Psychedelics and psychological flexibility – Results of a prospective web-survey using the Acceptance and Action Questionnaire II
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Most studies using an emotion regulation perspective have focused on acute emotional engagement and breakthrough rather than on evaluating and challenging automatic cognitions and core beliefs during a psychedelic session.
“However, most studies that have used an emotion regulation perspective have focused more heavily on acute emotional engagement and breakthrough rather than on the ability to evaluate and challenge the validity of automatic cognitions and core beliefs during a psychedelic session (Close et al., 2020; Roseman et al., 2019; Thiessen et al., 2018).”
From Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca (2022) · cites this paper as Close et al., 2020
Recent prospective studies indicate psychological flexibility is a key component in outcomes following psychedelic use.
“A few recent studies, including three prospective studies, have suggested that psychological flexibility is a key component in psychedelic-induced outcomes (Close et al., 2020; Davis et al., 2020; Zeifman et al., 2020).”
From Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca (2022) · cites this paper as Close et al., 2020
Two prospective studies used naturalistic volunteer samples with high attrition (>50%), which may have introduced self-selection and sample biases limiting generalizability.
“Second, although two of these studies employed prospective designs, their use of naturalistic, volunteer samples with high rates of attrition (> 50%) may have contributed self-selection and sample biases that limit generalizability (Close et al., 2020; Zeifman et al., 2020).”
From Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca (2022) · cites this paper as Close et al., 2020
Across three prospective samples, psychological flexibility increased and covaried over time with clinical outcomes such as depression and suicidality.
“In particular, across three prospective samples, psychological flexibility showed signs of increasing and covarying over time with clinical outcomes including depression and suicidality (Close et al., 2020; Zeifman et al., 2020).”
From Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca (2022) · cites this paper as Close et al., 2020
Prospective surveys have found psychological flexibility to be negatively correlated with depression scores post psychedelic use.
“Other prospective surveys have found psychological flexibility (a set of processes which allow one to adapt to various demands, maintain balance across various domains and be open to and committed to behaviours congruent to their values) to be negatively correlated with depression scores post psychedelic use [58, 59].”
From The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol (2022) · cites this paper as [58]
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“Several cross-sectional and observational studies have found that use of a classic psychedelic is associated with subsequent increases in psychological flexibility 21,36–38 .”
BackgroundResultInfluentialAgin-Liebes, G., Zeifman, R., Luoma, J. B., Garland, E. L., Campbell, W. K., & Weiss, B. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221080165 · Cited by 54 · see citing works
“%) may have contributed self-selection and sample biases that limit generalizability (Close et al., 2020; Zeifman et al., 2020).”
BackgroundResultInfluentialPrevalence and therapeutic impact of adverse life event reexperiencing under ceremonial ayahuasca
Weiss, B., Wingert, A., Erritzoe, D., & Campbell, W. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-36184-3 · Cited by 33 · see citing works
Johansen, L., Liknaitzky, P., Nedeljkovic, M., Mastin-Purcell, L., & Murray, G. (2022) · Systematic Reviews · doi:10.1186/s13643-022-01930-7 · Cited by 11 · see citing works
“Other prospective surveys have found psychological flexibility (a set of processes which allow one to adapt to various demands, maintain balance across various domains and be open to and committed to behaviours congruent to their values) to be negatively correlated with depression scores post psychedelic use [58, 59].”
Background
- Authors
- Close, J. B., Hajien, E. C., Watts, R., Roseman, L., & Carhart-Harris, R. L.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Close, James B.
- Venue
- Journal of Contextual Behavioral Science
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 16
- Pages
- 37-44
- ISSN
- 2212-1447 (ISSN-L)
- OpenAlex
- W2999812626
- Cited by
- 54
- References
- 92
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 8 · 2021: 3 · 2020: 5
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Contextual Behavioral Science (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- psychedelics, psychological flexibility, Acceptance and Action Questionnaire-II, depression, mystical experience, catharsis, psychedelic therapy
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