The DOI matches its Crossref record; 166 of the 168 references it cites were found in a registry or an index.
Physical Exercise: A Novel Tool to Protect Mitochondrial Health
Open accessAbstract
Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, associated with metabolic abnormalities. In response to energetic deficiency, the cardiomyocytes activate the Mitochondrial Quality Control (MQC), a critical process in maintaining mitochondrial health. This process is compromised in cardiovascular diseases depending on the pathology’s severity and represents, therefore, a potential therapeutic target. Several potential targeting molecules within this process have been identified in the last years, and therapeutic strategies have been proposed to ameliorate mitochondria monitoring and function. In this context, physical exercise is considered a non-pharmacological strategy to protect mitochondrial health. Physical exercise regulates MQC allowing the repair/elimination of damaged mitochondria and synthesizing new ones, thus recovering the metabolic state. In this review, we will deal with the effect of physical exercise on cardiac mitochondrial function tracing its ability to modulate specific steps in MQC both in physiologic and pathologic conditions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Engaging in regular physical activity or exercise training, which proves beneficial for enhancing mitochondrial homeostasis in individuals with sarcopenia, significantly regulates mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial redox biology [9,10,11].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019581108 · Cited by 320
RetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Progression Models in Resistance Training for Healthy Adults
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181915670 · Cited by 4,332
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674
Progression Models in Resistance Training for Healthy Adults
(2002) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200202000-00027 · Cited by 2,979
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835
Flagged first, then by citations
2 of the 168 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–118 of 118
Physical exercises can alleviate harmine toxicity in the case of oncological treatments
Hagiu, B.-A. (2025) · Medical Hypotheses · doi:10.1016/j.mehy.2025.111579
Age and Physical Activity Modulate the Spatial Mapping of Time-Related Words
Malyshevskaya, A., Fischer, M. H., Юрьевич, Ш. Ю., & Myachykov, A. (2026) · Journal of Cognition · doi:10.5334/joc.514
Mitochondria in focus: From structure and function to their role in human diseases. A review
Follprecht, D., Vavricka, J., Johankova, V., Broz, P., & Kroužecký, A. (2025) · Biomedical Papers · doi:10.5507/bp.2025.009
Pesticide exposure and hippocampal neurogenesis: Role of ER stress and mitochondrial dysfunction
Hossain, M. M. (2025) · Advances in neurotoxicology · doi:10.1016/bs.ant.2025.02.006
Metabolic disorders associated with mitochondrial dysfunction
Akash, M. S. H., & Rehman, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36312-2.00011-5
MITOCHONDRIAL THERAPIES IN AGING AND AGE-RELATED DISEASES
Borysova, O. (2025) · Anti-Aging Eastern Europe · doi:10.56543/aaeeu.2025.4.2.02
HIIT: Considered as Various Fluctuations for Adaptive Processes in the Metabolism
Slapšinskaitė, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-98787-8_8
Sabillah, M. I., Wibawa, J. C., Ayubi, N., Sceisarriya, V. M., Ndayisenga, J., & Kurnaz, M. (2025) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v9i2.2482 · Cited by 1
Metabolomic biomarkers predict long-term physical function in survivors of acute respiratory failure
Haastrup, A. I., Roberts, J. T., Gandotra, S., Hartsell, E. M., Daly, G. T., Pastukh, V. M., Purcell, L. D., Benton, R., Files, D. C., Stevens, T., et al. (2025) · Respiratory Research · doi:10.1186/s12931-025-03423-2
Correlation of serum cardiolipin levels with physical activity in type 2 diabetes mellitus patients
Aslam, A., Bokhari, S., Mehboob, R., Rafi, U., Mehboob, Z., Sabtan, D., Karami, M. M., & Shalabi, H. S. (2025) · Italian Journal of Medicine · doi:10.4081/itjm.2025.2363
Hereditary cancer syndromes linked to oxidative phosphorylation insufficiency
Kaplan, B., Duraj, T., Lee, D. C., & Seyfried, T. N. (2025) · ONCOLOGIE · doi:10.1515/oncologie-2025-0301
Physical Activity and Its Impact on Cardiometabolic Disorders
Vázquez-Jiménez, J. G., & Romero‐García, T. (2026) · Handbook of experimental pharmacology · doi:10.1007/164_2026_792
Mweene, B. C., Masenga, S. K., Katti, P., Venkhatesh, P., Neikirk, K., Marshall, A., Vetha, B. S. S., McMillian, R., Kirabo, A., Gamble‐George, J., et al. (2026) · Aging advances. · doi:10.4103/agingadv.agingadv-d-25-00046
Ciaccio, E. J., Hsia, H. H., Talke, M., Schwartz, S. M., Garan, H., Yarmohammadi, H., Peters, N. S., Coromilas, J., & BIVIANO, A. B. (2026) · Heart Rhythm · doi:10.1016/j.hrthm.2026.07.017
Singh, S. A., Godvarthi, R., Wankhade, P., Gaurav, A., & Narwade, S. (2026) · Biomedicines · doi:10.3390/biomedicines14081849
Balance of Life: Exercise as a Vehicle for the Soul and Mind
Ernandini, E., & Trinita, D. C. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017545
SantaBarbara, N. J., Kurdziel, L., Cellucci, J., Conz, K., Finlayson, H. A., McKinney, R., & Bharath, L. P. (2026) · Journal of the Association of Nurses in AIDS Care · doi:10.1097/jnc.0000000000000703
Metadata
- Authors
- Sorriento, D., Di Vaia, E., & Iaccarino, G.
- Affiliations
- Federico II University Hospital (IT)
- Corresponding author
- Iaccarino, Guido
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2021-04-27
- Volume
- 12
- Pages
- 660068-660068
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC8110831
- OpenAlex
- W3158316719
- Cited by
- 118
- References
- 168
- Citations by year
- 2026: 14 · 2025: 35 · 2024: 24 · 2023: 27 · 2022: 15 · 2021: 3
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- physical activity, mitochondrial quality control, mitochondrial dysfunction, cardiomyocytes, heart disease, reactive oxygen species, apoptosis, ATP production, energy metabolism, non-pharmacological treatment, mitochondrial biogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
