The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects
Open accessAbstract
It is accepted that the medicinal use of complex mixtures of plant-derived bioactive compounds is more effective than purified bioactive compounds due to beneficial combination interactions. However, synergy and antagonism are very difficult to study in a meticulous fashion since most established methods were designed to reduce the complexity of mixtures and identify single bioactive compounds. This study represents a critical review of the current scientific literature on the combined effects of plant-derived extracts/bioactive compounds. A particular emphasis is provided on the identification of antimicrobial synergistic or antagonistic combinations using recent metabolomics methods and elucidation of approaches identifying potential mechanisms that underlie their interactions. Proven examples of synergistic/antagonistic antimicrobial activity of bioactive compounds are also discussed. The focus is also put on the current challenges, difficulties, and problems that need to be overcome and future perspectives surrounding combination effects. The utilization of bioactive compounds from medicinal plant extracts as appropriate antimicrobials is important and needs to be facilitated by means of new metabolomics technologies to discover the most effective combinations among them. Understanding the nature of the interactions between medicinal plant-derived bioactive compounds will result in the development of new combination antimicrobial therapies.
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1 retracted
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Synergy, antagonism, and what the chequerboard puts between them
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Cited by
Centella asiatica: Advances in Extraction Technologies, Phytochemistry, and Therapeutic Applications
Hein, Z. M., Gopalakrishna, P. K., Kanuri, A. K., Thomas, W., Hussan, F., Naik, V. R., Shantakumari, N., Che Ramli, M. D., Mohd Moklas, M. A., Che Mohd Nassir, C. M. N., et al. (2025) · Life · doi:10.3390/life15071081 · Cited by 33
Metadata
- Authors
- Vaou, N., Stavropoulou, E., Voidarou, C. (., Tsakris, Z., Rozos, G., Tsigalou, C., & Bezirtzoglou, E.
- Venue
- Antibiotics
- Publisher
- MDPI AG
- Published
- 2022-07-28
- Volume
- 11
- Issue
- 8
- Pages
- 1014
- ISSN
- 2079-6382 (ISSN-L)
- OpenAlex
- W4288434000
- Cited by
- 406
- References
- 139
- FWCI
- 33.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects. https://app.cochat.ai/papers/10.3390/antibiotics11081014
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- Vaou, N., Stavropoulou, E., Voidarou, C. (., Tsakris, Z., Rozos, G., Tsigalou, C., & Bezirtzoglou, E. (2022). Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects. Antibiotics. https://doi.org/10.3390/antibiotics11081014
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
