The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases
Open accessAbstract
The purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is ubiquitously expressed in almost all tissues and organs of the body with the highest distribution in the immune cells of monocyte-macrophage origin. Classically, P2X7 receptor is involved in apoptotic cell death, and it is well known that extracellular ATP ligation to this purinergic receptor serves as an important secondary stimulus, which is also considered as danger signal for the interleukin (IL)-1β cleavage and secretion from pro-inflammatory cells. More recently, however, there has been substantial evidence of additional roles for the P2X7 receptor, both in innate immune response and as an adaptive link, including T-cell activation in a chronic state of inflammation. Also, compelling evidences have revealed an important role for ectonucleotidases as ATP-consuming enzymes in the control and fine-tuning of P2X7 function by regulating the time, concentration, and availability of ATP during infection-driven inflammation. This review focuses on the current evidences for P2X7 receptor involvement in the initial stages of inflammation, as well as for its role in acute and chronic stages of infection. Here, we also highlight the role of ectonucleotidase family in the control of P2X7 function, including the initial and resolution phases of inflammation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
P2X7 receptor modulates acute and chronic infection, inflammatory diseases, sepsis, neuropathic pain, and T-cell activation.
“It was already reported its capacity to modulate acute and chronic infection [81, 82], inflammatory diseases [82], sepsis [83, 84], neuropathic pain [85], and T-cell activation [86].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [81]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works
Receptors for Purines and Pyrimidines
Burnstock, G., & Verkhratsky, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28863-0_5 · Cited by 3,973 · see citing works
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works
Pathogen Recognition by the Innate Immune System
Kumar, H., Kawai, T., & Akira, S. (2011) · International Reviews of Immunology · doi:10.3109/08830185.2010.529976 · Cited by 2,264 · see citing works
Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898 · see citing works
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works
Abbracchio, M. P., Burnstock, G., Boeynaems, J., Barnard, E. A., Boyer, J. L., Kennedy, C., Knight, G. E., Fumagalli, M., Gachet, C., Jacobson, K. A., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.3 · Cited by 1,286 · see citing works
CD39 and CD73 in immunity and inflammation
Antonioli, L., Pacher, P., Vizi, E. S., & Haskó, G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.03.005 · Cited by 1,269 · see citing works
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works
Yegutkin, G. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.024 · Cited by 1,155 · see citing works
ATP drives lamina propria TH17 cell differentiation
Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089 · see citing works
Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.013 · Cited by 1,030 · see citing works
Cellular function and molecular structure of ecto-nucleotidases
Zimmermann, H., Zebisch, M., & Sträter, N. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9309-4 · Cited by 985 · see citing works
Robson, S. C., Sévigny, J., & Zimmermann, H. (2006) · Purinergic Signalling · doi:10.1007/s11302-006-9003-5 · Cited by 930 · see citing works
5′-Nucleotidase: molecular structure and functional aspects
Zimmermann, H. (1992) · Biochemical Journal · doi:10.1042/bj2850345 · Cited by 880 · see citing works
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
Burnstock, G., & Knight, G. E. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)40002-3 · Cited by 796 · see citing works
Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works
Alarmins: chemotactic activators of immune responses
Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780 · see citing works
Ízcue, A., Coombes, J. L., & Powrie, F. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00423.x · Cited by 473 · see citing works
Piccini, A., Carta, S., Tassi, S., Lasigliè, D., Fossati, G., & Rubartelli, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709684105 · Cited by 460 · see citing works
NPP-type ectophosphodiesterases: unity in diversity
Stefan, C., Jansen, S., & Bollen, M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.08.005 · Cited by 378 · see citing works
Eltzschig, H. K., Thompson, L. F., Karhausen, J., Cotta, R. J., Ibla, J. C., Robson, S. C., & Colgan, S. P. (2004) · Blood · doi:10.1182/blood-2004-06-2066 · Cited by 371 · see citing works
Goding, J. W., Grobben, B., & Slegers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(03)00058-9 · Cited by 366 · see citing works
Ecto‐enzyme and signaling functions of lymphocyte CD 7 3
Resta, R., Yamashita, Y., & Thompson, L. F. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01574.x · Cited by 332 · see citing works
Muralidharan, S., & Mandrekar, P. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313153 · Cited by 329 · see citing works
Woehrle, T., Yip, L., Elkhal, A., Sumi, Y., Chen, Y., Yao, Y., Insel, P. A., & JUNGER, W. G. (2010) · Blood · doi:10.1182/blood-2010-04-277707 · Cited by 315 · see citing works
A Novel Recombinant Plasma Membrane-targeted Luciferase Reveals a New Pathway for ATP Secretion
Pellegatti, P., Falzoni, S., Pinton, P., Rizzuto, R., & Virgilio, F. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-03-0222 · Cited by 296 · see citing works
Ferrari, D., Wesselborg, S., Bauer, M. K. A., & Schulze‐Osthoff, K. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1635 · Cited by 286 · see citing works
Schenk, U., Frascoli, M., Proietti, M., Geffers, R., Traggiai, E., Buer, J., Ricordi, C., Westendorf, A. M., & Grassi, F. (2011) · Science Signaling · doi:10.1126/scisignal.2001270 · Cited by 286 · see citing works
Autocrine regulation of T‐cell activation by ATP release and P2X 7 receptors
Yip, L., Woehrle, T., Corriden, R., Hirsh, M., Chen, Y., Inoue, Y., Ferrari, V., Insel, P. A., & JUNGER, W. G. (2009) · The FASEB Journal · doi:10.1096/fj.08-126458 · Cited by 284 · see citing works
Hama, K., Aoki, J., Fukaya, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313927200 · Cited by 277 · see citing works
Pelegrı́n, P., & Surprenant, A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.163 · Cited by 265 · see citing works
Ectonucleotidases as Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity
Deaglio, S., & Robson, S. C. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385526-8.00010-2 · Cited by 251 · see citing works
Kishi, Y., Okudaira, S., Tanaka, M., Hama, K., Shida, D., Kitayama, J., Yamori, T., Aoki, J., Fujimaki, T., & Arai, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601803200 · Cited by 245 · see citing works
Arulkumaran, N., Unwin, R. J., & Tam, F. W. K. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.578068 · Cited by 241 · see citing works
Jacob, F., Perez-Novo, C. A., Bachert, C., & Crombruggen, K. V. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9357-4 · Cited by 232 · see citing works
Regulation of Macrophage Function by Adenosine
Haskó, G., & Pacher, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226852 · Cited by 223 · see citing works
P2Z/P2X7receptor-dependent apoptosis of dendritic cells
Coutinho‐Silva, R., Persechini, P. M., Bisaggio, R. D. C., Perfettini, J., Neto, A. C. T. D. S., Kanellopoulos, J., Motta, I., Dautry‐Varsat, A., & Ojcius, D. M. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.5.c1139 · Cited by 221 · see citing works
Self-citationEctonucleotidases in the Nervous System
Zimmermann, H. (2006) · Novartis Foundation symposium · doi:10.1002/9780470032244.ch10 · Cited by 210 · see citing works
Gu, B. J., Zhang, W. Y., Bendall, L. J., Chessell, I. P., Buell, G. N., & Wiley, J. S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c1189 · Cited by 204 · see citing works
Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation
Chen, Y., Yao, Y., Sumi, Y., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2000549 · Cited by 201 · see citing works
Wiesch, J. S. Z., Thomssen, A., Hartjen, P., Tóth, I., Lehmann, C., Meyer‐Olson, D., Colberg, K., Frerk, S., Babikir, D., Schmiedel, S., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01758-10 · Cited by 173 · see citing works
Yilmaz, Ö., Yao, L., Maeda, K., Rose, T. M., Lewis, E. L., Duman, M., Lamont, R. J., & Ojcius, D. M. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01089.x · Cited by 165 · see citing works
Alarmins, inflammasomes and immunity
Ojcius, D. M., & Sadier, N. S. (2012) · Biomedical Journal · doi:10.4103/2319-4170.104408 · Cited by 163 · see citing works
Inhibition of Chlamydial Infectious Activity due to P2X7R-Dependent Phospholipase D Activation
Coutinho‐Silva, R., Welter-Stahl, L., Raymond, M., Jungas, T., Verbeke, P., Burnstock, G., Darville, T. L., & Ojcius, D. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00235-8 · Cited by 157 · see citing works
Self-citationBiswas, D., Qureshi, O. S., Lee, W.-Y. J., Croudace, J. E., Mura, M., & Lammas, D. A. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-35 · Cited by 156 · see citing works
Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase
Zanin, R. F., Braganhol, E., Bergamin, L. S., Campesato, L. F., Zanotto‐Filho, A., Moreira, J. C. F., Morrone, F. B., Sévigny, J., Schetinger, M. R. C., Wyse, Â. T. D. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031205 · Cited by 156 · see citing works
Feng, Y., Li, X., Wang, L., Zhou, L., & Gorodeski, G. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602999200 · Cited by 152 · see citing works
Kusner, D. J., & Barton, J. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3308 · Cited by 150 · see citing works
Cohen, H. B., Briggs, K. T., Marino, J. P., Ravid, K., Robson, S. C., & Mosser, D. M. (2013) · Blood · doi:10.1182/blood-2013-04-496216 · Cited by 146 · see citing works
Marques-da-Silva, C., Chaves, M. M., Castro, N. G., Coutinho‐Silva, R., & Guimaraes, M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01254.x · Cited by 145 · see citing works
Self-citationScheuplein, F., Schwarz, N., Adriouch, S., Krebs, C. F., Bannas, P., Rissiek, B., Séman, M., Haag, F., & Koch‐Nolte, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801711 · Cited by 138 · see citing works
Cloning and Characterization of Mouse Nucleoside Triphosphate Diphosphohydrolase-8,
Bigonnesse, F., Lévesque, S. A., Kukulski, F., et al. (2004) · Biochemistry · doi:10.1021/bi0362222 · Cited by 135 · see citing works
Lees, M. P., Fuller, S. J., McLeod, R. L., Boulter, N. R., Miller, C., Zakrzewski, A. M., Mui, E. J., Witola, W. H., Coyne, J. J., Hargrave, A. C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000012 · Cited by 132 · see citing works
Corriden, R., Chen, Y., Inoue, Y., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800039200 · Cited by 127 · see citing works
Gonçalves, R. G., Gabrich, L., Rosário, A., Takiya, C. M., Ferreira, M. L. L., Chiarini, L. B., Persechini, P. M., Coutinho‐Silva, R., & Leite, M. (2006) · Kidney International · doi:10.1038/sj.ki.5001804 · Cited by 126 · see citing works
Self-citationGenetics of the P2X7 receptor and human disease
Fuller, S. J., Stokes, L., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9136-4 · Cited by 125 · see citing works
Loomis, W. H., Namiki, S., Ostrom, R. S., Insel, P. A., & JUNGER, W. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207868200 · Cited by 117 · see citing works
CD39-L4 Is a Secreted Human Apyrase, Specific for the Hydrolysis of Nucleoside Diphosphates
Mulero, J. J., Yeung, G., Nelken, S. T., & Ford, J. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20064 · Cited by 116 · see citing works
NTPDase1 governs P2X7‐dependent functions in murine macrophages
Lévesque, S. A., Kukulski, F., Enjyoji, K., Robson, S. C., & Sévigny, J. (2010) · European Journal of Immunology · doi:10.1002/eji.200939741 · Cited by 112 · see citing works
Gu, B. J., Saunders, B. M., Jursik, C., & Wiley, J. S. (2009) · Blood · doi:10.1182/blood-2009-11-251744 · Cited by 111 · see citing works
Killeen, M. E., Ferris, L. K., Kupetsky, E. A., Falo, L. D., & Mathers, A. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202045 · Cited by 109 · see citing works
Modulation of P2Z/P2X7receptor activity in macrophages infected withChlamydia psittaci
Coutinho‐Silva, R., Perfettini, J., Persechini, P. M., Dautry‐Varsat, A., & Ojcius, D. M. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.1.c81 · Cited by 107 · see citing works
Self-citationPurinergic receptors in the endocrine and exocrine pancreas
Novak, I. (2008) · Purinergic Signalling Purinergic Signalling · doi:10.1007/s11302-007-9087-6 · Cited by 102 · see citing works
Lee, B. H., Hwang, D. M., Palaniyar, N., Grinstein, S., Philpott, D. J., & Hu, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035812 · Cited by 102 · see citing works
Corrêa, G., Marques-da-Silva, C., Moreira-Souza, A. C. A., Vommaro, R. C., & Coutinho‐Silva, R. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.03.004 · Cited by 98 · see citing works
Self-citationSansom, F. M., Robson, S. C., & Hartland, E. L. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00013-08 · Cited by 88 · see citing works
Chaves, S. P., Torres-Santos, E. C., Marques, C. F. D. O., Figliuolo, V. R., Persechini, P. M., Coutinho‐Silva, R., & Rossi‐Bergmann, B. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.05.001 · Cited by 87 · see citing works
Self-citationCrane, J. K., Olson, R. A., Jones, H. M., et al. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00484.2001 · Cited by 86 · see citing works
Fu, W., McCormick, T., Qi, X., Luo, L., Zhou, L., Li, X., Wang, B.-C., Gibbons, H. E., Abdul‐Karim, F. W., & Gorodeski, G. I. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-114 · Cited by 85 · see citing works
Sansom, F. M., Newton, H. J., Crikis, S., et al. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00924.x · Cited by 81 · see citing works
López‐Castejón, G., Baroja‐Mazo, A., & Pelegrı́n, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0609-y · Cited by 78 · see citing works
Santos, R. F., Pôssa, M. A. S., Bastos, M. S. E., Guedes, P. M. D. M., de Almeida, M. R., Demarco, R. C., Verjovski‐Almeida, S., Bahia, M. T., & Fietto, J. L. R. (2009) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000387 · Cited by 72 · see citing works
Extracellular ATP induces cell death in human intestinal epithelial cells
de Souza, C. O., Santoro, G. F., Figliuolo, V. R., Nanini, H. F., de Souza, H. S. P., Castelo-Branco, M. T. L., Abalo, A., Paiva, M. M., Coutinho, C. M. L. M., & Coutinho‐Silva, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.013 · Cited by 69 · see citing works
Self-citationP2X receptor characterization and IL‐1/IL‐1Ra release from human endothelial cells
Wilson, H. L., Varcoe, R. W., Stokes, L., Holland, K., Francis, S., Dower, S., Surprenant, A., & Crossman, D. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707213 · Cited by 65 · see citing works
Montreekachon, P., Chotjumlong, P., Bolscher, J. G. M., Nazmi, K., Reutrakul, V., & Krisanaprakornkit, S. (2011) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01346.x · Cited by 65 · see citing works
Darville, T. L., Welter-Stahl, L., da Cruz, C. M., Sater, A. A. A., Andrews, C. W., & Ojcius, D. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3707 · Cited by 63 · see citing works
Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract
Yu, Q., Zhao, Z., Sun, J., Guo, W. M., Fu, J., Burnstock, G., He, C., & Xiang, Z. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0659-0 · Cited by 63 · see citing works
NTPDase1 Controls IL-8 Production by Human Neutrophils
Kukulski, F., Bahrami, F., Yebdri, F. B., Lecka, J., Martı́n-Satué, M., Lévesque, S. A., & Sévigny, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002680 · Cited by 63 · see citing works
Lipopolysaccharide-induced lung injury: Role of P2X7 receptor
Monção-Ribeiro, L. C., Cagido, V. R., Lima-Murad, G., Santana, P. T., Riva, D. R., Borojević, R., Zin, W. A., Cavalcante, M. C. M., Riça, I. G., Brando-Lima, A. C., et al. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.09.015 · Cited by 62 · see citing works
Self-citationBerger, C., Chadwick, B. P., Frischauf, A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004723200 · Cited by 61 · see citing works
Testasicca, M. C. D. S., de Assis, E. A., Gomes, R. S., et al. (2010) · Acta Tropica · doi:10.1016/j.actatropica.2010.04.007 · Cited by 58 · see citing works
The P2X7 receptor and intracellular pathogens: a continuing struggle
Coutinho‐Silva, R., Corrêa, G., Sater, A. A. A., & Ojcius, D. M. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9130-x · Cited by 57 · see citing works
Self-citationCloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3
Lavoie, É. G., Kukulski, F., Lévesque, S. A., et al. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.02.012 · Cited by 57 · see citing works
Leal, D. B. R., Streher, C. A., Bertoncheli, C. D. M., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.10.009 · Cited by 55 · see citing works
Xiang, Y., Wang, X., Yan, C., Gao, Q., Li, S., Liu, J., Zhou, K., Guo, X., Lee, W., & Zhang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063759 · Cited by 55 · see citing works
Welter-Stahl, L., Marques-da-Silva, C., Schachter, J., Persechini, P. M., de Souza, H. S. P., Ojcius, D. M., & Coutinho‐Silva, R. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.03.006 · Cited by 48 · see citing works
Self-citationCrystallographic Snapshots along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases
Zebisch, M., Krauss, M., Schäfer, P., Lauble, P., & Sträter, N. (2013) · Structure · doi:10.1016/j.str.2013.05.016 · Cited by 47 · see citing works
Santos, A. A., Rodrigues-Junior, V. S., Zanin, R. F., Borges, T. J., Bonorino, C., Coutinho‐Silva, R., Takyia, C. M., Santos, D. S., Campos, M. M., & Morrone, F. B. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.03.003 · Cited by 45 · see citing works
Self-citationHeterogeneity in extracellular nucleotide hydrolysis among clinical isolates ofTrichomonas vaginalis
Tasca, T., Bonan, C. D., Carli, G. A. D., Sarkis, J. J. F., & Alderete, J. F. (2005) · Parasitology · doi:10.1017/s0031182005007377 · Cited by 40 · see citing works
Baroja‐Mazo, A., & Pelegrı́n, P. (2012) · Journal of Osteoporosis · doi:10.1155/2012/408242 · Cited by 38 · see citing works
Point Mutation in the Mouse P2X 7 Receptor Affects Intercellular Calcium Waves in Astrocytes
Suadicani, S. O., Iglesias, R., Spray, D. C., & Scemes, E. (2009) · ASN NEURO · doi:10.1042/an20090001 · Cited by 37 · see citing works
Kas-Deelen, A. M., Bakker, W. W., Olinga, P., et al. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02085-3 · Cited by 34 · see citing works
Endothelial P2X7 receptors’ expression is reduced by schistosomiasis
Oliveira, S. D., Coutinho‐Silva, R., & Silva, C. L. M. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9332-5 · Cited by 33 · see citing works
Self-citationChiao, C.-W., da Silva‐Santos, J. E., Giachini, F. R. C., Tostes, R. C., Su, M., & Webb, R. C. (2013) · Clinical Science · doi:10.1042/cs20120479 · Cited by 30 · see citing works
da Silva, G. L., Sperotto, N. D. D. M., Borges, T. J., Bonorino, C., Takyia, C. M., Coutinho‐Silva, R., Campos, M. M., Zanin, R. F., & Morrone, F. B. (2013) · Experimental Dermatology · doi:10.1111/exd.12094 · Cited by 28 · see citing works
Self-citationChanges in expression of P2X7receptors in NOD mouse pancreas during the development of diabetes
Coutinho‐Silva, R., Robson, T., Beales, P. E., et al. (2007) · Autoimmunity · doi:10.1080/08916930601118841 · Cited by 27 · see citing works
Self-citationCD73 and Adhesion of B-Cells to Follicular Dendritic Cells
Airas, L. M. (1998) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199809058380 · Cited by 24 · see citing works
Overexpression of CD39 in Mouse Airways Promotes Bacteria-Induced Inflammation
Théâtre, E., Frederix, K., Guilmain, W., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102600 · Cited by 24 · see citing works
Souza, V. D. C. G., Schlemmer, K. B., Noal, C. B., et al. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9322-7 · Cited by 21 · see citing works
Shaping immune responses through the activation of dendritic cells–P2 receptors
Ferrari, D., Gorini, S., Callegari, G., & Sala, A. (2006) · Purinergic Signalling · doi:10.1007/s11302-006-9024-0 · Cited by 20 · see citing works
Dar, H. H., Prasad, D., Varshney, G. C., et al. (2011) · Microbiology · doi:10.1099/mic.0.049221-0 · Cited by 19 · see citing works
Buffon, A., Casali, É. A., Cardoso, V. V., et al. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.01.015 · Cited by 17 · see citing works
Vuaden, F. C., Savio, L. E. B., Bastos, C. M. A., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.003 · Cited by 16 · see citing works
Self-citationEndotoxemia alters nucleotide hydrolysis in platelets of rats
Vuaden, F. C., Fürstenau, C. R., Savio, L. E. B., Sarkis, J. J. F., & Bonan, C. D. (2009) · Platelets · doi:10.1080/09537100802657743 · Cited by 7 · see citing works
Self-citationEndotoxin-induced effects on nucleotide catabolism in mouse kidney
Vuaden, F. C., Savio, L. E. B., Ramos, D. B., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.002 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 5
- Wiley JS, Gargett CE, Zhang W, Snook MB, Jamieson GP (1998) Partial agonists and antagonists reveal a second permeability state of human P2Z/P2X 7 channel. Am J Physiol 275: C1224-C1231.
- Wiley JS, Dao-Ung LP, Li C, Shemon AN, Gu BJ, et al. (2003) An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. J Biol Chem 278: 17108-17113.
- Fernando SL, Saunders BM, Sluyter R, Skarratt KK, Wiley JS, et al. (2007) A polymorphism in the P2X 7 gene increases susceptibility to extrapulmonary tuberculosis. Am J Resp Crit Care Med 175: 360-366.
- Saunders BM, Fernando SL, Sluyter R, Britton WJ, Wiley JS (2003) A loss-of- function polymorphism in the human P2X 7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol 171: 5442-5446.
- Fernando SL, Saunders BM, Sluyter R, Skarratt KK, Wiley JS, et al. (2005) Gene dosage determines the negative effects of polymorphic alleles of the P2X 7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages. J Infect Dis 192: 149-155.
Cited by
Sorted by citations
The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
Savio, L. E. B., de Andrade Mello, P., da Silva, C. G., & Coutinho-Silva, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00052 · Cited by 437 · see citing works
Self-citationThe P2X7 receptor: A main player in inflammation
Adinolfi, E., Giuliani, A. L., De Marchi, E., Pegoraro, A., Orioli, E., & Di Virgilio, F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.021 · Cited by 385 · see citing works
Burnstock, G., & Knight, G. E. (2018) · Purinergic Signalling · doi:10.1007/s11302-017-9593-0 · Cited by 248 · see citing works
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction
Savio, L. E. B., Andrade, M. G. J., de Andrade Mello, P., Santana, P. T., Moreira-Souza, A. C. A., Kolling, J., Longoni, A., Feldbrügge, L., Wu, Y., Wyse, A. T. S., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0168-9 · Cited by 64 · see citing works
Self-citation
- Authors
- Coutinho-Silva, R., Morandini, A., & Savio, L. B.
- Venue
- Biomedical Journal
- Publisher
- Elsevier BV
- Published
- 2014
- Volume
- 37
- Issue
- 4
- Pages
- 169
- ISSN
- 2319-4170 (ISSN-L)
- OpenAlex
- W2025173043
- Cited by
- 81
- References
- 107
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 14 · 2016: 8 · 2015: 9 · 2014: 2
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biomedical Journal (publishedVersion)
- PubMed (publishedVersion)
- Scholarly Commons (University of the Pacific) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica
- Universidade Federal do Rio de Janeiro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- P2X7 receptor, ectonucleotidases, purinergic signaling, extracellular ATP, innate immunity, adaptive immunity, T cell activation, chronic inflammation, acute infection, inflammation resolution, IL-1β, monocytes/macrophages
- MeSH terms
- Animals, Communicable Diseases, Humans, Inflammation, Signal Transduction, 5'-Nucleotidase, Apoptosis, Receptors, Purinergic P2X7, Purinergic P2X Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
