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Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?
Open accessAbstract
Addressing global mental health is a major 21st-century challenge. Current treatments have recognized limitations; in this context, new ones that are prophylactic and effective across diagnostic boundaries would represent a major advance. The view that there exists a core of transdiagnostic overlap between psychiatric disorders has re-emerged in recent years, and evidence that psychedelic therapy holds promise for a range of psychiatric disorders supports the position that it may be transdiagnostically effective. Here, we propose that psychedelic therapy's core, transdiagnostically relevant action lies in its ability to increase neuronal and mental plasticity, thus enhancing the potential for change, which we consider to be a key to its therapeutic benefits. Moreover, we suggest that enhanced plasticity via psychedelics, combined with a psychotherapeutic approach, can aid healthy adaptability and resilience, which are protective factors for long-term well-being. We present candidate neurological and psychological markers of this plasticity and link them with a predictive processing model of the action of psychedelics. We propose that a model of psychedelic-induced plasticity combined with an adequate therapeutic context has prophylactic and transdiagnostic potential, implying that it could have a broad, positive impact on public health.
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“Integrating mindfulness skills and psychedelic insights holds promise for sustained psychological flexibility by facilitating a balanced response to internal and external stimuli, and adaptive responses to life's challenges [93].”
From Mindfulness meditation and psychedelics: potential synergies and commonalities (2023) · cites this paper as [93]
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“All these preventive and remediation interventions, to varying degrees, foster neuroplasticity-related adaptations in brain regions involved in emotional regulation and cognitive flexibility [186-188].”
From Impact of Media-Induced Uncertainty on Mental Health: Narrative-Based Perspective. (2025) · cites this paper as [188]
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“Similar effects were seen for changes in measures of MA craving, depression, anxiety, stress and mental wellbeing, supporting the potential transdiagnostic treatment capability of PAT [60].”
From Psilocybin‐assisted psychotherapy for methamphetamine use disorder: A pilot open‐label safety and feasibility study. (2025) · cites this paper as [60]
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Metadata
- Authors
- Kočárová, R., Horáček, J., & Carhart-Harris, R.
- Affiliations
- Charles University (CZ)
- Imperial College London (GB)
- Corresponding author
- Kočárová, Rita
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2021-07-19
- Volume
- 12
- Pages
- 661233-661233
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC8327748
- OpenAlex
- W3185477803
- Cited by
- 96
- References
- 265
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 17 · 2023: 23 · 2022: 15 · 2021: 4
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Funders
- Technologická Agentura České Republiky
- Filozofická Fakulta, Univerzita Karlova v Praze
- Agentura Pro Zdravotnický Výzkum České Republiky
- Grantová Agentura České Republiky
- Ministerstvo Å kolstvÃ, Mládeže a TÄ›lovýchovy
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- psychedelic therapy, transdiagnostic mechanisms, prophylaxis, neuroplasticity, resilience, mental illness, global mental health, psychological markers
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