The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Oxidative Stress and Antioxidants in Neurodegenerative Disorders
Open accessAbstract
Neurodegenerative disorders constitute a substantial proportion of neurological diseases with significant public health importance. The pathophysiology of neurodegenerative diseases is characterized by a complex interplay of various general and disease-specific factors that lead to the end point of neuronal degeneration and loss, and the eventual clinical manifestations. Oxidative stress is the result of an imbalance between pro-oxidant species and antioxidant systems, characterized by an elevation in the levels of reactive oxygen and reactive nitrogen species, and a reduction in the levels of endogenous antioxidants. Recent studies have increasingly highlighted oxidative stress and associated mitochondrial dysfunction to be important players in the pathophysiologic processes involved in neurodegenerative conditions. In this article, we review the current knowledge of the general effects of oxidative stress on the central nervous system, the different specific routes by which oxidative stress influences the pathophysiologic processes involved in Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis and Huntington’s disease, and how oxidative stress may be therapeutically reversed/mitigated in order to stall the pathological progression of these neurodegenerative disorders to bring about clinical benefits.
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Cites
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Cited by
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 700
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 359
Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases
Yang, J., Luo, J., Tian, X., Zhao, Y., Li, Y., & Wu, X. (2024) · Antioxidants · doi:10.3390/antiox13040394 · Cited by 259
Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications
Tian, J., Han, Z., Song, D., Peng, Y., Xiong, M., Chen, Z., Duan, S., & Zhang, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s444582 · Cited by 246
Erkartal, H. Ş., Toy, S., Secgin, S., & Secgin, Y. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04723-z · Cited by 6
Metadata
- Authors
- Olufunmilayo, E. O., Gerke-Duncan, M. B., & Holsinger, R. M. D.
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2023-02-18
- Volume
- 12
- Issue
- 2
- Pages
- 517
- ISSN
- 2076-3921 (ISSN-L)
- OpenAlex
- W4321372477
- Cited by
- 670
- References
- 49
- FWCI
- 65.86
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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