
Oxidative Stress and Antioxidant Defense
Birben, E., Şahiner, Ü. M., Saçkesen, C., ERZURUM, S. C., & Kalaycı, Ö. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182439613 · Cited by 4,960 · see citing works
Oxidative Stress: Harms and Benefits for Human Health
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8416763 · Cited by 4,837 · see citing works
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works
Advances in metal-induced oxidative stress and human disease
Jomová, K., & Valko, M. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.001 · Cited by 3,226 · see citing works
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632 · see citing works
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484 · see citing works
Signal transduction by reactive oxygen species
Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322 · see citing works
Kurutas, E. B. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0186-5 · Cited by 2,152 · see citing works
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C. B., & Rahu, N. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7432797 · Cited by 2,088 · see citing works
Klein, E. A., Thompson, I. M., Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., et al. (2011) · JAMA · doi:10.1001/jama.2011.1437 · Cited by 1,787 · see citing works
Role of ROS and RNS Sources in Physiological and Pathological Conditions
Meo, S. D., Reed, T. T., Venditti, P., & Víctor, V. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1245049 · Cited by 1,638 · see citing works
Antioxidant and prooxidant properties of flavonoids
Procházková, D., Boušová, I., & Wilhelmová, N. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.01.018 · Cited by 1,572 · see citing works
Oxidant signals and oxidative stress
Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393 · see citing works
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377 · see citing works
Mitochondrial metabolism of reactive oxygen species
Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems
Lü, J., Lin, P. H., Yao, Q. C., & Chen, C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00897.x · Cited by 1,331 · see citing works
The emerging role of the Nrf2–Keap1 signaling pathway in cancerPreprint
Jaramillo, M. C., & Zhang, D. D. (2013) · Genes & Development · doi:10.1101/gad.225680.113 · Cited by 1,304 · see citing works
Jan, A. T., Azam, M., Siddiqui, K., Ali, A., Choi, I., & Haq, Q. M. R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226183 · Cited by 1,252 · see citing works
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137 · see citing works
Quantitative flux analysis reveals folate-dependent NADPH production
Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works
Targeting Free Radicals in Oxidative Stress-Related Human Diseases
Poprac, P., Jomova, K., Simunkova, M., Kollar, V., Rhodes, C. J., & Valko, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.005 · Cited by 1,107 · see citing works
Galati, G., & O'Brien, P. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.034 · Cited by 1,101 · see citing works
The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome
Zhang, J., Bottiglieri, T., & McCullough, P. A. (2016) · Cardiorenal Medicine · doi:10.1159/000452283 · Cited by 1,082 · see citing works
Endogenous DNA damage in humans: a review of quantitative data
Bont, R. D. (2004) · Mutagenesis · doi:10.1093/mutage/geh025 · Cited by 1,065 · see citing works
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059 · see citing works
Selective neuronal vulnerability to oxidative stress in the brain
Wang, X. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00012 · Cited by 1,008 · see citing works
Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future
Gutteridge, J. M. C., & Halliwell, B. B. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06182.x · Cited by 1,002 · see citing works
Mechanism of Oxidative Stress in Neurodegeneration
Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964 · see citing works
Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance
Hasanuzzaman, M., Nahar, K., Anee, T. I., & Fujita, M. (2017) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-017-0422-2 · Cited by 907 · see citing works
DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903 · cited 1× · see citing works
“Finally, ROS can damage DNA through oxidizing deoxyribose, breaking strand, removing nucleotides, modifying bases and crosslinking DNA-protein (Sharma et al., 2012; Cadet and Wagner, 2013; Cadet et al., 2017; Liang et al., 2020).”
BackgroundReactive oxygen species and cell signaling: Respiratory burst in macrophage signaling
Forman, H. J., & Torres, M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2206007 · Cited by 891 · see citing works
Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy
Barrera, G. (2012) · ISRN Oncology · doi:10.5402/2012/137289 · Cited by 822 · see citing works
Antioxidant and Prooxidant Properties of Carotenoids
Young, A. J., & Lowe, G. M. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2149 · Cited by 822 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works
Oxidative Stress and Cell Signalling
Poli, G., Leonarduzzi, G., Biasi, F., & Chiarpotto, E. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365323 · Cited by 721 · see citing works
Spitz, D. R., Azzam, E. I., Jian Li, J., & Gius, D. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031769.14728.bc · Cited by 710 · see citing works
Antioxidant Health Effects of Aged Garlic Extract
Borek, C. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.3.1010s · Cited by 688 · see citing works
Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity
Barbieri, R., Coppo, E., Marchese, A. E., Daglia, M., Sobarzo‐Sánchez, E., Nabavi, S. F., & Nabavi, S. M. (2016) · Microbiological Research · doi:10.1016/j.micres.2016.12.003 · Cited by 686 · see citing works
Vascular oxidative stress, nitric oxide and atherosclerosis
Li, H., Horke, S., & Förstermann, U. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.001 · Cited by 656 · see citing works
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Smith, M. T., Guyton, K., Gibbons, C., Fritz, J. M., Portier, C., Rusyn, I., DeMarini, D., Caldwell, J., Kavlock, R., Lambert, P., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509912 · Cited by 599 · see citing works
Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585 · see citing works
Protein aggregation in amyotrophic lateral sclerosis
Blokhuis, A. M., Groen, E. J. N., Koppers, M., van den Berg, L. H., & Pasterkamp, R. J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1125-6 · Cited by 573 · see citing works
Oxidative stress in neurodegenerative diseases.
Chen, X., Guo, C., & Kong, J. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.05.009 · Cited by 572 · see citing works
Zhou, H., Wang, S., Zhu, P., Hu, S., Chen, Y., & Ren, J. (2018) · Redox Biology · doi:10.1016/j.redox.2017.12.019 · Cited by 550 · see citing works
Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 527 · see citing works
Valavanidis, A., Vlachogianni, T., & Fiotakis, K. (2009) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph6020445 · Cited by 519 · see citing works
Vitamins E and C in the Prevention of Prostate and Total Cancer in Men
Gaziano, J. M., Glynn, R. J., Christen, W. G., Kurth, T., Belanger, C. F., MacFadyen, J. G., Bubes, V. Y., Manson, J. E., Sesso, H. D., & Buring, J. E. (2008) · JAMA · doi:10.1001/jama.2008.862 · Cited by 519 · see citing works
Oxidative Stress and Neurodegenerative Disorders
Li, J., Wuliji, O., Li, W., Jiang, Z.-G., & Ghanbari, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224438 · Cited by 511 · see citing works
Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports
Pingitore, A., Lima, G. P. P., Mastorci, F., Quinones, A., Iervasi, G., & Vassalle, C. (2015) · Nutrition · doi:10.1016/j.nut.2015.02.005 · Cited by 511 · see citing works
Pasinelli, P., Belford, M. E., Lennon, N. J., Bacskai, B. J., Hyman, B. T., Trotti, D., & Brown, R. H. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.021 · Cited by 506 · see citing works
The Molecular Mechanism of the Catalase Reaction
Alfonso‐Prieto, M., Biarnés, X., Vidossich, P., & Rovira, C. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9018572 · Cited by 504 · see citing works
Targeting antioxidants for cancer therapy
Glasauer, A., & Chandel, N. S. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.017 · Cited by 502 · see citing works
Karam, B. S., Alejandro, C.-M., Koh, W.-J., Akar, J. G., & Akar, F. G. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0604-9 · Cited by 502 · see citing works
Endothelial dysfunction: a comprehensive appraisal.
Esper, R. J., Nordaby, R. A., Vilariño, J. O., Paragano, A. J., Cacharrón, J. L., & Machado, R. A. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-4 · Cited by 493 · see citing works
Battin, E. E., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9054-7 · Cited by 479 · see citing works
Antioxidant Therapy: Current Status and Future Prospects
Firuzi, O., Miri, R., Tavakkoli, M., & Saso, L. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711803414368 · Cited by 470 · see citing works
Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't
Reid, M. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.724 · Cited by 450 · see citing works
Carotenoids bioavailability from foods: From plant pigments to efficient biological activities
Fernández‐García, E., Carvajal-Lérida, I., Jarén‐Galán, M., Garrido‐Fernández, J., Pérez‐Gálvez, A., & Hornero‐Méndez, D. (2011) · Food Research International · doi:10.1016/j.foodres.2011.06.007 · Cited by 420 · see citing works
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation
Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 399 · see citing works
Pathogenesis of atherosclerosis: A multifactorial process.
Singh, R. B., Mengi, S. A., Xu, Y., Arneja, A. S., & Dhalla, N. S. (2002) · PubMed Central · Cited by 381 · see citing works
Reactive oxygen species: Destroyers or messengers?
Bartosz, G. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.009 · Cited by 379 · see citing works
Duarte, T. L., & Lunec, J. (2005) · Free Radical Research · doi:10.1080/10715760500104025 · Cited by 374 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Crichton, R. R., & Ward, R. J. (2013) · Wiley eBooks · doi:10.1002/9781118553480.ch04 · Cited by 372 · see citing works
Oxidative Stress as a Mediator of Cardiovascular Disease
Elahi, M. M., Kong, Y. X. G., & Matata, B. M. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9441 · Cited by 362 · see citing works
NO/redox disequilibrium in the failing heart and cardiovascular system
Hare, J. M., & Stamler, J. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524459 · Cited by 356 · see citing works
Formation and repair of oxidatively generated damage in cellular DNA
Cadet, J., Davies, K. J. A., de Medeiros, M. H. G., Mascio, P. D., & Wagner, J. R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.049 · Cited by 356 · see citing works
Oxidative stress and neutrophil activation--the two keystones of ischemia/reperfusion injury.
Kamiński, K., Bonda, T., Korecki, J., & Musiał, W. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00189-4 · Cited by 353 · see citing works
Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention
Martí, R., Roselló, S., & Cebolla‐Cornejo, J. (2016) · Cancers · doi:10.3390/cancers8060058 · Cited by 342 · see citing works
Mitochondrial dysfunction in aging: Much progress but many unresolved questions
Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335 · see citing works
Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E. H., Younkin, L., Younkin, S., Carlson, G., McEwen, B. S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711568105 · Cited by 332 · see citing works
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
Sáez, I., & Vı́lchez, D. (2014) · Current Genomics · doi:10.2174/138920291501140306113344 · Cited by 318 · see citing works
Is SOD1 loss of function involved in amyotrophic lateral sclerosis?
Saccon, R. A., Bunton-Stasyshyn, R. K. A., Fisher, E., & Fratta, P. (2013) · Brain · doi:10.1093/brain/awt097 · Cited by 318 · see citing works
Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003638 · Cited by 315 · see citing works
Black garlic: A critical review of its production, bioactivity, and application
Kimura, S., Tung, Y., Pan, M., Su, N., Lai, Y., & Cheng, K. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.11.003 · Cited by 311 · see citing works
Egea, J., Fabregat, I., Frapart, Y., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K. I., Knaus, U. G., López, M. G., González, G. O., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.007 · Cited by 311 · see citing works
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial
Lin, J., Cook, N. R., Albert, C., Zaharris, E., Gaziano, J. M., Van Denburgh, M., Buring, J. E., & Manson, J. E. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn438 · Cited by 309 · see citing works
Kang, Y. J., Chen, Y., & Epstein, P. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12610 · Cited by 303 · see citing works
Sarcopenia: assessment of disease burden and strategies to improve outcomes
Liguori, I., Russo, G., Aran, L., Bulli, G., Curcio, F., Della‐Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s149232 · Cited by 302 · see citing works
Antioxidant Supplementation in the Treatment of Aging-Associated Diseases
Conti, V., Izzo, V., Corbi, G., Russomanno, G., Manzo, V., Lise, F. D., Donato, A. D., & Filippelli, A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00024 · Cited by 296 · see citing works
Sharifi‐Rad, J., Rodrigues, C. F., Sharopov, F. S., Docea, A. O., Karaça, A. C., Sharifi‐Rad, M., Kahveci, D., Gülseren, G., Şenol, E., Demircan, E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072326 · Cited by 295 · see citing works
Self-citationThe Oxidative Phosphorylation System in Mammalian Mitochondria
Papa, S., Martino, P. L., Capitanio, G., Gaballo, A., Rasmo, D. D., Signorile, A., & Petruzzella, V. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_1 · Cited by 285 · see citing works
Glutathione peroxidase 4: a new player in neurodegeneration?
Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 281 · see citing works
Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes
Ye, G., Metreveli, N. S., Donthi, R. V., Shen, X., Xu, M., Carlson, E. C., & Epstein, P. N. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1336 · Cited by 278 · see citing works
Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system
Aslani, B. A., & Ghobadi, S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.01.014 · Cited by 276 · see citing works
Liou, G.-Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P., & Storz, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.029 · Cited by 270 · see citing works
Hsu, T.-C., Young, M. R., Cmarik, J. L., & Colburn, N. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00220-3 · Cited by 265 · see citing works
Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
Sharifi‐Rad, M., Lankatillake, C., Dias, D. A., Docea, A. O., Mahomoodally, M. F., Lobine, D., Chazot, P. L., Kurt, B., Tumer, T. B., Moreira, A. C., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041061 · Cited by 260 · see citing works
Self-citationAntioxidants: Positive or Negative Actors?
Salehi, B., Martorell, M., Arbiser, J. L., Sureda, A., Martins, N. A., Maurya, P. K., Sharifi‐Rad, M., Kumar, P., & Sharifi‐Rad, J. (2018) · Biomolecules · doi:10.3390/biom8040124 · Cited by 259 · see citing works
Self-citationBattelli, M. G., Bolognesi, A., & Polito, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.022 · Cited by 256 · see citing works
Self-citationClinical trials of antioxidants as cancer prevention agents: Past, present, and future
Goodman, M. G., Bostick, R. M., Küçük, Ö., & Jones, D. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.018 · Cited by 255 · see citing works
Pathogenesis of Atherosclerosis: A Multifactorial Process
Buja, L. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-25879-4_2 · Cited by 252 · see citing works
Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
Kocot, J., Luchowska-Kocot, D., Kiełczykowska, M., Musik, I., & Kurzepa, J. (2017) · Nutrients · doi:10.3390/nu9070659 · Cited by 245 · see citing works
Redox Roles of Reactive Oxygen Species in Cardiovascular Diseases
He, F. J., & Zuo, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126059 · Cited by 240 · see citing works
Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications
Wattanapitayakul, S. K. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00114-5 · Cited by 239 · see citing works
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233 · see citing works
Expression and Modulation of an NADPH Oxidase in Mammalian Astrocytes
Abramov, A. Y., Jacobson, J., Wientjes, F. B., Hothersall, J. S., Canevari, L., & Duchen, M. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1632-05.2005 · Cited by 228 · see citing works
Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress
Imam, M. U., Zhang, S., Ma, J., Wang, H., & Wang, F. (2017) · Nutrients · doi:10.3390/nu9070671 · Cited by 226 · see citing works
Protein aggregation and degradation mechanisms in neurodegenerative diseases.
Takalo, M., Salminen, A., Soininen, H. S., Hiltunen, M. O., & Haapasalo, A. (2013) · Europe PMC (PubMed Central) · Cited by 219 · see citing works
Nitric oxide bioavailability dysfunction involves in atherosclerosis
Chen, J.-Y., Ye, Z.-X., Wang, X.-F., Chang, J., Yang, M.-W., Zhong, H.-H., Hong, F.-F., & Yang, S.-L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.122 · Cited by 216 · see citing works
Zhang, W., Wang, T., Qin, L., Gao, H., Wilson, B. C., Ali, S. F., Zhang, W., Hong, J., & Liu, B. (2004) · The FASEB Journal · doi:10.1096/fj.03-0983fje · Cited by 204 · see citing works
Oxidative and nitrative protein modifications in Parkinson's disease
Danielson, S. R., & Andersen, J. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.005 · Cited by 201 · see citing works
Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases
Salehi, B., Călina, D. C., Docea, A. O., Koirala, N., Aryal, S., Lombardo, D., Pasqua, L., Taheri, Y., Castillo, C. M. S., Martorell, M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020430 · Cited by 197 · see citing works
Self-citationCD40 signaling in vascular cells: A key role in atherosclerosis?
Mach, F., Schönbeck, U., & Libby, P. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00309-2 · Cited by 193 · see citing works
Programmed Cell Death, from a Cancer Perspective: An Overview
Mishra, A. P., Salehi, B., Sharifi‐Rad, M., Pezzani, R., Kobarfard, F., Sharifi‐Rad, J., & Nigam, M. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0329-9 · Cited by 192 · see citing works
Self-citationReactive Oxygen Species and the Cardiovascular System
Taverne, Y. J. H. J., Bogers, A. J. J. C., Duncker, D. J., & Merkus, D. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/862423 · Cited by 187 · see citing works
Reddy, P. H. (2009) · CNS Spectrums · doi:10.1017/s1092852900024901 · Cited by 186 · see citing works
Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
Battelli, M. G., Polito, L., & Bolognesi, A. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.006 · Cited by 179 · see citing works
Self-citationBalancing the generation and elimination of reactive oxygen species
Rodriguez, R. J., & Redman, R. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500367102 · Cited by 177 · see citing works
Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases
Park, M. H., Jo, M., Kim, Y. R., Lee, C., & Hong, J. T. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.018 · Cited by 175 · see citing works
A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma
Saçkesen, C., Sarıçoban, H. E., Dizdar, E. A., Soyer, Ö., Gümüş, P., Tosun, B. N., Büyüktuncer, Z., Karabulut, E., Besler, H. T., & Kalaycı, Ö. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.035 · Cited by 168 · see citing works
Unravelling UVA-induced mutagenesis
Sage, E., Girard, P.-M., & Francesconi, S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05219e · Cited by 167 · see citing works
Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress
Peake, J. M., & Suzuki, K. (2026) · PubMed · doi:10.22029/eir.2004.1610 · Cited by 165 · see citing works
Catalase immobilization—A review
Grigoras, A. G. (2016) · Biochemical Engineering Journal · doi:10.1016/j.bej.2016.10.021 · Cited by 161 · see citing works
Tse, G., Yan, B. P., Chan, Y. W. F., Tian, X. Y., & Huang, Y. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00313 · Cited by 160 · see citing works
Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential
Salehi, B., Çapanoğlu, E., Adrar, N., Çatalkaya, G., Shaheen, S., Jaffer, M., Giri, L., Suyal, R., Jugran, A. K., Călina, D. C., et al. (2019) · Molecules · doi:10.3390/molecules24101854 · Cited by 160 · see citing works
Self-citationLiang, X., Wang, S., Wang, L., Ceylan, A. F., Ren, J. T., & Zhang, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104846 · Cited by 160 · see citing works
Salehi, B., López‐Jornet, P., Pons-Fuster, E., Călina, D. C., Sharifi‐Rad, M., Ramírez‐Alarcón, K., Forman, K., Fernández, M., Martorell, M., Setzer, W. N., et al. (2019) · Biomolecules · doi:10.3390/biom9030106 · Cited by 155 · see citing works
Self-citationPotential role of green tea catechins in the management of oxidative stress-associated infertility
Roychoudhury, S., Agarwal, A. K., Virk, G., & Cho, C. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.02.006 · Cited by 151 · see citing works
Free radical‐induced pathology
Clark, I. A., Cowden, W. B., & Hunt, N. H. (1985) · Medicinal Research Reviews · doi:10.1002/med.2610050303 · Cited by 148 · see citing works
The Role of Oxidative Stress and Autophagy in Atherosclerosis
Perrotta, I. D., & Aquila, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/130315 · Cited by 147 · see citing works
A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse
Tsatsakis, A. M., Docea, A. O., Călina, D. C., Tsarouhas, K., Zamfira, L.-M., Mitruţ, R., Sharifi‐Rad, J., Kovatsi, L., Siokas, V., Dardiotis, E., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091295 · Cited by 143 · see citing works
Self-citationAdverse health effects of 5G mobile networking technology under real-life conditions
Kostoff, R. N., Héroux, P., Aschner, M., & Tsatsakis, A. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.01.020 · Cited by 143 · see citing works
Herrera, B. M., Murillo, M. M., Alvarez, A. M., Beltrán, J., Fernández, M., & Fabregat, I. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.09.020 · Cited by 139 · see citing works
8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer
Sova, H., Jukkola‐Vuorinen, A., Puistola, U., Kauppila, S., & Karihtala, P. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605565 · Cited by 139 · see citing works
Antioxidant properties of melatonin—an emerging mystery
Beyer, C. E., Steketee, J. D., & Saphier, D. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00180-4 · Cited by 135 · see citing works
Oxidative Stress in Methylmercury-Induced Cell Toxicity
dos Santos, A. A., Ferrer, B., Gonçalves, F. M., Tsatsakis, A. M., Renieri, E. A., Skalny, A. V., Farina, M., da Rocha, J. B. T., & Aschner, M. (2018) · Toxics · doi:10.3390/toxics6030047 · Cited by 134 · see citing works
Docea, A. O., Gofiţă, E., Γούμενου, Μ., Călina, D. C., Rogoveanu, O. C., Văruț, M. C., Olaru, C., Kerasioti, E., Fountoucidou, P., Taitzoglou, I., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.03.052 · Cited by 132 · see citing works
Self-citationSeo, M.-Y., & Lee, S.-M. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00236-7 · Cited by 131 · see citing works
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
Tsoukalas, D., Fragkiadaki, P., Docea, A. O., Alegakis, A. K., Sarandi, E., Thanasoula, M., Spandidos, D. A., Tsatsakis, A. M., Razgonova, M. P., & Călina, D. C. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10614 · Cited by 131 · see citing works
Self-citationPhysical Exercise and Selective Autophagy: Benefit and Risk on Cardiovascular Health
Wu, N. N., Tian, H., Chen, P., Wang, D., Ren, J. T., & Zhang, Y. (2019) · Cells · doi:10.3390/cells8111436 · Cited by 130 · see citing works
Oxidative Stress and Inflammation Interdependence in Multiple Sclerosis
Pădureanu, R., Albu, C. V., Mititelu, R. R., Bacanoiu, M. V., Docea, A. O., Călina, D. C., Pădureanu, V., Olaru, G., Sandu, R. E., Mălin, R. D., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111815 · Cited by 120 · see citing works
Self-citationSantis, D. D., Malchiodi, L., Cucchi, A., Cybulski, A., Verlato, G., Gelpi, F., & Nocini, P. F. (2019) · BioMed Research International · doi:10.1155/2019/9023548 · Cited by 119 · see citing works
Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants
Huai, J., & Zhang, Z. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00527 · Cited by 115 · see citing works
Tsatsakis, A. M., Docea, A. O., Călina, D. C., Bugă, A. M., Zlatian, O. M., Gutnikov, S. A., Kostoff, R. N., & Aschner, M. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.12.043 · Cited by 113 · see citing works
Self-citationPizzino, G., Bitto, A., Interdonato, M., Galfo, F., Irrera, N., Mecchio, A., Pallio, G., Ramistella, V., Luca, F. D., Minutoli, L., et al. (2014) · Redox Biology · doi:10.1016/j.redox.2014.05.003 · Cited by 107 · see citing works
Schöttker, B., Brenner, H., Jansen, E. H. J. M., Gardiner, J., Peasey, A., Kubínová, R., Pająk, A., Topór-Mądry, R., Tamošiūnas, A., Saum, K.-U., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0537-7 · Cited by 107 · see citing works
Chen, X., Wang, L., Wu, Y.-Z., Song, S.-Y., Min, H.-Y., Yang, Y., He, X., Liang, Q., Yi, L., Wang, Y., et al. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-017-0009-6 · Cited by 107 · see citing works
Oxidative Stress and Carcinogenesis: Potential of Phytochemicals in Breast Cancer Therapy
Forcados, G. E., James, D. B., Sallau, A. B., Muhammad, A. I., & Mabeta, P. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1267777 · Cited by 104 · see citing works
Haghi‐Aminjan, H., Abtahi, S. R., Hazrati, E., Chamanara, M., Jalili, M., & Paknejad, B. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116607 · Cited by 104 · see citing works
Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited
Salehi, B., Rescigno, A., Dettori, T., Călina, D. C., Docea, A. O., Singh, L., Cebeci, F., Özçelik, B., Bhia, M., Beirami, A. D., et al. (2020) · Biomolecules · doi:10.3390/biom10010130 · Cited by 103 · see citing works
Self-citationNO/redox disequilibrium in the failing heart and cardiovascular system
Hare, J. M., & Stamler, J. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24459 · Cited by 99 · see citing works
Regulatory principles in metabolism–then and now
Curi, R., Newsholme, P., Marzuca-Nassr, G. N., Takahashi, H., Hirabara, S. M., Cruzat, V. F., Krause, M. D. S., & de Bittencourt, P. I. H. (2016) · Biochemical Journal · doi:10.1042/bcj20160103 · Cited by 97 · see citing works
Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases
Tsoukalas, D., Fragoulakis, V., Sarandi, E., Docea, A. O., Papakonstaninou, E., Τσιλιμιδός, Γ., Anamaterou, C., Fragkiadaki, P., Aschner, M., Tsatsakis, A. M., et al. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00120 · Cited by 96 · see citing works
Self-citationProteasome activation delays aging in vitro and in vivo
Chondrogianni, N., Sakellari, M., Lefaki, M., Papaevgeniou, N., & Gonos, E. S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.031 · Cited by 94 · cited 1× · see citing works
“While proteasomal dysfunction is correlated with age progression and protein aggregation, proteasome activation slows the aging progress down and increases longevity (Chondrogianni et al., 2014).”
BackgroundAntioxidants may increase the probability of developing allergic diseases and asthma
Murr, C., Schroecksnadel, K., Winkler, C., Ledochowski, M., & Fuchs, D. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.11.011 · Cited by 93 · see citing works
Biological Activity of Vegetal Extracts Containing Phenols on Plant Metabolism
Ertani, A., Pizzeghello, D., Francioso, O., Tinti, A., & Nardi, S. (2016) · Molecules · doi:10.3390/molecules21020205 · Cited by 93 · see citing works
Sharifi‐Rad, J., Sharifi‐Rad, M., Salehi, B., Iriti, M., Roointan, A., Mnayer, D., Soltani‐Nejad, A., & Afshari, A. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.8.9 · Cited by 93 · see citing works
Self-citationEpibatidine: A Promising Natural Alkaloid in Health
Salehi, B., Sestito, S., Rapposelli, S., Peron, G., Calina, D., Sharifi-Rad, M., Sharopov, F., Martins, N., & Sharifi-Rad, J. (2018) · Biomolecules · doi:10.3390/biom9010006 · Cited by 91 · see citing works
Self-citationVeronica Plants—Drifting from Farm to Traditional Healing, Food Application, and Phytopharmacology
Salehi, B., Shetty, M. S., Kumar, N. V. A., Živković, J., Călina, D. C., Docea, A. O., Yazdi, S. E., Kılıç, C. S., Goloshvili, T., Nicola, S., et al. (2019) · Molecules · doi:10.3390/molecules24132454 · Cited by 91 · see citing works
Self-citationTovmasyan, A. G., Maia, C. G. C., Weitner, T., Carballal, S., Sampaio, R. S., Lieb, D., Ghazaryan, R. K., Ivanović‐Burmazović, I., Ferrer‐Sueta, G., Radí, R., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.018 · Cited by 89 · see citing works
Catalytic scavenging of peroxynitrite by catalase
Gȩbicka, L., & Didik, J. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.07.011 · Cited by 87 · see citing works
Lycopene: Progress in microbial production
Hernández‐Almanza, A., Montañez, J., Martínez-Ávila, G. C. G., Aguilar, O., Contreras‐Esquivel, J. C., & Aguilar, C. N. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.013 · Cited by 87 · see citing works
Cellular factories for coenzyme Q10 production
Lee, S. Q. E., Tan, T. S., Kawamukai, M., & Chen, E. S. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0646-4 · Cited by 86 · see citing works
Marchitti, S. A., Chen, Y., Thompson, D. C., & Vasiliou, V. (2011) · Eye & Contact Lens Science & Clinical Practice · doi:10.1097/icl.0b013e3182212642 · Cited by 84 · see citing works
Kucukgoncu, S., Zhou, E., Lucas, K. B., & Tek, C. (2017) · Obesity Reviews · doi:10.1111/obr.12528 · Cited by 84 · see citing works
Phytochemicals in Cancer Prevention: A Review of the Evidence
Mollakhalili‐Meybodi, N., Mortazavian, A. M., Monfared, A. B., Sohrabvandi, S., & Meybodi, F. A. (2017) · Iranian Journal of Cancer Prevention · doi:10.17795/ijcp-7219 · Cited by 81 · see citing works
The relative roles of DNA damage induced by UVA irradiation in human cells
Cortat, B., Garcia, C. C. M., Quinet, A., Schuch, A. P., de Lima-Bessa, K. M., & Menck, C. F. M. (2013) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50023c · Cited by 80 · see citing works
Rasouli, H., Farzaei, M. H., Mansouri, K., Mohammadzadeh, S., & Khodarahmi, R. (2016) · Molecules · doi:10.3390/molecules21091104 · Cited by 80 · see citing works
Fenga, C., Gangemi, S., Teodoro, M., Rapisarda, V., Golokhvast, K. S., Docea, A. O., Tsatsakis, A. M., & Costa, C. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.05.008 · Cited by 79 · see citing works
Self-citationAssociation of nutraceutical supplements with longer telomere length
Tsoukalas, D., Fragkiadaki, P., Docea, A. O., Alegakis, A. K., Sarandi, E., Vakonaki, E., Salataj, E., Kouvidi, E., Nikitovic, D., Kovatsi, L., et al. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4191 · Cited by 76 · see citing works
Self-citationDistribution and Features of the Six Classes of Peroxiredoxins
Poole, L. B., & Nelson, K. J. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2330 · Cited by 74 · see citing works
Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease
Buj, R., & Aird, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00177 · Cited by 74 · see citing works
Antioxidant and Antisenescence Effects of Bergamot Juice
Pozzo, E. D., Leo, M. D., Faraone, I., Milella, L., Cavallini, C., Piragine, E., Testai, L., Calderone, V., Pistelli, L., Braca, A., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9395804 · Cited by 74 · see citing works
Liu, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.112020 · Cited by 74 · see citing works
Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine
Spitz, D. R., & Hauer‐Jensen, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5769 · Cited by 73 · see citing works
Structure and antioxidant superoxide dismutase activity of copper(II) hydrazone complexes
Singh, Y. P., Patel, R. N., Singh, Y., Butcher, R. J., Vishwakarma, P., & Singh, R. K. B. (2016) · Polyhedron · doi:10.1016/j.poly.2016.11.013 · Cited by 72 · see citing works
Li, W., Cao, L., Han, L., Xu, Q., & Ma, Q. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2938 · Cited by 70 · see citing works
Water- and Fat-Soluble Antioxidants in Human Seminal Plasma and Serum of Fertile Males
Lazzarino, G., Listorti, I., Bilotta, G., Capozzolo, T., Amorini, A. M., Longo, S. A., Caruso, G., Caruso, G., Tavazzi, B., & Bilotta, P. (2019) · Antioxidants · doi:10.3390/antiox8040096 · Cited by 69 · see citing works
Fountoucidou, P., Veskoukis, A. S., Kerasioti, E., Docea, A. O., Taitzoglou, I., Liesivuori, J., Tsatsakis, A. M., & Kouretas, D. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.09.015 · Cited by 69 · see citing works
Self-citationMitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome
Aroor, A. R., Mandavia, C. H., Ren, J. T., Sowers, J. R., & Pulakat, L. (2012) · Cardiorenal Medicine · doi:10.1159/000335675 · Cited by 67 · see citing works
New Challenges to Study Heterogeneity in Cancer Redox Metabolism
Benfeitas, R., Uhlén, M., Nielsen, J., & Mardinoğlu, A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00065 · Cited by 65 · see citing works
Pei, Z., Deng, Q., Babcock, S. A., He, E. Y., Ren, J. T., & Zhang, Y. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.11.018 · Cited by 63 · see citing works
Electron carriers and energy conservation in mitochondrial respiration
Ramsay, R. R. (2019) · ChemTexts · doi:10.1007/s40828-019-0085-4 · Cited by 63 · see citing works
Redox homeostasis in sport: do athletes really need antioxidant support?
Antonioni, A., Fantini, C., Dimauro, I., & Caporossi, D. (2018) · Research in Sports Medicine · doi:10.1080/15438627.2018.1563899 · Cited by 60 · see citing works
Ren, J. T., & Taegtmeyer, H. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.03.001 · Cited by 59 · see citing works
Ściskalska, M., Zalewska, M., Grzelak, A., & Milnerowicz, H. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-9984-9 · Cited by 57 · see citing works
Zucca, P., Rescigno, A., Rinaldi, A. C., & Sanjust, E. (2013) · Journal of Molecular Catalysis A Chemical · doi:10.1016/j.molcata.2013.09.010 · Cited by 57 · see citing works
Self-citationMolecular and cellular stratagem of brain metastases associated with melanoma (Review)
Bugă, A. M., Docea, A. O., Albu, C. V., Mălin, R. D., Branisteanu, D. E., Ianoși, G., Ianoși, S. L., Iordache, A. M., & Călina, D. C. (2019) · Oncology Letters · doi:10.3892/ol.2019.9933 · Cited by 55 · see citing works
Self-citationDietary supplements and human health: For better or for worse?
Jerome‐Morais, A., Diamond, A. M., & Wright, M. E. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000415 · Cited by 54 · see citing works
Melatonin in the Promotion of Health
WATSON, R. R. (2011) · CRC Press eBooks · doi:10.1201/b11101 · Cited by 51 · see citing works
Mahajan, L., Verma, P. K., Raina, R., Pankaj, N. K., Sood, S., & Singh, M. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.11.003 · Cited by 48 · see citing works
Sani, T. A., Mohammadpour, E., Mohammadi, A., Memariani, T., Yazdi, M. V., Rezaee, R., Călina, D. C., Docea, A. O., Γούμενου, Μ., Etemad, L., et al. (2017) · Cited by 46 · see citing works
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Zhang, J., & McCullough, P. A. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000448666 · Cited by 45 · see citing works
Docea, A. O., Mitruț, P., Grigore, D., Pirici, D., Călina, D. C., & Gofiţă, E. (2012) · PubMed · Cited by 38 · see citing works
Self-citationde Bittencourt, P. I. H., & Curi, R. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00738-9 · Cited by 37 · see citing works
Mediterranean shrubs as potential antioxidant sources
Sanjust, E., Mocci, G., Zucca, P., & Rescigno, A. (2008) · Natural Product Research · doi:10.1080/14786410801997125 · Cited by 37 · see citing works
Self-citationOke, G. O., Abiodun, A. A., Imafidon, C. E., & Monsi, B. F. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.05.001 · Cited by 33 · see citing works
Coenzyme Q10 in breast cancer care
Tafazoli, A. (2017) · Future Oncology · doi:10.2217/fon-2016-0547 · Cited by 30 · see citing works
Perera, N. C. N., Godahewa, G. I., Lee, S., Kim, M., Hwang, J. Y., Kwon, M., Hwang, S. D., & Lee, J. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.07.049 · Cited by 30 · see citing works
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Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915 · see citing works
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 726 · see citing works
Free radicals and their impact on health and antioxidant defenses: a review
Chandimali, N., Bak, S. G., Park, E. H., Lim, H. J., Won, Y., Kim, E., Park, S., & Lee, S. (2025) · Cell Death Discovery · doi:10.1038/s41420-024-02278-8 · Cited by 689 · see citing works
Oxidative Stress in Cardiovascular Diseases
Dubois‐Deruy, E., Peugnet, V., Turkieh, A., & Pinet, F. (2020) · Antioxidants · doi:10.3390/antiox9090864 · Cited by 667 · see citing works
Cellular Red-Ox system in health and disease: The latest update
Jena, A. B., Samal, R. R., Bhol, N. K., & Duttaroy, A. K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114606 · Cited by 561 · see citing works
Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137273 · Cited by 510 · see citing works
Chen, S., Wang, X., Cheng, Y., Gao, H., & Chen, X. (2023) · Molecules · doi:10.3390/molecules28134982 · Cited by 512 · see citing works
Afzal, S., Manap, A. S. A., Attiq, A., Albokhadaim, I. F., Kandeel, M. K., & Alhojaily, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1269581 · Cited by 423 · see citing works
Rahaman, M. M., Hossain, R., Herrera‐Bravo, J., Islam, M. T., Atolanı, O., Adeyemı, O. S., Owolodun, O. A., Kambizi, L., Daştan, S. D., Călina, D. C., et al. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3217 · Cited by 402 · see citing works
Self-citationJanaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works
Salehi, B., Quispe, C., Chamkhi, I., Omari, N. E., Balahbib, A., Sharifi‐Rad, J., Bouyahya, A., Akram, M., Iqbal, M., Docea, A. O., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.592654 · Cited by 353 · see citing works
Self-citationCorreia, A. S., Cardoso, A., & Vale, N. (2023) · Antioxidants · doi:10.3390/antiox12020470 · Cited by 361 · see citing works
Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy
Sharifi‐Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 316 · see citing works
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Sharifi‐Rad, J., Martins, N. A., López‐Jornet, P., Pons-Fuster, E., Harun, N., Yeskaliyeva, B. K., Beyatlı, A., Sytar, O., Shaheen, S., Sharopov, F. S., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6492346 · Cited by 300 · see citing works
Self-citationSharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290 · see citing works
Self-citationSalehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01300 · Cited by 293 · see citing works
Self-citationTumilaar, S. G., Hardianto, A., Dohi, H., & Kurnia, D. (2024) · Journal of Chemistry · doi:10.1155/2024/5594386 · Cited by 327 · see citing works
Rudrapal, M., Rakshit, G., Singh, R. P., Garse, S., Khan, J., & Chakraborty, S. (2024) · Antioxidants · doi:10.3390/antiox13040429 · Cited by 267 · see citing works
Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. D. (2022) · Antioxidants · doi:10.3390/antiox11020408 · Cited by 262 · see citing works
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities
Kumar, M., Barbhai, M. D., Hasan, M., Punia, S., Dhumal, S., Radha, Rais, N., Chandran, D., Pandiselvam, R., Kothakota, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112498 · Cited by 240 · see citing works
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Usui, N., Kobayashi, H., & Shimada, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065487 · Cited by 267 · see citing works
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Duda‐Chodak, A., & Tarko, T. (2023) · Molecules · doi:10.3390/molecules28062536 · Cited by 244 · see citing works
Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation
Chen, T., Wang, H., Chang, C.-J., & Lee, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021314 · Cited by 241 · see citing works
Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management
Anwar, S., Alrumaihi, F., Sarwar, T., Babiker, A. Y., Khan, A. A., Prabhu, S. V., & Rahmani, A. H. (2024) · Biomolecules · doi:10.3390/biom14060697 · Cited by 263 · see citing works
New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases
Chen, S., Li, Q., Shi, H., Li, F., Duan, Y., & Guo, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117084 · Cited by 234 · see citing works
Exploring the potential of antioxidants from fruits and vegetables and strategies for their recovery
Arias, A., Feijóo, G., & Moreira, M. T. (2022) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2022.102974 · Cited by 215 · see citing works
Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Ali, E. S., Mitra, K., Akter, S., Ramproshad, S., Mondal, B., Khan, I. N., Islam, M. T., Sharifi‐Rad, J., Călina, D. C., & Cho, W. C. S. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02706-8 · Cited by 213 · see citing works
Self-citationChaudhary, M. R., Chaudhary, S., Sharma, Y., Singh, T. A., Mishra, A. K., Sharma, S. G., & Mehdi, M. M. (2023) · Biogerontology · doi:10.1007/s10522-023-10050-1 · Cited by 210 · see citing works
Amir, S., Shah, S. T. A., Mamoulakis, C., Docea, A. O., Kalantzi, O., Zachariou, A., Călina, D. C., Carvalho, F. D., Sofikitis, N., Makrigiannakis, A., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041464 · Cited by 203 · see citing works
Self-citationLactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods
Prete, R., Alam, M. K., Perpetuini, G., Perla, C., Pittia, P., & Corsetti, A. (2021) · Foods · doi:10.3390/foods10071653 · Cited by 194 · see citing works
Oxidative Stress and Male Infertility: The Protective Role of Antioxidants
Kaltsas, A. (2023) · Medicina · doi:10.3390/medicina59101769 · Cited by 221 · see citing works
Andrés, C. M. C., de la Lastra, J. M. P., Andrés, C., Plou, F. J., & Pérez‐Lebeña, E. (2023) · Processes · doi:10.3390/pr11092771 · Cited by 193 · see citing works
Probiotics: Versatile Bioactive Components in Promoting Human Health
Sharifi‐Rad, J., Rodrigues, C. F., Stojanović-Radić, Z. Z., Dimitrijević, M., Aleksić, A., Neffe‐Skocińska, K., Zielińska, D., Kołożyn‐Krajewska, D., Salehi, B., Prabu, S. M., et al. (2020) · Medicina · doi:10.3390/medicina56090433 · Cited by 191 · see citing works
Self-citationSharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N. C., Bouyahya, A., Vitalini, S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.600139 · Cited by 183 · see citing works
Self-citationOxidative stress and antioxidants in health and disease
Kıran, T. R., Otlu, Ö., & Karabulut, A. B. (2023) · Journal of Laboratory Medicine · doi:10.1515/labmed-2022-0108 · Cited by 181 · see citing works
Water physicochemical factors and oxidative stress physiology in fish, a review
Menon, S. V., Kumar, A., Middha, S. K., Paital, B., Mathur, S., Johnson, R., Kademane, A., Usha, T., Hemavathi, K. N., Dayal, S., et al. (2023) · Frontiers in Environmental Science · doi:10.3389/fenvs.2023.1240813 · Cited by 199 · see citing works
Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications
Losada‐Barreiro, S., Bayındır, Z. S., Paiva‐Martins, F., & Bravo‐Díaz, C. (2022) · Biomedicines · doi:10.3390/biomedicines10123051 · Cited by 178 · see citing works
Neuropharmacological Effects of Quercetin: A Literature-Based Review
Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665031 · Cited by 165 · see citing works
Self-citationROS signaling in innate immunity via oxidative protein modifications
Manoharan, R. R., Prasad, A., Pospı́šil, P., & Kzhyshkowska, J. G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1359600 · Cited by 163 · see citing works
Tsatsakis, A. M., Călina, D. C., Falzone, L., Petrakis, D., Mitruţ, R., Siokas, V., Pennisi, M., Lanza, G., Libra, M., Doukas, S. G., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111769 · Cited by 154 · see citing works
Self-citationTitin (TTN): from molecule to modifications, mechanics, and medical significance
Loescher, C. M., Hobbach, A. J., & Linke, W. A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab328 · Cited by 150 · see citing works
Oxidative Stress, Antioxidants and Hypertension
Amponsah-Offeh, M., Diaba‐Nuhoho, P., Speier, S., & Morawietz, H. (2023) · Antioxidants · doi:10.3390/antiox12020281 · Cited by 160 · see citing works
Polyol pathway and redox balance in diabetes
Garg, S. S., & Gupta, J. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106326 · Cited by 151 · see citing works
Labarrere, C. A., & Kassab, G. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1007816 · Cited by 146 · see citing works
The Role of Reactive Species on Innate Immunity
Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works
Oxidative Stress and Antioxidants in Age-Related Macular Degeneration
Kushwah, N. S., Bora, K., Maurya, M., Pavlovich, M. C., & Chen, J. (2023) · Antioxidants · doi:10.3390/antiox12071379 · Cited by 138 · see citing works
Lohvina, H. O., Makai, S., & Wink, M. (2021) · Diversity · doi:10.3390/d14010007 · Cited by 129 · see citing works
Grishanova, A. Y., & Perepechaeva, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126719 · Cited by 130 · see citing works
Butnariu, M., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Singh, L., Aborehab, N. M., Bouyahya, A., Venditti, A., Sen, S., Acharya, K., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8214821 · Cited by 126 · see citing works
Self-citationSharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
“The increase in life expectancy is one of the factors that has led to an increase in the number of AD cases worldwide [3,4].”
BackgroundSelf-citationWierzejska, R. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18178897 · Cited by 120 · see citing works
Alessandro de, S. I. R. E., Marotta, N., Ferrillo, M., Agostini, F., Sconza, C., Lippi, L., Respizzi, S., Giudice, A., Invernizzi, M., & Ammendolia, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052528 · Cited by 120 · see citing works
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species
Uchiyama, J., Akiyama, M., Hase, K., Kumagai, Y., & Kim, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110479 · Cited by 118 · see citing works
Lycopene: A Potent Antioxidant with Multiple Health Benefits
Shafe, M. O., Gumede, N. M., Nyakudya, T. T., & Chivandi, E. (2024) · Journal of Nutrition and Metabolism · doi:10.1155/2024/6252426 · Cited by 132 · see citing works
Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney
Chen, Q., Nan, Y., Yang, Y., Xiao, Z., Liu, M., Huang, J., Xiang, Y., Long, X., Zhao, T., Wang, X., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.021 · Cited by 113 · see citing works
Understanding the Role of Free Radicals and Antioxidant Enzymes in Human Diseases
Chaudhary, N., Roy, Z., Bansal, R., & Siddiqui, L. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666221121160822 · Cited by 114 · see citing works
Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation
Ahmadi, A., Jamialahmadi, T., & Sahebkar, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106414 · Cited by 111 · see citing works
Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability
Kothari, D., Lee, W., & Kim, S. (2020) · Antioxidants · doi:10.3390/antiox9090888 · Cited by 106 · see citing works
Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease
Ekundayo, B. E., Obafemi, T. O., Adewale, O. B., Obafemi, B. A., Oyinloye, B. E., & Ekundayo, S. K. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01248-2 · Cited by 108 · see citing works
Walke, G., Gaurkar, S. S., Prasad, R., Lohakare, T., & Wanjari, M. B. (2023) · Cureus · doi:10.7759/cureus.42583 · Cited by 104 · see citing works
Oxidative stress: fundamentals and advances in quantification techniques
Krishnamurthy, H. K., Pereira, M., Rajavelu, I., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1470458 · Cited by 116 · see citing works
Negative Impacts of Arsenic on Plants and Mitigation Strategies
Sinha, D., Datta, S., Mishra, R., Agarwal, P., Kumari, T., Adeyemi, S. B., Maurya, A. K., Ganguly, S., Atique, U., Seal, S., et al. (2023) · Plants · doi:10.3390/plants12091815 · Cited by 109 · see citing works
Ashraf, M. V., Khan, S., Misri, S., Gaira, K. S., Rawat, S., Rawat, B., Khan, M. A. H., Shah, A. A., Asgher, M., & Ahmad, S. (2024) · Pharmaceuticals · doi:10.3390/ph17080975 · Cited by 102 · see citing works
Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives
Sarkar, C. K., Mondal, M., Islam, M. T., Martorell, M., Docea, A. O., Maroyi, A., Sharifi‐Rad, J., & Călina, D. C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.572870 · Cited by 100 · see citing works
Self-citationMitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Bartman, S., Coppotelli, G., & Ross, J. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030130 · Cited by 101 · see citing works
Recent advances in the therapeutic potential of emodin for human health
Sharifi‐Rad, J., Herrera‐Bravo, J., Kamiloğlu, S., Petroni, K., Mishra, A. P., Monserrat-Mesquida, M., Sureda, A., Martorell, M., Dossymbetova, S., Yessimsiitova, Z. B., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113555 · Cited by 100 · see citing works
Self-citationMunteanu, C., Turnea, M. A., & Rotariu, M. (2023) · Antioxidants · doi:10.3390/antiox12091737 · Cited by 99 · see citing works
Healthy dietary patterns and the risk of individual chronic diseases in community-dwelling adults
Shang, X., Liu, J., Zhu, Z., Zhang, X., Huang, Y., Liu, S., Wang, W., Zhang, X., Tang, S., Hu, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42523-9 · Cited by 106 · see citing works
Ekiz, E., Öz, E., El‐Aty, A. M. A., Proestos, C., Brennan, C. S., Zeng, M., Tomasevic, I. B., Elobeid, T., Çadırcı, K., Bayrak, M., et al. (2023) · Foods · doi:10.3390/foods12071512 · Cited by 97 · see citing works
The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae
Pruteanu, L.-L., Bailey, D. S., Grădinaru, A. C., & Jäntschi, L. (2023) · Antioxidants · doi:10.3390/antiox12040860 · Cited by 114 · see citing works
Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis
Jain, D., Chaudhary, P., Varshney, N., Razzak, K. S. B., Verma, D., Zahra, T. R. K., Janmeda, P., Sharifi‐Rad, J., Daştan, S. D., Mahmud, S., et al. (2021) · Journal of Oncology · doi:10.1155/2021/5905357 · Cited by 96 · see citing works
Self-citationGlyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study
Chang, V. C., Andreotti, G., Ospina, M., Parks, C. G., Liu, D., Shearer, J. J., Rothman, N., Silverman, D. T., Sandler, D. P., Calafat, A. M., et al. (2023) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djac242 · Cited by 96 · see citing works
The Influence of Metabolic Factors and Diet on Fertility
Łakoma, K., Kukharuk, O., & Śliż, D. (2023) · Nutrients · doi:10.3390/nu15051180 · Cited by 97 · see citing works
Reactive Oxygen Species (ROS)-Responsive Biomaterials for the Treatment of Bone-Related Diseases
Ren, X., Liu, H., Wu, X., Weng, W., Wang, X., & Su, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.820468 · Cited by 95 · see citing works
Mokgalaboni, K., Ntamo, Y., Ziqubu, K., Nyambuya, T. M., Nkambule, B. B., Mazibuko-Mbeje, S. E., Gabuza, K., Chellan, N., Tiano, L., & Dludla, P. V. (2021) · Food & Function · doi:10.1039/d1fo02696h · Cited by 99 · see citing works
Khan, M. Z., Xiao, J., Ma, Y., Ma, J., Liu, S., Khan, A. A., Khan, J. M., & Cao, Z. (2021) · Antioxidants · doi:10.3390/antiox10050788 · Cited by 93 · see citing works
Andrade, B., Jara‐Gutiérrez, C., Paz-Araos, M., Vázquez, M. C., Díaz, P., & Murgas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315182 · Cited by 92 · see citing works
Ulhaq, Z. S., & Tse, W. K. F. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131722 · Cited by 90 · see citing works
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Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1221438 · Cited by 90 · see citing works
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Chavda, V. K., Chaurasia, B. K., Garg, K., Deora, H., Umana, G. E., Palmisciano, P., Scalia, G., & Lu, B. (2021) · Brain Disorders · doi:10.1016/j.dscb.2021.100029 · Cited by 94 · see citing works
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Patel, K. D., Keskin‐Erdogan, Z., Sawadkar, P., Sharifulden, N. S. A. N., Shannon, M. R., Patel, M., Silva, L. V. B., Patel, R., Chau, D. Y. S., Knowles, J. C., et al. (2024) · Nanoscale Horizons · doi:10.1039/d4nh00171k · Cited by 90 · see citing works
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Thiviya, P., Gamage, A., Arachchige, D., Merah, O., & Madhujith, T. (2021) · Cosmetics · doi:10.3390/cosmetics8040111 · Cited by 96 · see citing works
Manimegalai, P., Selvam, K., Loganathan, S., Kirubakaran, D., Shivakumar, M. S., Govindasamy, M., Rajaji, U., & Bahajjaj, A. A. A. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-04279-6 · Cited by 87 · see citing works
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Heavy metal and pesticide levels in dairy products: Evaluation of human health risk
Năstăsescu, V., Mititelu, M., Γούμενου, Μ., Docea, A. O., Renieri, E. A., Udeanu, D. I., Oprea, E., Arsene, A. L., Dinu‐Pîrvu, C. E., & Ghica, M. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111844 · Cited by 84 · see citing works
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Zhang, Y., Liu, W., Wang, X., Liu, Y., & Wei, H. (2022) · Small · doi:10.1002/smll.202204809 · Cited by 83 · see citing works
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Zarić, B. L., Mačvanin, M., & Isenović, E. R. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106346 · Cited by 100 · see citing works
Effiong, M. E., Umeokwochi, C. P., Afolabi, I. S., & Chinedu, S. N. (2024) · Scientific Reports · doi:10.1038/s41598-024-54201-x · Cited by 82 · see citing works
Arunachalam, K., Yang, X., & San, T. T. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114540 · Cited by 82 · see citing works
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Cheng, X., Hu, Y., Yang, T., Wu, N., & Wang, X.-N. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7906091 · Cited by 81 · see citing works
Salazar‐Puerta, A. I., Rincon‐Benavides, M. A., Cuellar‐Gaviria, T. Z., Aldana, J., Vasquez-Martinez, G., Ortega‐Pineda, L., Das, D., Dodd, D. J., Spencer, C. A., Deng, B., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210579 · Cited by 81 · see citing works
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Ansari, W. A., Srivastava, K., Nasibullah, M., & Khan, M. F. (2025) · Discover Chemistry. · doi:10.1007/s44371-025-00275-z · Cited by 89 · see citing works
Awadelkareem, A. M., Al-Shammari, E., Elkhalifa, A. E. O., Adnan, M., Siddiqui, A. J., Snoussi, M., Khan, M. I., Azad, Z. R. A. A., Patel, M. B., & Ashraf, S. A. (2022) · Molecules · doi:10.3390/molecules27041409 · Cited by 80 · see citing works
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Sirohi, P., Verma, H., Singh, S. K., Singh, V. K., Pandey, J., Khusharia, S., Kumar, D., Kaushalendra, K., Teotia, P., & Kumar, A. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44120427 · Cited by 85 · see citing works
Müller, L., & Benedetto, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020753 · Cited by 82 · see citing works
Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.
Painuli, S., Quispe, C., Herrera‐Bravo, J., Semwal, P., Martorell, M., Almarhoon, Z. M., Seilkhan, A., Ydyrys, A., Sharifi‐Rad, J., Alshehri, M. M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2910411 · Cited by 77 · see citing works
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Rashid, H., Jali, A. M., Akhter, M. S., & Abdi, S. A. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010003 · Cited by 77 · see citing works
- Authors
- Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., Prakash Mishra, A., Nigam, M., El Rayess, Y., Beyrouthy, M. E., Polito, L., Iriti, M., Martins, N., Martorell, M., Docea, A. O., Setzer, W. N., Calina, D., Cho, W. C., & Sharifi-Rad, J.
- Affiliations
- University of Cagliari (IT)
- University of Milan (IT)
- University of Salento (IT)
- Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (IT)
- Hemwati Nandan Bahuguna Garhwal University (IN)
- Holy Spirit University of Kaslik (LB)
- Universidade do Porto (PT)
- University of Concepción (CL)
- University of Medicine and Pharmacy of Craiova (RO)
- University of Alabama in Huntsville (US)
- Queen Elizabeth Hospital (CN)
- Corresponding author
- Martorell, Miquel
- Cho, William C.
- ORCID
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-07-02
- Volume
- 11
- Pages
- 694-694
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC7347016
- OpenAlex
- W3039077710
- Cited by
- 1,971
- References
- 211
- Citations by year
- 2026: 181 · 2025: 371 · 2024: 474 · 2023: 467 · 2022: 323 · 2021: 129 · 2020: 25 · 2012: 1
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences) (submittedVersion)
- AIRUS (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (01-0145, NORTE-01-0145-FEDER-000012, UID/BIM/04293/2013, UID/BIM/04293, NORTE2020, NORTE-01-0145)
- Comisión Nacional de Investigación Científica y Tecnológica (CCTE AFB170007, AFB170007)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- oxidative stress, antioxidants, lifestyle, chronic disease, cardiovascular disease, diabetes mellitus, neurodegenerative diseases, cancer, mitochondrial DNA damage, processed foods, chemical exposure, physical inactivity, medicinal plants, antioxidant defense, disease prevention
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