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P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease

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Purinergic Signaling in the Cardiovascular System

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Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

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Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

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Expression of P2X7 Receptor Increases In Vivo Tumor Growth

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Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

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ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

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Autocrine regulation of T‐cell activation by ATP release and P2X 7 receptors

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Upregulated Expression of Purinergic P2X ₇ Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus

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Evolutionary origins of the purinergic signalling system

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Extracellular ATP drives systemic inflammation, tissue damage and mortality

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Basal Activation of the P2X7 ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth

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P2X Receptors as Drug Targets

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Involvement of P2X₇ receptors in the regulation of neurotransmitter release in the rat hippocampus

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Efficacy and Safety of CE-224,535, an Antagonist of P2X 7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

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A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

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Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7Antagonists

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The capillary dilator substances in dry powders of spinal roots; a possible role of adenosine triphosphate in chemical transmission from nerve endings

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ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion

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The ATP4- receptor of rat mast cells

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Potentiation of Caspase-1 Activation by the P2X7 Receptor Is Dependent on TLR Signals and Requires NF-κB-Driven Protein Synthesis

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P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

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Identification and characterization of splice variants of the human P2X7 ATP channel

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P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia

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A role for tau at the synapse in Alzheimer’s disease pathogenesis

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A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis

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In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

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CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

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Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell line.

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The cytokine IL‐1β transiently enhances P2X 7 receptor expression and function in human astrocytes

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Induction of the P2z/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-γ in the human THP-1 monocytic cell line

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The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

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Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

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Two Models for Multiple Sclerosis: Experimental Allergic Encephalomyelitis and Theilerʼs Murine Encephalomyelitis Virus

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Biology of purinergic signalling: Its ancient evolutionary roots, its omnipresence and its multiple functional significance

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ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer’s patches to promote host-microbiota mutualism

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P2X7‐dependent, but differentially regulated release of IL‐6, CCL2, and TNF‐α in cultured mouse microglia

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Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7

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Astrocyte characterization in the multiple sclerosis glial scar

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Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB

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P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

Hung, S.-C., Choi, C. H., Sadier, N. S., Johnson, L., Atanasova, K. R., Sellami, H., Yilmaz, Ö., & Ojcius, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070210 · Cited by 171 · see citing works

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X 7 -mediated host-cell apoptosis

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Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor

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Inhibition of Chlamydial Infectious Activity due to P2X7R-Dependent Phospholipase D Activation

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ATP-Induced Killing of Virulent Mycobacterium tuberculosis Within Human Macrophages Requires Phospholipase D

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Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome

He, X., Mekasha, S., Mavrogiorgos, N. C., Fitzgerald, K. A., Lien, E., & Ingalls, R. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903937 · Cited by 157 · see citing works

Purinergic Signaling in the Airways

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A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization

Feng, Y., Li, X., Wang, L., Zhou, L., & Gorodeski, G. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602999200 · Cited by 152 · see citing works

The P2X7 Receptor Sustains the Growth of Human Neuroblastoma Cells through a Substance P–Dependent Mechanism

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Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release

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TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses

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The P2X7 receptor is a key modulator of aerobic glycolysis

Amoroso, F., Falzoni, S., Adinolfi, E., Ferrari, D., & Virgilio, F. D. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.105 · Cited by 145 · see citing works

Pyruvate Carboxylase Affinity Labelling of the Magnesium Adenosine Triphosphate Binding Site

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A role for P2X 7 in microglial proliferation

Bianco, F., Ceruti, S., Colombo, A. V., Fumagalli, M., Ferrari, D., Pizzirani, C., Matteoli, M., Virgilio, F. D., Abbracchio, M. P., & Verderio, C. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04101.x · Cited by 143 · see citing works

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

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Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate

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Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

Csóka, B., Németh, Z. H., Törő, G., Idzko, M., Zech, A., Koscsó, B., Spolarics, Z., Antonioli, L., Cseri, K., Erdélyi, K., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-272450 · Cited by 139 · see citing works

A comparison of the excitatory and inhibitory effects of non‐adrenergic, non‐cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species

Burnstock, G., Satchell, D. G., & Smythe, A. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06868.x · Cited by 139 · see citing works

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease

Eser, A., Colombel, J., Rutgeerts, P. J., Vermeire, S., Vogelsang, H., Braddock, M., Persson, T., & Reinisch, W. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000514 · Cited by 138 · see citing works

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

Hoque, R., Sohail, M. A., Salhanick, S. D., Malik, A. F., Ghani, A., Robson, S. C., & Mehal, W. Z. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00352.2011 · Cited by 138 · see citing works

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

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Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease

Ryu, J. K., & McLarnon, J. G. (2008) · NeuroReport · doi:10.1097/wnr.0b013e3283179333 · Cited by 134 · see citing works

Cellular localization of P2X7 receptor mRNA in the rat brain

Yu, Y., Ugawa, S., Ueda, T., Ishida, Y., Inoue, K., Kyaw Nyunt, A., Umemura, A., Mase, M., Yamada, K., & Shimada, S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.11.064 · Cited by 132 · see citing works

P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii , by Human and Murine Macrophages

Lees, M. P., Fuller, S. J., McLeod, R. L., Boulter, N. R., Miller, C., Zakrzewski, A. M., Mui, E. J., Witola, W. H., Coyne, J. J., Hargrave, A. C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000012 · Cited by 132 · see citing works

P2X7 receptor modulation of β-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia

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The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

do Carmo, M. R. S., Menezes, A. P. F., Nunes, A. C. L., Pliássova, A., Rolo, A. P., Palmeira, C. M., Cunha, R. A., Canas, P. M., & de Andrade, G. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.045 · Cited by 129 · see citing works

ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

Bianchi, G., Vuerich, M., Pellegatti, P., Marimpietri, D., Emionite, L., Marigo, I., Bronte, V., Virgilio, F. D., Pistoia, V., & Raffaghello, L. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.109 · Cited by 128 · see citing works

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

Giannuzzo, A., Pedersen, S. F., & Novak, I. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0472-4 · Cited by 128 · see citing works

P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells

Qiu, Y., Li, W., Zhang, H., Liu, Y., Tian, X., & Fang, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114371 · Cited by 126 · see citing works

The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice

Gonçalves, R. G., Gabrich, L., Rosário, A., Takiya, C. M., Ferreira, M. L. L., Chiarini, L. B., Persechini, P. M., Coutinho‐Silva, R., & Leite, M. (2006) · Kidney International · doi:10.1038/sj.ki.5001804 · Cited by 126 · see citing works

Essential role for Ca2+ in regulation of IL-1β secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells

Gudipaty, L., Munetz, J., Verhoef, P. A., & Dubyak, G. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00070.2003 · Cited by 126 · see citing works

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

Shu, B., Sun, X., Bai, A., Zhang, C., Li, L., Enjyoji, K., JUNGER, W. G., Robson, S. C., & Wu, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060184 · Cited by 125 · see citing works

P2Y2 Nucleotide Receptors Enhance α-Secretase-dependent Amyloid Precursor Protein Processing

Camden, J. M., Schrader, A. M., Camden, R. E., González, F. A., Erb, L., Seye, C. I., & Weisman, G. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500219200 · Cited by 125 · see citing works

P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy

Wang, H., Hong, L., Huang, J., Jiang, Q., Tao, R., Tan, C., Lu, N., Wang, C., Ahmed, M. M., Lu, Y., et al. (2015) · Cell Research · doi:10.1038/cr.2015.61 · Cited by 124 · see citing works

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

Jiang, T., Hoekstra, J., Heng, X., Kang, W., Ding, J., Liu, J., Chen, S., & Zhang, J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.03.015 · Cited by 123 · see citing works

Purinergic signalling and diabetes

Burnstock, G., & Novak, I. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9359-2 · Cited by 121 · see citing works

P2X7 receptors stimulate AKT phosphorylation in astrocytes

Jacques-Silva, M. C., Rodnight, R., Lenz, G., Liao, Z., Kong, Q., Tran, M., Kang, Y., Gonzalez, F. A., Weisman, G. A., & Neary, J. T. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705685 · Cited by 121 · see citing works

P2X7 receptor-mediated apoptosis of human cervical epithelial cells

Wang, Q., Wang, L., Feng, Y., Li, X., Zeng, R., & Gorodeski, G. I. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00256.2004 · Cited by 120 · see citing works

Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor‐independent mechanisms

Beigi, R. D., Kertesy, S. B., Aquilina, G. R., & Dubyak, G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705470 · Cited by 120 · see citing works

Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism

Sikora, A. G., Liu, J., Brosnan, C. F., Buell, G. N., Chessel, I., & Bloom, B. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.558 · Cited by 120 · see citing works

P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells

Coutinho‐Silva, R., & Persechini, P. M. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.6.c1793 · Cited by 119 · see citing works

Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection

Shimada, K., Crother, T. R., Karlin, J. N., Chen, S., Chiba, N., Ramanujan, V. K., Vergnes, L., Ojcius, D. M., & Arditi, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021477 · Cited by 118 · see citing works

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Zhong, C., Wade, C. L., Chandran, P., Zhu, C., Carroll, W. A., Perez‐Medrano, A., Iwakura, Y., et al. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.018 · Cited by 116 · see citing works

Research Article Improving the PCR protocol to amplify a repetitive DNA sequence.

Riet, J., Ramos, L. R. V., Lewis, R. V., et al. (2017) · Genetics and Molecular Research · doi:10.4238/gmr16039796 · Cited by 116 · see citing works

Expression, assembly and function of novel C‐terminal truncated variants of the mouse P2X7 receptor: re‐evaluation of P2X7 knockouts

Masin, M., Young, C., Lim, K., Barnes, S. J., Xu, X., Marschall, V., Brutkowski, W., Mooney, E. R., Górecki, D. C., & Murrell‐Lagnado, R. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01624.x · Cited by 112 · see citing works

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

Ali, Z., Laurijssens, B. E., Ostenfeld, T., McHugh, S. M., Stylianou, A., Scott‐Stevens, P., Hosking, L. K., Dewit, O., Richardson, J. C., & Chen, C. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04320.x · Cited by 111 · see citing works

P2X7 Receptor as a Therapeutic Target

Marchi, E. D., Orioli, E., Ben, D. D., & Adinolfi, E. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.11.004 · Cited by 111 · see citing works

P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer

Bae, J. Y., Lee, S.-W., Shin, Y., Lee, J.-H., Jahng, J. W., & Park, K. (2017) · Oncotarget · doi:10.18632/oncotarget.16903 · Cited by 111 · see citing works

Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity

Weitz, J., Makhmutova, M., Almaça, J., Stertmann, J., Aamodt, K. I., Briššová, M., Speier, S., Rodriguez‐Diaz, R., & Caicedo, A. (2017) · Diabetologia · doi:10.1007/s00125-017-4416-y · Cited by 111 · see citing works

Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer

Hofman, P. M., Cherfils‐Vicini, J., Bazin, M., Ilié, M., Juhel, T., Hébuterne, X., Gilson, É., Schmid‐Alliana, A., Boyer, O., Adriouch, S., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1778 · Cited by 110 · see citing works

The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

Delarasse, C., Auger, R., Gonnord, P., Fontaine, B., & Kanellopoulos, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200618 · Cited by 108 · see citing works

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

Boucher, A. A., Arnold, J. C., Hunt, G. E., Spiro, A., Spencer, J., Brown, C., McGregor, I. S., Bennett, M. R., & Kassiou, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.049 · Cited by 108 · see citing works

Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7

Vergani, A., Tezza, S., D’Addio, F., Fotino, C., Liu, K., Niewczas, M. A., Bassi, R., Molano, R. D., Kleffel, S., Petrelli, A., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.123653 · Cited by 108 · see citing works

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

Neves, A. R., Castelo-Branco, M. T. L., Figliuolo, V. R., Bernardazzi, C., Buongusto, F., Yoshimoto, A., Nanini, H. F., Coutinho, C. M. L. M., Carneiro, A. J. V., Coutinho-Silva, R., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000441201.10454.06 · Cited by 107 · see citing works

The purinergic 2X7 receptor participates in renal inflammation and injury induced by high‐fat diet: possible role of NLRP3 inflammasome activation

Solini, A., Menini, S., Rossi, C., Ricci, P. C., Santini, E., Fantauzzi, C. B., Iacobini, C., & Pugliese, G. (2013) · The Journal of Pathology · doi:10.1002/path.4237 · Cited by 107 · see citing works

Expression of the P2X7 Receptor Increases the Ca2+ Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis

Adinolfi, E., Callegari, M. G., Cirillo, M., Pinton, P., Giorgi, C., Cavagna, D., Rizzuto, R., & Virgilio, F. D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805805200 · Cited by 107 · see citing works

Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes

Hill, L. M., Gavala, M. L., Lenertz, L. Y., & Bertics, P. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001298 · Cited by 107 · see citing works

Modulation of P2Z/P2X7receptor activity in macrophages infected withChlamydia psittaci

Coutinho‐Silva, R., Perfettini, J., Persechini, P. M., Dautry‐Varsat, A., & Ojcius, D. M. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.1.c81 · Cited by 107 · see citing works

Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis

Jamieson, S., Rangel, A. L. P., Hargrave, A. C., de Roubaix, L.-A., Mui, E. J., Boulter, N. R., Miller, E. N., Fuller, S. J., Wiley, J. S., Castellucci, L. C., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.31 · Cited by 105 · see citing works

Purinergic signaling in kidney disease

Menzies, R. I., Tam, F. W. K., Unwin, R. J., & Bailey, M. A. (2016) · Kidney International · doi:10.1016/j.kint.2016.08.029 · Cited by 105 · see citing works

The P2X7 Receptor Mediates Toxoplasma gondii Control in Macrophages through Canonical NLRP3 Inflammasome Activation and Reactive Oxygen Species Production

Moreira-Souza, A. C. A., Almeida-da-Silva, C. L. C., Rangel, T. P., Rocha, G. D. C., Bellio, M., Zamboni, D. S., Vommaro, R. C., & Coutinho‐Silva, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01257 · Cited by 105 · see citing works

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation

Jiang, S., Zhang, Y., Zheng, J., Li, X., Yao, Y., Wu, Y., Song, S., Sun, P., Nan, J., & Lian, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.040 · Cited by 104 · see citing works

A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma

Gilbert, S. M., Baird, A. G., Glazer, S., Barden, J. A., Glazer, A., Teh, L. C., & King, J. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15364 · Cited by 104 · see citing works

Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

Mehta, N., Kaur, M., Singh, M., Chand, S., Vyas, B., Silakari, P., Bahia, M. S., & Silakari, O. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.10.054 · Cited by 103 · see citing works

Porphyromonas gingivalis -nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X 7 receptor/NADPH-oxidase signalling and contributes to persistence

Choi, C. H., Spooner, R., DeGuzman, J., Koutouzis, T., Ojcius, D. M., & Yilmaz, Ö. (2012) · Cellular Microbiology · doi:10.1111/cmi.12089 · Cited by 102 · see citing works

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

Lee, B. H., Hwang, D. M., Palaniyar, N., Grinstein, S., Philpott, D. J., & Hu, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035812 · Cited by 102 · see citing works

Ecto-5′-Nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis

Haskó, G., Csóka, B., Koscsó, B., Chandra, R., Pacher, P., Thompson, L. F., Deitch, E. A., Spolarics, Z., Virág, L., Gergely, P., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003379 · Cited by 102 · see citing works

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

Roger, S., Jelassi, B., Couillin, I., Pelegrı́n, P., Besson, P., & Jiang, L. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.10.029 · Cited by 101 · see citing works

Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

Giannuzzo, A., Saccomano, M., Napp, J., Ellegaard, M., Alves, F., & Novak, I. (2016) · International Journal of Cancer · doi:10.1002/ijc.30380 · Cited by 101 · see citing works

Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives

Mello, P. D. A., Coutinho‐Silva, R., & Savio, L. E. B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01526 · Cited by 100 · see citing works

Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths

Cortés, A., Muñoz-Antolí, C., Esteban, J. G., & Toledo, R. (2017) · Trends in Parasitology · doi:10.1016/j.pt.2017.05.004 · Cited by 99 · see citing works

Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages

Corrêa, G., Marques-da-Silva, C., Moreira-Souza, A. C. A., Vommaro, R. C., & Coutinho‐Silva, R. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.03.004 · Cited by 98 · see citing works

Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis

Amaral, E. P., Ribeiro, S. C. M., Lanes, V. R., Almeida, F. M., de Andrade, M. R. M., Bomfim, C. C. B., de Salles, É. M., Bortoluci, K. R., Coutinho‐Silva, R., Hirata, M. H., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004188 · Cited by 97 · see citing works

NLRP3 Inflammasome Activation in Dialyzed Chronic Kidney Disease Patients

Granata, S., Masola, V., Zoratti, E., Scupoli, M. T., Baruzzi, A., Messa, M., Sallustio, F., Gesualdo, L., Lupo, A., & Zaza, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122272 · Cited by 97 · see citing works

P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C

BRADFORD, M. D., & Soltoff, S. P. (2002) · Biochemical Journal · doi:10.1042/bj20020358 · Cited by 97 · see citing works

On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079

Marcellino, D., Suárez-Boomgaard, D., Sánchez-Reina, M. D., Aguirre, J. A., Yoshitake, T., Yoshitake, S., Hagman, B., Kehr, J., Agnati, L. F., Fuxe, K., et al. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0400-0 · Cited by 97 · see citing works

Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma

Giuliani, A. L., Colognesi, D., Ricco, T., Roncato, C., Capece, M., Amoroso, F., Wang, Q., Marchi, E. D., Gartland, A., Virgilio, F. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107224 · Cited by 97 · see citing works

Purinergic signaling during intestinal inflammation

Longhi, M. S., Moss, A. C., Jiang, Z. G., & Robson, S. C. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1545-1 · Cited by 97 · see citing works

Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung

Baxter, M. D., Eltom, S. M., Dekkak, B., Yew‐Booth, L., Dubuis, E. D., Maher, S. A., Belvisi, M. G., & Birrell, M. A. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205467 · Cited by 95 · see citing works

ATP released from β‐amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion

Kim, S. Y., Moon, J. H., Lee, H. G., Kim, S. U., & Lee, Y. B. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.89 · Cited by 93 · see citing works

ATP Signaling in Brain: Release, Excitotoxicity and Potential Therapeutic Targets

Cisneros-Mejorado, A., Pérez‐Samartín, A., Gottlieb, M., & Matute, C. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0092-3 · Cited by 93 · see citing works

Purinergic signalling in the kidney in health and disease

Burnstock, G., Evans, L. C., & Bailey, M. A. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9400-5 · Cited by 92 · see citing works

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

Alves, L. A., Soares‐Bezerra, R. J., Faria, R. X., Ferreira, L., & Frutuoso, V. D. S. (2013) · Molecules · doi:10.3390/molecules180910953 · Cited by 92 · see citing works

Purinergic Receptors Are Required for HIV-1 Infection of Primary Human Macrophages

Hazleton, J. E., Berman, J. W., & Eugenín, E. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102482 · Cited by 92 · see citing works

P2X7 receptor antagonists: a patent review (2010–2015)

Park, J.-H., & Kim, Y. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1246538 · Cited by 92 · see citing works

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice

Metzger, M. W., Walser, S. M., Aprile-Garcia, F., Dedic, N., Chen, A., Holsboer, F., ARZT, E. S., Wurst, W., & Deussing, J. M. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9546-z · Cited by 92 · see citing works

Extracellular ATP Mediates Necrotic Cell Swelling in SN4741 Dopaminergic Neurons through P2X7 Receptors

Jun, D., Kim, J. J., Jung, S., Song, R., Noh, J.-H., Park, Y., Ryu, S. H., Kim, J., Kong, Y., Chung, J.-M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707915200 · Cited by 91 · see citing works

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

Coutinho‐Silva, R., & Ojcius, D. M. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.05.009 · Cited by 91 · see citing works

Expression of P2X7 in human hematopoietic cell lines and leukemia patients

Zhang, X., Zheng, G., Ma, X., Yang, Y.-H., Li, G., Rao, Q., Nie, K., & Wu, K. (2004) · Leukemia Research · doi:10.1016/j.leukres.2004.04.001 · Cited by 90 · see citing works

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

Glas, R., Sauter, N. S., Schulthess, F. T., Shu, L., Oberholzer, J., & Maedler, K. (2009) · Diabetologia · doi:10.1007/s00125-009-1349-0 · Cited by 90 · see citing works

P2X7 purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability

Placido, R., Auricchio, G., Falzoni, S., Battistini, L., Colizzi, V., Brunetti, E., Virgilio, F. D., & Mancino, G. (2006) · Cellular Immunology · doi:10.1016/j.cellimm.2007.02.001 · Cited by 89 · see citing works

Chlamydial infection of monocytes stimulates IL-1β secretion through activation of the NLRP3 inflammasome

Sater, A. A. A., Sadier, N. S., Padilla, E. V., & Ojcius, D. M. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.04.008 · Cited by 88 · see citing works

Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury

Menzies, R. I., Booth, J. W. R., Mullins, J. J., Bailey, M. A., Tam, F. W. K., Norman, J. T., & Unwin, R. J. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.011 · Cited by 88 · see citing works

Modulation of P2X7 purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination

Chaves, S. P., Torres-Santos, E. C., Marques, C. F. D. O., Figliuolo, V. R., Persechini, P. M., Coutinho‐Silva, R., & Rossi‐Bergmann, B. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.05.001 · Cited by 87 · see citing works

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672 · see citing works

P2X7 Interactions and Signaling – Making Head or Tail of It

Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217 · see citing works

The P2X7 Receptor: Central Hub of Brain Diseases

Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works

Role of P2X7 Receptors in Immune Responses During Neurodegeneration

Oliveira-Giacomelli, Á., Petiz, L. L., Andrejew, R., Turrini, N., Silva, J. B., Sack, U., & Ulrich, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662935 · Cited by 68 · see citing works

The role of macrophages in protective and pathological responses to <i>Toxoplasma gondii</i>

Park, J., & Hunter, C. A. (2020) · Parasite Immunology · doi:10.1111/pim.12712 · Cited by 54 · see citing works

Pleiotropic Roles of P2X7 in the Central Nervous System

Kanellopoulos, J. M., & Delarasse, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00401 · Cited by 48 · see citing works

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

Crabbé, M., Van der Perren, A., Bollaerts, I., Kounelis, S., Baekelandt, V., Bormans, G., Casteels, C., Moons, L., & Van Laere, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00799 · Cited by 49 · see citing works

The Phospholipase C Linked P2y-Purinergic Receptor

Boyer, J., Cooper, C. L., Martin, M. W., et al. (1990) · Springer eBooks · doi:10.1007/978-1-4612-3400-5_39

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes

Rossato, M., Favaretto, F., Granzotto, M., Crescenzi, M., Boscaro, A., Vincenzo, A. D., Capone, F., Nora, E. D., Zabeo, E., & Vettor, R. (2022) · Molecules · doi:10.3390/molecules27061913 · Cited by 6 · see citing works

Agonist and Guanine Nucleotide Regulation of P2Y Purinergic Receptor-Linked Phospholipase C

Boyer, J. L., Martin, M. W., Cooper, C. L., et al. (1990) · Springer eBooks · doi:10.1007/978-3-642-83618-3_11

Distribution of P2Y and P2X purinergic receptor expression within the intestine

Engevik, K. A., Scribano, F. J., Gebert, J. T., Perry, J. L., Crawford, S. E., & Hyser, J. M. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00108.2023 · Cited by 7 · see citing works

Exploring The Role Of Purinergic Signaling In T Cell Activation

Bhate, M. M. (2011)