Cited by 54Psychedelics and Drug StudiesMindfulness and Compassion InterventionsReligion, Spirituality, and Psychology

Psychedelics and psychological flexibility – Results of a prospective web-survey using the Acceptance and Action Questionnaire II

Close, James B., Hajien, Eline C., Watts, Rosalind, Roseman, Leor, Carhart-Harris, Robin L.·2020·Journal of Contextual Behavioral Science

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Crossref · 10.1016/j.jcbs.2020.01.005

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  • Most studies using an emotion regulation perspective have focused on acute emotional engagement and breakthrough rather than on evaluating and challenging automatic cognitions and core beliefs during a psychedelic session.

    “However, most studies that have used an emotion regulation perspective have focused more heavily on acute emotional engagement and breakthrough rather than on the ability to evaluate and challenge the validity of automatic cognitions and core beliefs during a psychedelic session (Close et al., 2020; Roseman et al., 2019; Thiessen et al., 2018).”
  • Recent prospective studies indicate psychological flexibility is a key component in outcomes following psychedelic use.

    “A few recent studies, including three prospective studies, have suggested that psychological flexibility is a key component in psychedelic-induced outcomes (Close et al., 2020; Davis et al., 2020; Zeifman et al., 2020).”
  • Two prospective studies used naturalistic volunteer samples with high attrition (>50%), which may have introduced self-selection and sample biases limiting generalizability.

    “Second, although two of these studies employed prospective designs, their use of naturalistic, volunteer samples with high rates of attrition (> 50%) may have contributed self-selection and sample biases that limit generalizability (Close et al., 2020; Zeifman et al., 2020).”
  • Across three prospective samples, psychological flexibility increased and covaried over time with clinical outcomes such as depression and suicidality.

    “In particular, across three prospective samples, psychological flexibility showed signs of increasing and covarying over time with clinical outcomes including depression and suicidality (Close et al., 2020; Zeifman et al., 2020).”
  • Prospective surveys have found psychological flexibility to be negatively correlated with depression scores post psychedelic use.

    “Other prospective surveys have found psychological flexibility (a set of processes which allow one to adapt to various demands, maintain balance across various domains and be open to and committed to behaviours congruent to their values) to be negatively correlated with depression scores post psychedelic use [58, 59].”

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Authors
Close, J. B., Hajien, E. C., Watts, R., Roseman, L., & Carhart-Harris, R. L.
Affiliations
Imperial College London (GB)
Corresponding author
Close, James B.
Venue
Journal of Contextual Behavioral Science
Publisher
Elsevier BV
Published
2020-04
Volume
16
Pages
37-44
ISSN
2212-1447 (ISSN-L)
OpenAlex
W2999812626
Cited by
54
References
92
Citations by year
2026: 9 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 8 · 2021: 3 · 2020: 5
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Locations
Journal of Contextual Behavioral Science (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Health › Religion, Spirituality, and Psychology
Keywords
psychedelics, psychological flexibility, Acceptance and Action Questionnaire-II, depression, mystical experience, catharsis, psychedelic therapy

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