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Cited by 184Neuroendocrine regulation and behaviorStress Responses and CortisolAnimal Behavior and Reproduction

Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice

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Curley, James P.·2009·Frontiers in Behavioral Neuroscience
DOI 10.3389/neuro.08.025.2009PMC PMC2759344
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Abstract

Across species there is evidence that the quality of the early social environment can have a profound impact on neurobiology and behavior. In the present study we explore the effect of communal rearing conditions (three dams with three litters per cage) during the postnatal period on offspring (F1) and grand-offspring (F2) anxiety-like and maternal behavior in Balb/c mice. Females rearing pups in communal nests exhibited increased levels of postpartum maternal care and communal rearing was found to abolish sex-differences in weaning weights. In adulthood, communally reared offspring were observed to display reduced anxiety-like behavior when placed in a novel environment. When rearing their own offspring under standard conditions, communally reared females demonstrated higher levels of motivation to retrieve pups, built higher quality nests, and exhibited higher levels of postpartum care compared to standard reared females. When exposed to an intruder male, communally reared females were more subordinate and less aggressive. F2 offspring of communally reared females were observed to engage in reduced anxiety-like behavior, have larger litter sizes and an increased frequency of nursing on PND 1. Analysis of neuropeptide receptor levels suggest that a communal rearing environment may exert sustained effects on behavior through modification of oxytocin and vasopressin (V1a) receptor densities. Though Balb-C mice are often considered "socially-incompetent" and high in anxiety-like behavior, our findings suggest that through enrichment of the postnatal environment, these behavioral and neuroendocrine deficits may be attenuated both within and across generations.

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  • In mice, communal rearing and alloparents increase the amount of maternal care the offspring receives, which is highly correlated with increased sociality.

    “in mice, communal rearing and alloparents are known to increase the amount of maternal care the offspring receives which is highly correlated with increased sociality (Branchi et al., 2006; Curley et al., 2009).”

    From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Curley et al., 2009

    The Results (F0 maternal behavior; page unavailable) report more nursing contact in communally rearing Balb/c females, supporting increased maternal care. The Introduction reports increased social competency in previously studied communally reared mice, but this paper does not establish that maternal care is highly correlated with increased sociality. (LLM, conf=0.87)

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Authors
Curley, J. P.
Affiliations
Columbia University (US)
Corresponding author
Curley, James P.
ORCID
Curley, James P.
Venue
Frontiers in Behavioral Neuroscience
Publisher
Frontiers Media SA
Published
2009
Volume
3
Pages
25-25
ISSN
1662-5153 (ISSN-L)
DOI
10.3389/neuro.08.025.2009
PMC
PMC2759344
OpenAlex
W2131025545
Cited by
184
References
92
Citations by year
2026: 6 · 2025: 6 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 10 · 2016: 18 · 2015: 12 · 2014: 13 · 2013: 14 · 2012: 16
FWCI
19.15
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Leverhulme Trust
  • National Institutes of Health (1dp2od001674-01)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords
communal rearing, transgenerational effects, anxiety-like behavior, maternal behavior, postpartum care, nest building, social dominance, aggression, litter size, oxytocin receptor, vasopressin V1a receptor, neuropeptide receptors, BALB/c mice, social enrichment

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