Social reward among juvenile mice
Open accessAbstract
Mammalian social relationships, such as mother–offspring attachments and pair bonds, can directly affect reproductive output. However, conspecifics approach one another in a comparatively broad range of contexts, so conceivably there are motivations for social congregation other than those underlying reproduction, parental care or territoriality. Here, we show that reward mediated by social contact is a fundamental aspect of juvenile mouse sociality. Employing a novel social conditioned place preference (SCPP) procedure, we demonstrate that social proximity is rewarding for juvenile mice from three inbred strains (A/J, C57BL/6J and DBA/2J), while mice from a fourth strain (BALB/cJ) are much less responsive to social contact. Importantly, this strain‐dependent difference was not related to phenotypic variability in exploratory behavior or contextual learning nor influenced by the genetic background associated with maternal care or social conditioning. Furthermore, the SCPP phenotype was expressed early in development (postnatal day 25) and did not require a specific sex composition within the conditioning group. Finally, SCPP responses resulted from an interaction between two specifiable processes: one component of the interaction facilitated approach toward environments that were associated with social salience, whereas a second component mediated avoidance of environmental cues that predicted social isolation. We have thus identified a genetically prescribed process that can attribute value onto conditions predicting a general form of social contact. To our knowledge, this is the first definitive evidence to show that genetic variation can influence a form of social valuation not directly related to a reproductive behavior.
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Mice and rats show conditioned preference for places previously paired with social contact.
“They show conditioned preference for regions previously associated with social contact44”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [44]
Modifications in the conditioned place preference assay have expanded its use to investigate the rewarding properties of prosocial interactions.
“More recently, modifications in the CPP assay have been made to expand its use to investigate the rewarding properties of prosocial interactions [40,41].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [40]
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- Authors
- Panksepp, J. B., & Lahvis, G. P.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Lahvis, G. P.
- ORCID
- Lahvis, G. P.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2006-11-16
- Volume
- 6
- Issue
- 7
- Pages
- 661-671
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC2040181
- OpenAlex
- W2088446168
- Cited by
- 248
- References
- 84
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 13 · 2023: 17 · 2022: 11 · 2021: 14 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 8 · 2016: 14 · 2015: 13 · 2014: 9 · 2013: 15 · 2012: 17
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Waisman Center (P30 HD03352)
- National Institutes of Health
- National Institute of Mental Health (T32MH018931)
- National Institute on Drug Abuse (R01DA022543)
- National Institute of General Medical Sciences (T32 GM07507, T32GM007507)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD03352., R03HD046716, P30HD003352)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- social reward, juvenile mice, social contact, inbred mouse strains, strain differences, social valuation, social isolation, genetic variation, social behavior, maternal care
- MeSH terms
- Aging, Animals, Conditioning, Operant, Female, Food, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Motivation, Reward, Sex Characteristics, Social Behavior, Social Environment, Species Specificity, Parenting, Mice
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