The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
Open accessAbstract
Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and degradation. Excessive ECM deposition results in scarring and thickening of the affected tissue, and interferes with tissue and organ homeostasis - mimicking an exaggerated "wound healing" response. Many transforming growth factor-β (TGF-β) ligands are potent drivers of ECM deposition, and additionally, have a natural affinity for the ECM, creating a concentrated pool of pro-fibrotic factors at the site of injury. Consequently, TGF-β ligands are upregulated in many human fibrotic conditions and, as such, are attractive targets for fibrosis therapy. Here, we will discuss the contribution of TGF-β proteins in the pathogenesis of fibrosis, and promising anti-fibrotic approaches that target TGF-β ligands.
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1 retracted
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Skeletal muscle fibrosis: an overview
Mahdy, M. A. A. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-2955-2 · Cited by 363
Chen, L., Yang, T., Lu, D.-W., Zhao, H., Feng, Y.-L., Chen, H., Chen, D.-Q., Vaziri, N. D., & Zhao, Y.-Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.090 · Cited by 359
Time to redefine endometriosis including its pro-fibrotic nature
Vigano, P., Candiani, M., Monno, A., Giacomini, E., Vercellini, P., & Somigliana, E. (2018) · Human Reproduction · doi:10.1093/humrep/dex354 · Cited by 235
Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis
Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat9284 · Cited by 166
Guo, S.-W. (2018) · Human Reproduction · doi:10.1093/humrep/dey015 · Cited by 116
Metadata
- Authors
- Walton, K. L., Johnson, K. E., & Harrison, C. A.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2017-07-14
- Volume
- 8
- Pages
- 461-461
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2735790845
- Cited by
- 543
- References
- 120
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Walton, K. L., Johnson, K. E., & Harrison, C. A. (2017). Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2017.00461
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
