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Cellular and Molecular Targets of Menthol Actions
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“Beyond its effects on GI motility and the microbiome, menthol influences other pathophysiological mechanisms associated with IBS, such as analgesic effects via inhibition of 5-HT3 serotonin and gamma-aminobutyric acid (GABA) receptors, potassium and voltage-gated sodium channels, and transient receptor potential cation channels in vitro [26,27].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [26]
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Natural terpenes: Self-assembly and membrane partitioning
Turina, A. D. V., Nolan, M. V., Zygadlo, J. A., & Perillo, M. A. (2006) · Biophysical Chemistry · doi:10.1016/j.bpc.2006.02.007 · Cited by 305 · cited 4×
“It is not completely soluble in water (431 mg/L at 20 ◦ C), but freely soluble in chloroform, diethyl ether, and alcohol (Kamatou et al., 2013) with Log octanol/water value of 3.4, indicating that menthol is a lipophilic compound capable of interacting with membranes (Turina et al., 2006).”
InfluentialEffects of menthol on circular smooth muscle of human colon: Analysis of the mechanism of action
Amato, A., Liotta, R., & Mulè, F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.018 · Cited by 98
Research works printed but not linked: 144
- Ahijevych, 2004, Menthol pharmacology and its potential impact on cigarette smoking behavior, Nicotine Tob. Res., 1, 17, 10.1080/14622200310001649469 · DOI
- Ahijevych, 2010, The role of menthol in cigarettes as a reinforce of smoking behavior, Nicotine Tob. Res., 2, 110, 10.1093/ntr/ntq203 · DOI
- Albin, 2008, Modulation of oral heat and cold pain by irritant chemicals, Chem. Senses, 33, 3, 10.1093/chemse/bjm056 · DOI
- Albuquerque, 2009, Mammalian nicotinic acetylcholine receptors: from structure to function, Physiol. Rev., 89, 73, 10.1152/physrev.00015.2008 · DOI · Paper page
- Amato, Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation, Eur. J. Pharmacol., 745, 129, 10.1016/j.ejphar.2014.10.012 · DOI
- Anishkin, 2014, Feeling the hidden mechanical forces in lipid bilayer is an original sense, Proc. Natl. Acad. Sci. U.S.A., 111, 7898, 10.1073/pnas.1313364111 · DOI
- Ashoor, Menthol binding and inhibition of α7-nicotinic acetylcholine receptors, PLoS ONE, 8, e67674, 10.1371/journal.pone.0067674 · DOI
- Ashoor, Menthol inhibits 5-HT3 receptor-mediated currents, J. Pharmacol. Exp. Ther., 347, 398, 10.1124/jpet.113.203976 · DOI
- Badou, 2013, Emerging roles of L-type voltage-gated and other calcium channels in T lymphocytes, Front. Immunol., 4, 243, 10.3389/fimmu.2013.00243 · DOI
- Bandell, 2006, High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol, Nat. Neurosci., 9, 493, 10.1038/nn1665 · DOI
- Bandell, 2004, Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin, Neuron, 41, 849, 10.1016/S0896-6273(04)00150-3 · DOI
- Bannister, 2013, Ca(V)1.1: the atypical prototypical voltage-gated Ca2? channel, Biochim. Biophys. Acta, 1828, 1587, 10.1016/j.bbamem.2012.09.007 · DOI
- Barrantes, 2010, Boundary lipids in the nicotinic acetylcholine receptor microenvironment, J. Mol. Neurosci., 40, 87, 10.1007/s12031-009-9262-z · DOI
- Baylie, 2010, Inhibition of the cardiac L-type calcium channel current by the TRPM8 agonist, (−)-menthol, J. Physiol. Pharmacol., 61, 543, 10.1124/jpet.107.132456 · DOI
- Behrendt, 2004, Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay, Br. J. Pharmacol., 141, 737, 10.1038/sj.bjp.0705652 · DOI · Paper page
- Benowitz, 2011, The threat of menthol cigarettes to U.S. public health, N. Engl. J. Med., 364, 2179, 10.1056/NEJMp1103610 · DOI
- Billeter, 2014, Transient receptor potential ion channels: powerful regulators of cell function, Ann. Surg., 259, 229, 10.1097/SLA.0b013e3182a6359c · DOI
- Bradshaw, 2013, Opportunistic activation of TRP receptors by endogenous lipids: exploiting lipidomics to understand TRP receptor cellular communication, Life Sci., 92, 404, 10.1016/j.lfs.2012.11.008 · DOI
- Brody, 2013, Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers, Int. J. Neuropsychopharmacol., 16, 957, 10.1017/S1461145712001022 · DOI
- Cannon, 2014, Ion channels, overview, 747, 10.1016/B978-0-12-385157-4.00061-0 · DOI
- Catterall, 2013, Voltage-gated sodium channels: structure, function, and pathophysiology, 564, 10.1016/B978-0-12-378630-2.00208-5 · DOI
- Cheang, 2013, Menthol relaxes rat aortae, mesenteric and coronary arteries by inhibiting calcium influx, Eur. J. Pharmacol., 702, 79, 10.1016/j.ejphar.2013.01.028 · DOI
- Clapham, 2009, Transient receptor potential (TRP) channels, 1109, 10.1016/B978-008045046-9.01634-X · DOI
- Corvalán, 2009, Stereo-selective activity of menthol on GABA(A) receptor, Chirality, 21, 525, 10.1002/chir.20631 · DOI
- Daly, 2005, Nicotinic agonists, antagonists, and modulators from natural sources, Cell Mol. Neurobiol., 25, 513, 10.1007/s10571-005-3968-4 · DOI
- Dani, 2007, Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system, Annu. Rev. Pharmacol. Toxicol., 47, 699, 10.1146/annurev.pharmtox.47.120505.105214 · DOI · Paper page
- Deiml, 2004, a-Thujone reduces 5-HT3 receptor activity by an effect on the agonist-induced desensitization, Neuropharmacology, 46, 192, 10.1016/j.neuropharm.2003.09.022 · DOI
- Dessirier, 2001, Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine, Physiol. Behav., 73, 25, 10.1016/S0031-9384(01)00431-0 · DOI
- Dierkes, 1997, Voltage-dependent Ca2+ influx into identified leech neurones, Brain Res., 746, 285, 10.1016/S0006-8993(96)01264-4 · DOI
- Dineley, 2015, Nicotinic ACh receptors as therapeutic targets in CNS disorders, Trends Pharmacol. Sci., 36, 96, 10.1016/j.tips.2014.12.002 · DOI · Paper page
- Dutertre, 2012, Inhibitory glycine receptors: an update, J. Biol. Chem., 287, 40216, 10.1074/jbc.R112.408229 · DOI
- Eccles, 1994, Menthol and related cooling compounds, J. Pharm. Pharmacol., 46, 618, 10.1111/j.2042-7158.1994.tb03871.x · DOI · Paper page
- Engel, 2013, The serotonin 5-HT3 receptor: a novel neurodevelopmental target, Front. Cell Neurosci., 7, 76, 10.3389/fncel.2013.00076 · DOI
- Fantini, 2009, Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function, Biochim. Biophys. Acta, 1788, 2345, 10.1016/j.bbamem.2009.08.016 · DOI
- Faridi, 2011, Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation, Proteomics, 11, 2115, 10.1002/pmic.201000691 · DOI
- Filippov, 2009, Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol, Fiziol. Zh., 55, 30
- Foulds, 2010, Do smokers of menthol cigarettes find it harder to quit smoking?, Nicotine Tob. Res., 2, 102, 10.1093/ntr/ntq166 · DOI
- Freichel, 2007, Biological functions of TRPs unravelled by spontaneous mutations and transgenic animals, Biochem. Soc. Trans., 35, 120, 10.1042/BST0350120 · DOI
- Fritschy, 2012, Molecular and functional heterogeneity of GABAergic synapses, Cell Mol. Life Sci., 69, 2485, 10.1007/s00018-012-0926-4 · DOI
- Galeotti, 2002, Menthol: a natural analgesic compound, Neurosci. Lett., 322, 145, 10.1016/S0304-3940(01)02527-7 · DOI · Paper page
- Galeotti, 2001, Local anaesthetic activity of (+)- and (−)-menthol, Planta Med., 67, 174, 10.1055/s-2001-11515 · DOI
- García, 2006, Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons, Neuropharmacology, 50, 25, 10.1016/j.neuropharm.2005.07.009 · DOI
- Gaudioso, 2012, Menthol pain relief through cumulative inactivation of voltage-gated sodium channels, Pain, 153, 473, 10.1016/j.pain.2011.11.014 · DOI
- Gees, 2012, TRP channels, Compr. Physiol., 2, 563, 10.1002/cphy.c110026 · DOI
- Gonçalves, 2010, Distinct effects of carvone analogues on the isolated nerve of rats, Eur. J. Pharmacol., 645, 108, 10.1016/j.ejphar.2010.07.027 · DOI
- González, 2012, K(+) channels: function-structural overview, Compr. Physiol., 2, 2087, 10.1002/cphy.c110047 · DOI
- Green, 1986, Menthol inhibits the perception of warmth, Physiol. Behav., 38, 833, 10.1016/0031-9384(86)90050-8 · DOI
- Haeseler, 2002, Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol, Eur. J. Anaesthesiol., 19, 571, 10.1097/00003643-200208000-00005 · DOI · Paper page
- Hall, 2004, Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids, Eur. J. Pharmacol., 506, 9, 10.1016/j.ejphar.2004.10.026 · DOI
- Hans, 2012, Menthol suppresses nicotinic acetylcholine receptor functioning in sensory neurons via allosteric modulation, Chem. Senses, 37, 463, 10.1093/chemse/bjr128 · DOI
- Hatem, 2006, Psychophysical study of the effects of topical application of menthol in healthy volunteers, Pain, 122, 190, 10.1016/j.pain.2006.01.026 · DOI
- Hawthorn, 1988, The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations, Aliment. Pharmacol. Ther., 2, 101, 10.1111/j.1365-2036.1988.tb00677.x · DOI · Paper page
- Heimes, 2011, Mode of action of peppermint oil and (−)-menthol with respect to 5-HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum, Phytother. Res., 25, 702, 10.1002/ptr.3316 · DOI
- Henderson, 2017, Menthol enhances nicotine reward-related behavior by potentiating nicotine-induced changes in nAChR function, nAChR upregulation, and DA neuron excitability, Neuropsychopharmacology, 10.1038/npp.2017.72 · DOI
- Henderson, 2016, Menthol alone upregulates midbrain nAChRs, alters nAChR subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward, J. Neurosci., 36, 2957, 10.1523/JNEUROSCI.4194-15.2016 · DOI
- Hill, 2015, Dehydroepiandrosterone, its metabolites and ion channels, J. Steroid Biochem. Mol. Biol., 145, 293, 10.1016/j.jsbmb.2014.05.006 · DOI
- Hills, 1991, The mechanism of action of peppermint oil on gastrointestinal smooth muscle. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig, Gastroenterology, 101, 55, 10.1016/0016-5085(91)90459-X · DOI
- Hofmann, 2014, L-type CaV1.2 calcium channels: from in vitro findings to in vivo function, Physiol. Rev., 94, 303, 10.1152/physrev.00016.2013 · DOI
- Howard, 2014, Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics, Pharmacol. Rev., 66, 396, 10.1124/pr.113.007468 · DOI · Paper page
- Ito, 2008, Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction, Pulm. Pharmacol. Ther., 21, 812, 10.1016/j.pupt.2008.07.001 · DOI
- Janssens, 2011, Ligand stoichiometry of the cold- and menthol- activated channel TRPM8, J. Physiol., 15, 4827, 10.1113/jphysiol.2011.216523 · DOI
- Julius, 2013, TRP channels and pain, Annu. Rev. Cell Dev. Biol., 29, 355, 10.1146/annurev-cellbio-101011-155833 · DOI · Paper page
- Kabbani, 2013, Not so Cool? Menthol's discovered actions on the nicotinic receptor and its implications for nicotine addiction, Front. Pharmacol., 4, 95, 10.3389/fphar.2013.00095 · DOI
- Kamatou, 2013, Menthol: a simple monoterpene with remarkable biological properties, Phytochemistry, 96, 15, 10.1016/j.phytochem.2013.08.005 · DOI · Paper page
- Karashima, 2007, Bimodal action of menthol on the transient receptor potential channel TRPA1, J. Neurosci., 27, 9874, 10.1523/JNEUROSCI.2221-07.2007 · DOI · Paper page
- Kawasaki, 2013, Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves, Life Sci., 92, 359, 10.1016/j.lfs.2013.01.012 · DOI
- Kim, 2016, Menthol modulates pacemaker potentials through TRPA1 channels in cultured interstitial cells of cajal from murine small intestine, Cell Physiol. Biochem., 38, 1869, 10.1159/000445549 · DOI · Paper page
- Kim, 2008, TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands, Biochem. Biophys. Res. Commun, 370, 295, 10.1016/j.bbrc.2008.03.077 · DOI
- Kim, 2009, Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells, Biochim. Biophys. Acta, 1792, 33, 10.1016/j.bbadis.2008.09.012 · DOI
- Klein, 2010, Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats, Behav. Brain Res., 212, 179, 10.1016/j.bbr.2010.04.015 · DOI
- Klein, 2012, Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons, Neuroscience, 219, 234, 10.1016/j.neuroscience.2012.05.061 · DOI
- Lansdell, 2015, Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site, Mol. Pharmacol., 87, 87, 10.1124/mol.114.094540 · DOI
- Latorre, 2013, Voltage-dependent K+ channels, 555, 10.1016/B978-0-12-378630-2.00144-4 · DOI
- Latorre, 2009, Structure-functional intimacies of transient receptor potential channels, Q. Rev. Biophys., 42, 201, 10.1017/S0033583509990072 · DOI
- Lau, 2014, Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons, Br. J. Pharmacol., 171, 2803, 10.1111/bph.12602 · DOI
- Lee, 2011, Biological membranes: the importance of molecular detail, Trends. Biochem. Sci., 36, 493, 10.1016/j.tibs.2011.06.007 · DOI
- Lee, 2005, Eugenol inhibits calcium currents in dental afferent neurons, J. Dent. Res., 84, 848, 10.1177/154405910508400913 · DOI
- Li, 2009, Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24, Oncology, 77, 335, 10.1159/000264627 · DOI
- Lu, 2006, The role of Ca2+ in (−)-menthol-induced human promyelocytic leukemia HL-60 cell death, In vivo, 20, 69
- Lummis, 2012, 5-HT(3) receptors, J. Biol. Chem., 287, 40239, 10.1074/jbc.R112.406496 · DOI
- Macpherson, 2006, More than cool: promiscuous relationships of menthol and other sensory compounds, Mol. Cell Neurosci., 32, 335, 10.1016/j.mcn.2006.05.005 · DOI
- Mahieu, 2007, TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi, J. Biol. Chem., 282, 3325, 10.1074/jbc.M605213200 · DOI · Paper page
- Maljevic, 2013, Potassium channels: a review of broadening therapeutic possibilities for neurological diseases, J. Neurol., 260, 2201, 10.1007/s00415-012-6727-8 · DOI
- McKemy, 2002, Identification of a cold receptor reveals a general role for TRP channels in thermosensation, Nature, 416, 52, 10.1038/nature719 · DOI · Paper page
- Melanaphy, 2016, Ion channel mechanisms of rat tail artery contraction-relaxation by menthol involving, respectively, TRPM8 activation and L-type Ca2+ channel inhibition, Am. J. Physiol. Heart. Circ. Physiol., 311, H1416, 10.1152/ajpheart.00222.2015 · DOI
- Moreau, 2014, Biophysics, pathophysiology, and pharmacology of ion channel gating pores, Front. Pharmacol., 5, 53, 10.3389/fphar.2014.00053 · DOI
- Morenilla-Palao, 2009, Lipid raft segregation modulates TRPM8 channel activity, J. Biol. Chem., 284, 9215, 10.1074/jbc.M807228200 · DOI
- Morise, 2010, Heterologous regulation of anion transporters by menthol in human airway epithelial cells, Eur. J. Pharmacol., 635, 204, 10.1016/j.ejphar.2010.03.032 · DOI
- 1979, Bioassay of Dl-Menthol for Possible Carcinogenicity, Natl. Cancer Inst. Carcinog. Tech. Rep. Ser., 98, 1
- Neumann, 2011, Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators, Mol. Pharmacol., 80, 509, 10.1124/mol.111.071167 · DOI
- Nilius, 2013, Spices: the savory and beneficial science of pungency, Rev. Physiol. Biochem. Pharmacol., 164, 1, 10.1007/112_2013_11 · DOI
- Nilius, 2014, Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine, Pharmacol. Rev., 66, 676, 10.1124/pr.113.008268 · DOI · Paper page
- Oz, 2006, Receptors-independent actions of cannabinoids on cell membranes: focus on endocannabinoids, Pharmacol. Ther., 111, 114, 10.1016/j.pharmthera.2005.09.009 · DOI
- Oz, 2015, Effects of monoterpenes on ion channels of excitable cells, Pharmacol. Ther., 152, 83, 10.1016/j.pharmthera.2015.05.006 · DOI
- Palade, 1987, Drug-induced Ca2+ release from isolated sarcoplasmic reticulum. II. Releases involving a Ca2+-induced Ca2+ release channel, J. Biol. Chem., 262, 6142, 10.1016/S0021-9258(18)45549-4 · DOI
- Pan, 2012, Central mechanisms of menthol-induced analgesia, J. Pharmacol. Exp. Ther., 343, 661, 10.1124/jpet.112.196717 · DOI
- Patel, 2007, Menthol: a refreshing look at this ancient compound, J. Am. Acad. Dermatol., 57, 873, 10.1016/j.jaad.2007.04.008 · DOI · Paper page
- Peier, 2002, A TRP channel that senses cold stimuli and menthol, Cell, 108, 705, 10.1016/S0092-8674(02)00652-9 · DOI · Paper page
- Pertusa, 2012, N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons, J. Biol. Chem., 287, 18218, 10.1074/jbc.M111.312645 · DOI
- Peters, 2014, Introduction to sodium channels, Handb. Exp. Pharmacol., 221, 1, 10.1007/978-3-642-41588-3_1 · DOI
- Pezzoli, 2014, Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices, Sci. Rep., 4, 6825, 10.1038/srep06825 · DOI
- Poveda, 2014, Lipid modulation of ion channels through specific binding sites, Biochim. Biophys. Acta, 1838, 1560, 10.1016/j.bbamem.2013.10.023 · DOI
- Ramos-Filho, 2014, Menthol inhibits detrusor contractility independently of TRPM8 activation, PLoS ONE, 9, e111616, 10.1371/journal.pone.0111616 · DOI
- Reiner, 2009, Lipophilicity of some GABAergic phenols and related compounds determined by HPLC and partition coefficients in different systems, J. Pharm. Biomed. Anal., 49, 686, 10.1016/j.jpba.2008.12.040 · DOI
- Reuter, 2013, Voltage-gated Ca2+ channels, 560, 10.1016/B978-0-12-378630-2.00183-3 · DOI
- Romanelli, 2007, Central nicotinic receptors: structure, function, ligands, and therapeutic potential, Chem. Med. Chem., 2, 746, 10.1002/cmdc.200600207 · DOI
- Ruskin, 2008, Chronic menthol attenuates the effect of nicotine on body temperature in adolescent rats, Nicotine Tob. Res., 10, 1753, 10.1080/14622200802443734 · DOI
- Ruta, 2004, Localization of the voltage-sensor toxin receptor on KvAP, Biochemistry, 43, 10071, 10.1021/bi049463y · DOI
- Sánchez, 2004, Surface activity of thymol: implications for an eventual pharmacological activity, Colloids Surf. B. Biointerfaces, 34, 77, 10.1016/j.colsurfb.2003.11.007 · DOI
- Savio-Galimberti, 2012, Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies, Front. Pharmacol., 3, 124, 10.3389/fphar.2012.00124 · DOI
- Sidell, 1990, Menthol blocks dihydropyridine-insensitive Ca2+ channels and induces neurite outgrowth in human neuroblastoma cells, J. Cell Physiol., 142, 410, 10.1002/jcp.1041420226 · DOI
- Sigel, 2012, Structure, function, and modulation of GABA(A) receptors, J. Biol. Chem., 287, 40224, 10.1074/jbc.R112.386664 · DOI
- Simms, 2014, Neuronal voltage-gated calcium channels: structure, function, and dysfunction, Neuron, 82, 24, 10.1016/j.neuron.2014.03.016 · DOI · Paper page
- Slominski, 2008, Cooling skin cancer: menthol inhibits melanoma growth. Focus on “TRPM8 activation suppresses cellular viability in human melanoma.”, Am. J. Physiol. Cell Physiol., 295, C293, 10.1152/ajpcell.00312.2008 · DOI
- Spichiger, 2004, Determination of menthol in plasma and urine of rats and humans by headspace solid phase microextraction and gas chromatography–mass spectrometry, J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 799, 111, 10.1016/j.jchromb.2003.10.022 · DOI
- Swandulla, 1987, Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates, Pflugers Arch., 409, 52, 10.1007/BF00584749 · DOI
- Swandulla, 1986, Calcium channel current inactivation is selectively modulated by menthol, Neurosci. Lett., 68, 23, 10.1016/0304-3940(86)90223-5 · DOI
- Takeuchi, 1994, Effect of menthol on cytosolic Ca2+ levels in canine airway epithelium in culture, Biochem. Biophys. Res. Commun., 2001, 1333, 10.1006/bbrc.1994.1850 · DOI
- Tani, 2010, Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats, Neuroreport, 21, 1095, 10.1097/WNR.0b013e3283405bad · DOI
- Tian, 2014, Potassium channels: structures, diseases, and modulators, Chem. Biol. Drug Des., 83, 1, 10.1111/cbdd.12237 · DOI
- Tien, 2014, Chapter 11 - molecular properties of ion channels, 323, 10.1016/B978-0-12-397179-1.00011-7 · DOI
- Ton, 2015, Menthol enhances the desensitization of human α3β4 nicotinic acetylcholine receptors, Mol. Pharmacol., 88, 256, 10.1124/mol.115.098285 · DOI
- Tong, 2012, Quantitative structure-activity relationships of monoterpenoid binding activities to the housefly GABA receptor, Pest Manag. Sci., 68, 1122, 10.1002/ps.3280 · DOI
- Trudell, 2014, Alcohol dependence: molecular and behavioral evidence, Trends Pharmacol. Sci., 35, 317, 10.1016/j.tips.2014.04.009 · DOI
- Tsuzuki, 2004, Menthol-induced Ca2+ release from presynaptic Ca2+ stores potentiates sensory synaptic transmission, J. Neurosci., 24, 762, 10.1523/JNEUROSCI.4658-03.2004 · DOI
- Valiyaveetil, 2002, Lipids in the structure, folding, and function of the KcsA K+ channel, Biochemistry, 41, 10771, 10.1021/bi026215y · DOI
- Veldhuis, 2015, The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation, Pharmacol. Rev, 67, 36, 10.1124/pr.114.009555 · DOI
- Vetter, 2013, Amplified cold transduction in native nociceptors by M-channel inhibition, J. Neurosci., 33, 16627, 10.1523/JNEUROSCI.1473-13.2013 · DOI
- Vladymyrova, 2011, Comparative effects of menthol and icilin on the induced contraction of the smooth muscles of the vas deferens of normal and castrated rats, Fiziol. Zh., 57, 21, 10.15407/fz57.04.021 · DOI
- Voets, 2004, The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels, Nature, 430, 748, 10.1038/nature02732 · DOI · Paper page
- Voets, 2007, TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli, Nat. Chem. Biol., 3, 174, 10.1038/nchembio862 · DOI · Paper page
- Vogt-Eisele, 2007, Monoterpenoid agonists of TRPV3, Br. J. Pharmacol., 151, 530, 10.1038/sj.bjp.0707245 · DOI · Paper page
- Walstab, 2014, Natural compounds boldine and menthol are antagonists of human 5-HT3 receptors: implications for treating gastrointestinal disorders, Neurogastroenterol. Motil., 26, 810, 10.1111/nmo.12334 · DOI
- Wang, 2016, Menthol inhibiting parasympathetic function of tracheal smooth muscle, Int. J. Med. Sci, 13, 923, 10.7150/ijms.17042 · DOI
- Watt, 2008, Menthol shares general anesthetic activity and sites of action on the GABAA receptor with the intravenous agent, propofol, Eur. J. Pharmacol, 590, 120, 10.1016/j.ejphar.2008.06.003 · DOI
- Wickham, 2015, How menthol alters tobacco-smoking behavior: a biological perspective, Yale J. Biol. Med., 88, 279
- Willis, 2011, Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants, FASEB J., 12, 4434, 10.1096/fj.11-188383 · DOI
- Wondergem, 2009, Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration, J. Biomed. Sci., 16, 90, 10.1186/1423-0127-16-90 · DOI
- Wright, 1997, Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetised guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle, Br. J. Pharmacol., 121, 1645, 10.1038/sj.bjp.0701319 · DOI
- Yamamura, 2008, TRPM8 activation suppresses cellular viability in human melanoma, Am. J. Physiol. Cell. Physiol., 295, C296, 10.1152/ajpcell.00499.2007 · DOI
- Yevenes, 2011, Allosteric modulation of glycine receptors, Br. J. Pharmacol., 164, 224, 10.1111/j.1476-5381.2011.01471.x · DOI
- Zhang, 2008, A-type GABA receptor as a central target of TRPM8 agonist menthol, PLoS ONE, 3, e3386, 10.1371/journal.pone.0003386 · DOI
- Ziemba, 2015, Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances, Biochem. Biophys. Res. Commun., 467, 1090, 10.1016/j.bbrc.2015.09.074 · DOI
- Zunino, 2011, Stereoselective effects of monoterpenes on the microviscosity and curvature of model membranes assessed by DPH steady-state fluorescence anisotropy and light scattering analysis, Chirality, 23, 867, 10.1002/chir.20998 · DOI
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Metadata
- Authors
- Oz, M., El Nebrisi, E. G., Yang, K.-H. S., Howarth, F. C., & Al Kury, L. T.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2017-07-18
- Volume
- 8
- ISSN
- 1663-9812
- Cited by
- 98
- References
- 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cellular and Molecular Targets of Menthol Actions. https://app.cochat.ai/papers/10.3389/fphar.2017.00472
- The paper
- Oz, M., El Nebrisi, E. G., Yang, K.-H. S., Howarth, F. C., & Al Kury, L. T. (2017). Cellular and Molecular Targets of Menthol Actions. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2017.00472
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.