Insights into bone morphogenetic proteins in cardiovascular diseases

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension

Maruyama, H., Dewachter, C., Belhaj, A., Rondelet, B., Sakai, S., Remmelink, M., Vachiéry, J., Naeije, R., & Dewachter, L. (2014) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2014.09.011 · Cited by 32

Exogenous BMP-7 Facilitates the Recovery of Cardiac Function after Acute Myocardial Infarction through Counteracting TGF-β1 Signaling Pathway

Jin, Y., Cheng, X., Lu, J., & Li, X. (2017) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.244.1 · Cited by 32

Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4

Gallardo‐Vara, E., Gamella-Pozuelo, L., Pérez-Roque, L., Bartha, J. L., García‐Palmero, I., Casal, J. I., López-Novoa, J. M., Pericacho, M., & Bernabéu, C. (2020) · Cells · doi:10.3390/cells9040988 · Cited by 32

PPAR α Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model

Dou, F., Wu, B., Chen, J., Liu, T., Yu, Z., & Chen, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2045259 · Cited by 32

BMP‑2 alleviates heart failure with type 2 diabetes mellitus and doxorubicin‑induced AC16 cell injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis

Zhang, J., Yu, R.-Q., Wu, F.-Z., Qiao, L., Wu, X., Fu, Y.-J., Liang, Y.-F., Pang, Y., & Chun-yi, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10329 · Cited by 32

JAK2/STAT3/BMP-2 axis and NF-κB pathway are involved in erythropoietin-induced calcification in rat vascular smooth muscle cells

He, J., Zhong, X., Zhao, L., & Gan, H. (2018) · Clinical and Experimental Nephrology · doi:10.1007/s10157-018-1666-z · Cited by 31

Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging

Kim, S., Lee, E.-S., Lee, S., Kim, Y., Lee, C., Jo, D., & Kim, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902007116 · Cited by 31

Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors

Scimeca, M., Anemona, L., Granaglia, A., Bonfiglio, R., Urbano, N., Toschi, N., Santeusanio, G., Schiaroli, S., Mauriello, S., Tancredi, V., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.08.009 · Cited by 31

Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites

Souilhol, C., Gauci, I., Feng, S., Ayllón, B. T., Mahmoud, M. M., Canham, L., Fragiadaki, M., Serbanovic‐Canic, J., Ridger, V. C., & Evans, P. C. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz235 · Cited by 31

Improving Right Ventricular Function by Increasing BMP Signaling with FK506

Boehm, M., Tian, X., Ali, M. K., Mao, Y., Ichimura, K., Zhao, M., Kuramoto, K., Prosseda, S. D., Fajardo, G., Dufva, M. J., et al. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0528oc · Cited by 31

The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

Happé, C. M., Kurakula, K., Sun, X., Bós, D. D. S. G., Rol, N., Guignabert, C., Tu, L., Schalij, I., Wiesmeijer, K. C., Tura-Ceide, O., et al. (2020) · Cells · doi:10.3390/cells9061422 · Cited by 30

BMP-2 enhances the migration and proliferation of hypoxia-induced VSMCs via actin cytoskeleton, CD44 and matrix metalloproteinase linkage

Yang, M., Fan, Z., Wang, F., Tian, Z.-H., Ma, B., Dong, B., Li, Z., Zhang, M., & Zhao, W. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.05.004 · Cited by 29

Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity

Chen, L., Luo, G., Liu, Y., Lin, H., Zheng, C., Xie, D., Zhu, Y., Chen, L., Huang, X., Hu, D., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03954-8 · Cited by 28

BMPR1A promotes ID2–ZEB1 interaction to suppress excessive endothelial to mesenchymal transition

Lee, H., Adachi, T., Pak, B., Park, S., Hu, X., Choi, W., Kowalski, P. S., Chang, C., Clapham, K. R., Lee, A., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac159 · Cited by 28

BMP9/COX‐2 axial mediates high phosphate‐induced calcification in vascular smooth muscle cells via Wnt/β‐catenin pathway

He, F., Wang, H., Ren, W., Ma, Y., Liao, Y., Zhu, J., Cui, J., Deng, Z., Su, Y., Gan, H., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26460 · Cited by 27

Bone Morphogenic Protein 4-Smad–Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function

Hu, W., Zhang, Y., Wang, L., Lau, C. W., Xu, J., Luo, J., Gou, L., Yao, X., Chen, Z., Ronald, C. W., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306302 · Cited by 26

Bone Morphogenetic Proteins 2/4 Are Upregulated during the Early Development of Vascular Calcification in Chronic Kidney Disease

Wei, X., Wu, W., Li, L., Lin, J., Liu, Q., Gan, L., & Ou, S. (2018) · BioMed Research International · doi:10.1155/2018/8371604 · Cited by 26

Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis

Shoulders, H., Garner, K. H., & Singla, D. K. (2018) · Translational research · doi:10.1016/j.trsl.2018.07.006 · Cited by 26

Single-Cell Analysis Uncovers Osteoblast Factor Growth Differentiation Factor 10 as Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation Associated with Plaque Rupture in Human Carotid Artery Disease

Brandt, K. J., Burger, F., Baptista, D., Roth, A., da Silva, R., Montecucco, F., Mach, F., & Miteva, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031796 · Cited by 26

Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

Walker, R. G., Barrandon, O., Poggioli, T., Dağdeviren, S., Carroll, S. H., Mills, M. J., Mendello, K. R., Gomez, Y. D. L. C., Loffredo, F. S., Pancoast, J. R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61443-y · Cited by 25

BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages

Koga, M., Yamauchi, A., Kanaoka, Y., Jige, R., Tsukamoto, A., Teshima, N., Nishioku, T., & Kataoka, Y. (2013) · Journal of Inflammation · doi:10.1186/1476-9255-10-32 · Cited by 24

Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes

Izumi, M., Masaki, M., Hiramoto, Y., Sugiyama, S., Kuroda, T., Terai, K., Hori, M., Kawase, I., & Hirota, H. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.11.007 · Cited by 23

Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification

Gravesen, E., Mace, M. L., Nordholm, A., Hofman-Bang, J., Hruska, K. A., Nielsen, C. H., Kjær, A., Ølgaard, K., & Lewin, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190820 · Cited by 22

Effect of farnesyltransferase inhibition on cardiac remodeling in spontaneously hypertensive rats

Li, X., Han, J., Liang, L., Wang, K., & Hu, S. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.04.038 · Cited by 21

Activation of CD137 signaling accelerates vascular calcification in vivo and vitro

Chen, Y., Bangash, A. B., Song, J., Zhong, W. H., Wang, C., Shao, C., Wang, Z., & Yan, J. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.12.174 · Cited by 21

Bone Morphogenetic Protein 7 Gene Delivery Improves Cardiac Structure and Function in a Murine Model of Diabetic Cardiomyopathy

Tate, M., Perera, N., Prakoso, D., Willis, A. M., Deo, M., Oseghale, O., Qian, H., Donner, D. G., Kiriazis, H., Blasio, M. J. D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719290 · Cited by 21

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

Guo, J., Liu, B., Thorikay, M., Yu, M., Li, X., Tong, Z., Salmon, R. M., Read, R. J., ten Dijke, P., Morrell, N. W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30111-2 · Cited by 21

BMP-2 Overexpression Augments Vascular Smooth Muscle Cell Motility by Upregulating Myosin Va via Erk Signaling

Zhang, M., Yang, M., Liu, L., Lau, W. B., Gao, H., Xin, M., Su, L.-X., Wang, J., Cheng, S., Fan, Q., et al. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/294150 · Cited by 20

Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice

Garbern, J. C., Kristl, A. C., Bassaneze, V., Vujić, A., Schoemaker, H., Sereda, R., Peng, L., Ricci-Blair, E. M., Goldstein, J. M., Walker, R. G., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00615.2018 · Cited by 20

BMP7-based peptide agonists of BMPR1A protect the left ventricle against pathological remodeling induced by pressure overload

Salido-Medina, A. B., Gil, A., Expósito, V., Martínez, F., Redondo, J. M., Hurlé, M. A., Nistal, J. F., & García, R. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112910 · Cited by 20

Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10

Hirono, K., Saito, K., Munkhsaikhan, U., Xu, F., Wang, C., Lu, L., Ichida, F., Towbin, J. A., & Purevjav, E. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0116 · Cited by 19

Aloe-emodin inhibits osteogenic differentiation and calcification of mouse vascular smooth muscle cells

Sapkota, M., Shrestha, S. K., Yang, M., Park, Y. R., & Soh, Y. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172772 · Cited by 19

Bone Morphogenetic Protein-2 and Osteopontin Gene Expression in Epicardial Adipose Tissue from Patients with Coronary Artery Disease Is Associated with the Presence of Calcified Atherosclerotic Plaques

Luna‐Luna, M., Críales-Vera, S., Medina-Leyte, D. J., Díaz‐Zamudio, M., Flores-Zapata, A., Cruz‐Robles, D., López–Meneses, M., Cruz, S. O., Ramírez-Marroquín, S., Flores‐Castillo, C., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s253632 · Cited by 19

GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs

Ren, K., Li, B., Liu, Z., Xia, L., Zhai, M., Wei, X., Duan, W., & Yu, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16312 · Cited by 19

Bone morphogenetic protein 6—a possible new player in pathophysiology of heart failure

Banach, J., Gilewski, W., Słomka, A., Buszko, K., Błażejewski, J., Karasek, D., Rogowicz, D., Żekanowska, E., & Sinkiewicz, W. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12665 · Cited by 18

Salvianolic acid B ameliorates vascular endothelial dysfunction through influencing a bone morphogenetic protein 4-ROS cycle in diabetic mice

Liu, J., Zhang, Y., Qu, D. C., Zhang, H., Wang, L., Lau, C. W., Han, J., Pingcuo, D., Huang, Y., & Liu, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120039 · Cited by 16

Impaired Interleukin-15 Signaling via BMPR2 Loss Drives Natural Killer Cell Deficiency and Pulmonary Hypertension

Hilton, L., Rätsep, M. T., VandenBroek, M. M., Jafri, S., Laverty, K. J., Mitchell, M., Theilmann, A. L., Smart, J. A., Hawke, L. G., Moore, S. D., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19178 · Cited by 16

Platelet Bone Morphogenetic Protein-4 Mediates Vascular Inflammation and Neointima Formation after Arterial Injury

Jank, M., von Niessen, N., Olivier, C. B., Schmitt, H., Anto-Michel, N., Hilgendorf, I., Bode, C., Moser, M., Esser, J. S., & Zhou, Q. (2021) · Cells · doi:10.3390/cells10082027 · Cited by 15

Association of circulating BMP9 with coronary heart disease and hypertension in Chinese populations

Liu, R., Hu, W., Li, X., Pu, D., Yang, G., Liu, H., Tan, M., & Zhu, D. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1095-2 · Cited by 14

Bone morphogenetic protein 10 alleviates doxorubicin-induced cardiac injury via signal transducer and activator of transcription 3 signaling pathway

An, P., Fan, D., Guo, Z., Liu, F.-Y., Li, C.-F., Yang, D., Wang, M., Yang, Z., & Tang, Q. (2022) · Bioengineered · doi:10.1080/21655979.2022.2048994 · Cited by 13

Patchy deletion of Bmpr1a potentiates proximal pulmonary artery remodeling in mice exposed to chronic hypoxia

Vanderpool, R. R., El‐Bizri, N., Rabinovitch, M., & Chesler, N. C. (2012) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-012-0379-6 · Cited by 12

Elevated Levels of Circulating Bone Morphogenetic Protein 7 Predict Mortality in Pulmonary Arterial Hypertension

Liu, D., Wu, B.-X., Sun, N., Yan, Y., Yuan, P., Qu, J.-M., & Jing, Z. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.03.007 · Cited by 12

A rare homozygous missense GDF2 ( BMP9 ) mutation causing PAH in siblings: Does BMP10 status contribute?

Upton, P. D., Richards, S., Bates, A., Niederhoffer, K. Y., Morrell, N. W., & Christian, S. L. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62996 · Cited by 12

The effects of bone morphogenetic protein 2 and thrombopoietin treatment on angiogenic properties of endothelial cells derived from the lung and bone marrow of young and aged, male and female mice

Dadwal, U. C., Bhatti, F., Awosanya, O. D., Nagaraj, R. U., Perugini, A. J., Sun, S., Valuch, C. R., Staut, C. D. A., Mendenhall, S. K., Tewari, N. P., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202001616rr · Cited by 11

Recombinant BMP 4/7 fusion protein induces differentiation of bone marrow stem cells

Yuan, S., Pan, Q., Liu, W., Wu, B., Han, X., & Bi, Z. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23230 · Cited by 10

The low levels of bone morphogenic protein-4 and its antagonist noggin in type 2 diabetes

Yürekli, B. Ş., Kocabaş, G. Ü., Akşit, M., Kutbay, N. Ö., Süner, A., Yurekli, I. I., Çakır, H., Bozkaya, G., & Çetinkalp, Ş. (2018) · HORMONES · doi:10.1007/s42000-018-0041-5 · Cited by 10

Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells

Maruyama, H., Sakai, S., & Ieda, M. (2022) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2022-0104 · Cited by 10

Bone morphogenetic protein -7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor

Sovershaev, M. A., Egorina, E. M., Bogdanov, V. Y., Seredkina, N., Fallon, J. T., Valkov, A. Y., Østerud, B., & Hansen, J. B. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.06.026 · Cited by 9

GDF-5 promotes epidermal stem cells proliferation via Foxg1-cyclin D1 signaling

Zhao, X., Bian, R., Wang, F., Wang, Y., Li, X., Guo, Y., Zhang, X., Luo, G., & Zhan, R. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02106-7 · Cited by 9

A novel role of bone morphogenetic protein-7 in the regulation of adhesion and migration of human monocytic cells

Sovershaev, T., Unruh, D. J., Sveinbjørnsson, B., Fallon, J. T., Hansen, J. B., Bogdanov, V. Y., & Sovershaev, M. A. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.09.018 · Cited by 8

BMP-4 impedes endothelial cell migration in neointimal hyperplasia via FoXO-3 specific modulation of reactive oxygen species

Li, Q., Kou, X., Qin, X., Li, Z., Li, J., & chen, C. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.05.004 · Cited by 7

Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats

Lee, C., Kuo, W., Tain, Y., Wang, Y., & Lee, W. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.06.101 · Cited by 7

Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity

Park, C. S., Hong, O., Kim, M. K., Chung, W. B., Choi, Y. S., Baek, K., Song, K., Lee, M. Y., & Kwon, H.-S. (2015) · Medicine · doi:10.1097/md.0000000000001530 · Cited by 6

Large-scale gene analysis of rabbit atherosclerosis to discover new biomarkers for coronary artery disease

Yu, X., Guan, W. X., Zhang, Y., Deng, Q., Li, J., Ye, H., Deng, S., Han, W., & Yu, Y. (2019) · Open Biology · doi:10.1098/rsob.180238 · Cited by 5

Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia

Ruiz-Llorente, L., Chiapparino, E., Plumitallo, S., Danesino, C., Bayrak‐Toydemir, P., Pagella, F., Manfredi, G., Bernabéu, C., Jovine, L., & Olivieri, C. (2019) · Gene · doi:10.1016/j.gene.2019.02.016 · Cited by 5

Association between plasma BMP-2 and in-stent restenosis in patients with coronary artery disease

Zheng, W.-P., Yang, M., Su, L.-X., Ning, Y., Wen, W., Xin, M., Zhao, X., & Zhang, M. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.05.033 · Cited by 4

Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities

Ortega, M. A., León-Oliva, D. D., Gimeno, M. J., Boaru, D. L., Fraile‐Μartinez, O., Montero, C. G., de Castro, A. V., Barrena-Blázquez, S., López-González, L., Amor, S., et al. (2024) · Biomolecules · doi:10.3390/biom14030275 · Cited by 51

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Winters, J., Kawczynski, M. J., Gilbers, M. D., Isaacs, A. J., Zeemering, S., Bidar, E., Maesen, B. A. E., Rienstra, M., Gelder, I. C. V., Verheule, S., et al. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.03.003 · Cited by 26

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis

Chen, H., Peng, C.-Y., Fang, F., Li, Y., Liu, X., Hu, Y., Wang, G., Liu, X., & Shen, Y. (2025) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2025.100114 · Cited by 15

Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway

Hassanabad, A. F., Belke, D. D., Gordon, P. M. K., Teng, G., Dundas, J. A., Zarzycki, A. N., Turnbull, J., Deniset, J., & Fedak, P. W. M. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.06.007 · Cited by 10

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Peterson, T. E., Hahn, V. S., Moaddel, R., Zhu, M., Haberlen, S., Palella, F. J., Plankey, M. W., Bader, J. S., Lima, J. A. C., Gerszten, R. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55911-0 · Cited by 10

Targeting BMP signalling in cardiovascular disease and anaemia

Morrell, N. W., Bloch, D. B., ten Dijke, P., Goumans, M., Hata, A., Smith, J., Yu, P. B., & Bloch, K. D. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.156 · Cited by 229

Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system

Luo, J., Zhang, Y., Wang, L., & Huang, Y. (2015) · The Journal of Physiology · doi:10.1113/jp270207 · Cited by 31

Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension

Yang, P. B., & Yu, P. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47507-3_13

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

Rol, N., Kurakula, K., Happé, C. M., Bogaard, H. J., & Goumans, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092585 · Cited by 132

BMP signaling in vascular diseases

Cai, J., Pardali, E., Sánchez‐Duffhues, G., & ten Dijke, P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.04.030 · Cited by 280