Physical Exercise: A Novel Tool to Protect Mitochondrial Health

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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The Hallmarks of Aging

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Progression Models in Resistance Training for Healthy Adults

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Mitochondrial Fission, Fusion, and Stress

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Progression Models in Resistance Training for Healthy Adults

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

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American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Myocardial Substrate Metabolism in the Normal and Failing Heart

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Exercise Training for Blood Pressure: A Systematic Review and Meta‐analysis

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Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

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Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

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Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

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Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

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Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

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Mitophagy: mechanisms, pathophysiological roles, and analysis

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Beneficial effects of physical exercise on neuroplasticity and cognition

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Cardiovascular Effects and Benefits of Exercise

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The machineries, regulation and cellular functions of mitochondrial calcium

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Mitochondrial dynamics and mitochondrial quality control

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Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

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Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

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The mammalian ULK1 complex and autophagy initiation

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Acute exercise and oxidative stress: a 30 year history

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Mitochondrial dynamics, mitophagy and cardiovascular disease

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Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation

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Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

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Exercise and Insulin Sensitivity: A Review

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PGC1α and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

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mTORC1 as the main gateway to autophagy

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Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

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Exercise for women receiving adjuvant therapy for breast cancer

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Molecular basis of physiological heart growth: fundamental concepts and new players

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Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

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Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association

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Exercise Promotes Healthy Aging of Skeletal Muscle

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Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

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Exercise and Cardiovascular Health

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Mitochondrial biogenesis and dynamics in the developing and diseased heart

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Estrogen Increases Bone Marrow–Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation

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mTOR and autophagy: A dynamic relationship governed by nutrients and energy

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Aging and Autophagy in the Heart

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Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies

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Receptor-mediated mitophagy in yeast and mammalian systems

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Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise

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PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

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The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

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Pharmacological approaches to restore mitochondrial function

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Redox-optimized ROS balance: A unifying hypothesis

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Mitochondria removal by autophagy

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The Effect of Physical Exercise on Endothelial Function

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Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α

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Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

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Dynamin‐related protein 1 (Drp1)‐mediated diastolic dysfunction in myocardial ischemia‐reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

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Exercise and mitochondrial health

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Mitochondria as a Therapeutic Target in Heart Failure

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Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

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Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart

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Defining and measuring autophagosome flux—concept and reality

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Skeletal Muscle Adaptation to Exercise Training

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Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis

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Effect of Exercise Training on Peak Oxygen Consumption in Patients with Cancer: A Meta-Analysis

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Exercise for women receiving adjuvant therapy for breast cancer

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Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

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10-Year Exercise Training in Chronic Heart Failure

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Regulation of mitochondrial fusion and division

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Molecular mechanisms and physiologic functions of mitochondrial dynamics

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An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

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Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy

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AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

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Exercise and inflammation

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Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis

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Adaptations of skeletal muscle mitochondria to exercise training

Lundby, C., & Jacobs, R. A. (2015) · Experimental Physiology · doi:10.1113/ep085319 · Cited by 245

Benefits of Exercise in Rheumatoid Arthritis

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Correcting mitochondrial fusion by manipulating mitofusin conformations

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Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis

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Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes

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Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer

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Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart

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Obesity and Physical Activity

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Mechanisms and roles of mitophagy in neurodegenerative diseases

Wang, Y., Liu, N., & Lu, B. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13140 · Cited by 217

Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats

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Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts

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Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death

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Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

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Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

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Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study

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Mitochondria, Muscle Health, and Exercise with Advancing Age

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Modulation of Anthracycline-Induced Cardiotoxicity by Aerobic Exercise in Breast Cancer

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