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Cited by 482

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Extracellular Cysteine in Connexins: Role as Redox Sensors

Open access
Retamal, Mauricio A., García, Isaac E., Pinto, Bernardo I., Pupo, Amaury, Báez, David, Stehberg, Jimmy, Del Rio, Rodrigo, González, Carlos·2016·Frontiers in Physiology
DOI 10.3389/fphys.2016.00001
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Abstract

Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression.

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Metadata

Authors
Retamal, M. A., García, I. E., Pinto, B. I., Pupo, A., Báez, D., Stehberg, J., Del Rio, R., & González, C.
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2016-01-28
Volume
7
Pages
1-1
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2016.00001
OpenAlex
W2276139690
Cited by
482
References
52
FWCI
30.40
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

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