Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
Open accessAbstract
Nutritional improvements in intensive aquaculture production systems is necessary for the reduction of stress, maximum utilization of nutritional components, and expression of the genetic potential of fish. The objective of this study was to evaluate the hemato-immunological, and histological parameters and gut microbiota of Nile tilapia fed with the microalga Schizochytrium sp. Males of Nile tilapia were distributed among eight net cages (6 m3), and fed for 105 days with two diets: control (CON), without Schizochytrium sp., and supplemented (SUP), with 1.2% Schizochytrium sp. in the diet. The final weight, mortality, hematocrit, total erythrocyte count (RBC), hemoglobin, hematimetric indices, white blood cell count (WBC), total protein, and serum lysozyme were measured. Alterations in intestinal morphology were evaluated. The gut microbiota was evaluated with next-generation sequencing. No significant differences (p>0.05) were found in the final weight and mortality between diets. Regarding the hematological parameters, a difference (p<0.05) was detected only in RBC, with there being lower values in the SUP, although this group also showed a tendency toward having an increased mean corpuscular hemoglobin level. There were no differences (p>0.05) in total protein and serum lysozyme concentrations or in WBCs between diets, except for lymphocytes, which presented lower values (p<0.05) in the SUP, suggesting immunomodulation by the polyunsaturated fatty acids present in the microalga. There was no difference (p>0.05) in the intestinal morphology between diets. Metagenomic data indicated greater richness (represented by the Chao index) and a higher abundance of the bacterial phylum Firmicutes in the gut microbiota of the tilapia fed with the SUP diet, demonstrating that the digestion and use of the components of the microalga could influence the microbial community. The results indicated that the microalga had modulatory effects on blood cells and the intestinal microbiota, without affecting the structure and integrity of the intestinal villi.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The addition of a 1.2% Schizochytrium sp. meal to the diet influenced the gut microbiota, resulting in improved Nile tilapia health.
“The addition of a 1.2% Schizochytrium sp.meal to the diet influenced the gut microbiota, resulting in improved Nile tilapia health (Souza et al., 2020).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Souza et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 20,966 · see citing works
Kozich, J. J., Westcott, S. L., Baxter, N. T., Highlander, S. K., & Schloss, P. D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01043-13 · Cited by 7,004 · see citing works
Advances in Experimental Medicine and Biology
Lunt, G. G. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90020-3 · Cited by 1,881 · see citing works
Ellis, A. E. (1990) · Medical Entomology and Zoology · Cited by 1,826 · see citing works
Routine haematological methods for use with fish blood
Blaxhall, P. C., & Daisley, K. W. (1973) · Journal of Fish Biology · doi:10.1111/j.1095-8649.1973.tb04510.x · Cited by 1,653 · see citing works
Tsuchiya, C., Sakata, T., & Sugita, H. (2007) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2007.02258.x · Cited by 520 · see citing works
Extracellular Cysteine in Connexins: Role as Redox Sensors
Retamal, M. A., García, I. E., Pinto, B. I., Pupo, A., Báez-Nieto, D., Stehberg, J., Río, R. D., & Gonzalez, C. L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00001 · Cited by 482 · see citing works
Fish intestinal microbiome: diversity and symbiosis unravelled by metagenomics
Tarnecki, A. M., Burgos, F. A., Ray, C. L., & Arias, C. R. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13415 · Cited by 446 · see citing works
Gram, L., Melchiorsen, J., Spanggaard, B., Huber, I., & Nielsen, T. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.3.969-973.1999 · Cited by 423 · see citing works
Joseph, J. D., & ACKMAN, R. G. (1992) · Journal of AOAC International · doi:10.1093/jaoac/75.3.488 · Cited by 379 · see citing works
Effects of plant-based diets on the distal gut microbiome of rainbow trout (Oncorhynchus mykiss)
Desai, A. R., Links, M. G., Collins, S. A., Mansfield, G. S., Drew, M. D., Kessel, A. G. V., & Hill, J. E. (2012) · Aquaculture · doi:10.1016/j.aquaculture.2012.04.005 · Cited by 378 · see citing works
Dimitroglou, A., Merrifield, D. L., Moate, R. M., Davies, S. J., Spring, P., Sweetman, J. W., & Bradley, G. (2009) · Journal of Animal Science · doi:10.2527/jas.2008-1428 · Cited by 372 · see citing works
Panigrahi, A., Kiron, V., Kobayashi, T., Puangkaew, J., Satoh, S., & Sugita, H. (2004) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2004.08.006 · Cited by 342 · see citing works
Gerritsen, J., Fuentes, S., Grievink, W., van Niftrik, L., Tindall, B. J., Timmerman, H. M., Rijkers, G. T., & Smidt, H. (2014) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.059543-0 · Cited by 297 · see citing works
Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammation
Chapkin, R. S., Kim, W., Lupton, J. R., & McMurray, D. N. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.010 · Cited by 282 · see citing works
Environment shapes the fecal microbiome of invasive carp species
Eichmiller, J. J., Hamilton, M. J., Staley, C. M., Sadowsky, M. J., & Sorensen, P. W. (2016) · Microbiome · doi:10.1186/s40168-016-0190-1 · Cited by 255 · see citing works
Kohl, K. D., Amaya, J., Passement, C. A., Dearing, M. D., & McCue, M. D. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12442 · Cited by 249 · see citing works
The Biotechnological Potential of Thraustochytrids
Lewis, T. E., Nichols, P. D., & McMeekin, T. A. (1999) · Marine Biotechnology · doi:10.1007/pl00011813 · Cited by 247 · see citing works
Zhang, M., Sun, Y., Liu, Y., Qiao, F., Chen, L., Liu, W., Du, Z., & Li, E. (2015) · Aquaculture · doi:10.1016/j.aquaculture.2015.12.014 · Cited by 245 · see citing works
Standen, B., Peggs, D. L., Rawling, M. D., Foey, A., Davies, S. J., Santos, G. A., & Merrifield, D. L. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.11.037 · Cited by 240 · see citing works
Sarker, P. K., Kapuscinski, A. R. D., Lanois, A. J., Livesey, E. D., Bernhard, K. P., & Coley, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156684 · Cited by 233 · see citing works
Zahran, E., Risha, E., Abdelhamid, F., Mahgoub, H. A., & Ibrahim, T. M. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.03.002 · Cited by 215 · see citing works
Telli, G. S., Ranzani‐Paiva, M. J. T., Dias, D. D. C., Sussel, F. R., Ishikawa, C. M., & Tachibana, L. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.05.025 · Cited by 214 · see citing works
Standen, B., Rawling, M. D., Davies, S. J., Castex, M., Foey, A., Gioacchini, G., Carnevali, O., & Merrifield, D. L. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.07.018 · Cited by 209 · see citing works
Visentainer, J. V. (2012) · Química Nova · doi:10.1590/s0100-40422012000200008 · Cited by 193 · see citing works
Métodos para análise hematológica em peixes
Ranzani‐Paiva, M. J. T., de Pádua, S. B., Tavares‐Dias, M., & Egami, M. I. (2013) · doi:10.7476/9788576286530 · Cited by 187 · see citing works
Algae in Fish Feed: Performances and Fatty Acid Metabolism in Juvenile Atlantic Salmon
Norambuena, F., Hermon, K. M., Skrzypczyk, V. M., Emery, J. A., Sharon, Y., Beard, A., & Turchini, G. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124042 · Cited by 186 · see citing works
Cetobacterium somerae sp. nov. from Human Feces and Emended Description of the Genus Cetobacterium
Finegold, S. M., Väisänen, M., Molitoris, D. R., Tomzynski, T. J., Song, Y., Liu, C., Collins, M. D., & Lawson, P. A. (2003) · Systematic and Applied Microbiology · doi:10.1078/072320203322346010 · Cited by 172 · see citing works
Bledsoe, J. W., Peterson, B. C., Swanson, K. S., & Small, B. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166379 · Cited by 172 · see citing works
Gerritsen, J., Hornung, B., Renckens, B. A. M., van Hijum, S. A. F. T., dos Santos, V. A. P. M., Rijkers, G. T., Schaap, P. J., de Vos, W. M., & Smidt, H. (2017) · PeerJ · doi:10.7717/peerj.3698 · Cited by 171 · see citing works
Ramsey, D., Scoto, M., Mayhew, A. G., Main, M. L., Mazzone, E. S., Montes, J., Sanctis, R. D., Young, S. D., Salazar, R. L., Glanzman, A. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172346 · Cited by 165 · see citing works
Soybean meal-induced enteritis in Atlantic salmon (Salmo salarL.) at different temperatures
URN, P. A., Schrama, J. W., Rombout, J. H. W. M., Obach, A., Jensen, L. B., Koppe, W., & Verreth, J. A. J. (2008) · Aquaculture Nutrition · doi:10.1111/j.1365-2095.2007.00534.x · Cited by 164 · see citing works
Li, M. H., Robinson, E. H., Tucker, C. S., Manning, B. B., & Khoo, L. H. (2009) · Aquaculture · doi:10.1016/j.aquaculture.2009.04.033 · Cited by 151 · see citing works
Willingness-to-Pay for Community-Based Health Insurance among Informal Workers in Urban Bangladesh
Ahmed, S., Hoque, M. E., Sarker, A. R., Sultana, M., Islam, Z. U., Gazi, R., & Khan, J. A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148211 · Cited by 151 · see citing works
Gut Microbiota Dynamics during Dietary Shift in Eastern African Cichlid Fishes
Baldo, L., Riera, J. L., Tooming‐Klunderud, A., Albà, M. M., & Salzburger, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127462 · Cited by 142 · see citing works
Carda‐Diéguez, M., Mira, Á., & Fouz, B. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12236 · Cited by 139 · see citing works
Carvalho, M. E., Eler, J. P., Bonin, M. N., de Rezende, F. M., Biase, F. H., Meirelles, F. V., Regitano, L. C. D. A., Coutinho, L. L., Balieiro, J. C. D. C., & Ferraz, J. B. S. (2017) · Genetics and Molecular Research · doi:10.4238/gmr16018957 · Cited by 138 · see citing works
Lyons, P. P., Turnbull, J. F., Dawson, K. A., & Crumlish, M. (2016) · Aquaculture Research · doi:10.1111/are.13080 · Cited by 124 · see citing works
Dawood, M. A. O., Koshio, S., Elsabagh, M., Billah, M. M., Zaineldin, A. I., Zayed, M. M., & Omar, A. A. E.-D. (2016) · Aquaculture · doi:10.1016/j.aquaculture.2016.12.036 · Cited by 118 · see citing works
FOXP3 and Its Role in the Immune System
Kim, C. H. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1599-3_2 · Cited by 117 · see citing works
Reveco, F. E., Øverland, M., Romarheim, O. H., & Mydland, L. T. (2013) · Aquaculture · doi:10.1016/j.aquaculture.2013.11.007 · Cited by 111 · see citing works
Darley, W. M., Porter, D., & Fuller, M. S. (1973) · Archives of Microbiology · doi:10.1007/bf00414512 · Cited by 92 · see citing works
Wang, Y., Song, J., Zhai, Y., Zhang, C., Gerritsen, J., Wang, H., Chen, X., Li, Y., Zhao, B., Zhao, B., et al. (2015) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.000079 · Cited by 84 · see citing works
Silva, B., Martins, M. L., Jatobá, A., Neto, C. C. B., Vieira, F. D. N., Pereira, G. D. V., Jerônimo, G. T., Seiffert, W. Q., & Mouriño, J. L. P. (2009) · Pesquisa Veterinária Brasileira · doi:10.1590/s0100-736x2009001100002 · Cited by 82 · see citing works
Pereira, S. B., Santos, M., Leite, J. P., Flores, C., Eisfeld, C., Büttel, Z., Mota, R., Rossi, F., Philippis, R. D., Gales, L., et al. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.753 · Cited by 79 · see citing works
Wan, A. H. L., Soler‐Vila, A., O’Keeffe, D., Casburn, P., FitzGerald, R. D., & Johnson, M. P. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0821-8 · Cited by 76 · see citing works
Quezada‐Rodriguez, P. R., & Fajer-Avila, E. J. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0903-7 · Cited by 74 · see citing works
Etyemez, M., & Balcázar, J. L. (2015) · Research in Veterinary Science · doi:10.1016/j.rvsc.2015.03.026 · Cited by 72 · see citing works
Valladão, G. M. R., Gallani, S. U., Pala, G., de Jesus, R. B., Kotzent, S., da Costa, J. C., Silva, T. F. A., & Pilarski, F. (2017) · Aquaculture Research · doi:10.1111/are.13386 · Cited by 68 · see citing works
Han, S.-C., Koo, D.-H., Kang, N.-J., Yoon, W., Kang, G.-J., Kang, H.-K., & Yoo, E.-S. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.488 · Cited by 66 · see citing works
Shiffman, M. E., Soo, R. M., Dennis, P. G., Morrison, M., Tyson, G. W., & Hugenholtz, P. (2017) · Europe PMC (PubMed Central) · doi:10.7717/peerj.4075 · Cited by 65 · see citing works
Tavares‐Dias, M., Ono, E. A., Pilarski, F., & de Moraes, F. R. (2007) · Journal of Applied Ichthyology · doi:10.1111/j.1439-0426.2007.00850.x · Cited by 61 · see citing works
Bravo-Tello, K., Ehrenfeld, N., Solís, C. J., Ulloa, P. E., Hedrera, M. I., Pizarro‐Guajardo, M., Paredes‐Sabja, D., & Feijóo, C. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187696 · Cited by 61 · see citing works
Fan, L., Chen, J., Meng, S., Song, C., Qiu, L., Hu, G., & Xu, P. (2015) · Aquaculture Research · doi:10.1111/are.12894 · Cited by 60 · see citing works
Suphoronski, S. A., Chideroli, R. T., Facimoto, C. T., Mainardi, R. M., de Souza, F. P., Lopera-Barrero, N. M., Jesus, G. F. A., Martins, M. L., Santis, G. W. D., de Oliveira, A. G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42480-8 · Cited by 58 · see citing works
Yeganeh, S., & Adel, M. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1673-1 · Cited by 54 · see citing works
Comparative study of gut microbiota in wild and captive Malaysian Mahseer ( Tor tambroides )
Tan, C. K., Ikhsan, N. F. M., Suyub, I. B., Edward, M. J., Kaman, N., & Samsudin, A. A. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.734 · Cited by 49 · see citing works
Zheng, X., Yang, R., Hu, J., Lin, S., Gu, Z., & Ma, Z. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.03.054 · Cited by 43 · see citing works
The thraustochytrids: a protist group with mixed affinities
Chamberlain, A. H. L., & Moss, S. T. (1988) · Biosystems · doi:10.1016/0303-2647(88)90031-7 · Cited by 42 · see citing works
Mykhaylyk, V. B., Kraus, H., Bobb, L., Gamernyk, R. V., & Koroński, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-41768-z · Cited by 41 · see citing works
Martins, M. L., Pilarski, F., Onaka, E. M., Nomura, D. T., Fenerick-Junior, J., Ribeiro, K., Myiazaki, D. M. Y., de Castro, M. P., & Malheiros, E. B. (2018) · Boletim do Instituto de Pesca · Cited by 40 · see citing works
Marino, F., Di, G., Gugliandolo, C., Spanò, A., Faggio, C., Genovese, G., Morabito, M., Russo, A., Barreca, D., Fazio, F., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00459 · Cited by 35 · see citing works
Stress in Salminus brasiliensis fingerlings due to different densities and times of transportation
Adamante, W. B., Nuñer, A. P. D. O., Barcellos, L. J. G., Soso, A. B., & Finco, J. A. (2008) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/s0102-09352008000300034 · Cited by 27 · see citing works
Hematologia de tilápias-do-nilo alimentadas com dietas com óleos vegetais e estimuladas pelo frio
Araujo, D. D. M., Pezzato, A. C., Barros, M. M., Pezzato, L. E., & Nakagome, F. K. (2011) · Pesquisa Agropecuária Brasileira · doi:10.1590/s0100-204x2011000300010 · Cited by 18 · see citing works
Levy-Pereira, N., Yasui, G. S., Cardozo, M. V., Neto, J. D., Farias, T. H. V., Sakabe, R., de Pádua, S. B., & Pilarski, F. (2018) · Revista Brasileira de Zootecnia · doi:10.1590/rbz4720170006 · Cited by 16 · see citing works
Comparative study of gut microbiota in wild and captive Malaysian Mahseer (Tor tambroides)
Tan, C. K., Ikhsan, N. F. M., Suyub, I. B., et al. (2018) · Greater South Information System · doi:10.60692/vr46e-8dg88 · Cited by 8 · see citing works
Garcia, F., Schalch, S. H. C., Onaka, E. M., da Fonseca, F. S., & Batista, M. P. (2012) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/s0102-09352012000100028 · Cited by 7 · see citing works
Buck, E. L., Mizubuti, I. Y., Alfieri, A. A., Otonel, R. A. A., Buck, L. Y., de Souza, F. P., Prado-Calixto, O. P., Parra, Â. R. P., Filho, L. A., & Lopera-Barrero, N. M. (2017) · Genetics and Molecular Research · doi:10.4238/gmr16019404 · Cited by 7 · see citing works
de Oliveira, S. N., Ribeiro, R. P., de Oliveira, C. A. L., Lopera-Barrero, N. M., Borquis, R. R. A., Oliveira, A. M. D. S., de Souza, F. P., & Parra, Â. R. P. (2019) · Revista Brasileira de Zootecnia · doi:10.1590/rbz4820170179 · Cited by 7 · see citing works
Turco, P. H. N., Donadelli, A., Scorvo, C. M. D. F., Filho, J. D. S., & Tarsitano, M. A. A. (2015) · doi:10.13140/rg.2.1.3185.4565 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [1]FAO. The State of World Fisheries and Aquaculture 2018—Meeting the sustainable development goals [Internet]. Vol. 35. 2018. 176 p. ftp://ftp.fao.org/docrep/fao/011/i0250e/i0250e.pdf
- [14]dos Santos SKA, Guilherme de Souza Moura MMP, Aline Danielle Souza Prates ALF, Azevedo RC. Microalga Schizochytrium sp. em Rações para Tilápia do Nilo. Cad Ciências Agrárias. 2015; 7(1): 75– 9.
- [19]Kumala FB, Wahjuningrum D, Setiawati M. Effects of dietary algae, fungi and herb on the growth and innate immunity of Nile tilapia Oreochromis niloticus challenged with Streptococcus agalactiae. AACL Bioflux. 2018; 11(4): 1368– 77.
- [42]Araujo DDM, Pezzato AC, Barros MM. Hematology of Nile tilapia fed diets with vegetable oils and stimulated by cold. Pesqui Agropecu Bras. 2011; 46(3): 294– 302.
Cited by
Sorted by citations
Potential of microalgae as a sustainable feed ingredient for aquaculture
Nagappan, S., Das, P., AbdulQuadir, M., Thaher, M., Khan, S., Mahata, C., Al-Jabri, H., Vatland, A. K., & Kumar, G. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.09.003 · Cited by 364 · see citing works
Ahmad, A., Hassan, S. W., & BANAT, F. A. (2022) · Bioengineered · doi:10.1080/21655979.2022.2061148 · Cited by 257 · see citing works
Alternative Proteins for Fish Diets: Implications beyond Growth
Aragão, C., Gonçalves, A. T., Costas, B., Azeredo, R., Xavier, M. J., & Engrola, S. A. D. (2022) · Animals · doi:10.3390/ani12091211 · Cited by 225 · see citing works
Nagarajan, D., Varjani, S., Lee, D., & Chang, J. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2021.111549 · Cited by 206 · see citing works
Mansour, A. T., Ashour, M., Alprol, A. E., & Alsaqufi, A. S. (2022) · Sustainability · doi:10.3390/su14063257 · Cited by 82 · see citing works
Microalgae with immunomodulatory effects on fish
Bahi, A., Ramos‐Vega, A., Angulo, C., Monreal‐Escalante, E., & Guardiola, F. A. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12792 · Cited by 65 · see citing works
Hosny, S., Elshobary, M. E., & El-Sheekh, M. M. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-35885-8 · Cited by 63 · see citing works
Li, X., Liu, J., Tian, J., Pan, Z., Chen, Y., Ming, F., Wang, R., Wang, L., Zhou, H., Li, J., et al. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128733 · Cited by 60 · see citing works
Sansone, C., Bruno, A., Piscitelli, C., Baci, D., Fontana, A., Brunet, C., Noonan, D. M., & Albini, A. (2021) · Cells · doi:10.3390/cells10020231 · Cited by 53 · see citing works
Comparative study of gut microbiota in wild and captive Malaysian Mahseer ( Tor tambroides )
Tan, C. K., Ikhsan, N. F. M., Suyub, I. B., Edward, M. J., Kaman, N., & Samsudin, A. A. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.734 · Cited by 49 · see citing works
Sagaram, U. S., Gaikwad, M., Nandru, R., & Dasgupta, S. (2021) · FEMS Microbiology Letters · doi:10.1093/femsle/fnab071 · Cited by 47 · see citing works
Benefits of the microalgae Spirulina and Schizochytrium in fish nutrition: a meta-analysis
Trevi, S., Webster, T. M. U., Consuegra, S., & de Leániz, C. G. (2023) · Scientific Reports · doi:10.1038/s41598-023-29183-x · Cited by 47 · see citing works
Liao, H., Liu, P., Deng, Y., Zhang, W., Pan, C., Jia, Y., Long, F., & Tang, H. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738311 · Cited by 39 · see citing works
Nayak, S., Al‐Ashhab, A., Zilberg, D., & Khozin‐Goldberg, I. (2020) · Biology · doi:10.3390/biology9060119 · Cited by 38 · see citing works
Biotechnological Enhancement of Probiotics through Co-Cultivation with Algae: Future or a Trend?
Perković, L., Djedović, E., Vujović, T., Baković, M., Paradžik, T., & Čož‐Rakovac, R. (2022) · Marine Drugs · doi:10.3390/md20020142 · Cited by 40 · see citing works
Mueller, J., Pauly, M., Molkentin, J., Ostermeyer, U., van Muilekom, D. R., Rebl, A., Goldammer, T., Lindemeyer, J., Schultheiß, T., Seibel, H., et al. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1273614 · Cited by 35 · see citing works
de Souza, F. P., de Lima, E. C. S., Pandolfi, V. C. F., Leite, N. G., Murari, P. J. F., Leal, C. N. S., Mainardi, R. M., Suphoronski, S. A., Favero, L. M., Koch, J. F. A., et al. (2020) · Aquaculture Reports · doi:10.1016/j.aqrep.2020.100369 · Cited by 35 · see citing works
Skalli, A., Firmino, J. P., Andree, K. B., Salomón, R., Estévez, A., Puig, P., Sabater-Martínez, M., Hechavarría, T., & Gisbert, E. (2020) · Animals · doi:10.3390/ani10091656 · Cited by 33 · see citing works
Microalgae in Terms of Biomedical Technology: Probiotics, Prebiotics, and Metabiotics
Oleskin, A. V., & Boyang, C. (2022) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683822060126 · Cited by 27 · see citing works
Rosenau, S., Oertel, E., Mott, A. C., & Tetens, J. (2021) · Life · doi:10.3390/life11060558 · Cited by 26 · see citing works
Zahran, E., Elbahnaswy, S., Ibrahim, I. R., & Khaled, A. A. (2021) · Aquaculture Reports · doi:10.1016/j.aqrep.2021.100911 · Cited by 26 · see citing works
Huang, Z., Gao, J., Peng, C., Song, J., Xie, Z., Jia, J., Li, H., Zhao, S., Liang, Y., & Gong, B. (2023) · Microorganisms · doi:10.3390/microorganisms11041002 · Cited by 23 · see citing works
Shi, Y., Cao, X., Ye, Z., Xu, Y., Wang, Y., Li, Z., Hang, W., & He, N. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736631 · Cited by 22 · see citing works
Yao, X., Lin, Y., Shi, M., Chen, L., Qu, K., Liu, Y., Tan, B., & Xie, S. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.1090235 · Cited by 22 · see citing works
da Silva, V. G., Favero, L. M., Mainardi, R. M., Ferrari, N. A., Chideroli, R. T., Santis, G. W. D., de Souza, F. P., da Costa, A. R., Gonçalves, D. D., Nuez‐Ortín, W. G., et al. (2023) · Research in Veterinary Science · doi:10.1016/j.rvsc.2023.04.019 · Cited by 22 · see citing works
Saleh, R. S., Mohammady, E. Y., El‐Haroun, E., & hassaan, M. S. (2022) · Aquaculture Research · doi:10.1111/are.16116 · Cited by 21 · see citing works
Soudant, P., Ventura, M., Chauchat, L., Guerreiro, M., Mathieu‐Resuge, M., Grand, F. L., Simon, V., Collet, S., Zambonino‐Infante, J., Goïc, N. L., et al. (2022) · Sustainability · doi:10.3390/su142114573 · Cited by 20 · see citing works
Ali, S., Waqas, W., Bakky, M. A. H., Zada, S., Saif, U. M., Hasan, M. T., Shafiq, M., Dildar, T., & Hui, W. (2024) · Reviews in Aquaculture · doi:10.1111/raq.12980 · Cited by 19 · see citing works
Bera, A. K., Chowdhury, H., Ghatak, S., Malick, R. C., Chakraborty, N., Chakraborty, H. J., Swain, H. S., Hassan, M. A., & Das, B. K. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1168284 · Cited by 18 · see citing works
Li, Y., Le, Q., Zhang, M., Xu, S., He, S., Yan, X., Hu, J., & Wang, Y. (2023) · Journal of Marine Science and Engineering · doi:10.3390/jmse11020414 · Cited by 16 · see citing works
Bakky, M. A. H., Tran, N. T., Zhang, M., Zhang, Y., Liang, H., Wang, Y., Zhang, Y., Ma, H., Zheng, H., & Li, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125561 · Cited by 16 · see citing works
Marine thraustochytrid: exploration from taxonomic challenges to biotechnological applications
Wang, Q., Zhang, Y., Hui, R., & Zhu, Y. (2024) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1371713 · Cited by 16 · see citing works
Chattaraj, S., Ganguly, A., Mitra, D., Thatoi, H., & MOHAPATRA, P. K. D. (2026) · Waste and Biomass Valorization · doi:10.1007/s12649-026-03619-7 · Cited by 15 · see citing works
Microbiomes of Tilapia Culture Systems: Composition, Affecting Factors, and Future Perspectives
Huavas, J., Heyse, J., Props, R., Delamare‐Deboutteville, J., & Shelley, C. C. (2024) · Aquaculture Research · doi:10.1155/2024/5511461 · Cited by 12 · see citing works
Peng, D., Zhang, X., Zhu, F., Wen, H., Dong, L., Tian, J., Zhang, J., Yang, C., Xiao, J., Duan, X., et al. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03334-7 · Cited by 11 · see citing works
Shawky, W. A., El‐Sayed, H. S., Saleh, N. E., Ismael, A. A.-H., & El‐Sayed, A. M. (2021) · Aquaculture Nutrition · doi:10.1111/anu.13245 · Cited by 13 · see citing works
Power Play of Commensal Bacteria in the Buccal Cavity of Female Nile Tilapia
Abdelhafiz, Y. A., Fernandes, J. M. O., Stefani, E., Albanese, D., Donati, C., & Kiron, V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.773351 · Cited by 10 · see citing works
Algae for Aquaculture: Recent Technological Applications
Elshobary, M. E., & Ashour, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-42026-9_16 · Cited by 10 · see citing works
Katsoulis-Dimitriou, S., Nikouli, E., Gkalogianni, E. Z., Karapanagiotidis, I. Τ., & Kormas, K. A. (2024) · Peer Community Journal · doi:10.24072/pcjournal.498 · Cited by 8 · see citing works
Xu, J., Yao, X., Lin, Y., Chi, S., Zhang, S., Cao, J., Tan, B., & Xie, S. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101399 · Cited by 8 · see citing works
Meng, S., Xu, H., Qin, L., Chen, X., Qiu, L., Li, D., Song, C., Fan, L., Hu, G., & Xu, P. (2023) · Biology · doi:10.3390/biology12091209 · Cited by 8 · see citing works
Algal Biorefinery: A Paradigm to Sustainable Circular Bioeconomy
Sangtani, R., Sonbhadra, S., Nogueira, R., & Bala, K. (2022) · Energy, environment, and sustainability · doi:10.1007/978-981-16-8682-5_11 · Cited by 8 · see citing works
Galeana-López, J. A., Gómez‐Gil, B., Hernández, C., Leyva‐López, N., Lizárraga-Velázquez, C. E., & Zenteno‐Savín, T. (2021) · Waste and Biomass Valorization · doi:10.1007/s12649-020-01314-9 · Cited by 8 · see citing works
Trevi, S., Webster, T. M. U., Consuegra, S., & de Leániz, C. G. (2024) · Aquaculture Fish and Fisheries · doi:10.1002/aff2.164 · Cited by 9 · see citing works
Manoharan, R., Nair, C. S., Nishanth, D., Subramanian, R., Ahmed, Z. F. R., Rastrelli, L., Xie, X., Ren, M., & Jaleel, A. (2025) · Frontiers in Marine Science · doi:10.3389/fmars.2025.1661042 · Cited by 7 · see citing works
Teronpi, H., Kalita, N., Baruah, P. P., & Sarma, D. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107793 · Cited by 7 · see citing works
Salem, M. A. E. K., Adawy, R., Zaki, V. H., & Zahran, E. (2022) · Journal of Aquatic Animal Health · doi:10.1002/aah.10170 · Cited by 7 · see citing works
Al-Wakeel, A. H., Elbahnaswy, S., Risha, E., & Zahran, E. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04155-z · Cited by 7 · see citing works
Enzyme supplementation (phytase and xylanase) improves low quality diets in Nile tilapia
Maas, R. M., Kokou, F., Verdegem, M. C. J., & Schrama, J. W. (2025) · Aquaculture Reports · doi:10.1016/j.aqrep.2025.102650 · Cited by 6 · see citing works
Mosha, S. S. (2020) · Advances in Oceanography & Marine Biology · doi:10.33552/aomb.2020.02.000529 · Cited by 5 · see citing works
Application of Probiotics, Prebiotics, and Synbiotics in Aquaculture
Preena, P. G., Anjana, J. C., & Rejish Kumar, V. J. (2025) · Springer eBooks · doi:10.1007/978-981-97-7320-6_12 · Cited by 5 · see citing works
Effect of sex on hematology, morphology and blood cell characteristics of Schizothorax niger
Sheikh, Z. A., & Ahmed, I. (2020) · Comparative Clinical Pathology · doi:10.1007/s00580-020-03153-5 · Cited by 5 · see citing works
Abdelhafiz, Y. A., Fernandes, J. M. O., Larger, S., Albanese, D., Donati, C., Jafari, O., Nedoluzhko, A., & Kiron, V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.709611 · Cited by 5 · see citing works
Huang, J., Zhuo, D., Wang, M., Yeerda, S., Huang, J., Qin, X., Lu, M., Wang, Z., & Liu, X. (2024) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1413965 · Cited by 4 · see citing works
Karataş, B. (2024) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2024.111047 · Cited by 4 · see citing works
Wang, Y., Tang, W., Chen, S., Zhao, Z., Qing-qin, H., Li, J., Lin, C., Deng, H., Zhong, Z., Guo, W., et al. (2025) · Journal of the World Aquaculture Society · doi:10.1111/jwas.13126 · Cited by 4 · see citing works
Challenges in the field of toxicity of metals in India including the development of new treatment
Yadav, S. R., Chavan, B. R., Chadha, N. K., Naik, S. D., Krishnani, K. K., & Sawant, P. (2022) · Journal of Environmental Biology · doi:10.22438/jeb/43/4/mrn-2001 · Cited by 4 · see citing works
de Lima, E. C. S., de Souza, F. P., Murari, P. J. F., Pandolfi, V. C. F., Leite, N. G., Mainardi, R. M., Chideroli, R. T., Pereira, U. D. P., Araújo, E. J. D. A., Pupim, A. C. E., et al. (2024) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202420231006 · Cited by 4 · see citing works
Nonwachai, T., Boonprasert, W., Prisingkorn, W., Ngamsiri, T., Pholoeng, A., Labaiden, M., & Wangkahart, E. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743719 · Cited by 3 · see citing works
Adeniyi, O. V., Adedayo, M. R., & Afe, A. I. (2024) · Journal of Applied Aquaculture · doi:10.1080/10454438.2024.2382431 · Cited by 2 · see citing works
Alaoui, M. H., Moujtahid, A. E., Bamaarouf, M., & Arroussi, H. E. (2026) · Aquaculture Nutrition · doi:10.1155/anu/5217142 · Cited by 3 · see citing works
Ferrari, N. A., Mainardi, R. M., da Silva, M. B., Guimarães, G. D., Takashe, J. V. G., de Oliveira, A. G., Hayashi, R. M., Santis, G. W. D., & Pereira, U. D. P. (2024) · Fishes · doi:10.3390/fishes9090351 · Cited by 2 · see citing works
Amira, K. I., RAHMAN, M. R., Khatoon, H., Sıkder, S., Islam, S. A., Afruj, J., JAMAL, F., & Haque, M. E. (2022) · Bangladesh Journal of Fisheries · doi:10.52168/bjf.2021.33.27 · Cited by 2 · see citing works
Lopera-Barrero, N. M., de Souza, F. P., de Lima, E. C. S., Odebrecht, L. M., Pandolfi, V. C. F., Leal, C. N. S., Pereira, U. D. P., Pupim, A. C. E., Meletti, P. C., & Araújo, E. J. D. A. (2024) · Semina Ciências Agrárias · doi:10.5433/1679-0359.2024v45n3p727 · Cited by 2 · see citing works
Trevi, S., Webster, T. M. U., Consuegra, S., & de Leániz, C. G. (2023) · Research Square · doi:10.21203/rs.3.rs-2920591/v1 · Cited by 2 · see citing works
The importance of gut microbes for nutrition and health
Piazzon, M. C., Ghosh, K., Ringø, E., & Kokou, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21556-8.00013-2 · Cited by 2 · see citing works
Mixtures of Algal Oil and Terrestrial Oils in Diets of Tiger Puffer (Takifugu rubripes)
Zhang, L., Li, H., Song, Z., Gao, Q., Bian, C., Ma, Q., Wei, Y., Liang, M., & Xu, H. (2025) · Animals · doi:10.3390/ani15091187 · Cited by 1 · see citing works
Evidence of use of microalgae as antimicrobial agents
Stirk, W. A., & Staden, J. V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22080-7.00034-x · Cited by 1 · see citing works
Busti, S., Kortner, T. M., Valen, E. C., Benini, E., Bonaldo, A., Xiros, C., Brambilla, F., Scicchitano, D., Palladino, G., Candela, M., et al. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743729 · Cited by 1 · see citing works
Microalgae Biofertilizers Versus Chemical Fertilizers: Environmental and Agricultural Perspectives
González-González, J. L., Vargas-Pérez, M., Luna‐Olvera, H. A., Martínez-Amador, S. Y., Morales-Martínez, T. K., Ríos-González, L. J., Laredo-Alcalá, E. I., Lopez-Badillo, C. M., & la Garza, J. A. R.-D. (2026) · World sustainability series · doi:10.1007/978-3-032-10314-7_6 · Cited by 1 · see citing works
苏秋文, Jia, X., Lan, S., He, Y., Li, T., Zhou, A., & Tang, H. (2026) · Journal of Applied Phycology · doi:10.1007/s10811-026-03890-0 · Cited by 1 · see citing works
Dietary Fatty Acids, Gut Microbiome, and Gut–Brain Communication: A Current Perspective
Anand, S. K., Sukrutha, S. K., Shilpa, B. R., & Nagarathna, A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-4530-4_8 · Cited by 1 · see citing works
The benefits of the microalgae Spirulina and Schizochytrium in fish nutrition: a meta-analysisPreprint
Trevi, S., Webster, T. M. U., Consuegra, S., & de Leániz, C. G. (2022) · Research Square · doi:10.21203/rs.3.rs-2162417/v1 · Cited by 1 · see citing works
Qing-qin, H., Zhao, Z., Huang, J.-H., Liu, S.-L., Li, J., Lin, C., Deng, H., Zhong, Z.-H., Guo, W., Wang, S., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4674691 · Cited by 1 · see citing works
Curvo, L. R. V., Ferreira, M. W., Barbosa, G. R. C., Kreutz, F. I., Costa, C. S., da Silveira, U. S., & de Andrade, G. B. (2021) · Revista Ibero-Americana de Ciências Ambientais · doi:10.6008/cbpc2179-6858.2021.002.0040
Germán, C.-M., Jorge, C. M., Irlanda, T.-P. L., & Alejandra, S. N. K. (2023) · Journal of Entomology and Zoology Studies · doi:10.22271/j.ento.2023.v11.i6b.9264
Intestinal Microbiota of Tilapia: Characterization and Modulation
Zhang, Z., Teame, T., Wang, A., Ding, Q., Ran, C., Yang, Y., & Zhou, Z. (2023) · Applied environmental science and engineering for a sustainable future · doi:10.1007/978-3-031-38321-2_4
Qing-qin, H., Zhao, Z., Huang, J.-H., Liu, S.-L., Li, J., Lin, C., Deng, H., Zhong, Z.-H., Guo, W., Wang, S., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4684027
Karataş, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3858150/v1
Karataş, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3858150/v2
Karataş, B., & Kaya, D. (2024) · Acta Aquatica Turcica · doi:10.22392/actaquatr.1494714
Karataş, B. (2025) · Türk Tarım ve Doğa Bilimleri Dergisi · doi:10.30910/turkjans.1581615
Yazıcı, M., Naz, M., Mazlum, Y., Ürkü, Ç., Türkmen, M., & Dede, K. (2025) · Journal of Anatolian Environmental and Animal Sciences · doi:10.35229/jaes.1759435
L, O. A. D., P., L. I. G., MARROQUÍN, K., VIAFORA, D., VEGA, F., RODRÍGUEZ, E., & RUBIO, Z. (2025) · Conducta Científica · doi:10.65050/rcc.v8n2a3
Naiel, M. A. E., Zaki, E. M., Khames, D. K., Ismael, N. E. M., Meng, X., Alharbi, H. M., Alwutayd, K. M., & Anees, D. M. R. (2026) · Journal of Applied Phycology · doi:10.1007/s10811-025-03743-2
Cheong, H.-A., Christianus, A., de Cruz, C. R., Low, C. F., Lee, P., Abdullah, M., Yusoff, F. M., Shaari, K., Ismail, I. S., Ng, G. H.-S., et al. (2026) · Biology · doi:10.3390/biology15050374
DHA‐Rich Algae Feed Modulates Atlantic Salmon Health, Microbiota and Stress Response
Mueller, J., Suhr, M., Molkentin, J., Lautenschläger, I., Ehlers, J., Simon, A., Hornburg, S. C., Bang, C., Seibel, H., & Schulz, C. (2026) · Aquaculture Nutrition · doi:10.1155/anu/4185490
Xiao, K., 聂丽灵, Zhao, S., Gao, G., Zhao, C., Du, Y., Hu, R., Lin, R., Wang, J., Wang, M., et al. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.744480
- Authors
- Souza, F. P. D., Lima, E. C. S. D., Urrea-Rojas, A. M., Suphoronski, S. A., Facimoto, C. T., Bezerra Júnior, J. D. S., Oliveira, T. E. S. D., Pereira, U. D. P., Santis, G. W. D., Oliveira, C. A. L. D., & Lopera-Barrero, N. M.
- Affiliations
- Universidade Estadual de Londrina (BR)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-01-02
- Volume
- 15
- Issue
- 1
- Pages
- e0226977
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6940142
- OpenAlex
- W2996763297
- Cited by
- 90
- References
- 72
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 17 · 2023: 15 · 2022: 17 · 2021: 12 · 2020: 6 · 2018: 1
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- Schizochytrium, Oreochromis niloticus, fish immunomodulation, hematological parameters, serum lysozyme, white blood cell count, intestinal histology, gut microbiota, Firmicutes, polyunsaturated fatty acids, net cage aquaculture, fish nutrition
- MeSH terms
- Gastrointestinal Microbiome, Animals, Blood Cells, Body Weight, Intestines, Male, Dietary Supplements, Cichlids, Microalgae, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review