The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Oxidative stress-mediated HMGB1 biology
Open accessAbstract
High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e.g., necrosis, apoptosis, autophagic cell death, pyroptosis, and NETosis). Thus, targeting HMGB1 with antioxidant compounds may be an attractive therapeutic strategy for inflammation-associated diseases such as sepsis, ischemia and reperfusion injury, arthritis, diabetes, and cancer.
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1 retracted
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“HMGB1 has not only intracellular functions, but also many extracellular functions such as cytokine and chemokine activity , which are mediated by HMGB1 receptors [e.g., receptor for advanced glycation end products (RAGE) (Hori et al., 1995), toll-like receptors (TLRs, such as TLR2, TLR4, and TLR9) (Park et al., 2004;…”
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Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment
Chen, X., Song, M., Zhang, B., & Zhang, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1580967 · Cited by 326
Danger signals in stroke and their role on microglia activation after ischemia
Gülke, E., Gelderblom, M., & Magnus, T. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418774254 · Cited by 321
Prognostic and predictive value of DAMPs and DAMP-associated processes in cancer
Fucikova, J., Moserova, I., Urbanova, L., Bezu, L., Kepp, O., Cremer, I., Salek, C., Strnad, P., Kroemer, G., Galluzzi, L., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00402 · Cited by 159
Malignant mesothelioma as an oxidative stress-induced cancer: An update
Chew, S. H., & Toyokuni, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.002 · Cited by 102
Metabolic Rewiring and Redox Alterations in Malignant Pleural Mesothelioma
Urso, L., Cavallari, I., Sharova, E., Ciccarese, F., Pasello, G., & Ciminale, V. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0661-9 · Cited by 47
Metadata
- Authors
- Yu, Y., Tang, D., & Kang, R.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2015-04-07
- Volume
- 6
- Pages
- 93-93
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2015644932
- Cited by
- 256
- References
- 34
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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