The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Biologically Targeted Magnetic Hyperthermia: Potential and Limitations
Open accessAbstract
Hyperthermia, the mild elevation of temperature to 40-43°C, can induce cancer cell death and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full potential as a clinically relevant treatment modality has been restricted by its inability to effectively and preferentially heat malignant cells. The limited spatial resolution may be circumvented by the intravenous administration of cancer-targeting magnetic nanoparticles that accumulate in the tumor, followed by the application of an alternating magnetic field to raise the temperature of the nanoparticles located in the tumor tissue. This targeted approach enables preferential heating of malignant cancer cells whilst sparing the surrounding normal tissue, potentially improving the effectiveness and safety of hyperthermia. Despite promising results in preclinical studies, there are numerous challenges that must be addressed before this technique can progress to the clinic. This review discusses these challenges and highlights the current understanding of targeted magnetic hyperthermia.
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Progress and challenges towards targeted delivery of cancer therapeutics
Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220
Exploiting the enhanced permeability and retention effect for tumor targeting
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In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
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Hypoxia and Metabolic Adaptation of Cancer Cells
Eales, K. L., Hollinshead, K. E. R., & Tennant, D. A. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.50 · Cited by 724 · cited 1×
“Tumors are generally associated with hypoxic and acidic environments due to poor vasculature, conditions in which cells are known to be more susceptible to hyperthermia (Gerweck et al., 1979; Eales et al., 2016).”
BackgroundA Review of Clinical Translation of Inorganic Nanoparticles
Anselmo, A. C., & Mitragotri, S. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9780-2 · Cited by 509
Milowsky, M. I., Galsky, M. D., Morris, M. J., Crona, D. J., George, D. J., Dreicer, R., Tse, K., Petruck, J., Webb, I. J., Bander, N. H., et al. (2016) · Urologic Oncology: Seminars and Original Investigations · doi:10.1016/j.urolonc.2016.07.005 · Cited by 78
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Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies
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Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs
Wong, X. Y., Sena-Torralba, A., Álvarez-Diduk, R., Muthoosamy, K., & Merkoçi, A. (2020) · ACS Nano · doi:10.1021/acsnano.9b08133 · Cited by 363
Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting
Liu, J. F., Jang, B., Issadore, D., & Tsourkas, A. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1571 · Cited by 265
Microglia-targeting nanotherapeutics for neurodegenerative diseases
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Metadata
- Authors
- Chang, D., Lim, M., Goos, J. A. C. M., Qiao, R., Ng, Y. Y., Mansfeld, F. M., Jackson, M., Davis, T. P., & Kavallaris, M.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2018-08-02
- Volume
- 9
- Pages
- 831-831
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2886403656
- Cited by
- 495
- References
- 6
- FWCI
- 19.16
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chang, D., Lim, M., Goos, J. A. C. M., Qiao, R., Ng, Y. Y., Mansfeld, F. M., Jackson, M., Davis, T. P., & Kavallaris, M. (2018). Biologically Targeted Magnetic Hyperthermia: Potential and Limitations. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2018.00831
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