Antioxidant Effects of Walnut (Juglans regia L.) Kernel and Walnut Septum Extract in a D-Galactose-Induced Aging Model and in Naturally Aged Rats
Open accessAbstract
Antioxidant dietary intervention is considered a potential strategy in delaying age-related dysfunctions. In this study of 56 days, we assessed the antioxidant effects of walnut kernel (WK) and walnut septum extract (WSE) in a D-galactose (D-gal)-induced aging model and in a naturally aged rat model. Young Wistar rats, treated with D-gal (1200 mg/week), and old rats received daily WK or WSE added to the feed. After 8 weeks, blood, liver, and brain samples were collected and hematological, biochemical, oxidative stress biomarkers, histological, and immunohistochemical analyses were performed. Moreover, acetylcholinesterase activity was investigated in brain homogenates. The outcomes demonstrated significant improvement in cellular antioxidant activity and/or decrease of reactive oxygen species, advanced glycation end products, nitric oxide, malondialdehyde, or increase of glutathione after WK or WSE intake in both models. Additionally, WSE showed hypoglycemic effect, and both WK and WSE lowered acetylcholinesterase activity. Both diets could protect neurons against the induced senescence and could reverse the pathological conditions in the physiological aged brain. Thus, dietary supplementation with WK or WSE can maintain the liver and brain health and reduce the risk of age-related diseases, as well as delaying the onset of aging processes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GSH levels can be used as a biomarker for the oxidative status of the cell.
“As GSH levels can be used as a biomarker for the oxidative status of the cell [176,181,182,183]”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [182]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rahman, I., Kode, A., & Biswas, S. K. (2006) · Nature Protocols · doi:10.1038/nprot.2006.378 · Cited by 2,262 · see citing works
The Laboratory Rat: Relating Its Age With Human's.
(2013) · Europe PMC (PubMed Central) · Cited by 1,705 · see citing works
Anti-inflammatory effects of flavonoids
Maleki, S. J., Crespo, J. F., & Cabanillas, B. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125124 · Cited by 1,276 · see citing works
d-Galactose-induced accelerated aging model: an overview
Azman, K. F., & Zakaria, R. (2019) · Biogerontology · doi:10.1007/s10522-019-09837-y · Cited by 553 · see citing works
Oliveira, I. V., Sousa, A., Ferreira, I. C. F. R., Bento, A. A., Estevinho, L. M., & Pereira, J. A. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.03.017 · Cited by 484 · see citing works
Review of nut phytochemicals, fat-soluble bioactives, antioxidant components and health effects
Alasalvar, C., & Bolling, B. W. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003729 · Cited by 382 · see citing works
Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
OECD (2009) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264070684-en · Cited by 350 · see citing works
Klopfleisch, R. (2013) · BMC Veterinary Research · doi:10.1186/1746-6148-9-123 · Cited by 304 · see citing works
Rehman, S. U., Shah, S. A., Ali, T., Chung, J. I., & Kim, M. O. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9604-5 · Cited by 285 · see citing works
Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior
Joseph, J. A., Shukitt‐Hale, B., & Willis, L. (2009) · Journal of Nutrition · doi:10.3945/jn.109.108266 · Cited by 202 · see citing works
Jabir, N. R., Khan, F. R., & Tabrez, S. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12971 · Cited by 187 · see citing works
Chen, P., Chen, F., & Zhou, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-19732-0 · Cited by 175 · see citing works
Viguiliouk, E., Kendall, C. W. C., Mejía, S. B., Cozma, A. I., Ha, V., Mirrahimi, A., Jayalath, V. H., Augustin, L. S. A., Chiavaroli, L., Leiter, L. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103376 · Cited by 171 · see citing works
Gorji, N., Moeini, R., & Memariani, Z. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.003 · Cited by 154 · see citing works
Antioxidant activity and phenolic content of fresh and dry nuts with or without the seed coat
Arcan, İ., & Yemenicioğlu, A. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.10.016 · Cited by 144 · see citing works
Xu, L., Xie, Y., Gui, S., Zhang, X., Mo, Z., Sun, C., Li, C., Luo, D., Zhang, Z., Su, Z., et al. (2016) · Food & Function · doi:10.1039/c6fo01057a · Cited by 130 · see citing works
Mouser, P. E., Head, E., Ha, K.-H., & Rohn, T. T. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050798 · Cited by 121 · see citing works
Yu, Y., Bai, F., Wang, W., Liu, Y., Yuan, Q., Qu, S., Zhang, T., Tian, G., Li, S., Li, D., et al. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.020 · Cited by 119 · cited 1× · see citing works
“As previously shown, excess intracellular D-gal leads to ROS overproduction (Figure 6), a major cause of intracellular damage and a possible mechanism involved in D-gal-induced aging [39].”
BackgroundAntiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat
Garg, G., Singh, S., Singh, A. K., & Rizvi, S. I. (2016) · Rejuvenation Research · doi:10.1089/rej.2016.1883 · Cited by 116 · see citing works
Mocan, A., Schafberg, M., Crișan, G., & Rohn, S. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.05.007 · Cited by 110 · see citing works
Self-citationCancer Chemoprevention by Phytochemicals: Nature’s Healing Touch
Zubair, H., Azim, S., Ahmad, A., Khan, M. A., Patel, G. K., Singh, S., & Singh, A. P. (2017) · Molecules · doi:10.3390/molecules22030395 · Cited by 105 · see citing works
Damiano, S., Forino, M., De, A., Vitali, L. A., Lupidi, G., & Taglialatela‐Scafati, O. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.02.141 · Cited by 91 · see citing works
Vieira, V. A. A., Prieto, M. A., Barros, L., Coutinho, J. A. P., Ferreira, O., & Ferreira, I. C. F. R. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.06.012 · Cited by 84 · see citing works
Rusu, M. E., Gheldiu, A.-M., Mocan, A., Moldovan, C., Popa, D., Tomuță, I., & Vlase, L. (2018) · Molecules · doi:10.3390/molecules23112814 · Cited by 81 · see citing works
Self-citationMocan, A., Zengin, G., Uysal, A., Güneş, E., Mollica, A., Değirmenci, N. S., Alpsoy, L., & Aktümsek, A. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.05.010 · Cited by 75 · see citing works
Self-citationKenawy, S. M., Hegazy, R. R., Hassan, A. H. M., El-Shenawy, S. M. A., Gomaa, N., Zaki, H. F., & Attia, A. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183565 · Cited by 74 · see citing works
Health Benefits of Nut Consumption in Middle-Aged and Elderly Population
Rusu, M. E., Mocan, A., Ferreira, I. C. F. R., & Popa, D. (2019) · Antioxidants · doi:10.3390/antiox8080302 · Cited by 70 · see citing works
Self-citationWalnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects
Rusu, M. E., Fizeșan, I., Pop, A., Mocan, A., Gheldiu, A.-M., Babotă, M., Vodnar, D. C., Jurj, A. M., Berindan‐Neagoe, I., Vlase, L., et al. (2020) · Molecules · doi:10.3390/molecules25092187 · Cited by 70 · see citing works
Self-citationZhang, X., Wu, J., Lin, Z., Yuan, Q., Li, Y., Liang, J.-L., Zhan, J. Y.-X., Xie, Y., Su, Z., & Liu, Y. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.12.050 · Cited by 65 · see citing works
Poulose, S. M., Bielinski, D. F., & Shukitt‐Hale, B. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.009 · Cited by 61 · see citing works
Rusu, M. E., Fizeșan, I., Pop, A., Gheldiu, A.-M., Mocan, A., Crișan, G., Vlase, L., Loghin, F., Popa, D., & Tomuță, I. (2019) · Antioxidants · doi:10.3390/antiox8100460 · Cited by 61 · see citing works
Self-citationCurcumin and piperine abrogate lipid and protein oxidation induced by d-galactose in rat brain
Banji, D., Banji, O. J. F., Dasaroju, S., & Kranthi Kumar, C. H. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.023 · Cited by 60 · see citing works
Rusu, M. E., Gheldiu, A.-M., Mocan, A., Vlase, L., & Popa, D. (2018) · Food & Function · doi:10.1039/c7fo01967j · Cited by 59 · see citing works
Self-citationBenefits of tree nut consumption on aging and age-related diseases: Mechanisms of actions
Rusu, M. E., Simedrea, R., Gheldiu, A.-M., Mocan, A., Vlase, L., Popa, D., & Ferreira, I. C. F. R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.006 · Cited by 53 · see citing works
Self-citationLei, L., Ou, L., & Yu, X. (2016) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2015.06.023 · Cited by 51 · see citing works
Tucker, L. A. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0876-5 · Cited by 51 · see citing works
High‐fat diet protects the blood–brain barrier in an Alzheimer's disease mouse model
Goldman, S. E., Goez, D., Last, D., Naor, S., Zaltsman, S. L., Sharvit‐Ginon, I., Atrakchi, D., Shemesh, C., Twitto‐Greenberg, R., Tsach, S., et al. (2018) · Aging Cell · doi:10.1111/acel.12818 · Cited by 50 · see citing works
Mocan, A., Fernandes, Â. S. F., Barros, L., Crișan, G., Smiljkovic, M. S., Sokóvić, M., & Ferreira, I. C. F. R. (2017) · Food & Function · doi:10.1039/c7fo01514c · Cited by 49 · see citing works
Self-citationAbbassi, Y. A., Mohammadi, M. T., Foroshani, M. S., & Sarshoori, J. R. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.067 · Cited by 45 · see citing works
Pycia, K., Kapusta, I. T., & Jaworska, G. (2019) · Molecules · doi:10.3390/molecules24162936 · Cited by 44 · see citing works
Pandareesh, M. D., Chauhan, V. P. S., & Chauhan, A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180361 · Cited by 43 · see citing works
Feng, L., Wang, X., Peng, F., Liao, J., Nai, Y., Lei, H., Li, M., & Xu, H. (2018) · Molecules · doi:10.3390/molecules23092308 · Cited by 42 · see citing works
Porfire, A. S., Leucuta, S. E., Kiss, B., Loghin, F., & Pârvu, A. E. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.03.011 · Cited by 40 · see citing works
Self-citationBlueberry treatment attenuates D ‐galactose‐induced oxidative stress and tissue damage in rat liver
Çoban, J., Kalaz, E. B., Küçükgergin, C., Aydın, A., Doğan‐Ekici, I., Doğru‐Abbasoğlu, S., & Uysal, M. (2013) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12096 · Cited by 39 · see citing works
Cardoso, A., Magano, S., Marrana, F., & Andrade, J. P. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1684 · Cited by 39 · see citing works
Koh, S., Choi, Y. I., Kim, Y., Kim, Y. S., Choi, S., Kim, J. W., Kim, B. G., & Lee, K. L. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1704-3 · Cited by 36 · see citing works
Fisher, D. R., Poulose, S. M., Bielinski, D. F., & Shukitt‐Hale, B. (2014) · Nutritional Neuroscience · doi:10.1179/1476830514y.0000000150 · Cited by 31 · see citing works
Choi, J. G., Park, G., Kim, H. T., Oh, D., Kim, H., & Oh, M. G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010108 · Cited by 28 · see citing works
Influence of Genista tinctoria L. or methylparaben on subchronic toxicity of bisphenol A in rats.
Popa, D., Bolfă, P., Kiss, B., Vlase, L., Păltinean, R., Pop, A., Cătoi, C., Crișan, G., & Loghin, F. (2014) · PubMed · doi:10.3967/bes2014.021 · Cited by 27 · see citing works
Self-citationBleomycin-induced pulmonary toxicopathological changes in rats and its prevention by walnut extract
Beigh, S., Rashid, H., Sharma, S., Parvez, S., & Raisuddin, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.124 · Cited by 25 · see citing works
Vedeanu, N. S., Voica, C., Măgdaş, D. A., Kiss, B., Ștefan, M.-G., Simedrea, R., Georgiu, C., Berce, C., Voștinaru, O., Boros, R., et al. (2019) · Environmental Chemistry · doi:10.1071/en19249 · Cited by 23 · see citing works
Self-citationSong, E.-K., Park, H., & Kim, H. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.09.011 · Cited by 19 · see citing works
Xia, X., Xing, Y., Li, G., Wu, J., & Kan, J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.036 · Cited by 16 · see citing works
Acute and Subchronic Toxicity Study of the Median Septum of Juglans regia in Wistar Rats
Ravanbakhsh, A., Mahdavi, M., Jalilzadeh‐Amin, G., Javadi, S., Maham, M., Mohammadnejad, D., & Rashidi, M. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.068 · Cited by 16 · see citing works
Dehghani, F., Mashhoody, T., & Panjehshahin, M. R. (2012) · Iranian journal of pharmacology & therapeutics · Cited by 14 · see citing works
Noritake, K., Ikeda, T., Ito, K., Miwa, Y., Senuma, M., Takashima, H., Tateishi, T., Hisada, S., & Maki, E. (2013) · The Journal of Toxicological Sciences · doi:10.2131/jts.38.847 · Cited by 13 · see citing works
Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes
Gheldiu, A.-M., Popa, D., Loghin, F., & Vlase, L. (2015) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(15)30115-x · Cited by 10 · see citing works
Self-citationCurcumin effect on nitro-oxidative stress in ligature-induced rat periodontitis
Boşca, A. B., Dinte, E., Colosi, H. A., Ilea, A., Câmpian, R.-S., Uifălean, A., & Pârvu, A. E. (2015) · Cited by 10 · see citing works
Ramishvili, L., Gordeziani, M., Tavdishvili, E., Bedineishvili, N., Dzidziguri, D., & Kotrikadze, N. (2016) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Walnut Fruit Processing Equipment: Academic Insights and Perspectives
Liu, M., Li, C., Cao, C., Wang, L., Li, X., Che, J., Yang, H., Zhang, X., Zhao, H., He, G., et al. (2021) · Food Engineering Reviews · doi:10.1007/s12393-020-09273-6 · Cited by 152 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases
Popa, D., Bigman, G., & Rusu, M. E. (2021) · Antioxidants · doi:10.3390/antiox10040566 · Cited by 129 · see citing works
Self-citationBanc, R., Rusu, M. E., Filip, L. A., & Popa, D. (2023) · Foods · doi:10.3390/foods12020270 · Cited by 116 · see citing works
Self-citationYuan, H., Xu, Y., Luo, Y., Zhang, J., Zhu, X., & Xiao, J. (2022) · Aging Cell · doi:10.1111/acel.13686 · Cited by 74 · see citing works
Bourais, I., Elmarrkechy, S., Taha, D., Mourabit, Y., Bouyahya, A., Elyadini, M., Machich, O., Hajjaji, S. E., Boury, H. E., Dakka, N., et al. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2094401 · Cited by 69 · see citing works
Zhu, K., Ma, J., Cong, J., Zhang, T., Lei, H., Xu, H., Luo, Z., & Li, M. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104264 · Cited by 63 · see citing works
Zhang, M., Xu, Y., Xiang, J., Zheng, B., Yuan, Y., Luo, D., & Fan, J. (2021) · Journal of Cereal Science · doi:10.1016/j.jcs.2021.103217 · Cited by 60 · see citing works
Qian, J., Wang, X., Ji, C., Zhang, W., Lu, C., & Chen, X. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135963 · Cited by 60 · see citing works
Pop, A., Fizeșan, I., Vlase, L., Rusu, M. E., Cherfan, J., Babotă, M., Gheldiu, A.-M., Tomuță, I., & Popa, D. (2021) · Antioxidants · doi:10.3390/antiox10040607 · Cited by 55 · see citing works
Self-citationThe Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
Zimmerman, B., Kundu, P., Rooney, W. D., & Raber, J. (2021) · Molecules · doi:10.3390/molecules26113406 · Cited by 53 · see citing works
Elouafy, Y., Idrissi, Z. L. E., Yadini, A. E., Harhar, H., Alshahrani, M. M., Awadh, A. A. A., Goh, K. W., Ming, L. C., Bouyahya, A., & Tabyaouı, M. (2022) · Molecules · doi:10.3390/molecules27227693 · Cited by 50 · see citing works
Phytochemicals and Biological Activities of Walnut Septum: A Systematic Review
Mateș, L., Rusu, M. E., & Popa, D. (2023) · Antioxidants · doi:10.3390/antiox12030604 · Cited by 47 · see citing works
Self-citationFizeșan, I., Rusu, M. E., Georgiu, C., Pop, A., Ștefan, M.-G., Muntean, D. M., Mirel, S., Voștinaru, O., Kiss, B., & Popa, D. (2021) · Antioxidants · doi:10.3390/antiox10010119 · Cited by 47 · see citing works
Self-citationWalnut (J. regia) Agro-Residues as a Rich Source of Phenolic Compounds
Medič, A., Jakopič, J., Solar, A., Hudina, M., & Veberič, R. (2021) · Biology · doi:10.3390/biology10060535 · Cited by 45 · see citing works
Antioxidants in Age-Related Diseases and Anti-Aging Strategies
Rusu, M. E., Fizeșan, I., Vlase, L., & Popa, D. (2022) · Antioxidants · doi:10.3390/antiox11101868 · Cited by 48 · see citing works
Self-citationAlasalvar, C., Huang, G., Bolling, B. W., Jantip, P., Pegg, R. B., Wong, X. K., Chang, S. K., Pelvan, E., de Camargo, A. C., Mandalari, G., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142222 · Cited by 40 · see citing works
d ‐Galactose induced early aging in human erythrocytes: Role of band 3 protein
Remigante, A., Spinelli, S., Trichilo, V., Loddo, S., Sarikas, A., Pusch, M., Dossena, S., Marino, A., & Morabito, R. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30632 · Cited by 37 · see citing works
Liu, X., DILXAT, T., Shi, Q., Qiu, T., & Lin, J. (2022) · Gene · doi:10.1016/j.gene.2022.146348 · Cited by 34 · see citing works
Banc, R., Rusu, M. E., Filip, L. A., & Popa, D. (2023) · Plants · doi:10.3390/plants12223873 · Cited by 35 · see citing works
Self-citationRoles of tRNA metabolism in aging and lifespan
Zhou, Z. G., Sun, B., Yu, D., & Bian, M. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03838-x · Cited by 32 · see citing works
Elouafy, Y., Mortada, S., Yadini, A. E., Hnini, M., Aalilou, Y., Harhar, H., Khalid, A., Abdalla, A. N., Bouyahya, A., Faouzi, M. E. A., et al. (2023) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000325 · Cited by 28 · see citing works
Lin, L., Li, C., Li, T., Zheng, J., Shu, Y., Zhang, J., Shen, Y., & Ren, D. (2023) · Food Frontiers · doi:10.1002/fft2.210 · Cited by 27 · see citing works
Pop, C., Ștefan, M.-G., Muntean, D. M., Stoicescu, L., Adrian Florin, G. A. L., Kiss, B., Morgovan, C., Loghin, F., Rochette, L., Lauzier, B., et al. (2020) · Antioxidants · doi:10.3390/antiox9111073 · Cited by 25 · see citing works
Self-citationNacre Extract from Pearl Oyster Shell Prevents D-Galactose-Induced Brain and Skin Aging
Yamamoto, H., Shimomura, N., Oura, K., & Hasegawa, Y. (2023) · Marine Biotechnology · doi:10.1007/s10126-022-10192-2 · Cited by 26 · see citing works
Stefanucci, A., Marinaccio, L., Llorent-Martínez, E. J., Zengin, G., Bender, O., Dogan, R., Atalay, A., Adegbite, O., Ojo, F. O., Onaolapo, A. Y., et al. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103539 · Cited by 22 · see citing works
Pan, W., Wang, Y., Bai, X., Yin, Y., Dai, L., Zhou, H., Wu, Q., & Wang, Y. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00546-5 · Cited by 22 · see citing works
Genovese, C., Cambria, M. T., D’Angeli, F., Addamo, A. P., Malfa, G. A., Siracusa, L., Pulvirenti, L., Anfuso, C. D., Lupo, G., & Salmeri, M. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5130 · Cited by 21 · see citing works
Solcan, M.-B., Vlase, A.-M., Marc, G., Muntean, D. M., Casian, T., Nadăş, G., Novac, C. Ș., Popa, D., & Vlase, L. (2024) · Antibiotics · doi:10.3390/antibiotics13121118 · Cited by 19 · see citing works
Self-citationMeimei, C., Fei, Z., Xu, W., Lei, H., Zhenqiang, H., Rongjun, Y., Qiang, Z., Qiuyang, L., Xiaozhen, L., Yuan, Y., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118943 · Cited by 18 · see citing works
Ezzat, M. I., Issa, M. Y., Sallam, I. E., Zaafar, D. K., Khalil, H. M. A., Mousa, M. R., Sabry, D., Gawish, A. Y., Elghandour, A. H., & Mohsen, E. (2022) · Food & Function · doi:10.1039/d2fo00645f · Cited by 18 · see citing works
Anti‐skin aging effect of sea buckthorn proanthocyanidins in D‐galactose‐induced aging mice
Liu, X., Yuen, M., Yuen, T., Yuen, H., Wang, M., & Peng, Q. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3823 · Cited by 18 · see citing works
Hong, Q., Geng, S., Ji, J., Ye, Y., Xu, D., Zhang, Y., & Sun, X. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104422 · Cited by 17 · see citing works
El‐Sherbiny, M., Atef, H., Helal, G. M., Al‐Serwi, R. H., Elkattawy, H. A., Shaker, G. A., Said, E., Abulfaraj, M. W., Albalawi, M. A., & Elsherbiny, N. M. (2022) · Antioxidants · doi:10.3390/antiox11112150 · Cited by 17 · see citing works
Cintesun, S., Özman, Z., Koçyiğit, A., Mansuroğlu, B., & Kocaçalışkan, İ. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102327 · Cited by 13 · see citing works
Astounding the synergistic interplay of walnuts in combating inflammation and oxidative damage
Shabbir, M. A., Nawaz, M. F., Tariq, T., Khan, M. R., Saeed, H., Abdi, G., & Aadil, R. M. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106292 · Cited by 11 · see citing works
Wang, J., Wang, H., Yu, J., Wang, J., Cui, Q., Hou, L., & Tian, J. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116440 · Cited by 11 · see citing works
Recent advances on the effect of nut consumption on cognitive improvement
Wu, W., Niu, B., Peng, L., Chen, Q., Chen, H., Chen, H., Xia, W., Jin, L. X., Simal‐Gándara, J., & Gao, H. (2023) · Food Frontiers · doi:10.1002/fft2.298 · Cited by 10 · see citing works
Firdaus, Z., Gutti, G., Ganeshpurkar, A., Kumar, A., Krishnamurthy, S., Singh, S. K., & Singh, T. D. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117888 · Cited by 9 · see citing works
Rahbardar, M. G., Rashki, M., & Boskabady, M. H. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71081 · Cited by 9 · see citing works
Salemi, S., Zamanian, M. Y., Giménez‐Llort, L., Jalali, Z., Mahmoodi, M., Golmohammadi, M., Kaeidi, A., Taghipour, Z., Khademalhosseini, M., Modanloo, M., et al. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3422 · Cited by 9 · see citing works
Walnut Kernel Oil and Defatted Extracts Enhance Mesenchymal Stem Cell Stemness and Delay Senescence
Elsied, M. A., Sharawi, Z. W., Al-Amrah, H., Hegazy, R. A., Mohamed, A. E.-S., Saleh, R. M., El-Kholy, S. S., Farrag, F. A., Fayed, M. H., & El‐Magd, M. A. (2023) · Molecules · doi:10.3390/molecules28176281 · Cited by 9 · see citing works
Pai, V., Singh, B. N., & Singh, A. K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102753 · Cited by 8 · see citing works
Colon-targeted delivery systems of budesonide as second-line therapy in inflammatory bowel disease
Sardou, H. S., Abbaspour, M., Akhgari, A., Kesharwani, P., & Sahebkar, A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105472 · Cited by 8 · see citing works
Chronic oral d-galactose intake provokes age-related changes in the rat prefrontal cortex
Martinović, J., Kontić, M. Z., Dragić, M., Todorović, A., Stojanović, I. G., Mitrović, N., Grković, I., & Drakulić, D. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114072 · Cited by 8 · see citing works
Walnut extract protects against hepatic inflammation and toxicity induced by a high‐fat diet
Ali, G., Zeb, A., Usman, M., & Al‐Babili, S. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4405 · Cited by 6 · see citing works
Gurumayum, N., Devi, M. B., Khound, P., Bhattacharya, A., Sarma, H., Khan, M. R., & Devi, R. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.016 · Cited by 6 · see citing works
Жумахановна, С. М., Dalabayev, А., Saduakas, A., Nurysh, A., Акжанов, Н., & Yakiyayeva, M. A. (2023) · Potravinarstvo Slovak Journal of Food Sciences · doi:10.5219/1862 · Cited by 6 · see citing works
Samei, M., Dowlatkhahi, N., Boozari, M., & Hosseinzadeh, H. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.3972 · Cited by 6 · see citing works
Javed, K., Rakha, A., Butt, M. S., & Faisal, M. N. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14082 · Cited by 6 · see citing works
Effect of Antioxidant Therapy on Oxidative Stress in Vivo
Pasini, A. M. F., & Cominacini, L. (2021) · Antioxidants · doi:10.3390/antiox10030344 · Cited by 5 · see citing works
Singh, H., Mohanto, S., Bhunia, A., Singh, B. K., Chauhan, K., Kumar, A., Mishra, A., Mishra, A. K., & Shrivastav, A. (2024) · Antioxidants · doi:10.1002/9781394270576.ch8 · Cited by 5 · see citing works
Alharbi, A. M., Albasyouni, S., Al-Shaebi, E., Quraishy, S. A., & Abdel-Gaber, R. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1537686 · Cited by 4 · see citing works
Xu, X.-J., Yutong, S. O. N. G., Jiang, M., Meihan, L. I. U., Zhang, X., Dong-mei, W. A. N. G., Pan, Y., Ren, S., & Xiaoqiu, L. I. U. (2022) · Food Science and Technology · doi:10.1590/fst.19722 · Cited by 4 · see citing works
Şenol, N., Şahin, M., & Şahin, U. (2023) · Research in Veterinary Science · doi:10.1016/j.rvsc.2023.104987 · Cited by 4 · see citing works
Liu, Y., Liu, Y., Wang, X., Xiu, C., Hu, Y., Wang, J., Lei, Y., & Yang, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25253 · Cited by 4 · see citing works
Gvozdić, V., Kovač-Andrić, E., Kirchbaher, K., Ćorić, I., Užarević, Z., Jokić, S., & Pavić, V. (2025) · Green Processing and Synthesis · doi:10.1515/gps-2024-0235 · Cited by 3 · see citing works
Ma, X., Han, L., Xu, M., Feng, Y., Liu, C., Zhao, Y., Zhang, M., Xu, G., & Sun, X. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47110895 · Cited by 3 · see citing works
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac125.71257135 · Cited by 3 · see citing works
Overview of Fatty Acids and Volatiles in Selected Nuts: Their Composition and Analysis
Alagbe, G., Urbanová, K., & Alagbe, O. A. (2025) · Processes · doi:10.3390/pr13082444 · Cited by 2 · see citing works
Walnut Paste: A Healthy Alternative for Nutella Consumers
Covaliov, E., Siminiuc, R., & Popovici, V. (2023) · The Eurasia Proceedings of Health Environment and Life Sciences · doi:10.55549/ephels.49 · Cited by 2 · see citing works
Fatemeh Aghapour, S. K., & Sisakhtnezhad, S. (2021) · Jentashapir Journal of Cellular and Molecular Biology · doi:10.5812/jjcmb.115014 · Cited by 2 · see citing works
Azhar, R., Ali, S., Khan, H. F., Farooq, F., Noureen, F., & Anjum, A. F. (2021) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs2115123955 · Cited by 2 · see citing works
Dietary microRNAs in aging: sources, mechanisms, translational potential, and future directions
Xue, Y., Yin, R., Yin, L., Qin, R., Wang, X., Li, Y.-S., Zhang, C., & Wei, Y. (2025) · Food & Function · doi:10.1039/d5fo01825k · Cited by 1 · see citing works
Guo, T., Liu, J., Zhou, Q., Zheng, M., Huang, F., & Wan, C. (2024) · LWT · doi:10.1016/j.lwt.2024.116216 · Cited by 1 · see citing works
Nuts-Based Non-Alcoholic Drinks For A Healthy Diet
Жебо, А. В., & Zemliak, K. (2022) · The European Proceedings of Social & Behavioural Sciences · doi:10.15405/epsbs.2022.06.125
KILIÇLE, P. A., Koç, E., Sarı, E. K., Doğan, A., Asker, H., & Asker, Y. Y. (2024) · Journal of Advances in VetBio Science and Techniques · doi:10.31797/vetbio.1454981
Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics
Abaidullah, R., Ali, S., Summer, M., & Tahir, H. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01792-5
Real-Time Deep Learning-Based Object Detection for Walnut Processing
Mihajlov, I., Ivanovski, Z. A., & Pejchinoski, D. (2026) · Procedia Computer Science · doi:10.1016/j.procs.2026.02.172
Wille, A. P. B., Martins, C. C., da Motta, K. P., Paltian, J. J., MOURA, L. F., Sacramento, M., Prado, V. C., Alves, D. A. C., & Wilhelm, E. A. (2026) · Phosphorus, sulfur, and silicon and the related elements · doi:10.1080/10426507.2026.2652369
CHOUARI, K., Loukidi, B., Belyagoubi-Benhammou, N., Mokhtari-Soulimane, N. A., Yelles, N., Habi, S., Belyagoubi, L., D’Agostino, A., Canini, A., Marco, G. D., et al. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109614
Al‐Shaebi, E. M., Al‐Quraishy, S., Dkhil, M. A., Abdelmeguid, K. A., Santourlidis, S., Ghfar, A. A., Al-Selwey, W. A., & Abdel‐Gaber, R. (2026) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/1678-4162-13815
Zhao, L., Jia, S., Zhang, N., Li, C., Kang, K., Zhou, T., Wang, C., Wang, M., Li, D., & Tian, H. (2026) · International Dairy Journal · doi:10.1016/j.idairyj.2026.106843
Eraj, A., Khatoon, H., Sımjee, S. U., Aziz, A., & Aziz, S. (2026) · International Journal of Pharmacology · doi:10.31083/ijp54494
- Authors
- Rusu, M. E., Georgiu, C., Pop, A., Mocan, A., Kiss, B., Vostinaru, O., Fizesan, I., Stefan, M.-G., Gheldiu, A.-M., Mates, L., Moldovan, R., Muntean, D. M., Loghin, F., Vlase, L., & Popa, D.-S.
- Affiliations
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania
- Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania
- Corresponding author
- Pop, Anca
- Vlase, Laurian
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2020-05-14
- Volume
- 9
- Issue
- 5
- Pages
- 424
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7278598
- OpenAlex
- W3024245268
- Cited by
- 74
- References
- 60
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 13 · 2023: 16 · 2022: 13 · 2021: 16 · 2020: 2
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- walnut kernel, Juglans regia, D-galactose-induced aging, dietary antioxidant supplementation, oxidative stress, advanced glycation end products, acetylcholinesterase, neuroprotection, hypoglycemic effect, aging rats, age-related diseases, liver health
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review