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Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa
Open accessAbstract
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).
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Cited by
A review on cholinesterase inhibitors for Alzheimer’s disease
Anand, P., & Singh, B. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0036-3 · Cited by 709
Neuroprotective Effects of Quercetin in Alzheimer’s Disease
Khan, H., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 537
Natural products as a source of Alzheimer's drug leads
Williams, P., Sorribas, A., & Howes, M.-J. R. (2011) · Nat. Prod. Rep. · doi:10.1039/c0np00027b · Cited by 404
Jabir, N. R., Khan, F. R., & Tabrez, S. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12971 · Cited by 187
Neuropharmacological Effects of Quercetin: A Literature-Based Review
Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665031 · Cited by 165
Metadata
- Authors
- Jung, M., & Park, M.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2007-09-03
- Volume
- 12
- Issue
- 9
- Pages
- 2130-2139
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2157461655
- Cited by
- 270
- References
- 0
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- gold
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