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Cited by 39Tryptophan and brain disordersInflammatory Biomarkers in Disease PrognosisTreatment of Major Depression

Correlation of systemic immune-inflammation index and moderate/major depression in patients with depressive disorders: a large sample cross-sectional study

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Cui, Shu, Li, Juanjuan, Liu, Yun, Yao, Gaofeng, Wu, Yanhai, Liu, Zhiwei, Sun, Liang, Sun, Longlong +1 more·2023·Frontiers in Psychiatry
DOI 10.3389/fpsyt.2023.1159889PMC PMC10232846
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Abstract

Objective To evaluate the clinical value of systemic immune-inflammation index (SII) based on peripheral blood neutrophil, lymphocyte, and platelet count in evaluating the subtype and severity of depression in patients with depressive disorder. Methods This retrospective cohort study was conducted in the Third People’s Hospital of Fuyang City from January 1, 2020 to December 31, 2022. The data included sociodemographic information at admission, clinical data, discharge diagnosis and inflammatory markers. Patients were divided into low SII group and high SII group according to the optimal threshold of SII determined by receiver operating characteristic curve (ROC curve). Binary logistic regression was used to analyze the correlation between moderate/major depression and SII level. Results Compared to the low SII group, the high SII group had a higher age level (χ2 = 7.663, p = 0.006), more smokers (χ2 = 9.458, p = 0.002), more moderate/major depression patients (χ2 = 45.645, p < 0.001), and a higher proportion of patients with accompanying somatic symptoms (χ2 = 14.867, p < 0.001). In the final logistic regression model, after controlling for confounding factors, SII at admission was significantly associated with moderate/major depression [β =1.285, p < 0.001; odds ratio (95% confidence intervals) = 3.614 (2.693–4.850)]. Patients with high SII scores were 3.614 times more likely to have moderate/severe depression than those with low SII scores. We propose a cut-off value of SII =540.78 (sensitivity = 36.4% and specificity = 80.3%) according to the maximum Youden index. Conclusion Our research indicates that SII may be a useful, repeatable, convenient, and affordable index to identify moderate/major depression in depressive disorder.

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  • There has only been 1 study that included only patients with MDD and found that SII at admission was significantly associated with moderate and severe MDD.

    “There has only been 1 study that included only patients with MDD and found that SII at admission was significantly associated with moderate and severe MDD.25”

    From Association Between Mood Disorder Severity, Treatment Response and Systemic Inflammatory Markers: Exploring the Role of NLR, PLR, MLR, and SII (2024) · cites this paper as [25]

    The Results passage reports that SII at admission was significantly associated with moderate/major depression. However, the Study participants section says enrollment required an ICD-10 depressive-disorder diagnosis, not specifically MDD, and the paper does not establish that it was the only such study. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Cui, S., Li, J., Liu, Y., Yao, G., Wu, Y., Liu, Z., Sun, L., Sun, L., & Liu, H.
Affiliations
Anhui Medical University (CN)
Corresponding author
  • Cui, Shu
  • Liu, Huanzhong
ORCID
Venue
Frontiers in Psychiatry
Publisher
Frontiers Media SA
Published
2023-05-18
Volume
14
Pages
1159889-1159889
ISSN
1664-0640 (ISSN-L)
DOI
10.3389/fpsyt.2023.1159889
PMC
PMC10232846
OpenAlex
W4377104680
Cited by
39
References
12
Citations by year
2026: 8 · 2025: 15 · 2024: 14 · 2023: 2
FWCI
3.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
systemic immune-inflammation index, depression severity, depressive disorders, inflammatory markers, neutrophil count, lymphocyte count, platelet count, somatic symptoms

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