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Cited by 31Mangiferin and Mango ExtractsPhytochemicals and Antioxidant ActivitiesPsidium guajava Extracts and Applications

Mangifera indica L. Leaves as a Potential Food Source of Phenolic Compounds with Biological Activity

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Sferrazzo, Giuseppe, Palmeri, Rosa, Restuccia, Cristina, Parafati, Lucia, Siracusa, Laura, Spampinato, Mariarita, Carota, Giuseppe, Distefano, Alfio +6 more·2022·Antioxidants
DOI 10.3390/antiox11071313PMC PMC9312095
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Abstract

It is well recognized that functional foods rich in antioxidants and antiinflammation agents including polyphenols, probiotics/prebiotics, and bioactive compounds have been found to have positive effects on the aging process. In particular, fruits play an important role in regular diet, promoting good health and longevity. In this study, we investigated on biological properties of extract obtained from Mangifera indica L. leaves in preclinical in vitro models. Specifically, the profile and content of bioactive compounds, the antimicrobial potential toward food spoilage and pathogenic bacterial species, and the eventually protective effect in inflammation were examined. Our findings revealed that MLE was rich in polyphenols, showing a content exclusively in the subclass of benzophenone/xanthone metabolites, and these phytochemical compounds demonstrated the highest antioxidant capacity and greatest in vitro antibacterial activity toward different bacterial species such as Bacillus cereus, B. subtilis, Pseudomonas fluorescens, Staphylococcus aureus, and St. haemolyticus. Furthermore, our data showed an in vitro anti-inflammatory, antioxidant, and antifibrotic activity.

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  • Mango leaf extract treatment in humans reduced gene expression of pro-inflammatory enzymes and cytokines IL-1β, IL-6, TNFα, and COX2.

    “This activity was confirmed by using MLE treatment in humans, reducing the gene expression of pro-inflammatory enzymes and cytokines such as IL-1β, IL-6, TNFα, and COX2.”

    From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [67]

    Section 3.6 reports that MLE reduced expression of IL-1β, IL-6, TNF-α, and COX-2 in LPS-treated macrophages. But Sections 2.8 and 3.6 describe in vitro experiments using human-derived cell lines, not MLE treatment in humans. Page numbers were not provided in the passages. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • MLE downregulated LPS-induced pro-inflammatory genes COX-2, IL6, IL-1β, and TNF-α to regular levels in macrophages.

    “The use of LPS caused an increase in pro-inflammatory genes such as cyclooxygenase-2 (COX-2), interleukin-6 (IL6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), which was downregulated to regular levels by the use of MLE.”

    From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [67]

  • MLE reduced pro-inflammatory cytokine genes IL-1β, IL-6, and COX-2 in hepatic stellate cells treated with LPS.

    “The extract also caused a reduction in pro-inflammatory cytokines genes, IL-1β, IL-6, and COX-2 in hepatic stellate cells treated with LPS [67].”

    From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [67]

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Authors
Sferrazzo, G., Palmeri, R., Restuccia, C., Parafati, L., Siracusa, L., Spampinato, M., Carota, G., Distefano, A., Di Rosa, M., Tomasello, B., Costantino, A., Gulisano, M., Li Volti, G., & Barbagallo, I.
Affiliations
  • University of Catania (IT)
  • Istituto di Chimica Biomolecolare (IT)
  • Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 87, 95125 Catania, Italy
Corresponding author
Barbagallo, Ignazio
ORCID
Venue
Antioxidants
Publisher
MDPI AG
Published
2022-06-30
Volume
11
Issue
7
Pages
1313
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox11071313
PMC
PMC9312095
OpenAlex
W4283744514
Cited by
31
References
1
Citations by year
2026: 5 · 2025: 11 · 2024: 5 · 2023: 8 · 2022: 2
FWCI
6.79
Type
journal article
Language
en
Open access
Licence
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • University of Catania PIA.CE.RI (57722172123, F/200110/02/X45)
  • Italian Ministry of Economic Development M.I.S.E (57722172123, F/200110/02/X45)
  • Italian Ministry of Education University and Research (MIUR) (57722172123, F/200110/02/X45)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Psidium guajava Extracts and Applications
Keywords
mango, mango leaf extract, phenolic compounds, xanthones, antioxidant activity, antibacterial activity, spoilage bacteria, anti-inflammatory activity, antifibrotic activity, functional foods, bioactive compounds

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