The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

Savio, Luiz E. B., de Andrade Mello, Paola, da Silva, Cleide Gonçalves, Coutinho-Silva, Robson·2018·Frontiers in Pharmacology

DOI 10.3389/fphar.2018.00052

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Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease
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Effect of adenosine 5′-triphosphate infusions on the nutritional status and survival of preterminal cancer patients
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Multiple Sclerosis: Autoimmune Disease or Autoimmune Reaction?
Peter K. Stys · 2010 · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis
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The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway
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The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine/chemokine production in infected human monocytes
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Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice
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Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist
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Endogenously Expressed Truncated P2X7 Receptor Lacking the C-Terminus is Preferentially Upregulated in Epithelial Cancer Cells and Fails to Mediate Ligand-Induced Pore Formation and Apoptosis
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Interaction of Chlamydiae with human macrophages
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Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis
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Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway
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P2×7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation
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Cell cooperation and role of the P2X7receptor in pulmonary inflammation induced by nanoparticles
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Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.
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Activation of the P2Z/P2X7Receptor in Human Lymphocytes Produces a Delayed Permeability Lesion: Involvement of Phospholipase D
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The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control
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Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists
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P2X7 receptor predicts postoperative cancer‐specific survival of patients with clear‐cell renal cell carcinoma
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The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages
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Potential role of P2X7R in esophageal squamous cell carcinoma proliferation
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Endothelial P2X7 receptors’ expression is reduced by schistosomiasis
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Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis
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Role of P2X7 and P2Y 2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “ in vivo ” by P2X7 receptor
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Variation in Glucose Homeostasis Traits Associated With P2RX7 Polymorphisms in Mice and Humans
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Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation
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Expression and function of the purinergic receptor P2X7 in patients with pulmonary tuberculosis
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Randomized Clinical Trial on the Effects of Adenosine 5'-Triphosphate Infusions on Quality of Life, Functional Status, and Fatigue in Preterminal Cancer Patients
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Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view
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Differential Modulation of ATP-Induced P2X7-Associated Permeabilities to Cations and Anions of Macrophages by Infection with Leishmania amazonensis
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The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis
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Characterizing the Presence and Sensitivity of the P2X7 Receptor in Different Compartments of the Gut
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P2RX7: A receptor with a split personality in inflammation and cancer
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Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis
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P2X7 receptor knockout prevents streptozotocin-induced type 1 diabetes in mice
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Stimulation of Insulin Secretion in vitro by Adenosine Triphosphate
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Large pore formation uniquely associated with P2X7 purinergic receptor channels. Focus on “Are second messengers crucial for opening the pore associated with P2X7 receptor?”
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Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice
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Purinergic signaling during Porphyromonas gingivalis infection
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Contribution of theP2X71513A/C loss-of-function polymorphism to extrapulmonary tuberculosis susceptibility in Tunisian populations
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Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+ T lymphocytes
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Changes in expression of P2X7receptors in NOD mouse pancreas during the development of diabetes
Robson Coutinho‐Silva, Tim Robson, Philip E. Beales · 2007 · Autoimmunity
Expression of purinergic P2X(7) receptor in rat brain during the symptomatic phase of experimental autoimmune encephalomyelitis and after recovery of neurological deficits
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Single Nucleotide Polymorphisms inP2X7Gene Are Associated with Serum Immunoglobulin G Responses toMycobacterium tuberculosisin Tuberculosis Patients
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Purinergic Antagonism Prevents Mitochondrial Dysfunction and Behavioral Deficits Associated with Dopaminergic Toxicity Induced by 6-OHDA in Rats
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Purinergic Signalling in the Gut
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Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G
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Dissecting Individual Current Components of Co-expressed Human P2X1 and P2X7 Receptors
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Targeting P2X7 receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes
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P2X7Receptor Expression in Coexistence of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis
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P2RX7 genotype association in severe sepsis identified by a novel Multi-Individual Array for rapid screening and replication of risk SNPs
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Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1
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Mast Cell Function and Death in Trypanosoma cruzi Infection
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The P2X7 Receptor Involved in gp120-Induced Cell Injury in BV2 Microglia
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Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs
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Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate
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Purinergic signaling in infection and autoimmune disease
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P2X7 modulatory web in Trypanosoma cruzi infection
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P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis
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Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes
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Association of IFN-γ and P2X7 Receptor Gene Polymorphisms in Susceptibility to Tuberculosis Among Iranian Patients
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Further observations on ATP-induced histamine release from rat mast cells.
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Purinergic signaling in schistosomal infection
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Purinergic receptors in tubulointerstitial inflammatory cells: a pathophysiological mechanism of salt‐sensitive hypertension
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Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae
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P2X7 from j774 murine macrophages acts as a scavenger receptor for bacteria but not yeast
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Evaluation of P2X7 receptor expression in peripheral lymphocytes and immune profile from patients with indeterminate form of Chagas disease
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P2X7 receptor as a novel drug delivery system to increase the entrance of hydrophilic drugs into cells during photodynamic therapy
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Periodate‐oxidized ATP modulates macrophage functions during infection with Leishmania amazonensis
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P2X7 receptor in the hippocampus is involved in gp120-induced cognitive dysfunction
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Endotoxin-induced effects on nucleotide catabolism in mouse kidney
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P2X7 1513 A>C Polymorphism Confers Increased Risk of Extrapulmonary Tuberculosis: A Meta-analysis of Case-Control Studies
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