Mechanisms of impaired brown adipose tissue recruitment in obesity
Open accessAbstract
Brown adipose tissue (BAT) dissipates energy to produce heat. Thus, it has the potential to regulate body temperature by thermogenesis. For the last decade, BAT has been in the spotlight due to its rediscovery in adult humans. This is evidenced by over a hundred clinical trials that are currently registered to target BAT as a therapeutic tool in the treatment of metabolic diseases, such as obesity or diabetes. The goal of most of these trials is to activate the BAT thermogenic program via several approaches such as adrenergic stimulation, natriuretic peptides, retinoids, capsinoids, thyroid hormones, or glucocorticoids. However, the impact of BAT activation on total body energy consumption and the potential effect on weight loss is still limited. Other studies have focused on increasing the mass of thermogenic BAT. This can be relevant in obesity, where the activity and abundance of BAT have been shown to be drastically reduced. The aim of this review is to describe pathological processes associated with obesity that may influence the correct differentiation of BAT, such as catecholamine resistance, inflammation, oxidative stress, and endoplasmic reticulum stress. This will shed light on the thermogenic potential of BAT as a therapeutic approach to target obesity-induced metabolic diseases.
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In patients with obesity, brown adipose tissue function is significantly impaired, partially explained by the systemic proinflammatory state and accompanying catecholamine resistance.
“In patients with obesity, BAT function is significantly impaired, partially explained by the systemic proinflammatory state and the accompanying catecholamine-resistance that ensues [13]”
The lack of observable browning in obese populations might represent a pathophysiological phenomenon rather than a lack of such an effect.
“Another interesting possibility is that the lack of observable browning in obese populations might represent a pathophysiological phenomenon, rather than a lack of such an effect [13]”
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“Another interesting possibility is that the lack of observable browning in obese populations might represent a pathophysiological phenomenon, rather than a lack of such an effect [13], given that browning in VAT has not been studied in this population and that any detectable effect is likely dampened by the proinflamm…”
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- Authors
- Alcalá, M., Calderon-Dominguez, M., Serra, D., Herrero, L., & Viana, M.
- Affiliations
- Universidad San Pablo CEU (ES)
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Serra, Dolors
- Herrero, Laura
- Viana, Marta
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2019-02-13
- Volume
- 10
- Pages
- 94-94
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC6381290
- OpenAlex
- W2913067888
- Cited by
- 106
- References
- 123
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 19 · 2022: 26 · 2021: 20 · 2020: 18 · 2019: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- CEU Repositorio Institucional (Fundación Universitaria San Pablo CEU) (submittedVersion, cc-by-nc-nd)
- Funders
- Universitat de Barcelona
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, obesity, thermogenesis, catecholamine resistance, inflammation, oxidative stress, endoplasmic reticulum stress, BAT activation, weight loss, metabolic disorders
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