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Cited by 116Visual perception and processing mechanismsSchizophrenia research and treatmentHallucinations in medical conditions

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Visual Surround Suppression in Schizophrenia

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Tibber, Marc S., Anderson, Elaine J., Bobin, Tracy, Antonova, Elena, Seabright, Alice, Wright, Bernice, Carlin, Patricia, Shergill, Sukhwinder S., Dakin, Steven C.·2013·Frontiers in Psychology
DOI 10.3389/fpsyg.2013.00088PMC PMC3584288
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Abstract

Compared to unaffected observers patients with schizophrenia (SZ) show characteristic differences in visual perception, including a reduced susceptibility to the influence of context on judgments of contrast - a manifestation of weaker surround suppression (SS). To examine the generality of this phenomenon we measured the ability of 24 individuals with SZ to judge the luminance, contrast, orientation, and size of targets embedded in contextual surrounds that would typically influence the target's appearance. Individuals with SZ demonstrated weaker SS compared to matched controls for stimuli defined by contrast or size, but not for those defined by luminance or orientation. As perceived luminance is thought to be regulated at the earliest stages of visual processing our findings are consistent with a suppression deficit that is predominantly cortical in origin. In addition, we propose that preserved orientation SS in SZ may reflect the sparing of broadly tuned mechanisms of suppression. We attempt to reconcile these data with findings from previous studies.

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Crossref · 10.3389/fpsyg.2013.00088

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Figure 1 Stimuli used to measure surround suppression for judgments of (A) luminance, (B) contrast, (C) orientation, and (D) size. The stimulus consists of a central patch (the “reference”) presented within a surround of (A) higher luminance, (B) higher-contrast, (C) more anti-clockwise orientation, and (D) larger elements. Here, for the purpose of illustration, each stimulus is also surrounded by eight test-patches at different signal levels. A typical perceptual match to the central reference-patch is shown at “12 O’clock” whereas the true/physical match is at “6 O’clock.”
Figure 1 Stimuli used to measure surround suppression for judgments of (A) luminance, (B) contrast, (C) orientation, and (D) size. The stimulus consists of a central patch (the “reference”) presented within a surround of (A) higher luminance, (B) higher-contrast, (C) more anti-clockwise orientation, and (D) larger elements. Here, for the purpose of illustration, each stimulus is also surrounded by eight test-patches at different signal levels. A typical perceptual match to the central reference-patch is shown at “12 O’clock” whereas the true/physical match is at “6 O’clock.”CC BY · PubMed Central
Figure 2 Data taken from a single control observer (upper plots) and a single observer with schizophrenia (lower plots). These were selected on the basis that they were typical of group trends. Red triangles denote the point of subjective equality (PSE) on the abscissa, which represents the test signal level at which the test and reference were perceptually matched. The white triangles denote the test signal when test and reference were physically (i.e. veridically) matched. Error bars represent 95% confidence intervals for parameter estimates obtained through boot-strapping of the observer’s responses.
Figure 2 Data taken from a single control observer (upper plots) and a single observer with schizophrenia (lower plots). These were selected on the basis that they were typical of group trends. Red triangles denote the point of subjective equality (PSE) on the abscissa, which represents the test signal level at which the test and reference were perceptually matched. The white triangles denote the test signal when test and reference were physically (i.e. veridically) matched. Error bars represent 95% confidence intervals for parameter estimates obtained through boot-strapping of the observer’s responses.CC BY · PubMed Central
Figure 3 Discrimination performance for the four judgments of relative (A) luminance, (B) contrast, (C) orientation, and (D) size. Each data-point plots bias (the test level leading the isolated test to be perceptually matched to the surrounded reference) against threshold (the difference in reference and test signal required to successfully discriminate the two on 83% of trials). The performance of control observers is plotted in blue, and of patients in red; two-toned squares show group averages. Ellipses denote 95% confidence intervals for parameter estimates. The vertical dotted line denotes a veridical (unbiased) match. Large negative biases reflect strong suppressive effects of the surround whilst larger threshold values (on the ordinate axis) reflect poorer performance. In, inpatients; Out, outpatients.
Figure 3 Discrimination performance for the four judgments of relative (A) luminance, (B) contrast, (C) orientation, and (D) size. Each data-point plots bias (the test level leading the isolated test to be perceptually matched to the surrounded reference) against threshold (the difference in reference and test signal required to successfully discriminate the two on 83% of trials). The performance of control observers is plotted in blue, and of patients in red; two-toned squares show group averages. Ellipses denote 95% confidence intervals for parameter estimates. The vertical dotted line denotes a veridical (unbiased) match. Large negative biases reflect strong suppressive effects of the surround whilst larger threshold values (on the ordinate axis) reflect poorer performance. In, inpatients; Out, outpatients.CC BY · PubMed Central
Figure 4 Bias data from the schizophrenia group have been converted into z-scores relative to control group means and standard deviations for each of the four tasks, with individual parameter estimates weighted by their associated confidence interval. Negative and positive values, respectively, denote weaker and stronger contextual effects in the patient group. For each patient, a mean of these four standardized z-scores was calculated, generating a contextual modulation index (CMI) that represents a measure of general susceptibility to surround suppression (white bar). Error bars indicate the standard error of the mean (SEM) of the patient group; the blue shaded region indicates the SEM of the control group.*Significant effect at the 5% level following correction for multiple comparisons and single-tailed tests.
Figure 4 Bias data from the schizophrenia group have been converted into z-scores relative to control group means and standard deviations for each of the four tasks, with individual parameter estimates weighted by their associated confidence interval. Negative and positive values, respectively, denote weaker and stronger contextual effects in the patient group. For each patient, a mean of these four standardized z-scores was calculated, generating a contextual modulation index (CMI) that represents a measure of general susceptibility to surround suppression (white bar). Error bars indicate the standard error of the mean (SEM) of the patient group; the blue shaded region indicates the SEM of the control group.*Significant effect at the 5% level following correction for multiple comparisons and single-tailed tests.CC BY · PubMed Central

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Metadata

Authors
Tibber, M. S., Anderson, E. J., Bobin, T., Antonova, E., Seabright, A., Wright, B., Carlin, P., Shergill, S. S., & Dakin, S. C.
Affiliations
  • National Institute for Health and Care Research (GB)
  • NIHR Moorfields Biomedical Research Centre (GB)
  • King's College London (GB)
  • University College London (GB)
Corresponding author
Tibber, Marc S.
ORCID
Venue
Frontiers in Psychology
Publisher
Frontiers Media SA
Published
2013
Volume
4
Pages
88-88
ISSN
1664-1078 (ISSN-L)
DOI
10.3389/fpsyg.2013.00088
PMC
PMC3584288
OpenAlex
W2129294405
Cited by
116
References
83
Citations by year
2026: 7 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 6 · 2013: 7
FWCI
6.22
Type
journal article
Language
en
Update notices
corrigendum (2019-08-22)
Open access
Licence
cc-by
Locations
  • Frontiers in Psychology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion, cc-by)
  • ResearchSpace (University of Auckland) (submittedVersion, cc-by)
  • Brunel University Research Archive (BURA) (Brunel University London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
schizophrenia, surround suppression, visual perception, contrast perception, luminance perception, orientation perception, size perception

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