Barriers to Use Artificial Intelligence Methodologies in Health Technology Assessment in Central and East European Countries
Open accessAbstract
The aim of this paper is to identify the barriers that are specifically relevant to the use of Artificial Intelligence (AI)-based evidence in Central and Eastern European (CEE) Health Technology Assessment (HTA) systems. The study relied on two main parallel sources to identify barriers to use AI methodologies in HTA in CEE, including a scoping literature review and iterative focus group meetings with HTx team members. Most of the other selected articles discussed AI from a clinical perspective (n = 25), and the rest are from regulatory perspective (n = 13), and transfer of knowledge point of view (n = 3). Clinical areas studied are quite diverse—from pediatric, diabetes, diagnostic radiology, gynecology, oncology, surgery, psychiatry, cardiology, infection diseases, and oncology. Out of all 38 articles, 25 (66%) describe the AI method and the rest are more focused on the utilization barriers of different health care services and programs. The potential barriers could be classified as data related, methodological, technological, regulatory and policy related, and human factor related. Some of the barriers are quite similar, especially concerning the technologies. Studies focusing on the AI usage for HTA decision making are scarce. AI and augmented decision making tools are a novel science, and we are in the process of adapting it to existing needs. HTA as a process requires multiple steps, multiple evaluations which rely on heterogenous data. Therefore, the observed range of barriers come as a no surprise, and experts in the field need to give their opinion on the most important barriers in order to develop recommendations to overcome them and to disseminate the practical application of these tools.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A recent literature review identified technological support and a lack of experts in AI in medicine as the main barriers to the integration of AI into medical education, as reported by students from Central and Eastern European countries.
“Similarly, a recent literature review identified technological support and a lack of experts in AI in medicine as the main barriers to the integration of AI into medical education, as reported by students from Central and Eastern European countries [38].”
From Shaping the future: perspectives on the Integration of Artificial Intelligence in health profession education: a multi-country survey (2024) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,759 · see citing works
Duan, Y., Edwards, J. S., & Dwivedi, Y. K. (2019) · International Journal of Information Management · doi:10.1016/j.ijinfomgt.2019.01.021 · Cited by 2,628 · cited 1× · see citing works
“Firstly, AI systems, since their inception, have been considered purely as augmenting tools, helping human intelligence (55).”
BackgroundArtificial intelligence in medicine
Hamet, P., & Tremblay, J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.011 · Cited by 2,334 · see citing works
Greenhalgh, T., & Peacock, R. (2005) · BMJ · doi:10.1136/bmj.38636.593461.68 · Cited by 2,045 · see citing works
Overview of artificial intelligence in medicine
Amisha, Malik, P., Pathania, M., & Rathaur, V. K. (2019) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_440_19 · Cited by 1,106 · cited 1× · see citing works
“There is little doubt that AI plays an important role for medical practice and science (5, 6), as more and more new medical devices and digital health solutions are supported by AI components.”
BackgroundWahl, B., Cossy-Gantner, A., Germann, S., & Schwalbe, N. R. (2018) · BMJ Global Health · doi:10.1136/bmjgh-2018-000798 · Cited by 796 · see citing works
Principles of artificial intelligence
Schliferstein, A. (1981) · Proceedings of the IEEE · doi:10.1109/proc.1981.12145 · Cited by 648 · see citing works
Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study
Hosny, A., Parmar, C., Coroller, T. P., Grossmann, P., Zeleznik, R., Kumar, A., Bussink, J., Gillies, R. J., Mak, R. H., & Aerts, H. J. W. L. (2018) · PLOS Medicine · doi:10.1371/journal.pmed.1002711 · Cited by 579 · see citing works
Decision Making and Problem Solving
Simon, H. A., Dantzig, G. B., Hogarth, R. M., Plott, C. R., Raiffa, H., Schelling, T. C., Shepsle, K. A., Thaler, R. H., Tversky, A., & Winter, S. G. (1987) · INFORMS Journal on Applied Analytics · doi:10.1287/inte.17.5.11 · Cited by 566 · see citing works
Emergency department triage prediction of clinical outcomes using machine learning models
Raita, Y., Goto, T., Faridi, M. K., Brown, D., Camargo, C. A., & Hasegawa, K. (2019) · Critical Care · doi:10.1186/s13054-019-2351-7 · Cited by 533 · see citing works
Questions for artificial intelligence in health care
Maddox, T. M., Rumsfeld, J. S., & Payne, P. R. O. (2019) · JAMA · doi:10.1001/jama.2018.18932 · Cited by 385 · see citing works
Systematic Review of Economic Impact Studies of Artificial Intelligence in Health Care
Wolff, J., Pauling, J. K., Keck, A., & Baumbach, J. (2019) · Journal of Medical Internet Research · doi:10.2196/16866 · Cited by 277 · see citing works
Kassahun, Y., Yu, B., Tibebu, A. T., Stoyanov, D., Giannarou, S., Metzen, J. H., & Vander Poorten, E. (2016) · International Journal of Computer Assisted Radiology and Surgery · doi:10.1007/s11548-015-1305-z · Cited by 238 · see citing works
Mobile Health Devices as Tools for Worldwide Cardiovascular Risk Reduction and Disease Management
Piette, J. D., List, J. M., Rana, G., Townsend, W. A., Striplin, D., & Heisler, M. (2015) · Circulation · doi:10.1161/circulationaha.114.008723 · Cited by 223 · see citing works
Makady, A., ten Ham, R. M. T., de Boer, A., Hillege, H. L., Klungel, O. H., & Goettsch, W. (2017) · Value in Health · doi:10.1016/j.jval.2016.12.003 · Cited by 206 · see citing works
Digital diabetes: Perspectives for diabetes prevention, management and research
Fagherazzi, G., & Ravaud, P. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.08.012 · Cited by 191 · see citing works
Artificial Intelligence and Health Technology Assessment: Anticipating a New Level of Complexity
Alami, H., Lehoux, P., Auclair, Y., de Guise, M., Gagnon, M., Shaw, J., Roy, D. A., Fleet, R. P., Ahmed, M. A. A., & Fortin, J. (2020) · Journal of Medical Internet Research · doi:10.2196/17707 · Cited by 180 · see citing works
Artificial intelligence and deep learning – Radiology's next frontier?
Mayo, R. C., & Leung, J. W. T. (2017) · Clinical Imaging · doi:10.1016/j.clinimag.2017.11.007 · Cited by 128 · see citing works
Kristensen, F. B., Husereau, D., Huić, M., Drummond, M., Berger, M. L., Bond, K., Augustovski, F., Booth, A., Bridges, J. F. P., Grimshaw, J., et al. (2018) · Value in Health · doi:10.1016/j.jval.2018.08.010 · Cited by 125 · see citing works
Spänig, S., Emberger‐Klein, A., Sowa, J., Canbay, A. E., Menrad, K., & Heider, D. (2019) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2019.101706 · Cited by 125 · see citing works
Marcos, M., Maldonado, J. A., Martínez‐Salvador, B., Boscá, D., & Robles, M. (2013) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2013.05.004 · Cited by 117 · see citing works
Makady, A., van Veelen, A., Jonsson, P. F., Moseley, O., d’Andon, A., de Boer, A., Hillege, H. L., Klungel, O. H., & Goettsch, W. (2017) · PharmacoEconomics · doi:10.1007/s40273-017-0596-z · Cited by 112 · see citing works
López-García, G., Jerez, J. M., Franco, L., & Veredas, F. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230536 · Cited by 105 · see citing works
Ethical analysis to improve decision-making on health technologies
Saarni, S. I. (2008) · Bulletin of the World Health Organization · doi:10.2471/blt.08.051078 · Cited by 104 · see citing works
Predictive Modeling of Implantation Outcome in an In Vitro Fertilization Setting
Uyar, A., Bener, A., & Ciray, H. N. (2014) · Medical Decision Making · doi:10.1177/0272989x14535984 · Cited by 91 · see citing works
Clinical decision support systems in the pediatric intensive care unit*
Mack, E. H., Wheeler, D. S., & Embi, P. J. (2009) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181936b23 · Cited by 76 · see citing works
HTA Implementation Roadmap in Central and Eastern European Countries
Kaló, Z., Gheorghe, A., Huić, M., Csanádi, M., & Kristensen, F. B. (2016) · Health Economics · doi:10.1002/hec.3298 · Cited by 76 · see citing works
Archetype-based conversion of EHR content models: pilot experience with a regional EHR system
Chen, R., Klein, G. O., Sundvall, E., et al. (2009) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-9-33 · Cited by 74 · see citing works
Wulff, A., Haarbrandt, B., Tute, E., Marschollek, M., Beerbaum, P., & Jack, T. (2018) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2018.04.012 · Cited by 74 · see citing works
What Makes Artificial Intelligence Exceptional in Health Technology Assessment?
Bélisle‐Pipon, J., Couture, V., Roy, M., Ganache, I., Goetghebeur, M. M., & Cohen, I. G. (2021) · Frontiers in Artificial Intelligence · doi:10.3389/frai.2021.736697 · Cited by 72 · see citing works
Remove obstacles to sharing health data with researchers outside of the European Union
Bentzen, H. B., Castro, R., Fears, R., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01460-0 · Cited by 69 · see citing works
Bangladesh’s digital health journey: reflections on a decade of quiet revolution
Azad, A. K., Khan, M. A. H., & Cruz, V. O. (2019) · WHO South-East Asia Journal of Public Health · doi:10.4103/2224-3151.264849 · Cited by 65 · see citing works
Nicod, E., & Kanavos, P. G. (2015) · Health Policy · doi:10.1016/j.healthpol.2015.11.007 · Cited by 60 · see citing works
Formalization of treatment guidelines using Fuzzy Cognitive Maps and semantic web tools
Papageorgiou, E. I., Roo, J. D., Huszka, C., et al. (2011) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2011.08.018 · Cited by 53 · see citing works
Wollersheim, D., Sari, A. K., & Rahayu, W. J. (2009) · Health Information Management Journal · doi:10.1177/183335830903800202 · Cited by 52 · see citing works
Practical engineering of knowledge-based systems
Bader, J., Edwards, J., Harris-Jones, C., & Hannaford, D. (1988) · Information and Software Technology · doi:10.1016/0950-5849(88)90019-5 · Cited by 45 · see citing works
Beletsi, A., Koutrafouri, V., Karampli, E., et al. (2018) · Value in Health Regional Issues · doi:10.1016/j.vhri.2018.08.002 · Cited by 43 · see citing works
Chung, Y., Salvador‐Carulla, L., Salinas-Pérez, J. A., et al. (2018) · Health Research Policy and Systems · doi:10.1186/s12961-018-0308-y · Cited by 42 · see citing works
CHALLENGES FACED IN TRANSFERRING ECONOMIC EVALUATIONS TO MIDDLE INCOME COUNTRIES
Drummond, M., Augustovski, F., Kaló, Z., et al. (2015) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462315000604 · Cited by 41 · see citing works
Edwards, J. S. (1992) · European Journal of Operational Research · doi:10.1016/0377-2217(92)90273-c · Cited by 39 · see citing works
Lin, F. P. Y., Pokorny, A. M. J., Teng, C. T., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2972-z · Cited by 39 · see citing works
Jenders, R. A., Corman, R., & Dasgupta, B. (2003) · PubMed · Cited by 35 · see citing works
Kopanitsa, G. (2017) · Methods of Information in Medicine · doi:10.3414/me16-01-0057 · Cited by 33 · see citing works
Pichón-Rivière, A., Augustovski, F., Martí, S. G., et al. (2012) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462312000074 · Cited by 27 · see citing works
REVIEWING TRANSFERABILITY IN ECONOMIC EVALUATIONS ORIGINATING FROM EASTERN EUROPE
Mandrik, O., Knies, S., Kaló, Z., & Severens, J. L. (2015) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462315000677 · Cited by 22 · see citing works
Technology and Women's Health in Developing Countries
MacCormack, C. P. (1989) · International Journal of Health Services · doi:10.2190/hjg0-wdut-898t-td05 · Cited by 14 · see citing works
Jabbour, S., Nishtar, S., Prabhakaran, D., Chockalingam, A., Achutti, A., Agrawal, A., Luna, M. A., Garofalo, F., & Wielgosz, A. T. (2003) · International Journal of Cardiology · doi:10.1016/s0167-5273(03)00093-7 · Cited by 13 · see citing works
Basch, P. F. (1993) · Tubercle and Lung Disease · doi:10.1016/0962-8479(93)90077-b · Cited by 10 · see citing works
Kaló, Z., Zemplenyi, A. T., Mölken, M. R., et al. (2020) · Croatian Medical Journal · doi:10.3325/cmj.2020.61.252 · Cited by 7 · see citing works
Self-citationNémeth, B., Kulchaitanaroaj, P., Lester‐George, A., et al. (2018) · Addiction · doi:10.1111/add.14092 · Cited by 5 · see citing works
Assessing Medical Technology in Less-Developed Countries
Sideman, S., & BenDak, J. D. (1997) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462300010734 · Cited by 4 · see citing works
A 3-step eHealth approach to transfer knowledge on HIV and sexual violence in developing countries
Hendra, V. Z., & Dartnall, L. (2010) · Studies in health technology and informatics · doi:10.3233/978-1-60750-588-4-471 · Cited by 3 · see citing works
Kulchaitanaroaj, P., Kaló, Z., West, R., et al. (2018) · BMC Health Services Research · doi:10.1186/s12913-018-2923-2 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [53]Journal of Information Technology & Politics Special Issue: Digital Media, Democracy and Civil Society in Central and Eastern Europe. Available online at: https://think.taylorandfrancis.com/special_issues/digital-media-democracy-civil-society-central-eastern-europe/ (accessed January 16, 2022).
Cited by
Sorted by citations
A Review of the Role of Artificial Intelligence in Healthcare
Al Kuwaiti, A., Nazer, K., Al-Reedy, A., Al-Shehri, S., Al-Muhanna, A., Subbarayalu, A. V., Al Muhanna, D., & Al-Muhanna, F. A. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13060951 · Cited by 915 · see citing works
Issa, W. B., Shorbagi, A., Al-Sharman, A., Rababa, M., Al-Majeed, K., Radwan, H., Refaat Ahmed, F., Al-Yateem, N., Mottershead, R., Abdelrahim, D. N., et al. (2024) · BMC Medical Education · doi:10.1186/s12909-024-06076-9 · Cited by 78 · see citing works
“Barriers could be then addressed and classified as data, methodologi- cal, technological, regulatory-, policy, and human-related factors [38].”
BackgroundO'Reilly, D., McGrath, J., & Martin-Loeches, I. (2024) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2023.10.001 · Cited by 55 · see citing works
Abogunrin, S., Muir, J. M., Zerbini, C., & Sarri, G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1454245 · Cited by 27 · see citing works
- Authors
- Tachkov, K., Zemplenyi, A., Kamusheva, M., Dimitrova, M., Siirtola, P., Pontén, J., Nemeth, B., Kalo, Z., & Petrova, G.
- Affiliations
- Medical University of Sofia (BG)
- Syreon Research Institute (Hungary) (HU)
- University of Oulu (FI)
- Corresponding author
- Petrova, Guenka
- ORCID
- Venue
- Frontiers in Public Health
- Publisher
- Frontiers Media SA
- Published
- 2022-07-14
- Volume
- 10
- Pages
- 921226-921226
- ISSN
- 2296-2565 (ISSN-L)
- PMC
- PMC9330148
- OpenAlex
- W4285386115
- Cited by
- 49
- References
- 55
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 13 · 2023: 13
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission (825162)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- artificial intelligence, health technology assessment, AI adoption barriers, Central and Eastern Europe, health policy, regulatory challenges, data quality, AI decision support
- MeSH terms
- Artificial Intelligence, Child, Humans, Technology Assessment, Biomedical
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review