The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
Abstract
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic cells. Biofilm-based infections are, as a result, extremely difficult to cure. A wide range of molecular mechanisms contribute to the high degree of recalcitrance that is characteristic of biofilm communities. These mechanisms include, among others, interaction of antimicrobials with biofilm matrix components, reduced growth rates and the various actions of specific genetic determinants of antibiotic resistance and tolerance. Alone, each of these mechanisms only partially accounts for the increased antimicrobial recalcitrance observed in biofilms. Acting in concert, however, these defences help to ensure the survival of biofilm cells in the face of even the most aggressive antimicrobial treatment regimens. This review summarises both historical and recent scientific data in support of the known biofilm resistance and tolerance mechanisms. Additionally, suggestions for future work in the field are provided.
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Mechanisms of Candida Biofilm Drug Resistance
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Cited by
Marine Plastic Debris: A New Surface for Microbial Colonization
Wright, R. J., Erni-Cassola, G., Zadjelovic, V., Latva, M., & Christie-Oleza, J. A. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c02305 · Cited by 513
Fleitas Martínez, O., Cardoso, M. H., Ribeiro, S. M., & Franco, O. L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00074 · Cited by 304
Fungicide Resistance: Progress in Understanding Mechanism, Monitoring, and Management
Yin, Y., Miao, J., Shao, W., Liu, X., Zhao, Y., & Ma, Z. (2023) · Phytopathology® · doi:10.1094/phyto-10-22-0370-kd · Cited by 279
Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation
Versey, Z., da Cruz Nizer, W. S., Russell, E., Zigic, S., DeZeeuw, K. G., Marek, J. E., Overhage, J., & Cassol, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648554 · Cited by 253
Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms
Saxena, P., Joshi, Y., Rawat, K., & Bisht, R. (2019) · Indian Journal of Microbiology · doi:10.1007/s12088-018-0757-6 · Cited by 216
Metadata
- Authors
- Hall, C. W., & Mah, T.-F.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-25
- Volume
- 41
- Issue
- 3
- Pages
- 276-301
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2603755876
- Cited by
- 1,696
- References
- 14
- FWCI
- 37.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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