The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling
Abstract
Aging is referred to progressive dysfunction of body organs, including the brain. This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells. Both in vivo and in vitro aging models were established using D-galactose (D-gal). The combination showed a trend to superiority over monotherapy in preventing aging in vivo and in vitro. Morris water maze test showed that NMN + Lyco effectively improved the ability of spatial location learning and memory of aging model rats. NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content. CCK-8 assay, senescence-associated β-galactosidase staining, and flow cytometer confirmed the cellular senescence of PC12 cells after exposing D-gal, and indicated the anti-senescence effect of NMN + Lyco in vitro. Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models. In total, NMN + Lyco protected rats and PC12 cells from cognitive impairment and cellular senescence induced by D-gal, of which effects might be linked to the reduction of oxidative stress and the activation of Keap1-Nrf2 signaling.
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The combination of lycopene with nicotinamide mononucleotide (NMN) is effective in reducing OS both in vitro and in vivo by enhancing the activity of SOD, CAT, GPx enzymes.
“Moreover, the combination of lycopene with the anti-aging compound nicotinamide mononucleotide (NMN) has proven effective in reducing OS both in vitro and in vivo by enhancing the activity of SOD, CAT, GPx enzymes [175].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [175]
The effect of lycopene with NMN, combined with activation of the Kaep1-Nrf2 antioxidant pathway, efficiently prevents cells to become senescent.
“This effect, combined with the activation of the Kaep1-Nrf2 antioxidant pathway, efficiently prevents cells to become senescent, therefore confirming the promising role of lycopene in improving the anti-aging effect of already established compounds [175].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [175]
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- Authors
- Liu, X., DILXAT, T., Shi, Q., Qiu, T., & Lin, J.
- Affiliations
- Xinjiang Agricultural Vocational and Technical University (CN)
- Corresponding author
- Liu, Xuxin
- ORCID
- Shi, Qiang
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 822
- Pages
- 146348
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W4213257899
- Cited by
- 34
- References
- 53
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 7
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- nicotinamide mononucleotide, lycopene, combination therapy, aging, D-galactose-induced aging, cognitive impairment, oxidative stress, Nrf2/Keap1 pathway, cellular senescence, PC12 cells, senescence-associated β-galactosidase, p53, p21, p16, spatial learning and memory, neuroprotection
- MeSH terms
- Kelch-Like ECH-Associated Protein 1, Lycopene, Morris Water Maze Test, Aging, Animals, Drug Therapy, Combination, Galactose, Gene Expression Regulation, Male, Nicotinamide Mononucleotide, Signal Transduction, PC12 Cells, Treatment Outcome, Oxidative Stress, NF-E2-Related Factor 2, Rats, Cognitive Dysfunction, Spatial Learning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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