The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Eccentric Muscle Contractions: Risks and Benefits
Open accessAbstract
Eccentric contractions, characterized by the lengthening of the muscle-tendon complex, present several unique features compared with other types of contractions, which may lead to unique adaptations. Due to its specific physiological and mechanical properties, there is an increasing interest in employing eccentric muscle work for rehabilitation and clinical purposes. However, unaccustomed eccentric exercise is known to cause muscle damage and delayed pain, commonly defined as "Delayed-Onset Muscular Soreness" (DOMS). To date, the most useful preventive strategy to avoid these adverse effects consists of repeating sessions involving submaximal eccentric contractions whose intensity is progressively increased over the training. Despite an increased number of investigations focusing on the eccentric contraction, a significant gap still remains in our understanding of the cellular and molecular mechanisms underlying the initial damage response and subsequent adaptations to eccentric exercise. Yet, unraveling the molecular basis of exercise-related muscle damage and soreness might help uncover the mechanistic basis of pathological conditions as myalgia or neuromuscular diseases. In addition, a better insight into the mechanisms governing eccentric training adaptations should provide invaluable information for designing therapeutic interventions and identifying potential therapeutic targets.
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Citations
Cites
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Delayed Onset Muscle Soreness: Treatment Strategies and Performance Factors
Cheung, K., Hume, P. A., & Maxwell, L. (2003) · Sports Medicine · doi:10.2165/00007256-200333020-00005 · Cited by 1,350
Myofibrillar damage following intense eccentric exercise in man
Fridén, J., Sjöström, M., & Ekblom, B. (1983) · International Journal of Sports Medicine · doi:10.1055/s-2008-1026030 · Cited by 1,005
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“The magnitude of changes in EIMD indirect markers (in particular, the plasma CK activity) shows a marked interindividual variability even when subjects are submitted to standardized eccentric protocols (Clarkson et al., 1992; Nosaka and Clarkson, 1996; Hody et al., 2013c).”
BackgroundMuscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875
Franchi, M. V., Atherton, P. J., Reeves, N. D., Flück, M., Williams, J., Mitchell, W. K., Selby, A., Beltran Valls, R. M., & Narici, M. V. (2014) · Acta Physiologica · doi:10.1111/apha.12225 · Cited by 389
Muscle stiffness, strength loss, swelling and soreness following exercise-induced injury in humans
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Differential adaptations to eccentric versus conventional resistance training in older humans
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Cited by
Sato, S., Yoshida, R., Murakoshi, F., Sasaki, Y., Yahata, K., Nosaka, K., & Nakamura, M. (2022) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.14138 · Cited by 27
Morya, V. K., Shahid, H., Lang, J., Kwak, M. K., Park, S.-H., & Noh, K.-C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111846 · Cited by 20
Dominguez-Balmaseda, D., Diez-Vega, I., Larrosa, M., San Juan, A. F., Issaly, N., Moreno-Pérez, D., Burgos, S., Sillero-Quintana, M., Gonzalez, C., Bas, A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00826 · Cited by 15
Metadata
- Authors
- Hody, S., Croisier, J.-L., Bury, T., Rogister, B., & Leprince, P.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-03
- Volume
- 10
- Pages
- 536-536
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2272991862
- Cited by
- 393
- References
- 14
- FWCI
- 24.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hody, S., Croisier, J.-L., Bury, T., Rogister, B., & Leprince, P. (2019). Eccentric Muscle Contractions: Risks and Benefits. Frontiers in Physiology. https://doi.org/10.3389/fphys.2019.00536
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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