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Physical Exercise: A Novel Tool to Protect Mitochondrial Health
Open accessAbstract
Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, associated with metabolic abnormalities. In response to energetic deficiency, the cardiomyocytes activate the Mitochondrial Quality Control (MQC), a critical process in maintaining mitochondrial health. This process is compromised in cardiovascular diseases depending on the pathology’s severity and represents, therefore, a potential therapeutic target. Several potential targeting molecules within this process have been identified in the last years, and therapeutic strategies have been proposed to ameliorate mitochondria monitoring and function. In this context, physical exercise is considered a non-pharmacological strategy to protect mitochondrial health. Physical exercise regulates MQC allowing the repair/elimination of damaged mitochondria and synthesizing new ones, thus recovering the metabolic state. In this review, we will deal with the effect of physical exercise on cardiac mitochondrial function tracing its ability to modulate specific steps in MQC both in physiologic and pathologic conditions.
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“Engaging in regular physical activity or exercise training, which proves beneficial for enhancing mitochondrial homeostasis in individuals with sarcopenia, significantly regulates mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial redox biology [9,10,11].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [10]
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Shastry, S., Mizrahi, D., & Kanzawa-Lee, G. A. (2023) · Physiologia · doi:10.3390/physiologia3040042 · Cited by 1
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Santos, K. O., Filho, D. M. P., Ventura, T. M. O., Grizzo, L. T., Macedo, A. G., Buzalaf, M. A. R., Braga, A. S., Faria, M. H., & Magalhães, A. C. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3936 · Cited by 1
Roholamini, Z., Abbaspoor, M., Aminizadeh, S., & Saberi, S. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101802 · Cited by 1
Efficacy and Safety of Photobiomodulation in MELAS: Protocol for a Series of N-of-1 Trials
Laakso, E., Ewais, T., McMahon, K. L., Forbes, J. M., & Phillips, L. K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062047 · Cited by 1
Alldritt, I., Sligar, J., Campelj, D. G., Padilha, C. S., Ritenis, E. J., Mantamadiotis, T., Widodo, S. S., Dinevska, M., Nielsen, J., Philp, A. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.03.686168 · Cited by 1
khirabadi, J., Etemad, Z., Azizbeigi, K., & Salamat, K. M. (2023) · Journal of Sport and Exercise Physiology · doi:10.52547/joeppa.16.1.67
The Acute Effects of Exercise on Saliva-Derived Regional Mitochondrial DNA from Trained Runners
McGlynn, M. L., Rosales, A. M., Collins, C. W., & Slivka, D. R. (2023) · Exercise Sport and Movement · doi:10.1249/esm.0000000000000009
Kerr, N. R. (2023) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/97056
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Greggi, C., & Tarantino, U. (2023) · International Journal of Bone Fragility · doi:10.57582/ijbf.230302.050
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Peel, C. (2024) · British Journal of Neuroscience Nursing · doi:10.12968/bjnn.2024.20.2.54
Aging: Generation of oxidative stress
Rehman, R., Zulkipli, I. N., & Khan, H. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18807-7.00007-7
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Iu, E. C. Y., So, H., & Chan, C. B. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1403463
Feretzakis, G., Sakagianni, A., Paxinou, E., & Verykios, V. S. (2024) · International Conference on Information, Intelligence, Systems & Applications (IISA) · doi:10.1109/iisa62523.2024.10786641
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Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_7
Metadata
- Authors
- Sorriento, D., Di Vaia, E., & Iaccarino, G.
- Affiliations
- Federico II University Hospital (IT)
- Corresponding author
- Iaccarino, Guido
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2021-04-27
- Volume
- 12
- Pages
- 660068-660068
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC8110831
- OpenAlex
- W3158316719
- Cited by
- 118
- References
- 168
- Citations by year
- 2026: 14 · 2025: 35 · 2024: 24 · 2023: 27 · 2022: 15 · 2021: 3
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- physical activity, mitochondrial quality control, mitochondrial dysfunction, cardiomyocytes, heart disease, reactive oxygen species, apoptosis, ATP production, energy metabolism, non-pharmacological treatment, mitochondrial biogenesis
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