The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types
Open accessAbstract
Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and therapy. Transporters are expressed differentially on the cell-surface of different cell types, and also specific transporters are expressed at higher than normal levels in selective cell types under pathological conditions. They also play a key role in intestinal absorption, delivery via non-oral routes (e.g., pulmonary route and nasal route), and transfer across biological barriers (e.g., blood-brain barrier and blood-retinal barrier. As such, the cell-surface transporters represent ideal targets for nano-drug delivery systems to facilitate drug delivery to selective cell types under normal or pathological conditions and also to avoid off-target adverse side effects of the drugs. There is increasing evidence in recent years supporting the utility of cell-surface transporters in the field of nano-drug delivery to increase oral bioavailability, to improve transfer across the blood-brain barrier, and to enhance delivery of therapeutics in a cell-type selective manner in disease states. Here we provide a comprehensive review of recent advancements in this interesting and important area. We also highlight certain key aspects that need to be taken into account for optimal development of transporter-assisted nano-drug delivery systems.
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Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery
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Metadata
- Authors
- Kou, L., Bhutia, Y. D., Yao, Q., He, Z., Sun, J., & Ganapathy, V.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2018-01-26
- Volume
- 9
- Pages
- 27-27
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2792971737
- Cited by
- 308
- References
- 101
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kou, L., Bhutia, Y. D., Yao, Q., He, Z., Sun, J., & Ganapathy, V. (2018). Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2018.00027
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